Helena Richardson

Basic and Translational Models of Cooperative Oncogenesis

Helena E Richardson, Julia B Cordero, Daniela Grifoni

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

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Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model.

John E La Marca, Helena E Richardson

Journal article  |  2020  |  Front Cell Dev Biol

The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many functions, regulating a diversity of processes: fro..

Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis

John E La Marca, Sarah T Diepstraten, Amy L Hodge, Hongyan Wang, Adam H Hart, Helena E Richardson, W Gregory Somers

Journal article  |  2019  |  DEVELOPMENT

One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such..

Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis.

Natasha Fahey-Lozano, John E La Marca, Marta Portela, Helena E Richardson

Journal article  |  2019  |  Adv Exp Med Biol

Cell competition is an important surveillance mechanism that measures relative fitness between cells in a tissue during developmen..

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Cuiping Xia, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane JF Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger

Journal article  |  2018  |  PLOS GENETICS

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for..

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Rebecca Stephens, Krystle Lim, Marta Portela, Marc Kvansakul, Patrick O Humbert, Helena E Richardson

Journal article  |  2018  |  JOURNAL OF MOLECULAR BIOLOGY

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-2-giant larvae (Lgl), has a tumor su..

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

Marta Portela, Liu Yang, Sayantanee Paul, Xia Li, Alexey Veraksa, Linda M Parsons, Helena E Richardson

Journal article  |  2018  |  SCIENCE SIGNALING

Epithelial cell polarity is linked to the control of tissue growth and tumorigenesis. The tumor suppressor and cell polarity prote..

Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue

Carole LC Poon, Anthony M Brumby, Helena E Richardson

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Ras oncogene (Rat Sarcoma oncogene, a small GTPase) is a key driver of human cancer, however alone it is insufficient to produ..

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large

Sofia Caria, Charlene M Magtoto, Tinaz Samiei, Marta Portela, Krystle YB Lim, Jing Yuan How, Bryce Z Stewart, Patrick O Humbert, Helena E Richardson, Marc Kvansakul

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial cell polarity is controlled by components of the Scribble polarity module, and its regulation is critical for tissue ar..

POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation

Xianjue Ma, Xiaowei Guo, Helena E Richardson, Tian Xu, Lei Xue

Journal article  |  2018  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo signaling pathway is a master regulator of organ growth, tissue homeostasis, and tumorigenesis. The activity of the Hipp..