With expertise in electronic engineering and software development, Dr Thushara Perera develops clinical tools to help optimise and guide treatments for those afflicted with chronic neurological disorders. Much of Thushara’s work is focussed on developing precise instruments to quantify and track patient health.
Movement disorder symptoms such as tremor, rigidity, postural instability, and bradykinesia worsen over time and can fluctuate from day-to-day. A clinic visit only allows us to take a snapshot of the patient condition and makes it difficult to determine the best course of treatment. Additionally, clinical trials seeking to establish new therapies often lack monitoring tools to determine efficacy. Thushara is bridging the gap with his healthcare technology which could lead to in-home symptom assessments, similar to monitoring your blood pressure or glucose levels. This technology is currently being used in clinics across Melbourne to trial new therapies for Parkinson’s disease and Multiple Sclerosis. At the Bionics Institute, his instruments are used to inform the development of a next generation deep brain stimulator that can automatically adjust therapy to suit patient needs.Thushara has also contributed to the Bionic Vision project, developing the Institute’s bionic eye software platform allowing clinicians to send information to the retinal implant. He was part of the team that designed, manufactured and implanted a state-of-the-art bionic eye in Australia’s first human clinical trial. Witnessing the first bionic eye being successfully switched on and restoring rudimentary vision to a blind participant was one of the most memorable moments in Thushara’s career thus far.Prior to joining the Bionics Institute, Thushara completed his PhD at La Trobe University investigating a novel technique to monitor depth of anaesthesia in young children. He also worked part time as a Biomedical Engineer at the Royal Children’s Hospital redesigning a unique audiometer to test the hearing of children who have developmental problems.
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Thushara Perera's selected work
Improving A New Form Of Deep Brain Stimulation To Treat Gait And Balance Disturbance In Pa..
OnabotulinumtoxinA treatment for MS-tremor modifies fMRI tremor response in central sensor..
Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical..
Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontan..
SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION EVOKED RESONANT NEURAL ACTIVITY PREDICTS CLINIC..
Displaying the most recent project by Thushara Perera.
Displaying the 23 most recent scholarly works by Thushara Perera.
Acoustic Speech Analytics Are Predictive of Cerebellar Dysfunction in Multiple Sclerosis
Gustavo Noffs, Frederique MC Boonstra, Thushara Perera, Scott C Kolbe, Jim Stankovich, Helmut Butzkueven, Andrew Evans, Adam P Vogel, Anneke van der Walt
Journal article | 2020 | The Cerebellum
Speech production relies on motor control and cognitive processing and is linked to cerebellar function. In diseases where the cer..
OnabotulinumtoxinA treatment for MS-tremor modifies fMRI tremor response in central sensory-motor integration areas
Frederique MC Boonstra, Andrew Evans, Gustavo Noffs, Thushara Perera, Vilija Jokubaitis, Jim Stankovich, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Scott C Kolbe, Anneke van der Walt
Journal article | 2020 | Multiple Sclerosis and Related Disorders
BACKGROUND: Treatment of tremor in MS is an unmet need. OnabotulinumtoxinA (BoNT-A) has shown promising results; however, little i..
Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis.
Frederique Mc Boonstra, Gustavo Noffs, Thushara Perera, Vilija G Jokubaitis, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Andrew Evans, Anneke van der Walt, Scott C Kolbe
Journal article | 2020 | Multiple Sclerosis Journal
BACKGROUND: Tremor is present in almost half of multiple sclerosis (MS) patients. The lack of understanding of its pathophysiology..
Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity
Nicholas C Sinclair, Hugh J McDermott, James B Fallon, Thushara Perera, Peter Brown, Kristian J Bulluss, Wesley Thevathasan
Journal article | 2019 | Neurobiology of Disease
Deep brain stimulation is an established therapy for Parkinson's disease; however, its effectiveness is hindered by limited unders..
SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION EVOKED RESONANT NEURAL ACTIVITY PREDICTS CLINICAL RESPONSE TO DBS
San San Xu, Nicholas C Sinclair, Kristian J Bulluss, Thushara Perera, Wee-Lih Lee, Hugh J McDermott, Wesley Theathasan
Conference Proceedings | 2019 | Journal of Neurology, Neurosurgery & Psychiatry
Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging
Andreas Horn, Ningfei Li, Till A Dembek, Ari Kappel, Chadwick Boulay, Siobhan Ewert, Anna Tietze, Andreas Husch, Thushara Perera, Wolf-Julian Neumann, Marco Reisert, Hang Si, Robert Oostenveld, Christopher Rorden, Fang-Cheng Yeh, Qianqian Fang, Todd M Herrington, Johannes Vorwerk, Andrea A Kuehn
Journal article | 2019 | NeuroImage
Validation of a precision tremor measurement system for multiple sclerosis
Thushara Perera, Wee-Lih Lee, Shivanthan AC Yohanandan, Nguyen Ai-Lan, Belinda Cruse, Frederique MC Boonstra, Gustavo Noffs, Adam P Vogel, Scott C Kolbe, Helmut Butzkueven, Andrew Evans, Anneke van der Walt
Journal article | 2019 | JOURNAL OF NEUROSCIENCE METHODS
What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis
Gustavo Noffs, Thushara Perera, Scott C Kolbe, Camille J Shanahan, Frederique MC Boonstra, Andrew Evans, Helmut Butzkueven, Anneke van der Walt, Adam P Vogel
Journal article | 2018 | AUTOIMMUNITY REVIEWS
Balance control systems in Parkinson's disease and the impact of pedunculopontine area stimulation
Thushara Perera, Joy L Tan, Michael H Cole, Shivy AC Yohanandan, Paul Silberstein, Raymond Cook, Richard Peppard, Tipu Aziz, Terry Coyne, Peter Brown, Peter A Silburn, Wesley Thevathasan
Journal article | 2018 | Brain
Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor
Frederique MC Boonstra, Thushara Perera, Gustavo Noffs, Cassandra Marotta, Adam P Vogel, Andrew H Evans, Helmut Butzkueven, Bradford A Moffat, Anneke van der Walt, Scott C Kolbe
Journal article | 2018 | FRONTIERS IN NEUROLOGY
Identification of Characters and Localization of Images Using Direct Multiple-Electrode Stimulation With a Suprachoroidal Retinal Prosthesis
Mohit N Shivdasani, Nicholas C Sinclair, Lisa N Gillespie, Matthew A Petoe, Samuel A Titchener, James B Fallon, Thushara Perera, Darien Pardinas-Diaz, Nick M Barnes, Peter J Blarney
Journal article | 2017 | Investigative Opthalmology & Visual Science
Clinical validation of a precision electromagnetic tremor measurement system in participants receiving deep brain stimulation for essential tremor
Thushara Perera, Shivanthan AC Yohanandan, Wesley Thevathasan, Mary Jones, Richard Peppard, Andrew H Evans, Joy L Tan, Colette M McKay, Hugh J McDermott
Journal article | 2016 | Physiological Measurement
The feasibility of using acoustic markers of speech for optimizing patient outcomes during randomized amplitude variation in deep brain stimulation: a proof of principle methods study
A Vogel, H Mcdermott, T Perera, M Jones, R Peppard, C McKay
Journal article | 2015 | Frontiers of Bioengineering and Biotechnology
Background: Deep brain stimulation (DBS) is an effective treatment for reducing symptoms of tremor. A common and typically subject..
Honours, Awards and Fellowships
Leadership in Innovation & Research Translation
2017 Emerging Health Researcher Finalist
Victoria Fellowship in Life Sciences
Harold Mitchell Travelling Fellowship
Medical Bionics Department
La Trobe University
Paediatric depth of anaesthesia monitoring
La Trobe University & Murdoch Children's Research Institute
La Trobe University