Simone Park

Tissue-resident memory T (T-RM) cells: Front-line workers of the immune system

Maleika Osman, Simone LL Park, Laura KK Mackay

Journal article  |  2023  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-resident memory T (TRM ) cells play a vital role in local immune protection against infection and cancer. The location of T..

Runx3 drives a CD8( ) T cell tissue residency program that is absent in CD4( ) T cells

Raissa Fonseca, Thomas N Burn, Luke C Gandolfo, Sapna Devi, Simone L Park, Andreas Obers, Maximilien Evrard, Susan N Christo, Frank A Buquicchio, Caleb A Lareau, Keely M McDonald, Sarah K Sandford, Natasha M Zamudio, Nagela G Zanluqui, Ali Zaid, Terence P Speed, Ansuman T Satpathy, Scott N Mueller, Francis R Carbone, Laura K Mackay

Journal article  |  2022  |  NATURE IMMUNOLOGY

Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized infections. While the transcription fac..

ICOS-play: dressing T cells for residency

Simone LL Park, Susan NN Christo, Laura KK Mackay

Journal article  |  2022  |  TRENDS IN IMMUNOLOGY

Efficient generation of tissue-resident memory T (TRM) cells is essential for long-lived immune protection in barrier tissues. Pen..

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes

Maximilien Evrard, Erica Wynne-Jones, Changwei Peng, Yu Kato, Susan N Christo, Raissa Fonseca, Simone L Park, Thomas N Burn, Maleika Osman, Sapna Devi, Jerold Chun, Scott N Mueller, George Kannourakis, Stuart P Berzins, Daniel G Pellicci, William R Heath, Stephen C Jameson, Laura K Mackay

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T (TRM) cells provide long-lasting immune protection. One of the key events controlling TRM cell developmen..

Decoding Tissue-Residency: Programming and Potential of Frontline Memory T Cells

Simone L Park, Laura K Mackay

Journal article  |  2021  |  COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Memory T-cell responses are partitioned between the blood, secondary lymphoid organs, and nonlymphoid tissues. Tissue-resident mem..

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various org..

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

Yannick O Alexandre, Sapna Devi, Simone L Park, Laura K Mackay, William R Heath, Scott N Mueller

Journal article  |  2020  |  CELL REPORTS

Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered..

Analysis of Skin-Resident Memory T Cells Following Drug Hypersensitivity Reactions

Jason A Trubiano, Claire L Gordon, Clara Castellucci, Susan N Christo, Simone L Park, Effie Mouhtouris, Katherine Konvinse, Morgan Rose, Michelle Goh, Alan S Boyd, Elizabeth J Phillips, Laura K Mackay

Journal article  |  2020  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Organ-specific isoform selection of fatty acid binding proteins in tissue-resident lymphocytes

Raissa Fonseca, Hannah Frizzell, Susan Christo, Maximilien Evrard, Simone L Park, David Freestone, Laura K Mackay

Journal article  |  2020  |  The Journal of Immunology

Abstract Tissue-resident memory T (TRM) cells exist throughout the body where they are poised to mediate local immu..