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Ms

Simone Park

Research Fellow
Microbiology And Immunology
science & technology
life sciences & biomedicine
immunology
animals
cd8-positive t-lymphocytes
rm cells
immunologic memory
mice
humans
Simone Park's Profile Picture
Ms

Simone Park

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
T cell immunology
Simone Park's Profile Picture
Ms

Simone Park

 

Simone is an NHMRC Emerging Leadership Postdoctoral Fellow in the L. Mackay Laboratory at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne. She completed a highly successful PhD in 2019, during which she uncovered important roles for immune cells known as tissue-resident memory T cells in protection against cancer and viral infections.

Simone's exceptional research achievements have led to her publishing first-author papers in leading scientific journals including Nature and Nature Immunology, and resulted in her receiving multiple competitive awards including the Centenary Institute Medical Innovation Award (In Memory of Neil Lawrence Prize), VCCC Picchi Award for Excellence in Cancer Research (Basic Science), QIAGEN PhD Achievement Award for top PhD student, American Association of Immunologists Trainee Achievement Award and the Morgan Mansell Young Melanoma Researcher of the Year Award (2019).

Projects

Displaying the 5 most recent projects by Simone Park.

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Targeting Tissue-Resident Memory T Cells In Cancer Immunotherapy

2020 - 2021
Active
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Tissue-Resident Memory T Cells In Solid Cancer Immunotherapy

2020 - 2024
Active
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Identifying Regulators Of Tissue-Resident Memory T Cell Development In Cancer

2020 - 2021
Active
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In Memory Of Neil Lawrence Prize

2019 - 2019
Completed
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Targeting Tissue-Resident Cd8+ Memory T Cells Using Immunotherapies

2019 - 2019
Completed

5

Projects

Project Types

3

Research Grant

1

Internal Research Grant

1

Research Contracts

Scholarly Works

Displaying the 12 most recent scholarly works by Simone Park.

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Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions

Jason A Trubiano, Claire L Gordon, Clara Castellucci, Susan N Christo, Simone L Park, Effie Mouhtouris, Katherine Konvinse, Morgan Rose, Michelle Goh, Alan S Boyd, Elizabeth J Phillips, Laura K Mackay

Journal article  |  2020  |  Journal of Investigative Dermatology

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Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes

H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay

Journal article  |  2020  |  Science Immunology

Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..

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PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

Journal article  |  2020  |  The EMBO Journal

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Bhlhe40 Keeps Resident T Cells Too Fit to Quit

Simone L Park, Laura K Mackay

Journal article  |  2019  |  Immunity

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PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis

Journal article  |  2019

ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..

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Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Simone L Park, Thomas Gebhardt, Laura K Mackay

Journal article  |  2019  |  Trends in Immunology

Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without r..

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TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.

Journal article  |  2019  |  Journal of Experimental Medicine

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Tissue-resident memory T cells orchestrate tumour-immune equilibrium.

Simone L Park, Laura K Mackay, Jason Waithman, Thomas Gebhardt

Journal article  |  2019  |  Cell Stress

The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune ce..

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Tissue-resident memory CD8( ) T cells promote melanoma-immune equilibrium in skin

Simone L Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S Wilmott, Richard A Scolyer, Thomas Tueting, Umaimainthan Palendria, David Gyorki, Scott N Mueller, Nicholas D Huntington, Sammy Bedoui, Michael Hoelzel, Laura K Mackay, et al.

Journal article  |  2019  |  Nature

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Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay

Journal article  |  2018  |  Nature Immunology

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PD-1: always on my mind

Simone L Park, Laura K Mackay

Journal article  |  2017  |  Immunology & Cell Biology

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Distinct recirculation potential of CD69( )CD103(-) and CD103( ) thymic memory CD8( ) T cells

Simone L Park, Laura K Mackay, Thomas Gebhardt

Journal article  |  2016  |  Immunology & Cell Biology

12

Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)
Immunology
Oncology and Carcinogenesis
Clinical Sciences
Expanding Knowledge

Honours, Awards and Fellowships

2019

Morgan Mansell Young Victorian Melanoma Researcher of the Year Award

Melanoma Research Victoria
2019

Centenary Institute Medical Innovation Award (1st Place)

Centenary Institute of Medical Research
2019

American Association of Immunologists-Thermofisher Trainee Achievement Award

American Association of Immunologists
2018

Qiagen PhD Achievement Award

Dept. Microbiology & Immunology
2018

Picchi Award for Excellence in Cancer Research (Basic Science)

Victorian Comprehensive Cancer Center/Picchi Foundation
2020

NHMRCF - NHMRC Fellowship

2019

NOTINLIST - Not in List

7

Awards

Credentials

Positions

Research Fellow

Microbiology And Immunology

Member

American Association of Immunologists

Member

Australasian Society for Immunology

Education

Doctor of Philosophy (Immunology)

University of Melbourne

Bachelor of Science (Honours)

University of Melbourne

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