Matt Perugini

Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

Tatiana P Soares da Costa, Cody J Hall, Santosh Panjikar, Jessica A Wyllie, Rebecca M Christoff, Saadi Bayat, Mark D Hulett, Belinda M Abbott, Anthony R Gendall, Matthew A Perugini

Journal article  |  2021  |  ELIFE

Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. There..

Differential lysine-mediated allosteric regulation of plant dihydrodipicolinate synthase isoforms

Cody J Hall, Mihwa Lee, Matthew P Boarder, Alexandra M Mangion, Anthony R Gendall, Santosh Panjikar, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2021  |  FEBS JOURNAL

Lysine biosynthesis in plants occurs via the diaminopimelate pathway. The first committed and rate-limiting step of this pathway i..

Situational experience around the world: A replication and extension in 62 countries.

Daniel I Lee, Gwendolyn Gardiner, Erica Baranski, undefined Members of the International Situations Project, David C Funder

Journal article  |  2020  |  J Pers

OBJECTIVE: The current study seeks to replicate and extend principal findings reported in The World at 7:00, a project that examin..

An intact membrane is essential for small extracellular vesicle-induced modulation of alpha-synuclein fibrillization

Cathryn L Ugalde, Shane E Gordon, Mitch Shambrook, Amirmohammad Nasiri Kenari, Bradley M Coleman, Matthew A Perugini, Victoria A Lawson, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  JOURNAL OF EXTRACELLULAR VESICLES

The misfolding and fibrillization of the protein, α-synuclein (αsyn), is associated with neurodegenerative disorders referred to a..

Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA plus protease CLPXP

Philip R Strack, Erica J Brodie, Hanmiao Zhan, Verena J Schuenemann, Liz J Valente, Tamanna Saiyed, Bradley R Lowth, Lauren M Angley, Matthew A Perugini, Kornelius Zeth, Kaye N Truscott, David A Dougan

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Over a decade ago Polymerase δ interacting protein of 38 kDa (PDIP38) was proposed to play a role in DNA repair. Since this time, ..

The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)

Dhanasekaran Sakthivel, Sarah Preston, Robin B Gasser, Tatiana P Soares da Costa, Julia N Hernandez, Adam Shahine, MD Shakif-Azam, Peter Lock, Jamie Rossjohn, Matthew A Perugini, Jorge Francisco Gonzalez, Els Meeusen, David Piedrafita, Travis Beddoe

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of imp..

Review: amino acid biosynthesis as a target for herbicide development

Cody J Hall, Emily RR Mackie, Anthony R Gendall, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2020  |  PEST MANAGEMENT SCIENCE

There are three amino acid biosynthesis pathways that are targeted by current herbicides, namely those leading to the production o..

Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens

Rachael E Impey, Mihwa Lee, Daniel A Hawkins, J Mark Sutton, Santosh Panjikar, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2020  |  FEBS LETTERS

The rise of antibiotic resistance combined with the lack of new products entering the market has led to bacterial infections becom..

Misfolded alpha-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

Cathryn L Ugalde, Sarah J Annesley, Shane E Gordon, Katelyn Mroczek, Matthew A Perugini, Victoria A Lawson, Paul R Fisher, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  DISEASE MODELS & MECHANISMS

The misfolding and aggregation of the largely disordered protein, α-synuclein, is a central pathogenic event that occurs in the sy..

Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

Rebecca M Christoff, Chamodi K Gardhi, Tatiana P Soares da Costa, Matthew A Perugini, Belinda M Abbott

Journal article  |  2019  |  MEDCHEMCOMM

Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resist..