Matt Perugini

An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillization.

Cathryn L Ugalde, Shane E Gordon, Mitch Shambrook, Amirmohammad Nasiri Kenari, Bradley M Coleman, Matthew A Perugini, Victoria A Lawson, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  Journal of Extracellular Vesicles

The misfolding and fibrillization of the protein, α-synuclein (αsyn), is associated with neurodegenerative disorders referred to a..

Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA plus protease CLPXP

Philip R Strack, Erica J Brodie, Hanmiao Zhan, Verena J Schuenemann, Liz J Valente, Tamanna Saiyed, Bradley R Lowth, Lauren M Angley, Matthew A Perugini, Kornelius Zeth, Kaye N Truscott, David A Dougan

Journal article  |  2020  |  Communications Biology

Over a decade ago Polymerase δ interacting protein of 38 kDa (PDIP38) was proposed to play a role in DNA repair. Since this time, ..

The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)

Dhanasekaran Sakthivel, Sarah Preston, Robin B Gasser, Tatiana P Soares da Costa, Julia N Hernandez, Adam Shahine, MD Shakif-Azam, Peter Lock, Jamie Rossjohn, Matthew A Perugini, Jorge Francisco Gonzalez, Els Meeusen, David Piedrafita, Travis Beddoe

Journal article  |  2020  |  Communications Biology

Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of imp..

Review: amino acid biosynthesis as a target for herbicide development

Cody J Hall, Emily RR Mackie, Anthony R Gendall, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2020  |  Pest Management Science

Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens

Rachael E Impey, Mihwa Lee, Daniel A Hawkins, J Mark Sutton, Santosh Panjikar, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2020  |  FEBS Letters

The rise of antibiotic resistance combined with the lack of new products entering the market has led to bacterial infections becom..

Misfolded alpha-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

Cathryn L Ugalde, Sarah J Annesley, Shane E Gordon, Katelyn Mroczek, Matthew A Perugini, Victoria A Lawson, Paul R Fisher, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  Disease Models and Mechanisms

The misfolding and aggregation of the largely disordered protein, α-synuclein, is a central pathogenic event that occurs in the sy..

Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

Rebecca M Christoff, Chamodi K Gardhi, Tatiana P Soares da Costa, Matthew A Perugini, Belinda M Abbott

Journal article  |  2019  |  MedChemComm

Identification of two dihydrodipicolinate synthase isoforms from Pseudomonas aeruginosa that differ in allosteric regulation

Rachael E Impey, Santosh Panjikar, Cody J Hall, Lucy J Bock, J Mark Sutton, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2019  |  The FEBS Journal

Pseudomonas aeruginosa is one of the leading causes of nosocomial infections, accounting for 10% of all hospital-acquired infectio..

The purification of the sigma(FPvI)/FpvR(20) and sigma(Pvds)/FpvR(20) protein complexes is facilitated at room temperature

G Patricia Casas Garcia, Matthew A Perugini, Lain L Lamont, Megan J Maher

Journal article  |  2019  |  Protein Expression and Purification

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

Erinna F Lee, Nicholas A Smith, Tatiana P Soares da Costa, Nastaran Meftahi, Shenggen Yao, Tiffany J Harris, Sharon Tran, Anne Pettikiriarachchi, Matthew A Perugini, David W Keizer, Marco Evangelista, Brian J Smith, W Douglas Fairlie

Journal article  |  2019  |  Autophagy