Thushara Perera

Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis

G Noffs, FMC Boonstra, T Perera, H Butzkueven, SC Kolbe, F Maldonado, LE Cofre Lizama, MP Galea, J Stankovich, A Evans, A van Der Walt, AP Vogel

Journal article  |  2020  |  European Journal of Neurology

BACKGROUND AND PURPOSE: Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis..

Acoustic Speech Analytics Are Predictive of Cerebellar Dysfunction in Multiple Sclerosis

Gustavo Noffs, Frederique MC Boonstra, Thushara Perera, Scott C Kolbe, Jim Stankovich, Helmut Butzkueven, Andrew Evans, Adam P Vogel, Anneke van der Walt

Journal article  |  2020  |  The Cerebellum

Speech production relies on motor control and cognitive processing and is linked to cerebellar function. In diseases where the cer..

OnabotulinumtoxinA treatment for MS-tremor modifies fMRI tremor response in central sensory-motor integration areas

Frederique MC Boonstra, Andrew Evans, Gustavo Noffs, Thushara Perera, Vilija Jokubaitis, Jim Stankovich, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Scott C Kolbe, Anneke van der Walt

Journal article  |  2020  |  Multiple Sclerosis and Related Disorders

BACKGROUND: Treatment of tremor in MS is an unmet need. OnabotulinumtoxinA (BoNT-A) has shown promising results; however, little i..

Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis.

Frederique Mc Boonstra, Gustavo Noffs, Thushara Perera, Vilija G Jokubaitis, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Andrew Evans, Anneke van der Walt, Scott C Kolbe

Journal article  |  2020  |  Multiple Sclerosis Journal

BACKGROUND: Tremor is present in almost half of multiple sclerosis (MS) patients. The lack of understanding of its pathophysiology..

Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity

Nicholas C Sinclair, Hugh J McDermott, James B Fallon, Thushara Perera, Peter Brown, Kristian J Bulluss, Wesley Thevathasan

Journal article  |  2019  |  Neurobiology of Disease

Deep brain stimulation is an established therapy for Parkinson's disease; however, its effectiveness is hindered by limited unders..

SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION EVOKED RESONANT NEURAL ACTIVITY PREDICTS CLINICAL RESPONSE TO DBS

San San Xu, Nicholas C Sinclair, Kristian J Bulluss, Thushara Perera, Wee-Lih Lee, Hugh J McDermott, Wesley Theathasan

Conference Proceedings  |  2019  |  Journal of Neurology Neurosurgery & Psychiatry

A palm-worn device to quantify rigidity in Parkinson's disease

Thushara Perera, Wee-Lih Lee, Mary Jones, Joy L Tan, Elizabeth L Proud, Angus Begg, Nicholas C Sinclair, Richard Peppard, Hugh J McDermott

Journal article  |  2019  |  Journal of Neuroscience Methods

An Instrumented Pull Test to Characterize Postural Responses

Joy Tan, Wesley Thevathasan, Jennifer McGinley, Peter Brown, Thushara Perera

Journal article  |  2019  |  Journal of Visualized Experiments

An Instrumented Pull Test to Characterize Postural Responses (vol 146, e6331, 2019)

Joy Tan, Thushara Perera

Journal article  |  2019  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Objective evaluation of bradykinesia in Parkinson's disease using an inexpensive marker-less motion tracking system

Wee Lih Lee, Nicholas C Sinclair, Mary Jones, Joy L Tan, Elizabeth L Proud, Richard Peppard, Hugh J McDermott, Thushara Perera

Journal article  |  2019  |  Physiological Measurement