Elizabeth graduated with a BSc. honours in Pharmacology from Sunderland University and went to the University of Saskatchewan where she studied Neuropsychopharmacology.
Having been awarded a PhD she spent a year in Dunedin, New Zealand working on the rat hypoxic/ischaemic model. In 1996 she moved to Melbourne, joining the Rebecca L. Cooper Research Laboratories at the Mental Health Research Institute, where she started working with human post-mortem tissue. Associate Professor Scarr was an ARC Future Fellow in the Department of Psychiatry. She is currently a student in the Doctor of Veterinary Medicine program in the Faculty of Veterinary and Agricultural Sciences.
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Common and disparate changes in gene expression in Brodmann's area 9, but not 10 or 33, in..
Identifying And Understanding The Changes In Brain Chemistry Associated With Schizophrenia..
Displaying the 13 most recent projects by Elizabeth Scarr.
Displaying the 142 most recent scholarly works by Elizabeth Scarr.
Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders
Elizabeth Scarr, Madhara Udawela, Brian Dean
Journal article | 2019 | Australian & New Zealand Journal of Psychiatry
BACKGROUND: Mood disorders likely occur in someone with a genetic predisposition who encounters a deleterious environmental factor..
Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide.
Brian Dean, Andrew Tsatsanis, Linh Q Lam, Elizabeth Scarr, James A Duce
Journal article | 2019 | World J Biol Psychiatry
OBJECTIVES: The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis coul..
Low levels of muscarinic M1 receptor-positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia
Elizabeth Scarr, Shaun Hopper, Valentina Vos, Myoung Suk Seo, Ian Paul Everall, Timothy Douglas Aumann, Gursharan Chana, Brian Dean
Journal article | 2018 | Journal of Psychiatry & Neuroscience
The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder.
Srisaiyini Kidnapillai, Chiara C Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia M Dean, Tamsyn Crowley, Stéphane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk, Ken Walder
Journal article | 2018 | The World Journal of Biological Psychiatry
OBJECTIVES: To create a gene expression signature (GES) to represent the biological effects of a combination of known drugs for bi..
Studies on Prostaglandin-Endoperoxide Synthase 1: Lower Levels in Schizophrenia and After Treatment with Antipsychotic Drugs in Conjunction with Aspirin
Brian Dean, Andrew Gibbons, Andrea Gogos, Madhara Udawela, Elizabeth Thomas, Elizabeth Scarr
Journal article | 2018 | International Journal of Neuropsychopharmacology
Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants
Andrew Stuart Gibbons, Won Je Jeon, Elizabeth Scarr, Brian Dean
Journal article | 2016 | International Journal of Neuropsychopharmacology
Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia
Elizabeth Scarr, Madhara Udawela, Mark A Greenough, Jaclyn Neo, Myoung Suk Seo, Tammie T Money, Aradhana Upadhyay, Ashley I Bush, Ian P Everall, Elizabeth A Thomas, Brian Dean
Journal article | 2016 | npj Schizophrenia
Changes in cortical N-methyl-D-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide
Brian Dean, Andrew S Gibbons, Simone Boer, Akihito Uezato, James Meador-Woodruff, Elizabeth Scarr, Robert E McCullumsmith
Journal article | 2016 | Australian & New Zealand Journal of Psychiatry
Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue
C-Y Lai, S-Y Lee, E Scarr, Y-H Yu, Y-T Lin, C-M Liu, T-J Hwang, MH Hsieh, C-C Liu, Y-L Chien, M Udawela, AS Gibbons, IP Everall, H-G Hwu, B Dean, WJ Chen
Journal article | 2016 | Translational Psychiatry
Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia
Caitlin E McOmish, Geoff Pavey, Andrew Gibbons, Shaun Hopper, Madhara Udawela, Elizabeth Scarr, Brian Dean
Journal article | 2016 | Journal of Affective Disorders
The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia
Vanessa L Cropley, Elizabeth Scarr, Alex Fornito, Paul Klauser, Chad A Bousman, Rodney Scott, Murray J Cairns, Paul A Tooney, Christos Pantelis, Brian Dean
Journal article | 2015 | Psychiatry Research: Neuroimaging
Biomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank
Elizabeth Scarr, Mark J Millan, Sabine Bahn, Alessandro Bertolino, Christoph W Turck, Shitij Kapur, Hans-Juergen Moeller, Brian Dean
Journal article | 2015 | International Journal of Neuropsychopharmacology
A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania
Jayashri Kulkarni, Michael Berk, Wei Wang, Ling Mu, Elizabeth Scarr, Tamsyn E Van Rheenen, Roisin Worsley, Caroline Gurvich, Ernorfia Gavrilidis, Anthony de Castella, Paul Fitzgerald, Susan R Davis
