Isabelle Lucet

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity

Valentin J Heim, Laura F Dagley, Che A Stafford, Fynn M Hansen, Elise Clayer, Aleksandra Bankovacki, Andrew Webb, Isabelle S Lucet, John Silke, Ueli Nachbur

Journal article  |  2020  |  EMBO Reports

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein.

Brad E Sleebs, Kate E Jarman, Sonja Frolich, Wilson Wong, Julie Healer, Weiwen Dai, Isabelle S Lucet, Danny W Wilson, Alan F Cowman

Journal article  |  2020  |  International Journal for Parasitology: Drugs and Drug Resistance

The P. falciparum parasite, responsible for the disease in humans known as malaria, must invade erythrocytes to provide an environ..

Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway

Catia L Pierotti, Maria C Tanzer, Annette Jacobsen, Joanne M Hildebrand, Jean-Marc Garnier, Pooja Sharma, Isabelle S Lucet, Angus D Cowan, Wilhelmus JA Kersten, Meng-Xiao Luo, Lung-Yu Liang, Cheree Fitzgibbon, Sarah E Garnish, Anne Hempel, Ueli Nachbur, David CS Huang, Peter E Czabotar, John Silke, Mark F van Delft, James M Murphy, et al.

Journal article  |  2020  |  ACS Chemical Biology

Necroptosis is an inflammatory form of programmed cell death that has been implicated in various human diseases. Compound 2 is a m..

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Wayland Yeung, Diane Coursier, Richard W Birkinshaw, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Isabelle S Lucet, James D Chalmers, Wayne M Patrick, Natarajan Kannan, Emma J Petrie, Peter E Czabotar, James M Murphy

Journal article  |  2020  |  Nature Communications

Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum

Hai TN Bui, Igor Niederwieser, Megan J Bird, Weiwen Dai, Nicolas MB Brancucci, Suzette Moes, Paul Jenoe, Isabelle S Lucet, Christian Doerig, Till S Voss

Journal article  |  2019  |  Scientific Reports

Previous studies in model eukaryotes have demonstrated that phosphorylation of heterochromatin protein 1 (HP1) is important for dy..

The PEAK family of pseudokinases, their role in cell signalling and cancer

Onisha Patel, Michael J Roy, James M Murphy, Isabelle S Lucet

Journal article  |  2019  |  The FEBS Journal

The study of pseudokinases has uncovered that catalysis-independent functions play a critical role in cell signalling regulation. ..

Eph receptor signalling: from catalytic to non-catalytic functions

Lung-Yu Liang, Onisha Patel, Peter W Janes, James M Murphy, Isabelle S Lucet

Journal article  |  2019  |  Oncogene

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy

Journal article  |  2019  |  Cell Reports

A Structural Perspective of the Pseudokinome: Defining the Targetable Space

Isabelle S Lucet, James M Murphy

Book Chapter  |  2019  |  RSC Drug Discovery Series

CHAPTER 13: A Structural Perspective of the Pseudokinome: Defining the Targetable Space

IS Lucet, JM Murphy

Book Chapter  |  2019  |  RSC Drug Discovery Series