Simone Nussing

Viral burden, inflammatory milieu and CD8( )T-cell responses to influenza virus in a second-generation thiazolide (RM-5061) and oseltamivir combination therapy study

Simone Nuessing, Edin Mifsud, Luca Hensen, Marios Koutsakos, Zhongfang Wang, Lukasz Kedzierski, Francesca Mercuri, Jean-Francois Rossignol, Aeron C Hurt, Katherine Kedzierska

Journal article  |  2020  |  Influenza and Other Respiratory Viruses

BACKGROUND: Influenza viruses cause significant morbidity and mortality, especially in young children, elderly, pregnant women and..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Hui Fern Koay, Shian Su, Daniela Amann-Zalcenstein, Stephen R Daley, Iain Comerford, Carly E Whyte, Igor E Konstantinov, Yves d'Udekem, Tracey Baldwin, Peter F Hickey, Stuart P Berzins, Jeffrey YW Mak, Axel Kallies, Zhenjun Chen, Simone Nussing, Katherine Kedzierska, Laura K Mackay, Shaun R McColl, Elissa K Deenick, David P Fairlie, et al.

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies

Simone Nussing, Imran G House, Conor J Kearney, Amanda XY Chen, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article  |  2020  |  The Journal of Immunology

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

H-F Koay, S Su, D Amann-Zalcenstein, SR Daley, I Comerford, L Miosge, CE Whyte, IE Konstantinov, Y d'Udekem, T Baldwin, PF Hickey, SP Berzins, JYW Mak, Y Sontani, CM Roots, T Sidwell, A Kallies, Z Chen, S Nussing, K Kedzierska, et al.

Journal article  |  2019  |  Science Immunology

MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymi..

Divergent SATB1 expression across human life span and tissue compartments

Simone Nussing, Hui-Fern Koay, Sneha Sant, Thomas Loudovaris, Stuart I Mannering, Martha Lappas, Yves d'Udekem, Igor E Konstantinov, Stuart P Berzins, Guus F Rimmelzwaan, Stephen J Turner, E Bridie Clemens, Dale I Godfrey, HO Nguyen Thi, Katherine Kedzierska

Journal article  |  2019  |  Immunology and Cell Biology

MAIT CELLS CONTRIBUTE TO A PROTECTIVE ANTIVIRAL INNATE RESPONSE TO INFLUENZA INFECTION

TSC Hinks, B van Wilgenburg, L Loh, TJ Pediongco, H Wang, M Shi, Z Zhao, M Koutsakos, S Nussing, S Sant, Z Wang, C D'Souza, CF Almeida, P Reading, AJ Corbett, J McCluskey, P Klenerman, K Kedzierska

Conference Proceedings  |  2018  |  The influence of influenza: from cells to humans

Limited Phenotypic and Functional Plasticity of Influenza Virus-Specific Memory CD8( ) T Cells during Activation in an Alternative Cytokine Environment

Kim L Harland, Annette Fox, Simone Nussing, Luca Hensen, Katherine Kedzierska, Stephen J Turner, Anne Kelso

Journal article  |  2018  |  The Journal of Immunology

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Xiaoxiao Jia, Catarina F Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn S Meehan, Axel Kallies, Dale I Godfrey, Patrick C Reading, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

MAIT cells contribute to a protective antiviral innate response to influenza infection

Timothy Hinks, Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Patrick Reading, Alexandra Corbett, James Mccluskey, Paul Klenerman, Katherine Kedzierska

Conference Proceedings  |  2018  |  Respiratory infections

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn Meehan, Dale Godfrey, Patrick Reading, Alexandra Corbett, James McCluskey, et al.

Journal article  |  2018  |  Nature Communications

Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lung..