Esteban Gurzov

Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation.

Tatiana Takiishi, Peng Xiao, Marie Franchimont, Eduardo H Gilglioni, Erick N Arroba, Esteban N Gurzov, Mathieu Jm Bertrand, Alessandra K Cardozo

Journal article  |  2023  |  Mol Metab

OBJECTIVES: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detr..

Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice.

Manoja K Brahma, Peng Xiao, Madalina Popa, Javier Negueruela, Valerie Vandenbempt, Stéphane Demine, Alessandra K Cardozo, Esteban N Gurzov

Journal article  |  2022  |  Nutrients

The loss of functional pancreatic β-cell mass is an important hallmark of both type 1 and type 2 diabetes. The RNA-binding protein..

NF-kappa B-inducing kinase (NIK) is activated in pancreatic beta-cells but does not contribute to the development of diabetes

Peng Xiao, Tatiana Takiishi, Natalia Moretti Violato, Giada Licata, Francesco Dotta, Guido Sebastiani, Lorella Marselli, Sumeet Pal Singh, Mozes Sze, Geert Van Loo, Emmanuel Dejardin, Esteban Nicolas Gurzov, Alessandra Kupper Cardozo

Journal article  |  2022  |  CELL DEATH & DISEASE

The transcription factor nuclear factor-κB (NF-κB) has a key role in the pathogenesis of diabetes and its complications. Although ..

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic beta-Cells in Autoimmune Diabetes

Bernat Elvira, Valerie Vandenbempt, Julia Bauza-Martinez, Raphael Crutzen, Javier Negueruela, Hazem Ibrahim, Matthew L Winder, Manoja K Brahma, Beata Vekeriotaite, Pieter-Jan Martens, Sumeet Pal Singh, Fernando Rossello, Pascale Lybaert, Timo Otonkoski, Conny Gysemans, Wei Wu, Esteban N Gurzov

Journal article  |  2022  |  DIABETES

Type 1 diabetes (T1D) results from autoimmune destruction of β-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are can..

Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation

Kirstine J Bell, Sonia Saad, Bree J Tillett, Helen M McGuire, Sara Bordbar, Yu Anne Yap, Long T Nguyen, Marc R Wilkins, Susan Corley, Shannon Brodie, Sussan Duong, Courtney J Wright, Stephen Twigg, Barbara Fazekas de St Groth, Leonard C Harrison, Charles R Mackay, Esteban N Gurzov, Emma E Hamilton-Williams, Eliana Marino

Journal article  |  2022  |  MICROBIOME

BACKGROUND: Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis e..

Insulin-Binding Peptide Probes Provide a Novel Strategy for Pancreatic beta-Cell Imaging

Maria Eriksson, Sara A Litwak, Yan Yun, William J Stanley, Peter Thorn, Ulf Ahlgren, Esteban N Gurzov

Journal article  |  2021  |  MOLECULAR PHARMACEUTICS

Type 1 diabetes develops in childhood and adolescence, with peak incidence in the early teenage years. There is an urgent need for..

STAT3 Regulates Mitochondrial Gene Expression in Pancreatic beta-Cells and Its Deficiency Induces Glucose Intolerance in Obesity

Anais Schaschkow, Lokman Pang, Valerie Vandenbempt, Bernat Elvira, Sara A Litwak, Beata Vekeriotaite, Elisa Maillard, Marjorie Vermeersch, Flavia MM Paula, Michel Pinget, David Perez-Morga, Daniel J Gough, Esteban N Gurzov

Journal article  |  2021  |  DIABETES

Most obese and insulin-resistant individuals do not develop diabetes. This is the result of the capacity of β-cells to adapt and p..

Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

Manoja K Brahma, Eduardo H Gilglioni, Lang Zhou, Eric Trepo, Pengyu Chen, Esteban N Gurzov

Journal article  |  2021  |  ONCOGENE

Obesity affects more than 650 million individuals worldwide and is a well-established risk factor for the development of hepatocel..

Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes.

Esteban N Gurzov, Pu Chun Ke, Ulf Ahlgren, Rita S Garcia Ribeiro, Martin Gotthardt

Journal article  |  2020  |  Trends Endocrinol Metab

A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell..

Multimodal nanoprobe for pancreatic beta cell detection and amyloidosis mitigation

F Xin, Y Li, C Fu, I Javed, X Huang, A Schaschkow, RSG Ribeiro, EN Gurzov, TP Davis, X Zhang, PC Ke, R Qiao

Journal article  |  2020  |  Chemistry of Materials

Type 2 diabetes (T2D) is a metabolic disease and a global health crisis. Because of the small mass and high dispersity of beta cel..