Scott Kolbe

MR-EYE: High-Resolution MRI of the Human Eye and Orbit at Ultrahigh Field (7T)

Rebecca K Glarin, Bao N Nguyen, Jon O Cleary, Scott C Kolbe, Roger J Ordidge, Bang Bui, Allison M McKendrick, Bradford A Moffat

Journal article  |  2021  |  Magnetic Resonance Imaging Clinics of North America

Key points • Dedicated eye imaging can be implemented at 7T to acquire high-resolution, high contrast-to-noise, and high signal-to..

QSMART: Quantitative Susceptibility Mapping Artifact Reduction Technique

Negin Yaghmaie, Warda Syeda, Chengchuan Wu, Yicheng Zhang, Tracy D Zhang, Emma L Burrows, Amy Brodtmann, Bradford A Moffat, David K Wright, Rebecca Glarin, Scott Kolbe, Leigh Johnston

Journal article  |  2021  |  NeuroImage

PURPOSE: Quantitative susceptibility mapping (QSM) is a novel MR technique that allows mapping of tissue susceptibility values fro..

Increased functional sensorimotor network efficiency relates to disability in multiple sclerosis.

Myrte Strik, Declan T Chard, Iris Dekker, Kim A Meijer, Anand Jc Eijlers, Matteo Pardini, Bernard Mj Uitdehaag, Scott C Kolbe, Jeroen Jg Geurts, Menno M Schoonheim

Journal article  |  2020  |  Multiple Sclerosis Journal

BACKGROUND: Network abnormalities could help explain physical disability in multiple sclerosis (MS), which remains poorly understo..

Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis

G Noffs, FMC Boonstra, T Perera, H Butzkueven, SC Kolbe, F Maldonado, LE Cofre Lizama, MP Galea, J Stankovich, A Evans, A van Der Walt, AP Vogel

Journal article  |  2020  |  European Journal of Neurology

BACKGROUND AND PURPOSE: Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis..

Acoustic Speech Analytics Are Predictive of Cerebellar Dysfunction in Multiple Sclerosis

Gustavo Noffs, Frederique MC Boonstra, Thushara Perera, Scott C Kolbe, Jim Stankovich, Helmut Butzkueven, Andrew Evans, Adam P Vogel, Anneke van der Walt

Journal article  |  2020  |  The Cerebellum

Speech production relies on motor control and cognitive processing and is linked to cerebellar function. In diseases where the cer..

An Experimental Investigation of White Matter Venous Hemodynamics: Basic Physiology and Disruption in Neuroinflammatory Disease

Scott C Kolbe, Sanuji I Gajamange, Jon O Cleary, Trevor J Kilpatrick

Journal article  |  2020  |  Frontiers in Neurology

OnabotulinumtoxinA treatment for MS-tremor modifies fMRI tremor response in central sensory-motor integration areas

Frederique MC Boonstra, Andrew Evans, Gustavo Noffs, Thushara Perera, Vilija Jokubaitis, Jim Stankovich, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Scott C Kolbe, Anneke van der Walt

Journal article  |  2020  |  Multiple Sclerosis and Related Disorders

BACKGROUND: Treatment of tremor in MS is an unmet need. OnabotulinumtoxinA (BoNT-A) has shown promising results; however, little i..

Microstructural correlates of 23Na relaxation in human brain at 7 Tesla.

Scott C Kolbe, Warda Syeda, Yasmin Blunck, Rebecca Glarin, Meng Law, Leigh A Johnston, Jon O Cleary

Journal article  |  2020  |  Neuroimage

23Na provides the second strongest MR-observable signal in biological tissue and exhibits bi-exponential T2∗ relaxation in micro-e..

Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis.

Frederique Mc Boonstra, Gustavo Noffs, Thushara Perera, Vilija G Jokubaitis, Adam P Vogel, Bradford A Moffat, Helmut Butzkueven, Andrew Evans, Anneke van der Walt, Scott C Kolbe

Journal article  |  2020  |  Multiple Sclerosis Journal

BACKGROUND: Tremor is present in almost half of multiple sclerosis (MS) patients. The lack of understanding of its pathophysiology..

Extracting more for less: multi-echo MP2RAGE for simultaneous T-1-weighted imaging, T-1 mapping, R-2* mapping, SWI, and QSM from a single acquisition

Hongfu Sun, Jon O Cleary, Rebecca Glarin, Scott C Kolbe, Roger J Ordidge, Bradford A Moffat, G Bruce Pike

Journal article  |  2020  |  Magnetic Resonance in Medicine