Ghazaleh Dashti

Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis

S Ghazaleh Dashti, Dallas R English, Julie A Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Anne Tjonneland, Jytte Halkjaer, Christina C Dahm, Helene Tilma Vistisen, Florence Menegaux, Vittorio Perduca, Gianluca Severi, Krasimira Aleksandrova, Matthias B Schulze, Giovanna Masala, Sabina Sieri, Rosario Tumino, et al.

Journal article  |  2021  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Adiposity increases endometrial cancer risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens..

Explaining the link between adiposity and colorectal cancer risk in men and postmenopausal women in the UK Biobank: A sequential causal mediation analysis

S Ghazaleh Dashti, Vivian Viallon, Julie A Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Dallas R English, Marc J Gunter, Neil Murphy

Journal article  |  2020  |  International Journal of Cancer

Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Using UK Biobank data, we investi..

Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC cohort

Nada Assi, Sabina Rinaldi, Vivian Viallon, S Ghazaleh Dashti, Laure Dossus, Agnes Fournier, Iris Cervenka, Marina Kvaskoff, Renee Turzanski-Fortner, Manuela Bergmann, Heiner Boeing, Salvatore Panico, Fulvio Ricceri, Domenico Palli, Rosario Tumino, Sara Grioni, Maria Jose Sanchez Perez, Maria-Dolores Chirlaque, Catalina Bonet, Aurelio Barricarte Gurrea, et al.

Journal article  |  2020  |  International Journal of Cancer

Alcohol consumption is associated with higher risk of breast cancer (BC); however, the biological mechanisms underlying this assoc..

Explaining the mechanisms underlying the effect of adiposity on the risk of colorectal, postmenopausal breast, and endometrial cancer using data from four prospective cohort studies

Seyedeh Ghazaleh Dashti

Thesis / Dissertation  |  2020

Background Excess adiposity in adulthood is an established risk factor for several types of cancer, including colorectal, estroge..

Sedentary Behavior and Chronic Disease: Mechanisms and Future Directions

Paddy C Dempsey, Chuck E Matthews, S Ghazaleh Dashti, Aiden R Doherty, Audrey Bergouignan, Eline H van Roekel, David W Dunstan, Nicholas J Wareham, Thomas E Yates, Katrien Wijndaele, Brigid M Lynch

Journal article  |  2020  |  Journal of Physical Activity and Health

BACKGROUND: Recent updates to physical activity guidelines highlight the importance of reducing sedentary time. However, at presen..

Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome

S Ghazaleh Dashti, Wing Yan Li, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Finlay A Macrae, Graham G Giles, Sheetal Hardikar, Xinwei Hua, Stephen N Thibodeau, Jane C Figueiredo, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, John D Potter, Noralane M Lindor, John L Hopper, et al.

Journal article  |  2019  |  British Journal of Cancer

BACKGROUND: Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colore..

Adiposity and estrogen receptor-positive, postmenopausal breast cancer risk: Quantification of the mediating effects of fasting insulin and free estradiol.

S Ghazaleh Dashti, Julie A Simpson, Amalia Karahalios, Vivian Viallon, Margarita Moreno-Betancur, Lyle C Gurrin, Robert J MacInnis, Brigid M Lynch, Laura Baglietto, Howard A Morris, Marc J Gunter, Pietro Ferrari, Roger L Milne, Graham G Giles, Dallas R English

Journal article  |  2019  |  International Journal of Cancer

Adiposity increases estrogen receptor (ER)-positive postmenopausal breast cancer risk. While mechanisms underlying this relationsh..

Physical activity and the risk of colorectal cancer in Lynch syndrome

S Ghazaleh Dashti, Aung Ko Win, Sheetal S Hardikar, Stephen E Glombicki, Sheila Mallenahalli, Selvi Thirumurthi, Susan K Peterson, Y Nancy You, Daniel D Buchanan, Jane C Figueiredo, Peter T Campbell, Steven Gallinger, Polly A Newcomb, John D Potter, Noralane M Lindor, Loic Le Marchand, Robert W Haile, John L Hopper, Mark A Jenkins, Karen M Basen-Engquist, et al.

Journal article  |  2018  |  International Journal of Cancer

Greater physical activity is associated with a decrease in risk of colorectal cancer for the general population; however, little i..

Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers

S Ghazaleh Dashti, Daniel D Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Finlay A Macrae, Graham G Giles, Susan Parry, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Stephen N Thibodeau, Noralane M Lindor, Polly A Newcomb, John D Potter, John A Baron, John L Hopper, et al.

Journal article  |  2017  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For..

Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study

Harindra Jayasekara, Jeanette C Reece, Daniel D Buchanan, Christophe Rosty, S Ghazaleh Dashti, Driss Ait Ouakrim, Ingrid M Winship, Finlay A Macrae, Alex Boussioutas, Graham G Giles, Dennis J Ahnen, Jan Lowery, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, Noralane M Lindor, John L Hopper, Susan Parry, et al.

Journal article  |  2016  |  INTERNATIONAL JOURNAL OF CANCER