Journal article | 2014 | Psychoneuroendocrinology
Problems and solutions to filling the drying drug pipeline for psychiatric disorders: a report from the inaugural 2012 CINP Think Tank
Brian Dean, Hans-Juergen Moller, Torgny H Svensson, Mark A Geyer, Dan Rujescu, Elizabeth Scarr, Mark J Millan
Journal article | 2014 | International Journal of Neuropsychopharmacology
Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA
E Scarr, JM Craig, MJ Cairns, MS Seo, JC Galati, NJ Beveridge, A Gibbons, S Juzva, B Weinrich, M Parkinson-Bates, AP Carroll, R Saffery, B Dean
Journal article | 2013 | Translational Psychiatry
Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels
Anna Bromberg, Elad Lerer, Madhara Udawela, Elizabeth Scarr, Brian Dean, RH Belmaker, Richard Ebstein, Galila Agam
Journal article | 2012 | The International Journal of Neuropsychopharmacology
Muscarinic M1 receptor sequence: Preliminary studies on its effects on cognition and expression
Elizabeth Scarr, Suresh Sundram, Azita Deljo, Tiffany Francis Cowie, Andrew Stuart Gibbons, Susan Juzva, Andrew Mackinnon, Stephen J Wood, Renee Testa, Christos Pantelis, Brian Dean
Journal article | 2012 | Schizophrenia Research
Altered neuronal markers following treatment with mood stabilizer and antipsychotic drugs indicate an increased likelihood of neurotransmitter release.
Elizabeth Scarr, Brian Dean
Journal article | 2012 | Clinical Psychopharmacology and Neuroscience
OBJECTIVE: Given the ability of mood stabilizers and antipsychotics to promote cell proliferation, we wanted to determine the effe..
Low Density Lipoprotein Receptor-Related Protein and Apolipoprotein E Expression is Altered in Schizophrenia.
Andrew Stuart Gibbons, Elizabeth A Thomas, Elizabeth Scarr, Brian Dean
Journal article | 2010 | Frontiers in Psychiatry
Our recent microarray study reported altered mRNA expression of several low density lipoprotein receptor-related proteins (LRP) as..
Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation
Laura Gray, Maarten van den Buuse, Elizabeth Scarr, Brian Dean, Anthony J Hannan
Journal article | 2009 | International Journal of Neuropsychopharmacology
Possible involvement of post-dopamine D-2 receptor signalling components in the pathophysiology of schizophrenia
Shirly Amar, Galit Shaltiel, Liad Mann, Alon Shamir, Brian Dean, Elizabeth Scarr, Yuly Bersudsky, RH Belmaker, Galila Agam
Journal article | 2008 | International Journal of Neuropsychopharmacology
Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.
Brian Dean, Elizabeth Scarr, Mark McLeod
Journal article | 2005 | Molecular Brain Research
Postmortem CNS studies have suggested an uncoupling of the gamma-aminobutyric acid (GABA) and benzodiazepine binding sites on the ..
Is Fos protein expressed by dying striatal neurons after immature hypoxic-ischemic brain injury?
DE Oorschot, MJ Black, F Rangi, E Scarr
Journal article | 2000 | Experimental Neurology
The transient induction of mRNA for the immediate-early gene c-fos has been reported following hypoxic-ischemic brain injury in th..
The effects of administration of monoamine oxidase-B inhibitors on rat striatal neurone responses to dopamine.
MD Berry, E Scarr, MY Zhu, IA Paterson, AV Juorio
Journal article | 1994 | British Journal of Pharmacology
1. (-)-Deprenyl has been shown to potentiate rat striatal neurone responses to dopamine agonists at doses not altering dopamine me..
The effects of monoamine oxidase B inhibition on dopamine metabolism in rats with nigro-striatal lesions.
E Scarr, DM Wingerchuk, AV Juorio, IA Paterson
Journal article | 1994 | Neurochemical Research
The purpose of this study was to examine whether monoamine oxidase type B (MAO-B) has a role in striatal dopamine metabolism in an..
Studies on the properties of some peripheral MAO inhibitors.
E Scarr, PH Yu, BA Davis, AA Boulton
Journal article | 1991 | Progress in Neuro-Psychopharmacology and Biological Psychiatry
1. Studies were carried out on three monoamine oxidase (MAO) inhibitors, two of which, debrisoquine and para- hydroxyphenelzine, a..
Honours, Awards and Fellowships
FSB, Fellow of the Society of Biology
Melbourne Veterinary School
Florey Department Of Neuroscience And Mental Health
Australian Society for Psychiatric Research
Collegium Interationale Neuropsychopharmacologicum
Society for Neuroscience
Australian Society for Medical Research
Australian Neuroscience Society
University of Saskatchewan
Bachelor of Science (Honours) Pharmacology
University of Sunderland