Stefano Mangiola

A Transcriptional Signature of IL-2 Expanded Natural Killer Cells Predicts More Favorable Prognosis in Bladder Cancer

Yuhan Sun, Alexander James Sedgwick, Md Abdullah-Al-Kamran Khan, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Activation of natural killer (NK) cell function is regulated by cytokines, such as IL-2, and secreted factors upregulated in the t..

A Transcriptional Signature of PDGF-DD Activated Natural Killer Cells Predicts More Favorable Prognosis in Low-Grade Glioma

Yuhan Sun, Alexander James Sedgwick, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

The binding of platelet-derived growth factor D (PDGF-DD) to the NKp44 receptor activates a distinct transcriptional program in pr..

Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression

Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G Williams, Anthony J Costello, Paul J Neeson, Bhupinder Pal, Nicholas D Huntington, et al.

Journal article  |  2021  |  BMC CANCER

BACKGROUND: Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings ..

Interfacing Seurat with the R tidy universe

Stefano Mangiola, Maria A Doyle, Anthony T Papenfuss

Journal article  |  2021  |  BIOINFORMATICS

MOTIVATION: Seurat is one of the most popular software suites for the analysis of single-cell RNA sequencing data. Considering the..

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

Jean Berthelet, Verena C Wimmer, Holly J Whitfield, Antonin Serrano, Thomas Boudier, Stefano Mangiola, Michal Merdas, Farrah El-Saafin, David Baloyan, Jordan Wilcox, Steven Wilcox, Adam C Parslow, Anthony T Papenfuss, Belinda Yeo, Matthias Ernst, Bhupinder Pal, Robin L Anderson, Melissa J Davis, Kelly L Rogers, Frederic Hollande, et al.

Journal article  |  2021  |  SCIENCE ADVANCES

Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in ..

MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer

Patrick McCoy, Stefano Mangiola, Geoff Macintyre, Ryan Hutchinson, Ben Tran, Bernard Pope, Peter Georgeson, Matthew KH Hong, Natalie Kurganovs, Sebastian Lunke, Michael J Clarkson, Marek Cmero, Michael Kerger, Ryan Stuchbery, Ken Chow, Izhak Haviv, Andrew Ryan, Anthony J Costello, Niall M Corcoran, Christopher M Hovens

Journal article  |  2021  |  PROSTATE CANCER AND PROSTATIC DISEASES

BACKGROUND: Recent publications have shown patients with defects in the DNA mismatch repair (MMR) pathway driven by either MSH2 or..

Loss of SNAI2 in Prostate Cancer Correlates With Clinical Response to Androgen Deprivation Therapy

Marek Cmero, Natalie J Kurganovs, Ryan Stuchbery, Patrick McCoy, Corrina Grima, Anne Ngyuen, Ken Chow, Stefano Mangiola, Geoff Macintyre, Nicholas Howard, Michael Kerger, Philip Dundee, Paul Ruljancich, David Clarke, Jeremy Grummet, Justin S Peters, Anthony J Costello, Sam Norden, Andrew Ryan, Phillip Parente, et al.

Journal article  |  2021  |  JCO PRECISION ONCOLOGY

PURPOSE: Androgen receptor (AR) signaling is important in prostate cancer progression, and therapies that target this pathway have..

Prognostic Utility of a Whole-blood Androgen Receptor-based Gene Signature in Metastatic Castration-resistant Prostate Cancer

Edmond M Kwan, Heidi Fettke, Maria M Docanto, Sarah Q To, Patricia Bukczynska, Andrew Mant, David Pook, Nicole Ng, Lisa-Jane K Graham, Stefano Mangiola, Eva Segelov, Kate Mahon, Ian D Davis, Phillip Parente, Carmel Pezaro, Tilman Todenhoefer, Lisa G Horvath, Arun A Azad

Journal article  |  2021  |  EUROPEAN UROLOGY FOCUS

BACKGROUND: The treatment paradigm for metastatic castration-resistant prostate cancer (mCRPC) has evolved significantly in recent..

Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma

Emily J Lelliott, Stefano Mangiola, Kelly M Ramsbottom, Magnus Zethoven, Lydia Lim, Peter KH Lau, Amanda J Oliver, Luciano G Martelotto, Laura Kirby, Claire Martin, Riyaben P Patel, Alison Slater, Carleen Cullinane, Anthony T Papenfuss, Nicole M Haynes, Grant A McArthur, Jane Oliaro, Karen E Sheppard

Journal article  |  2021  |  CANCER IMMUNOLOGY RESEARCH

Combined inhibition of BRAF, MEK, and CDK4/6 is currently under evaluation in clinical trials for patients with melanoma harboring..

tidybulk: an R tidy framework for modular transcriptomic data analysis

Stefano Mangiola, Ramyar Molania, Ruining Dong, Maria A Doyle, Anthony T Papenfuss

Journal article  |  2021  |  GENOME BIOLOGY

Recently, efforts have been made toward the harmonization of transcriptomic data structures and workflows using the concept of dat..