Esteban Gurzov

Novel Strategies to Protect and Visualize Pancreatic β Cells in Diabetes.

Esteban N Gurzov, Pu Chun Ke, Ulf Ahlgren, Rita S Garcia Ribeiro, Martin Gotthardt

Journal article  |  2020  |  Trends in Endocrinology and Metabolism

A common feature in the pathophysiology of different types of diabetes is the reduction of β cell mass and/or impairment of β cell..

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Marcus Grohmann, Florian Wiede, Garron T Dodd, Esteban N Gurzov, Geraldine J Ooi, Tariq Butt, Aliki A Rasmiena, Supreet Kaur, Twishi Gulati, Pei K Goh, Aislinn E Treloar, Stuart Archer, Wendy A Brown, Mathias Muller, Matthew J Watt, Osamu Ohara, Catriona A McLean, Tony Tiganis

Journal article  |  2018  |  Cell

Can GABA turn pancreatic α-cells into β-cells?

Decio L Eizirik, Esteban N Gurzov

Journal article  |  2018  |  Nature Reviews Endocrinology

Sweet Killing in Obesity and Diabetes: The Metabolic Role of the BH3-only Protein BIM.

Michela Miani, Bernat Elvira, Esteban N Gurzov

Journal article  |  2018  |  Journal of Molecular Biology

Diabetes is a metabolic disorder affecting more than 400 million individuals and their families worldwide. The major forms of diab..

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

Jibran A Wali, Sandra Galic, Christina YR Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas WH Kay, Sean L Mcgee, Helen E Thomas

Journal article  |  2018  |  Cell Death & Differentiation

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice.

Jibran A Wali, Sandra Galic, Christina Yr Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas Wh Kay, Sean L McGee, Helen E Thomas

Journal article  |  2018  |  Cell death and differentiation

BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary ..

Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation

Emily H Pilkington, May Lai, Xinwei Ge, William J Stanley, Bo Wang, Miaoyi Wang, Aleksandr Kakinen, Marc-Antonie Sani, Michael R Whittaker, Esteban N Gurzov, Feng Ding, John F Quinn, Thomas P Davis, Pu Chun Ke

Journal article  |  2017  |  BIOMACROMOLECULES

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity

Sara A Litwak, Lokman Pang, Sandra Galic, Mariana Igoillo-Esteve, William J Stanley, Jean-Valery Turatsinze, Kim Loh, Helen E Thomas, Arpeeta Sharma, Eric Trepo, Christophe Moreno, Daniel J Gough, Decio L Eizirik, Judy B de Haan, Esteban N Gurzov

Journal article  |  2017  |  Diabetes

The members of the BCL-2 family are crucial regulators of the mitochondrial pathway of apoptosis in normal physiology and disease...

Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic β-cells.

William J Stanley, Prerak M Trivedi, Andrew P Sutherland, Helen E Thomas, Esteban N Gurzov

Journal article  |  2017  |  Journal of Molecular Endocrinology

Type 1 diabetes (T1D) is characterized by the destruction of insulin-producing β-cells by immune cells in the pancreas. Pro-inflam..

Inhibition of Y1 receptor signaling improves islet transplant outcome

Kim Loh, Yan-Chuan Shi, Stacey Walters, Mohammed Bensellam, Kailun Lee, Katsuya Dezaki, Masanori Nakata, Chi Kin Ip, Jeng Yie Chan, Esteban N Gurzov, Helen E Thomas, Michaela Waibel, James Cantley, Thomas W Kay, Toshihiko Yada, D Ross Laybutt, Shane T Grey, Herbert Herzog

Journal article  |  2017  |  Nature Communications