Moira O'Bryan

The endocrine disruptor 17β-trenbolone alters the relationship between pre- and post-copulatory sexual traits in male mosquitofish (Gambusia holbrooki).

Hung Tan, Michael G Bertram, Jake M Martin, Tiarne E Ecker, Stephanie L Hannington, Minna Saaristo, Moira K O'Bryan, Bob BM Wong

Journal article  |  2021  |  Sci Total Environ

It is now well-established that reproduction in wildlife can be disrupted by anthropogenic environmental changes, such as chemical..

Delta and epsilon tubulin in mammalian development

G Gemma Stathatos, EM Jessica Dunleavy, Jennifer Zenker, K Moira O'Bryan

Journal article  |  2021  |  TRENDS IN CELL BIOLOGY

Delta (δ-) and epsilon (ε-) tubulin are lesser-known cousins of alpha (α-) and beta (β-) tubulin. They are likely to regulate cent..

Curvature in the reproductive tract alters sperm-surface interactions

Mohammad Reza Raveshi, Melati S Abdul Halim, Sagar N Agnihotri, Moira K O'Bryan, Adrian Neild, Reza Nosrati

Journal article  |  2021  |  NATURE COMMUNICATIONS

The fallopian tube is lined with a highly complex folded epithelium surrounding a lumen that progressively narrows. To study the i..

Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure

Jimmaline J Hardy, Margot J Wyrwoll, William Mcfadden, Agnieszka Malcher, Nadja Rotte, Nijole C Pollock, Sarah Munyoki, Maria V Veroli, Brendan J Houston, Miguel J Xavier, Laura Kasak, Margus Punab, Maris Laan, Sabine Kliesch, Peter Schlegel, Thomas Jaffe, Kathleen Hwang, Josip Vukina, Miguel A Brieno-Enriquez, Kyle Orwig, et al.

Journal article  |  2021  |  HUMAN GENETICS

Male infertility impacts millions of couples yet, the etiology of primary infertility remains largely unknown. A critical element ..

Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm

Ashwin Nandagiri, Avinash Satish Gaikwad, David L Potter, Reza Nosrati, Julio Soria, Moira K O'Bryan, Sameer Jadhav, Ranganathan Prabhakar

Journal article  |  2021  |  ELIFE

We demonstrate a technique for investigating the energetics of flagella or cilia. We record the planar beating of tethered mouse s..

New Insights Into Sperm Ultrastructure Through Enhanced Scanning Electron Microscopy

Denis Korneev, D Jo Merriner, Gediminas Gervinskas, Alex de Marco, Moira K O'Bryan

Journal article  |  2021  |  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

The analysis of spermatozoa morphology is fundamental to understand male fertility and the etiology of infertility. Traditionally ..

Lack of evidence for a role of PIWIL1 variants in human male infertility

MS Oud, L Volozonoka, C Friedrich, S Kliesch, L Nagirnaja, C Gilissen, MK O'Bryan, RI McLachlan, KI Aston, F Tuettelmann, DF Conrad, JA Veltman

Journal article  |  2021  |  CELL

Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility

Chunyu Liu, Chaofeng Tu, Lingbo Wang, Huan Wu, Brendan J Houston, Francesco K Mastrorosa, Wen Zhang, Ying Shen, Jiaxiong Wang, Shixiong Tian, Lanlan Meng, Jiangshan Cong, Shenmin Yang, Yiwen Jiang, Shuyan Tang, Yuyan Zeng, Mingrong Lv, Ge Lin, Jinsong Li, Hexige Saiyin, et al.

Journal article  |  2021  |  AMERICAN JOURNAL OF HUMAN GENETICS

Asthenoteratozoospermia characterized by multiple morphological abnormalities of the flagella (MMAF) has been identified as a sub-..

The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse

Brendan J Houston, Liina Nagirnaja, D Jo Merriner, Anne E O'Connor, Hidenobu Okuda, Kenan Omurtag, Craig Smith, Kenneth I Aston, Donald F Conrad, Moira K O'Bryan

Journal article  |  2021  |  DEVELOPMENTAL DYNAMICS

BACKGROUND: Male infertility is a prevalent clinical presentation for which there is likely a strong genetic component due to the ..

Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

Fernando Gordillo Altamirano, John H Forsyth, Ruzeen Patwa, Xenia Kostoulias, Michael Trim, Dinesh Subedi, Stuart K Archer, Faye C Morris, Cody Oliveira, Luisa Kielty, Denis Korneev, Moira K O'Bryan, Trevor J Lithgow, Anton Y Peleg, Jeremy J Barr

Journal article  |  2021  |  NATURE MICROBIOLOGY

We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii and established that th..