Ashish Sethi

Characterizing Conformational Diversity of G Protein-coupled Receptors by Solution NMR Spectroscopy

Feng-Jie Wu, Fabian Bumbak, Mohammad Hossein Tanipour, Kazem Asadollahi, Tasneem M Vaid, Ashish Sethi, Daniel J Scott, Paul R Gooley

Book Chapter  |  2022  |  New Developments in NMR

G protein-coupled receptors are the largest family of integral membrane proteins in humans that have roles in almost all physiolog..

The AAA ATPase p97 as a novel parasite and tuberculosis drug target

George Kobakhidze, Ashish Sethi, Sepideh Valimehr, Stuart A Ralph, Isabelle Rouiller

Journal article  |  2022  |  TRENDS IN PARASITOLOGY

The multifunctional AAA+ ATPase p97 is an unfoldase/segregase involved in various cellular processes and present in all kingdoms o..

Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody

Behnaz Heydarchi, Danielle S Fong, Hongmei Gao, Natalia A Salazar-Quiroz, Jack M Edwards, Christopher A Gonelli, Samantha Grimley, Turgut E Aktepe, Charlene Mackenzie, William J Wales, Marit J van Gils, Albert Cupo, Isabelle Rouiller, Paul R Gooley, John P Moore, Rogier W Sanders, David Montefiori, Ashish Sethi, Damian FJ Purcell

Journal article  |  2022  |  CELL REPORTS MEDICINE

Human immunodeficiency virus type 1 (HIV-1) vaccination of cows has elicited broadly neutralizing antibodies (bNAbs). In this stud..

Molecular Basis of Functional Effects of Phosphorylation of the C-Terminal Domain of the Rabies Virus P Protein

Jingyu Zhan, Ericka Watts, Aaron M Brice, Riley D Metcalfe, Ashley M Rozario, Ashish Sethi, Fei Yan, Toby DM Bell, Michael DW Griffin, Gregory W Moseley, Paul R Gooley

Journal article  |  2022  |  JOURNAL OF VIROLOGY

The rabies virus (RABV) phosphoprotein (P protein) is expressed as several isoforms, which differ in nucleocytoplasmic localizatio..

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

Ashish Sethi, Christopher R Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine A Davies, Sarah E Garnish, Annette Jacobsen, Andre L Samson, Joanne M Hildebrand, Ahmad Wardak, Peter E Czabotar, Emma J Petrie, Paul R Gooley, James M Murphy

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Necroptosis is a lytic programmed cell death pathway with origins in innate immunity that is frequently dysregulated in inflammato..

Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2

Ashish Sethi, Shoni Bruell, Tim Ryan, Fei Yan, Mohammad Hossein Tanipour, Yee-Foong Mok, Chris Draper-Joyce, Yogesh Khandokar, Riley D Metcalfe, Michael DW Griffin, Daniel J Scott, Mohammad Akhter Hossain, Emma J Petrie, Ross AD Bathgate, Paul R Gooley

Journal article  |  2021  |  JOURNAL OF MOLECULAR BIOLOGY

Our poor understanding of the mechanism by which the peptide-hormone H2 relaxin activates its G protein coupled receptor, RXFP1 an..

Definition of the immune evasion-replication interface of rabies virus P protein

Jingyu Zhan, Angela R Harrison, Stephanie Portelli, Thanh Binh Nguyen, Isshu Kojima, Siqiong Zheng, Fei Yan, Tatsunori Masatani, Stephen M Rawlinson, Ashish Sethi, Naoto Ito, David B Ascher, Gregory W Moseley, Paul R Gooley

Journal article  |  2021  |  PLOS PATHOGENS

Rabies virus phosphoprotein (P protein) is a multifunctional protein that plays key roles in replication as the polymerase cofacto..

Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38

Klara Kirsch, Andras Zeke, Orsolya Toke, Peter Sok, Ashish Sethi, Anna Sebo, Ganesan Senthil Kumar, Peter Egri, Adam L Poti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Remenyi

Journal article  |  2020  |  NATURE COMMUNICATIONS

Transcription factor phosphorylation at specific sites often activates gene expression, but how environmental cues quantitatively ..

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G Lieu, Yee-Foong Mok, Michael DW Griffin, Naoto Ito, Toyoyuki Ose, Herve Bourhy, Gregory W Moseley, Paul R Gooley

Journal article  |  2019  |  CELL REPORTS

To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of path..

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

Thomas G Meikle, Ashish Sethi, David W Keizer, Jeffrey J Babon, Frances Separovic, Paul R Gooley, Charlotte E Conn, Shenggen Yao

Journal article  |  2019  |  JOURNAL OF MAGNETIC RESONANCE

Lipidic cubic phases, which form spontaneously via the self-assembly of certain lipids in an aqueous environment, are highly prosp..