Emma McHugh

Functional Characterization of the m6A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite.

Ameya Sinha, Sebastian Baumgarten, Amy Distiller, Emma McHugh, Patty Chen, Meetali Singh, Jessica M Bryant, Jiaqi Liang, Germano Cecere, Peter C Dedon, Peter R Preiser, Stuart A Ralph, Artur Scherf

Journal article  |  2021  |  mBio

Posttranscriptional regulation of gene expression is central to the development and replication of the malaria parasite, Plasmodiu..

A divergent nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential

Emma McHugh, Michaela Bulloch, Steven Batinovic, Drishti Sarna, Stuart Ralph

Journal article  |  2021

ABSTRACT Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that eliminates transcripts bearing a premature..

Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics

Simon A Cobbold, Madel Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville

Journal article  |  2021  |  MOLECULAR SYSTEMS BIOLOGY

The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sou..

Role of Plasmodium falciparum Protein GEXPO7 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

Emma McHugh, Olivia MS Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy JY Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew WA Dixon

Journal article  |  2020  |  MBIO

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to..

Alternative splicing is required for stage differentiation in malaria parasites

Lee M Yeoh, Christopher D Goodman, Vanessa Mollard, Emma McHugh, V Vern Lee, Angelika Sturm, Anton Cozijnsen, Geoffrey I McFadden, Stuart A Ralph

Journal article  |  2019  |  GENOME BIOLOGY

BACKGROUND: In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protis..

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

Kit Kennedy, Simon A Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J Spillman, Emma McHugh, Hannah Brown, Leann Tilley, Tobias Spielmann, Malcolm J McConville, Stuart A Ralph

Journal article  |  2019  |  PLOS BIOLOGY

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeepi..

Spatial organization of protein export in malaria parasite blood stages

Sarah C Charnaud, Thorey K Jonsdottir, Paul R Sanders, Hayley E Bullen, Benjamin K Dickerman, Betty Kouskousis, Catherine S Palmer, Halina M Pietrzak, Annamarie E Laumaea, Anna-Belen Erazo, Emma McHugh, Leann Tilley, Brendan S Crabb, Paul R Gilson

Journal article  |  2018  |  TRAFFIC

Plasmodium falciparum, which causes malaria, extensively remodels its human host cells, particularly erythrocytes. Remodelling is ..

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew WA Dixon

Journal article  |  2017  |  PLOS PATHOGENS

Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the hu..

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

Steven Batinovic, Emma McHugh, Scott A Chisholm, Kathryn Matthews, Boiyin Liu, Laure Dumont, Sarah C Charnaud, Molly Parkyn Schneider, Paul R Gilson, Tania F de Koning-Ward, MatthewW A Dixon, Leann Tilley

Journal article  |  2017  |  NATURE COMMUNICATIONS

The malaria parasite, Plasmodium falciparum, displays the P. falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of ..

Contrasting Inducible Knockdown of the Auxiliary PTEX Component PTEX88 in P-falciparum and P-berghei Unmasks a Role in Parasite Virulence

Scott A Chisholm, Emma McHugh, Rachel Lundie, Matthew WA Dixon, Sreejoyee Ghosh, Meredith O'Keefe, Leann Tilley, Ming Kalanon, Tania F de Koning-Ward

Journal article  |  2016  |  PLOS ONE

Pathogenesis of malaria infections is linked to remodeling of erythrocytes, a process dependent on the trafficking of hundreds of ..