Nicholas Barnes

Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation.

Alexander Roberts, Lindsay Bentley, Tina Tang, Fay Stewart, Chiara Pallini, Joel Juvvanapudi, Graham R Wallace, Alison J Cooper, Aaron Scott, David Thickett, Sebastian T Lugg, Hollie Bancroft, Bridget Hemming, Charlotte Ferris, Gerald Langman, Andrew Robinson, Joanne Chapman, Babu Naidu, Thomas Pinkney, Graham S Taylor, et al.

Journal article  |  2021  |  Sci Rep

Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are..

ILB® resolves inflammatory scarring and promotes functional tissue repair.

Lisa J Hill, Hannah F Botfield, Ghazala Begum, Omar Qureshi, Vasanthy Vigneswara, Imran Masood, Nicholas M Barnes, Lars Bruce, Ann Logan

Journal article  |  2021  |  NPJ Regen Med

Fibrotic disease is a major cause of mortality worldwide, with fibrosis arising from prolonged inflammation and aberrant extracell..

Deconstructing depression and negative symptoms of schizophrenia; differential and longitudinal immune correlates, and response to minocycline treatment.

Carl R Krynicki, Paola Dazzan, Carmine M Pariante, Nicholas M Barnes, Rachel C Vincent, Alex Roberts, Annalisa Giordano, Andrew Watson, John Suckling, Thomas RE Barnes, Nusrat Husain, Peter B Jones, Eileen Joyce, Stephen M Lawrie, Shôn Lewis, Bill Deakin, Rachel Upthegrove, undefined BeneMin Study team

Journal article  |  2021  |  Brain Behav Immun

BACKGROUND: Immune dysfunction has been implicated in negative symptoms of schizophrenia and also in depression. These disorders a..

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Nicholas M Barnes, Gerard P Ahern, Carine Becamel, Joel Bockaert, Michael Camilleri, Severine Chaumont-Dubel, Sylvie Claeysen, Kathryn A Cunningham, Kevin C Fone, Michael Gershon, Giuseppe Di Giovanni, Nathalie M Goodfellow, Adam L Halberstadt, Rachel M Hartley, Gherici Hassaine, Katharine Herrick-Davis, Ruud Hovius, Enza Lacivita, Evelyn K Lambe, Marcello Leopoldo, et al.

Journal article  |  2021  |  PHARMACOLOGICAL REVIEWS

5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Thei..

Geissospermiculatine, a New Alkaloid from Geissospermum reticulatum Bark.

Joanna J Sajkowska-Kozielewicz, Paweł Kozielewicz, Katerina Makarova, Marcin Stocki, Nicholas M Barnes, Katarzyna Paradowska

Journal article  |  2020  |  Molecules

A new alkaloid, geissospermiculatine was characterized in Geissospermum reticulatum A. H. Gentry bark (Apocynaceae). Here, followi..

SPAK and OSR1 kinases bind and phosphorylate the β2-Adrenergic receptor.

Abdulrahman Elzwawi, Gillian Grafton, Nicholas M Barnes, Youcef Mehellou

Journal article  |  2020  |  Biochem Biophys Res Commun

SPAK and OSR1 are two cytoplasmic serine/threonine protein kinases that regulate the function of a series of sodium, potassium and..

Central 5-HT receptors and their function; present and future.

Trevor Sharp, Nicholas M Barnes

Journal article  |  2020  |  Neuropharmacology

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT receptor has been discovered and there..

Low Molecular Weight Dextran Sulfate (ILB®) Administration Restores Brain Energy Metabolism Following Severe Traumatic Brain Injury in the Rat.

Giacomo Lazzarino, Angela Maria Amorini, Nicholas M Barnes, Lars Bruce, Alvaro Mordente, Giuseppe Lazzarino, Valentina Di Pietro, Barbara Tavazzi, Antonio Belli, Ann Logan

Journal article  |  2020  |  Antioxidants (Basel)

Traumatic brain injury (TBI) is the leading cause of death and disability in people less than 40 years of age in Western countries..

Abstract 3274: A robust enhancement of cytokine production in a human chronic activation model of T cell exhaustionin vitrothrough blockade of PD-1/PDL-1 interactions using pembrolizumab or nivolumab; correlation with dissociated tumor immune cell responses

Omar S Qureshi, Alexander Roberts, Lindsay Bentley, Tina Tang, Fay Stewart, Graham Wallace, Alison Cooper, Aaron Scott, David Thickett, Babu Naidu, Thomas Pinkney, Graham Taylor, Kristian Brock, Louise Healy, Zania Stamataki, Catherine Brady, SJ Curnow, John Gordon, Nicholas M Barnes

Conference Proceedings  |  2020  |  Immunology

CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome.

Alexander Roberts, Gillian Grafton, Andrew D Powell, Kristian Brock, Chunlin Chen, Dejian Xie, Jinkun Huang, Shuang Liu, Alison J Cooper, Catherine A Brady, Omar Qureshi, Zania Stamataki, David D Manning, Nicholas A Moore, Bruce J Sargent, Peter R Guzzo, Nicholas M Barnes

Journal article  |  2020  |  J Pharmacol Exp Ther

The 5-hydroxytryptamine (5-HT) (serotonin) 5-HT3 receptor represents a clinical target for antagonists to deliver symptomatic reli..