Lloyd Pereira

First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427)

Toan Pham, Lloyd Pereira, Sara Roth, Laura Galletta, Emma Link, Tim Akhurst, Ben Solomon, Michael Michael, Phillip Darcy, Shienny Sampurno, Alexander Heriot, Robert Ramsay, Jayesh Desai

Journal article  |  2019  |  Contemporary Clinical Trials Communications

Background: MYB is a transcription factor that is overexpressed in colorectal cancer (CRC) and also a driver mutation in adenoid c..

Novel vaccine targeting colonic adenoma: A pre-clinical model

Toan D Pham, Sandra Carpinteri, Shienny Sampurno, Lloyd Pereira, Sara Roth, Vignesh Narasimhan, Kasmira Wilson, Phillip Darcy, Jayesh Desai, Alexander G Heriot, Robert G Ramsay

Conference Proceedings  |  2019  |  CANCER RESEARCH

Novel Vaccine Targeting Colonic Adenoma: a Pre-clinical Model

Toan Pham, Sandra Carpinteri, Shienny Sampurno, Lloyd Pereira, Sara Roth, Vignesh Narasimhan, Phillip Darcy, Jayesh Desai, Alexander G Heriot, Robert G Ramsay

Journal article  |  2019  |  JOURNAL OF GASTROINTESTINAL SURGERY

BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the USA. Over 80% of CRC develop fr..

E mu Tel-Jak2 T-ALL mouse model is dependent upon Myb function and susceptible to immune checkpoint therapy

Sara Roth, Shienny Sampurno, Michaela Waibel, Leonie Cluse, Lloyd A Pereira, Ricky W Johnstone, Robert G Ramsay

Conference Proceedings  |  2019  |  CANCER IMMUNOLOGY RESEARCH

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer, predominantly in children..

Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis

Dane Cheasley, Lloyd Pereira, Shienny Sampurno, Oliver Sieber, Robert Jorissen, Huiling Xu, Markus Germann, Yuqian Yan, Robert G Ramsay, Jordane Malaterre

Journal article  |  2015  |  MOLECULAR CANCER RESEARCH

UNLABELLED: Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic mutant Myb mice (Myb(P..

MYB Elongation Is Regulated by the Nucleic Acid Binding of NF kappa B p50 to the Intronic Stem-Loop Region

Lloyd A Pereira, Honor J Hugo, Jordane Malaterre, Huiling Xu, Secondo Sonza, Alina Cures, Damian FJ Purcell, Paul A Ramsland, Steven Gerondakis, Thomas J Gonda, Robert G Ramsay

Journal article  |  2015  |  PLOS ONE

MYB transcriptional elongation is regulated by an attenuator sequence within intron 1 that has been proposed to encode a RNA stem ..

Myb and the Regulation of Stem Cells in the Intestine and Brain: A Tale of Two Niches

Jordane Malaterre, Lloyd Pereira, Robert G Ramsay

Journal article  |  2013  |  TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION OF STEM CELLS

Adult stem cells reside in most parts of the body where high tissue turn-over is evident. However there are vastly different deman..

The Mix family of homeobox genes-Key regulators of mesendoderm formation during vertebrate development

Lloyd A Pereira, Michael S Wong, Sue Mei Lim, Edouard G Stanley, Andrew G Elefanty

Journal article  |  2012  |  DEVELOPMENTAL BIOLOGY

The Mix/Bix family of paired-like homeobox genes encode evolutionarily conserved, sequence specific, DNA-binding transcription fac..