Amanda Au

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  The EMBO Journal

Activated CD8( ) T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Maria Daglas, Dominik F Draxler, Heidi Ho, Fiona McCutcheon, Adam Galle, Amanda E Au, Pia Larsson, Julia Gregory, Frank Alderuccio, Maithili Sashindranath, Robert L Medcalf

Journal article  |  2019  |  Cell Reports

Traumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged immune response in the brain may cause..

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy

Journal article  |  2019  |  Cell Reports

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

Dominik F Draxler, Maria Daglas, Anushka Fernando, Gryselda Hanafi, Fiona McCutcheon, Heidi Ho, Adam Galle, Julia Gregory, Pia Larsson, Charithani Keragala, David K Wright, Elnaz Tavancheh, Amanda E Au, Be'eri Niego, Kirsty Wilson, Magdalena Plebanski, Maithili Sashindranath, Robert L Medcalf

Journal article  |  2019  |  Journal of Thrombosis and Haemostasis

BACKGROUND: Traumatic brain injury (TBI) is known to promote immunosuppression, making patients more susceptible to infection, yet..

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E Au, Rachael M Lane, Katya J Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E Jarman, Sarah Ellis, Donald Metcalf, Shaun P Jackson, Simone M Schoenwaelder, Benjamin T Kile, Emma C Josefsson

Journal article  |  2018  |  Blood

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling

Amanda E Au, Marion Lebois, Starling A Sim, Ping Cannon, Jason Corbin, Pradnya Gangatirkar, Craig D Hyland, Diane Moujalled, Angelika Rutgersson, Fatme Yassinson, Benjamin T Kile, Kylie D Mason, Ashley P Ng, Warren S Alexander, Emma C Josefsson

Journal article  |  2017  |  SCIENTIFIC REPORTS

Selective inhibition of brain endothelial Rhokinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Be'eri Niego, Natasha Lee, Pia Larsson, T Michael de Silva, Amanda E-Ling Au, Fiona McCutcheon, Robert L Medcalf

Journal article  |  2017  |  PLoS One

Regulation of platelet membrane protein shedding in health and disease

Amanda E Au, Emma C Josefsson

Journal article  |  2017  |  Platelets

Regulation of megakaryocyte and platelet survival

AE Au, M Lebois, I Pleines, EC Josefsson

Book Chapter  |  2017

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells.

Andre L Samson, Bosco Ho, Amanda E Au, Simone M Schoenwaelder, Mark J Smyth, Stephen P Bottomley, Oded Kleifeld, Robert L Medcalf

Journal article  |  2016  |  Open Biology

Amyloidogenic protein aggregation impairs cell function and is a hallmark of many chronic degenerative disorders. Protein aggregat..