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A/Prof

Helena Richardson

Honorary
Anatomy and Physiology
science & technology
life sciences & biomedicine
animals
drosophila proteins
drosophila
drosophila melanogaster
cell biology
biochemistry & molecular biology
signal transduction
Helena Richardson's Profile Picture
A/Prof

Helena Richardson

 
Division
Medicine, Dentistry and Health Sciences
Helena Richardson's Profile Picture
A/Prof

Helena Richardson

 
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Helena's  Short Profile
 

Projects

Displaying the 10 most recent projects by Helena Richardson.

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DECIPHERING THE ROLE OF SCRIBBLE IN DEVELOPMENT AND DISEASE

Scribble is a protein that controls the orientation and organization of all cells within our body. Mutations in the Scribble gene are found ..

2016 - 2016
Completed
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Understanding tumour formation driven by the signalling protein Ras

Cancer is a cooperative process, involving mutations in several genes. Activation of the signaling protein, Ras, contributes to ~30% of huma..

2012 - 2014
Completed
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Regulation of a hyperplasic tumour suppressor pathway by polarity complexes

Cancer is a multi-hit process involving the activation of critical signaling pathways leading to increased proliferation, survival and incre..

2010 - 2012
Completed
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Regulation of cell signalling, proliferation and death by Lgl

Cancer is a disease that affects 1-3 people at some point in their lifetime. Therefore, understanding what causes cancer is of major importa..

2008 - 2010
Completed
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DROSOPHILA AS A NOVEL TOOL FOR ANTI-CANCER DRUG DISCOVERY

2007 - 2011
Completed
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SENIOR RESEARCH FELLOWSHIP 2007 - RICHARDSON

I am a developmental cell biologist and molecular geneticist focusing on mechanisms controlling cell proliferation and modelling the develop..

2007 - 2011
Completed
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A novel role for Scribble & Dlg in cell protrusions.

Dlg and Scribble are recently discovered proteins that are required during development, immune regulation, neural signalling and tumour supp..

2007 - 2009
Completed
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SPARC cluster genes in tumourigenesis

Expression profiling of many cancers has revealed a common signature, including upregulation of SPARC and other extracellular matrix protein..

2007 - 2009
Completed
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A GENOME-WIDE SCREEN TO IDENTIFY NOVEL THERAPEUTIC TARGETS FOR INVASIVE BREAST CANCER

2006 - 2007
Completed
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SORVAL RC-5C PLUS - 2004 NHMRC EQUIPMENT GRANT ALLOCATION

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17

Projects

Project Types

17

Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works by Helena Richardson.

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Basic and Translational Models of Cooperative Oncogenesis

Helena E Richardson, Julia B Cordero, Daniela Grifoni

Journal article  |  2020  |  International Journal of Molecular Sciences

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Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model.

John E La Marca, Helena E Richardson

Journal article  |  2020  |  Frontiers in Cell and Developmental Biology

The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many functions, regulating a diversity of processes: fro..

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Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis

John E La Marca, Sarah T Diepstraten, Amy L Hodge, Hongyan Wang, Adam H Hart, Helena E Richardson, W Gregory Somers

Journal article  |  2019  |  Development

One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such..

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Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis.

Natasha Fahey-Lozano, John E La Marca, Marta Portela, Helena E Richardson

Journal article  |  2019  |  Advances in experimental medicine and biology

Cell competition is an important surveillance mechanism that measures relative fitness between cells in a tissue during developmen..

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A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Cuiping Xia, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane JF Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger

Journal article  |  2018  |  PLoS Genetics

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The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Rebecca Stephens, Krystle Lim, Marta Portela, Marc Kvansakul, Patrick O Humbert, Helena E Richardson

Journal article  |  2018  |  Journal of Molecular Biology

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Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

Marta Portela, Liu Yang, Sayantanee Paul, Xia Li, Alexey Veraksa, Linda M Parsons, Helena E Richardson

Journal article  |  2018  |  Science Signaling

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Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue

Carole LC Poon, Anthony M Brumby, Helena E Richardson

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large

Sofia Caria, Charlene M Magtoto, Tinaz Samiei, Marta Portela, Krystle YB Lim, Jing Yuan How, Bryce Z Stewart, Patrick O Humbert, Helena E Richardson, Marc Kvansakul

Journal article  |  2018  |  Journal of Biological Chemistry

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POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation

Xianjue Ma, Xiaowei Guo, Helena E Richardson, Tian Xu, Lei Xue

Journal article  |  2018  |  Proceedings of the National Academy of Sciences of the United States of America

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Scholarly Works

Keyword Analysis

Biochemistry and Cell Biology
Clinical Health (organs, Diseases and Abnormal Conditions)
Expanding Knowledge
Oncology and Carcinogenesis
Genetics
Clinical (organs, Diseases and Abnormal Conditions)
Zoology
Immunology
Other Health
Biomedical Engineering

Credentials

Positions

Honorary

Anatomy and Physiology

Honorary

Biochemistry and Pharmacology

Member

ANZSCDCB

Member

National Associateion of Research Fellows

Education

Bachelor of Science (Honours)

Adelaide University

Doctor of Philosophy

Adelaide University

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