Kirsten Fairfax

The effects of B-cell-activating factor on the population size, maturation and function of murine natural killer cells

Pin Shie Quah, Vivien Sutton, Eden Whitlock, William A Figgett, Daniel M Andrews, Kirsten A Fairfax, Fabienne Mackay

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

The role of B-cell-activating factor (BAFF) in B-lymphocyte biology has been comprehensively studied, but its contributions to inn..

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease

Seyhan Yazar, Jose Alquicira-Hernandez, Kristof Wing, Anne Senabouth, M Grace Gordon, Stacey Andersen, Qinyi Lu, Antonia Rowson, Thomas RP Taylor, Linda Clarke, Katia Maccora, Christine Chen, Anthony L Cook, Chun Jimmie Ye, Kirsten A Fairfax, Alex W Hewitt, Joseph E Powell

Journal article  |  2022  |  SCIENCE

The human immune system displays substantial variation between individuals, leading to differences in susceptibility to autoimmune..

Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

Lahiru Gangoda, Robyn L Schenk, Sarah A Best, Christina Nedeva, Cynthia Louis, Damian B D'Silva, Kirsten Fairfax, Andrew G Jarnicki, Hamsa Puthalakath, Kate D Sutherland, Andreas Strasser, Marco J Herold

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Inflammation is a natural defence mechanism of the body to protect against pathogens. It is induced by immune cells, such as macro..

A new lymphoid-primed progenitor marked byDach1downregulation identified with single cell multi-omics

Daniela Amann-Zalcenstein, Luyi Tian, Jaring Schreuder, Sara Tomei, Dawn S Lin, Kirsten A Fairfax, Jessica E Bolden, Mark D McKenzie, Andrew Jarratt, Adrienne Hilton, Jacob T Jackson, Ladina Di Rago, Matthew P McCormack, Carolyn A de Graaf, Olivia Stonehouse, Samir Taoudi, Warren S Alexander, Stephen L Nutt, Matthew E Ritchie, Ashley P Ng, et al.

Journal article  |  2020  |  NATURE IMMUNOLOGY

A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-rest..

ImmGen at 15

Stephanie Vargas Aguilar, Oscar Aguilar, Rhys Allan, El Ad David Amir, Veronique Angeli, Maxim N Artyomov, Natasha Asinovski, Jilian Astarita, K Frank Austen, Geetika Bajpai, Nora Barrett, Alev Baysoy, Christophe Benoist, Angelique Bellemare-Pelletier, Brad Berg, Adam Best, Natalie Bezman, David Blair, Julie M Blander, Milena Bogunovic, et al.

Journal article  |  2020  |  NATURE IMMUNOLOGY

The role of BAFF in the biology of NK cells

PS Quah, K Fairfax, D Andrews, F Mackay

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2019  |  NUCLEIC ACIDS RESEARCH

During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many..

Fluorescent antibiotics, vomocytosis, vaccine candidates and the inflammasome

Rachel J Lundie, Karla J Helbig, Jaclyn S Pearson, Kirsten A Fairfax

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

This article summarises recent advances reported at the 9th Lorne Infection and Immunity Conference. This exciting conference host..

Identification of a Siglec-F plus granulocyte-macrophage progenitor

Jessica E Bolden, Erin C Lucas, Geyu Zhou, Jeremy A O'Sullivan, Carolyn A de Graaf, Mark D McKenzie, Ladina Di Rago, Tracey M Baldwin, Jake Shortt, Warren S Alexander, Bruce S Bochner, Matthew E Ritchie, Douglas J Hilton, Kirsten A Fairfax

Journal article  |  2018  |  JOURNAL OF LEUKOCYTE BIOLOGY

In recent years multi-parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pl..

Transcriptional profiling of eosinophil subsets in interleukin-5 transgenic mice

Kirsten A Fairfax, Jessica E Bolden, Aaron J Robinson, Erin C Lucas, Tracey M Baldwin, Kerry A Ramsay, Rebecca Cole, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2018  |  JOURNAL OF LEUKOCYTE BIOLOGY

Eosinophils are important in fighting parasitic infections and are implicated in the pathogenesis of asthma and allergy. IL-5 is a..