Simone is an NHMRC Emerging Leadership Postdoctoral Fellow in the L. Mackay Laboratory at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne. She completed a highly successful PhD in 2019, during which she uncovered important roles for immune cells known as tissue-resident memory T cells in protection against cancer and viral infections.
Simone's exceptional research achievements have led to her publishing first-author papers in leading scientific journals including Nature and Nature Immunology, and resulted in her receiving multiple competitive awards including the Centenary Institute Medical Innovation Award (In Memory of Neil Lawrence Prize), VCCC Picchi Award for Excellence in Cancer Research (Basic Science), QIAGEN PhD Achievement Award for top PhD student, American Association of Immunologists Trainee Achievement Award and the Morgan Mansell Young Melanoma Researcher of the Year Award (2019).
Find out more about Simone Park's experience
Simone Park's highlights
Simone Park's selected work
Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphoc..
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficac..
Identifying Regulators Of Tissue-Resident Memory T Cell Development In Cancer
Internal Research Grant
Displaying the 5 most recent projects by Simone Park.
Internal Research Grant
Displaying the 12 most recent scholarly works by Simone Park.
Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions
Jason A Trubiano, Claire L Gordon, Clara Castellucci, Susan N Christo, Simone L Park, Effie Mouhtouris, Katherine Konvinse, Morgan Rose, Michelle Goh, Alan S Boyd, Elizabeth J Phillips, Laura K Mackay
Journal article | 2020 | Journal of Investigative Dermatology
Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes
H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay
Journal article | 2020 | Science Immunology
Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours
Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis
Journal article | 2020 | The EMBO Journal
PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours
Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis
Journal article | 2019
ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..
TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis
Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.
Journal article | 2019 | Journal of Experimental Medicine
Tissue-resident memory T cells orchestrate tumour-immune equilibrium.
Simone L Park, Laura K Mackay, Jason Waithman, Thomas Gebhardt
Journal article | 2019 | Cell Stress
The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune ce..
Tissue-resident memory CD8( ) T cells promote melanoma-immune equilibrium in skin
Simone L Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S Wilmott, Richard A Scolyer, Thomas Tueting, Umaimainthan Palendria, David Gyorki, Scott N Mueller, Nicholas D Huntington, Sammy Bedoui, Michael Hoelzel, Laura K Mackay, et al.
Journal article | 2019 | Nature
Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses
Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay
Journal article | 2018 | Nature Immunology
Honours, Awards and Fellowships
Morgan Mansell Young Victorian Melanoma Researcher of the Year Award
Centenary Institute Medical Innovation Award (1st Place)
American Association of Immunologists-Thermofisher Trainee Achievement Award
Qiagen PhD Achievement Award
Picchi Award for Excellence in Cancer Research (Basic Science)
NHMRCF - NHMRC Fellowship
NOTINLIST - Not in List
Microbiology And Immunology
American Association of Immunologists
Australasian Society for Immunology
Doctor of Philosophy (Immunology)
University of Melbourne
Bachelor of Science (Honours)
University of Melbourne