Moira O'Bryan

Lifestyle and environmental risk factors for unexplained male infertility: study protocol for Australian Male Infertility Exposure (AMIE), a case-control study.

Sarah N Biggs, Joanne Kennedy, Sharon L Lewis, Stephen Hearps, Moira K O'Bryan, Robert McLachlan, Simon von Saldern, Georgina Chambers, Jane Halliday

Journal article  |  2023  |  Reprod Health

BACKGROUND: Approximately 1 in 20 men are sub-fertile or infertile yet the aetiologies of male infertility remain largely unexplai..

Diverse monogenic subforms of human spermatogenic failure.

Liina Nagirnaja, Alexandra M Lopes, Wu-Lin Charng, Brian Miller, Rytis Stakaitis, Ieva Golubickaite, Alexandra Stendahl, Tianpengcheng Luan, Corinna Friedrich, Eisa Mahyari, Eloise Fadial, Laura Kasak, Katinka Vigh-Conrad, Manon S Oud, Miguel J Xavier, Samuel R Cheers, Emma R James, Jingtao Guo, Timothy G Jenkins, Antoni Riera-Escamilla, et al.

Journal article  |  2022  |  Nat Commun

Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable. Defining the genetic basis ..

The metabolic health of young men conceived using intracytoplasmic sperm injection

SR Catford, J Halliday, S Lewis, MK O'Bryan, DJ Handelsman, RJ Hart, J McBain, L Rombauts, DJ Amor, R Saffery, R McLachlan

Journal article  |  2022  |  HUMAN REPRODUCTION

STUDY QUESTION: Is the metabolic health of men conceived using ICSI different to that of IVF and spontaneously conceived (SC) men?..

Zinc finger RNA binding protein 2 (ZFR2) is not required for male fertility in the mouse

Lachlan M Cauchi, Brendan J Houston, Liina Nagirnaja, Anne E O'Connor, D Jo Merriner, Kenneth Aston, Peter N Schlegel, Don F Conrad, Richard Burke, Moira K O'Bryan

Journal article  |  2022  |  DEVELOPMENTAL BIOLOGY

BACKGROUND: Thousands of genes are expressed during spermatogenesis and male infertility has a strong genetic component. Within th..

Sperm Syringe: 3D Sorting Platform for Assisted Reproduction (Adv. Mater. Technol. 9/2022)

Farin Yazdan Parast, Moira K O'Bryan, Reza Nosrati

Journal article  |  2022  |  Advanced Materials Technologies

Large-scale analyses of the X chromosome in 2,354 infertile men discover recurrently affected genes associated with spermatogenic failure

Antoni Riera-Escamilla, Matthias Vockel, Liina Nagirnaja, Miguel J Xavier, Albert Carbonell, Daniel Moreno-Mendoza, Marc Pybus, Ginevra Farnetani, Viktoria Rosta, Francesca Cioppi, Corinna Friedrich, Manon S Oud, Godfried W van der Heijden, Armin Soave, Thorsten Diemer, Elisabet Ars, Josvany Sanchez-Curbelo, Sabine Kliesch, Moira K O'Bryan, Eduard Ruiz-Castane, et al.

Journal article  |  2022  |  AMERICAN JOURNAL OF HUMAN GENETICS

Although the evolutionary history of the X chromosome indicates its specialization in male fitness, its role in spermatogenesis ha..

DDB1-and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice

Brendan J Houston, Alexandra M Lopes, Maris Laan, Liina Nagirnaja, Anne E O'Connor, D Jo Merriner, Joseph Nguyen, Margus Punab, Antoni Riera-Escamilla, Csilla Krausz, Kenneth Ivan Aston, Donald F Conrad, Moira K O'Bryan

Journal article  |  2022  |  DEVELOPMENTAL BIOLOGY

Male infertility is a common condition affecting at least 7% of men worldwide and is often genetic in origin. Using whole exome se..

Actionable secondary findings following exome sequencing of 836 non-obstructive azoospermia cases and their value in patient management.

Laura Kasak, Kristiina Lillepea, Liina Nagirnaja, Kenneth I Aston, Peter N Schlegel, João Gonçalves, Filipa Carvalho, Daniel Moreno-Mendoza, Kristian Almstrup, Michael L Eisenberg, Keith A Jarvi, Moira K O'Bryan, Alexandra M Lopes, Donald F Conrad, undefined GEMINI Consortium, Margus Punab, Maris Laan

Journal article  |  2022  |  Hum Reprod

STUDY QUESTION: What is the load, distribution and added clinical value of secondary findings (SFs) identified in exome sequencing..

P-094 Fundamental understanding of sperm motion in viscoelastic media

F Yazdan Parast, AS Gaikwad, S Veeraragavan, S Powar, R Prabhakar, MK O'Bryan, R Nosrati

Journal article  |  2022  |  Human Reproduction

Abstract Study question How does viscosity influence the flagellar beating beh..

Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases

Wing-Hong Jonathan Ho, Andrew MK Law, Etienne Masle-Farquhar, Lesley E Castillo, Amanda Mawson, Moira K O'Bryan, Christopher C Goodnow, David Gallego-Ortega, Samantha R Oakes, Christopher J Ormandy

Journal article  |  2022  |  BREAST CANCER RESEARCH

BACKGROUND: The interferon response can influence the primary and metastatic activity of breast cancers and can interact with chec..