Amelia Jayne Brennan

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Vivien R Sutton, Amelia J Brennan, Sarah Ellis, Jill Danne, Kevin Thia, Misty R Jenkins, Ilia Voskoboinik, Gunnar Pejler, Ricky W Johnstone, Daniel M Andrews, Joseph A Trapani

Journal article  |  2016  |  FEBS JOURNAL

The anionic proteoglycan serglycin is a major constituent of secretory granules in cytotoxic T lymphocyte (CTL)/natural killer (NK..

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

Imran G House, Kevin Thia, Amelia J Brennan, Richard Tothill, Alexander Dobrovic, Wei Z Yeh, Richard Saffery, Zac Chatterton, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2015  |  IMMUNOLOGY AND CELL BIOLOGY

The production and delivery of functional perforin (PRF; PRF1 gene) by cytotoxic lymphocytes maintains immune homeostasis and tumo..

The Role of the Immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor Immunity

Conor J Kearney, Amelia J Brennan, Phillip K Darcy, Jane Oliaro

Journal article  |  2015  |  CRITICAL REVIEWS IN IMMUNOLOGY

A synapse is a specialized structure that forms when the plasma membrane of two cells come into close contact to facilitate commun..

Defining the interaction of perforin with calcium and the phospholipid membrane

Daouda AK Traore, Amelia J Brennan, Ruby HP Law, Con Dogovski, Matthew A Perugini, Natalya Lukoyanova, Eleanor WW Leung, Raymond S Norton, Jamie A Lopez, Kylie A Browne, Hideo Yagita, Gordon J Lloyd, Annette Ciccone, Sandra Verschoor, Joseph A Trapani, James C Whisstock, Ilia Voskoboinik

Journal article  |  2013  |  BIOCHEMICAL JOURNAL

Following its secretion from cytotoxic lymphocytes into the immune synapse, perforin binds to target cell membranes through its Ca..

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

Jamie A Lopez, Amelia J Brennan, James C Whisstock, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2012  |  TRENDS IN IMMUNOLOGY

Considerable progress has been made in understanding how cytotoxic lymphocytes use the highly toxic pore-forming protein perforin ..

Perforin deficiency and susceptibility to cancer

AJ Brennan, J Chia, JA Trapani, I Voskoboinik

Journal article  |  2010  |  CELL DEATH AND DIFFERENTIATION

Cytotoxic lymphocytes (CLs) are the killer cells that destroy intracellular pathogen-infected and transformed cells, predominantly..

The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development

Walid T Khaled, Eliot KC Read, Sandra E Nicholson, Fiona O Baxter, Amelia J Brennan, Paul J Came, Naomi Sprigg, Andrew NJ McKenzie, Christine J Watson

Journal article  |  2007  |  DEVELOPMENT

Naïve T helper cells differentiate into Th1 and Th2 subsets, which have unique cytokine signatures, activators and transcriptional..