Onisha Patel

Crystal structure of the putative cell-wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis.

Onisha Patel, Rajini Brammananth, Weiwen Dai, Santosh Panjikar, Ross L Coppel, Isabelle S Lucet, Paul K Crellin

Journal article  |  2022  |  Acta Crystallogr D Struct Biol

The bacterial genus Mycobacterium includes important pathogens, most notably M. tuberculosis, which infects one-quarter of the ent..

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family

Jianmei Hou, Elizabeth Nguyen, Minglyanna Surudoi, Michael J Roy, Onisha Patel, Isabelle S Lucet, Xiuquan Ma, Roger J Daly

Journal article  |  2022  |  SCIENCE SIGNALING

The pseudokinase scaffolds PEAK1 and PEAK2 are implicated in cancer cell migration and metastasis. We characterized the regulation..

Production and purification of the PEAK pseudokinases for structural and functional studies.

Onisha Patel, Minglyanna Surudoi, Weiwen Dai, Joshua M Hardy, Michael J Roy, Isabelle S Lucet

Book Chapter  |  2022  |  Methods in Enzymology

The PEAK family of pseudokinases, which comprises PEAK1, PEAK2 and PEAK3, are newly identified scaffolds that dynamically assemble..

Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1

Onisha Patel, Michael J Roy, Ashleigh Kropp, Joshua M Hardy, Weiwen Dai, Isabelle S Lucet

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Doublecortin-like kinase 1 (DCLK1) is an understudied bi-functional kinase with a proven role in tumour growth and development. Ho..

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs

Lung-Yu Liang, Michael Roy, Christopher R Horne, Jarrod J Sandow, Minglyanna Surudoi, Laura F Dagley, Samuel N Young, Toby Dite, Jeffrey J Babon, Peter W Janes, Onisha Patel, James M Murphy, Isabelle S Lucet

Journal article  |  2021  |  BIOCHEMICAL JOURNAL

EphB6 and EphA10 are two poorly characterised pseudokinase members of the Eph receptor family, which collectively serves as mediat..

Zinc preconditioning protects against renal ischaemia-reperfusion injury through manipulation of key metabolic pathways

D O'kane, G Baldwin, D Bolton, O Patel, J Ischia

Conference Proceedings  |  2020  |  BJU INTERNATIONAL

alpha-Glucuronosyl and alpha-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi

Satvika Burugupalli, Catarina F Almeida, Dylan GM Smith, Sayali Shah, Onisha Patel, Jamie Rossjohn, Adam P Uldrich, Dale I Godfrey, Spencer J Williams

Journal article  |  2020  |  CHEMICAL SCIENCE

Natural killer T cells express T cell receptors (TCRs) that recognize glycolipid antigens in association with the antigen-presenti..

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Catarina F Almeida, Srinivasan Sundararaj, Jerome Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan GM Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2019  |  NATURE COMMUNICATIONS

Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an und..

The PEAK family of pseudokinases, their role in cell signalling and cancer

Onisha Patel, Michael J Roy, James M Murphy, Isabelle S Lucet

Journal article  |  2019  |  FEBS JOURNAL

The study of pseudokinases has uncovered that catalysis-independent functions play a critical role in cell signalling regulation. ..

Eph receptor signalling: from catalytic to non-catalytic functions

Lung-Yu Liang, Onisha Patel, Peter W Janes, James M Murphy, Isabelle S Lucet

Journal article  |  2019  |  ONCOGENE

Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative disease, such as cancer, as a res..