Rhea Longley

SARS-CoV-2 multi-antigen serology assay

R Mazhari, S Ruybal-Pesántez, F Angrisano, N Kiernan-Walker, S Hyslop, RJ Longley, C Bourke, C Chen, DA Williamson, LJ Robinson, I Mueller, EM Eriksson

Journal article  |  2021  |  Methods and Protocols

Serology tests are extremely useful for assessing whether a person has been infected with a pathogen. Since the onset of the COVID..

Sensitive detection of Plasmodium vivax malaria by the rotating-crystal magneto-optical method in Thailand

Agnes Orban, Rhea J Longley, Piyarat Sripoorote, Nongnuj Maneechai, Wang Nguitragool, Adam Butykai, Ivo Mueller, Jetsumon Sattabongkot, Stephan Karl, Istvan Kezsmarki

Journal article  |  2021  |  SCIENTIFIC REPORTS

The rotating-crystal magneto-optical detection (RMOD) method has been developed for the rapid and quantitative diagnosis of malari..

Application of 23 Novel Serological Markers for Identifying Recent Exposure to Plasmodium vivax Parasites in an Endemic Population of Western Thailand

Sadudee Chotirat, Narimane Nekkab, Chalermpon Kumpitak, Jenni Hietanen, Michael T White, Kirakorn Kiattibutr, Patiwat Sa-angchai, Jessica Brewster, Kael Schoffer, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Chetan E Chitnis, Julie Healer, Wai-Hong Tham, Wang Nguitragool, Ivo Mueller, Jetsumon Sattabongkot, Rhea J Longley

Journal article  |  2021  |  FRONTIERS IN MICROBIOLOGY

Thailand is aiming for malaria elimination by the year 2030. However, the high proportion of asymptomatic infections and the prese..

Ultra-low dose immunization and multi-component vaccination strategies enhance protection against malaria in mice.

Katharine A Collins, Florian Brod, Rebecca Snaith, Marta Ulaszewska, Rhea J Longley, Ahmed M Salman, Sarah C Gilbert, Alexandra J Spencer, David Franco, W Ripley Ballou, Adrian VS Hill

Journal article  |  2021  |  Sci Rep

An effective vaccine would be a valuable tool for malaria control and elimination; however, the leading malaria vaccine in develop..

Multiplex assays for the identification of serological signatures of SARS-CoV-2 infection: an antibody-based diagnostic and machine learning study

Jason Rosado, Stephane Pelleau, Charlotte Cockram, Sarah Helene Merkling, Narimane Nekkab, Caroline Demeret, Annalisa Meola, Solen Kerneis, Benjamin Terrier, Samira Fafi-Kremer, Jerome de Seze, Timothee Bruel, Francois Dejardin, Stephane Petres, Rhea Longley, Arnaud Fontanet, Marija Backovic, Ivo Mueller, Michael T White

Journal article  |  2021  |  LANCET MICROBE

Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces an antibody response targeting mul..

Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts

Jason Rosado, Michael T White, Rhea J Longley, Marcus Lacerda, Wuelton Monteiro, Jessica Brewster, Jetsumon Sattabongkot, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph M Vinetz, Dionicia Gamboa, Ivo Mueller

Journal article  |  2021  |  PLOS NEGLECTED TROPICAL DISEASES

BACKGROUND: Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, bu..

A comparison of non-magnetic and magnetic beads for measuring IgG antibodies against Plasmodium vivax antigens in a multiplexed bead-based assay using Luminex technology (Bio-Plex 200 or MAGPIX)

Ramin Mazhari, Jessica Brewster, Rich Fong, Caitlin Bourke, Zoe SJ Liu, Eizo Takashima, Takafumi Tsuboi, Wai-Hong Tham, Matthias Harbers, Chetan Chitnis, Julie Healer, Maria Ome-Kaius, Jetsumon Sattabongkot, James Kazura, Leanne J Robinson, Christopher King, Ivo Mueller, Rhea J Longley

Journal article  |  2020  |  PLOS ONE

Multiplexed bead-based assays that use Luminex® xMAP® technology have become popular for measuring antibodies against proteins of ..

IgG antibody responses are preferential compared to IgM for use as serological markers for detecting recent exposure to Plasmodium vivax infection

Rhea Longley, Michael White, Jessica Brewster, Zoe SJ Liu, Caitlin Bourke, Eizo Takashima, Matthias Harbers, Wai-Hong Tham, Julie Healer, Chetan Chitnis, Wuelton Monteiro, Marcus Lacerda, Jetsumon Sattabongkot, Takafumi Tsuboi, Ivo Mueller

Journal article  |  2020

To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax . Recently, a novel panel of P. vivax..

Heterogeneity in response to serological exposure markers of recentPlasmodium vivaxinfections in contrasting epidemiological contexts

Jason Rosado, Michael White, Rhea Longley, Marcus Lacerda, Wuelton Monteiro, Jessica Brewster, Jetsumon Sattabongkot, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph Vinetz, Dionicia Gamboa, Ivo Mueller

Journal article  |  2020

Background Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but..

Development and validation of serological markers for detecting recent Plasmodium vivax infection

Rhea J Longley, Michael T White, Eizo Takashima, Jessica Brewster, Masayuki Morita, Matthias Harbers, Thomas Obadia, Leanne J Robinson, Fumie Matsuura, Zoe SJ Liu, Connie SN Li-Wai-Suen, Wai-Hong Tham, Julie Healer, Christele Huon, Chetan E Chitnis, Wang Nguitragool, Wuelton Monteiro, Carla Proietti, Denise L Doolan, Andre M Siqueira, et al.

Journal article  |  2020  |  NATURE MEDICINE

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undete..