Matt Perugini

Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase.

Rebecca M Christoff, Tatiana P Soares da Costa, Saadi Bayat, Jessica K Holien, Matthew A Perugini, Belinda M Abbott

Journal article  |  2021  |  Bioorg Med Chem

Dihydrodipicolinate synthase (DHDPS), responsible for the first committed step of the diaminopimelate pathway for lysine biosynthe..

Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

Tatiana P Soares da Costa, Cody J Hall, Santosh Panjikar, Jessica A Wyllie, Rebecca M Christoff, Saadi Bayat, Mark D Hulett, Belinda M Abbott, Anthony R Gendall, Matthew A Perugini

Journal article  |  2021  |  ELIFE

Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. There..

Differential lysine-mediated allosteric regulation of plant dihydrodipicolinate synthase isoforms

Cody J Hall, Mihwa Lee, Matthew P Boarder, Alexandra M Mangion, Anthony R Gendall, Santosh Panjikar, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2021  |  FEBS JOURNAL

Lysine biosynthesis in plants occurs via the diaminopimelate pathway. The first committed and rate-limiting step of this pathway i..

Situational experience around the world: A replication and extension in 62 countries.

Daniel I Lee, Gwendolyn Gardiner, Erica Baranski, undefined Members of the International Situations Project, David C Funder

Journal article  |  2020  |  J Pers

OBJECTIVE: The current study seeks to replicate and extend principal findings reported in The World at 7:00, a project that examin..

An intact membrane is essential for small extracellular vesicle-induced modulation of alpha-synuclein fibrillization

Cathryn L Ugalde, Shane E Gordon, Mitch Shambrook, Amirmohammad Nasiri Kenari, Bradley M Coleman, Matthew A Perugini, Victoria A Lawson, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  JOURNAL OF EXTRACELLULAR VESICLES

The misfolding and fibrillization of the protein, α-synuclein (αsyn), is associated with neurodegenerative disorders referred to a..

Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA plus protease CLPXP

Philip R Strack, Erica J Brodie, Hanmiao Zhan, Verena J Schuenemann, Liz J Valente, Tamanna Saiyed, Bradley R Lowth, Lauren M Angley, Matthew A Perugini, Kornelius Zeth, Kaye N Truscott, David A Dougan

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Over a decade ago Polymerase δ interacting protein of 38 kDa (PDIP38) was proposed to play a role in DNA repair. Since this time, ..

The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries)

Dhanasekaran Sakthivel, Sarah Preston, Robin B Gasser, Tatiana P Soares da Costa, Julia N Hernandez, Adam Shahine, MD Shakif-Azam, Peter Lock, Jamie Rossjohn, Matthew A Perugini, Jorge Francisco Gonzalez, Els Meeusen, David Piedrafita, Travis Beddoe

Journal article  |  2020  |  COMMUNICATIONS BIOLOGY

Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of imp..

Review: amino acid biosynthesis as a target for herbicide development

Cody J Hall, Emily RR Mackie, Anthony R Gendall, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2020  |  PEST MANAGEMENT SCIENCE

There are three amino acid biosynthesis pathways that are targeted by current herbicides, namely those leading to the production o..

Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens

Rachael E Impey, Mihwa Lee, Daniel A Hawkins, J Mark Sutton, Santosh Panjikar, Matthew A Perugini, Tatiana P Soares da Costa

Journal article  |  2020  |  FEBS LETTERS

The rise of antibiotic resistance combined with the lack of new products entering the market has led to bacterial infections becom..

Misfolded alpha-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

Cathryn L Ugalde, Sarah J Annesley, Shane E Gordon, Katelyn Mroczek, Matthew A Perugini, Victoria A Lawson, Paul R Fisher, David I Finkelstein, Andrew F Hill

Journal article  |  2020  |  DISEASE MODELS & MECHANISMS

The misfolding and aggregation of the largely disordered protein, α-synuclein, is a central pathogenic event that occurs in the sy..