Simone Park

Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

Yannick O Alexandre, Sapna Devi, Simone L Park, Laura K Mackay, William R Heath, Scott N Mueller

Journal article  |  2020  |  Cell Reports

Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered..

Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions

Jason A Trubiano, Claire L Gordon, Clara Castellucci, Susan N Christo, Simone L Park, Effie Mouhtouris, Katherine Konvinse, Morgan Rose, Michelle Goh, Alan S Boyd, Elizabeth J Phillips, Laura K Mackay

Journal article  |  2020  |  Journal of Investigative Dermatology

Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes

H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay

Journal article  |  2020  |  Science Immunology

Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

Journal article  |  2020  |  The EMBO Journal

Bhlhe40 Keeps Resident T Cells Too Fit to Quit

Simone L Park, Laura K Mackay

Journal article  |  2019  |  Immunity

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis

Journal article  |  2019

ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Simone L Park, Thomas Gebhardt, Laura K Mackay

Journal article  |  2019  |  Trends in Immunology

Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without r..

TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.

Journal article  |  2019  |  Journal of Experimental Medicine

Tissue-resident memory T cells orchestrate tumour-immune equilibrium

Simone L Park, Laura K Mackay, Jason Waithman, Thomas Gebhardt

Journal article  |  2019  |  Cell Stress

The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune ce..

Tissue-resident memory CD8( ) T cells promote melanoma-immune equilibrium in skin

Simone L Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S Wilmott, Richard A Scolyer, Thomas Tueting, Umaimainthan Palendria, David Gyorki, Scott N Mueller, Nicholas D Huntington, Sammy Bedoui, Michael Hoelzel, Laura K Mackay, et al.

Journal article  |  2019  |  Nature