Jessica Bridgford

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

Jessica L Bridgford, Su Min Lee, Christine MM Lee, Paola Guglielmelli, Elisa Rumi, Daniela Pietra, Stephen Wilcox, Yash Chhabra, Alan F Rubin, Mario Cazzola, Alessandro M Vannucchi, Andrew J Brooks, Matthew E Call, Melissa J Call

Journal article  |  2020  |  BLOOD

The single transmembrane domain (TMD) of the human thrombopoietin receptor (TpoR/myeloproliferative leukemia [MPL] protein), encod..

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  CELL REPORTS

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch1..

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Jessica L Bridgford, Stanley C Xie, Simon A Cobbold, Charisse Flerida A Pasaje, Susann Herrmann, Tuo Yang, David L Gillett, Lawrence R Dick, Stuart A Ralph, Con Dogovski, Natalie J Spillman, Leann Tilley

Journal article  |  2018  |  NATURE COMMUNICATIONS

Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum inf..

A thiol probe for measuring unfolded protein load and proteostasis in cells

Moore Z Chen, Nagaraj S Moily, Jessica L Bridgford, Rebecca J Wood, Mona Radwan, Trevor A Smith, Zhegang Song, Ben Zhong Tang, Leann Tilley, Xiaohong Xu, Gavin E Reid, Mahmoud A Pouladi, Yuning Hong, Danny M Hatters

Journal article  |  2017  |  NATURE COMMUNICATIONS

When proteostasis becomes unbalanced, unfolded proteins can accumulate and aggregate. Here we report that the dye, tetraphenylethe..

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnaedig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley

Journal article  |  2015  |  PLOS BIOLOGY

Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that r..