Emma McHugh

Role of Plasmodium falciparum Protein GEXPO7 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

Emma McHugh, Olivia MS Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy JY Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew WA Dixon

Journal article  |  2020  |  MBIO

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to..

Alternative splicing is required for stage differentiation in malaria parasites

Lee M Yeoh, Christopher D Goodman, Vanessa Mollard, Emma McHugh, V Vern Lee, Angelika Sturm, Anton Cozijnsen, Geoffrey I McFadden, Stuart A Ralph

Journal article  |  2019  |  Genome Biology

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

Kit Kennedy, Simon A Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J Spillman, Emma McHugh, Hannah Brown, Leann Tilley, Tobias Spielmann, Malcolm J McConville, Stuart A Ralph

Journal article  |  2019  |  PLOS BIOLOGY

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeepi..

Spatial organization of protein export in malaria parasite blood stages

Sarah C Charnaud, Thorey K Jonsdottir, Paul R Sanders, Hayley E Bullen, Benjamin K Dickerman, Betty Kouskousis, Catherine S Palmer, Halina M Pietrzak, Annamarie E Laumaea, Anna-Belen Erazo, Emma McHugh, Leann Tilley, Brendan S Crabb, Paul R Gilson

Journal article  |  2018  |  Traffic

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew WA Dixon

Journal article  |  2017  |  PLOS PATHOGENS

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

Steven Batinovic, Emma McHugh, Scott A Chisholm, Kathryn Matthews, Boiyin Liu, Laure Dumont, Sarah C Charnaud, Molly Parkyn Schneider, Paul R Gilson, Tania F de Koning-Ward, MatthewW A Dixon, Leann Tilley

Journal article  |  2017  |  NATURE COMMUNICATIONS

Contrasting Inducible Knockdown of the Auxiliary PTEX Component PTEX88 in P-falciparum and P-berghei Unmasks a Role in Parasite Virulence

Scott A Chisholm, Emma McHugh, Rachel Lundie, Matthew WA Dixon, Sreejoyee Ghosh, Meredith O'Keefe, Leann Tilley, Ming Kalanon, Tania F de Koning-Ward

Journal article  |  2016  |  PLOS ONE

A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking

Emma McHugh, Steven Batinovic, Eric Hanssen, Paul J McMillan, Shannon Kenny, Michael DW Griffin, Simon Crawford, Katharine R Trenholme, Donald L Gardiner, Matthew WA Dixon, Leann Tilley

Journal article  |  2015  |  Molecular Microbiology