Helena Richardson

A Drosophila chemical screen reveals targeting MEK and DGKa mitigates Ras-driven polarity-impaired tumour growth.

John E La Marca, Robert W Ely, Sarah T Diepstraten, Peter Burke, Gemma L Kelly, Patrick O Humbert, Helena E Richardson

Journal article  |  2023  |  Dis Model Mech

Elevated RAS signalling is highly prevalent in human cancer, however targeting RAS-driven cancers with RAS-pathway inhibitors ofte..

Ptp61F integrates Hippo, TOR, and actomyosin pathways to control three-dimensional organ size.

Peng Liu, Yifan Guo, Wenyan Xu, Sha Song, Xiaoqin Li, Xing Wang, Jinyu Lu, Xiaowei Guo, Helena E Richardson, Xianjue Ma

Journal article  |  2022  |  Cell Rep

Precise organ size control is fundamental for all metazoans, but how organ size is controlled in a three-dimensional (3D) way rema..

TSPAN6 is a suppressor of Ras-driven cancer (Feb, 10.1038/s41388-022-02223-y, 2022)

Patrick O Humbert, Tamara Zoranovic Pryjda, Blanka Pranjic, Andrew Farrell, Kohei Fujikura, Ricardo de Matos Simoes, Rezaul Karim, Ivona Kozieradzki, Shane JF Cronin, G Gregory Neely, Thomas F Meyer, Astrid Hagelkruys, Helena E Richardson, Josef M Penninger

Journal article  |  2022  |  ONCOGENE

In this article, the sentence “In this newly described mechanism, TSPAN6 is physically linked to TNF-alpha via the adapter protein..

TSPAN6 is a suppressor of Ras-driven cancer

Patrick O Humbert, Tamara Zoranovic Pryjda, Blanka Pranjic, Andrew Farrell, Kohei Fujikura, Ricardo de Matos Simoes, Rezaul Karim, Ivona Kozieradzki, Shane JF Cronin, G Gregory Neely, Thomas F Meyer, Astrid Hagelkruys, Helena E Richardson, Josef M Penninger

Journal article  |  2022  |  ONCOGENE

Oncogenic mutations in the small GTPase RAS contribute to ~30% of human cancers. In a Drosophila genetic screen, we identified nov..

PTP61F Mediates Cell Competition and Mitigates Tumorigenesis

John E La Marca, Lee F Willoughby, Kirsten Allan, Marta Portela, Pei Kee Goh, Tony Tiganis, Helena E Richardson

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tissue homeostasis via the elimination of aberrant cells is fundamental for organism survival. Cell competition is a key homeostat..

Tumor-derived MMPs regulate cachexia in a Drosophila cancer model

William Lodge, Michael Zavortink, Sofia Golenkina, Francesca Froldi, Callum Dark, Shane Cheung, Benjamin L Parker, Ronnie Blazev, Daniel Bakopoulos, Elizabeth L Christie, Verena C Wimmer, Brigette C Duckworth, Helena E Richardson, Louise Y Cheng

Journal article  |  2021  |  DEVELOPMENTAL CELL

Cachexia, the wasting syndrome commonly observed in advanced cancer patients, accounts for up to one-third of cancer-related morta..

Basic and Translational Models of Cooperative Oncogenesis

Helena E Richardson, Julia B Cordero, Daniela Grifoni

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model.

John E La Marca, Helena E Richardson

Journal article  |  2020  |  Front Cell Dev Biol

The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many functions, regulating a diversity of processes: fro..

Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis

John E La Marca, Sarah T Diepstraten, Amy L Hodge, Hongyan Wang, Adam H Hart, Helena E Richardson, W Gregory Somers

Journal article  |  2019  |  DEVELOPMENT

One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such..

Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis.

Natasha Fahey-Lozano, John E La Marca, Marta Portela, Helena E Richardson

Journal article  |  2019  |  Adv Exp Med Biol

Cell competition is an important surveillance mechanism that measures relative fitness between cells in a tissue during developmen..