Nicholas Barnes

ILB® resolves inflammatory scarring and promotes functional tissue repair.

Lisa J Hill, Hannah F Botfield, Ghazala Begum, Omar Qureshi, Vasanthy Vigneswara, Imran Masood, Nicholas M Barnes, Lars Bruce, Ann Logan

Journal article  |  2021  |  npj Regenerative Medicine

Fibrotic disease is a major cause of mortality worldwide, with fibrosis arising from prolonged inflammation and aberrant extracell..

Deconstructing depression and negative symptoms of schizophrenia; differential and longitudinal immune correlates, and response to minocycline treatment.

Carl R Krynicki, Paola Dazzan, Carmine M Pariante, Nicholas M Barnes, Rachel C Vincent, Alex Roberts, Annalisa Giordano, Andrew Watson, John Suckling, Thomas RE Barnes, Nusrat Husain, Peter B Jones, Eileen Joyce, Stephen M Lawrie, Shôn Lewis, Bill Deakin, Rachel Upthegrove, undefined BeneMin Study team

Journal article  |  2021  |  Brain Behavior and Immunity

BACKGROUND: Immune dysfunction has been implicated in negative symptoms of schizophrenia and also in depression. These disorders a..

Geissospermiculatine, a New Alkaloid from Geissospermum reticulatum Bark.

Joanna J Sajkowska-Kozielewicz, Paweł Kozielewicz, Katerina Makarova, Marcin Stocki, Nicholas M Barnes, Katarzyna Paradowska

Journal article  |  2020  |  Molecules

A new alkaloid, geissospermiculatine was characterized in Geissospermum reticulatum A. H. Gentry bark (Apocynaceae). Here, followi..

SPAK and OSR1 kinases bind and phosphorylate the β2-Adrenergic receptor.

Abdulrahman Elzwawi, Gillian Grafton, Nicholas M Barnes, Youcef Mehellou

Journal article  |  2020  |  Biochemical and Biophysical Research Communications

SPAK and OSR1 are two cytoplasmic serine/threonine protein kinases that regulate the function of a series of sodium, potassium and..

Central 5-HT receptors and their function; present and future.

Trevor Sharp, Nicholas M Barnes

Journal article  |  2020  |  Neuropharmacology

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT receptor has been discovered and there..

Low Molecular Weight Dextran Sulfate (ILB®) Administration Restores Brain Energy Metabolism Following Severe Traumatic Brain Injury in the Rat.

Giacomo Lazzarino, Angela Maria Amorini, Nicholas M Barnes, Lars Bruce, Alvaro Mordente, Giuseppe Lazzarino, Valentina Di Pietro, Barbara Tavazzi, Antonio Belli, Ann Logan

Journal article  |  2020  |  Antioxidants

Traumatic brain injury (TBI) is the leading cause of death and disability in people less than 40 years of age in Western countries..

Abstract 3274: A robust enhancement of cytokine production in a human chronic activation model of T cell exhaustionin vitrothrough blockade of PD-1/PDL-1 interactions using pembrolizumab or nivolumab; correlation with dissociated tumor immune cell responses

Omar S Qureshi, Alexander Roberts, Lindsay Bentley, Tina Tang, Fay Stewart, Graham Wallace, Alison Cooper, Aaron Scott, David Thickett, Babu Naidu, Thomas Pinkney, Graham Taylor, Kristian Brock, Louise Healy, Zania Stamataki, Catherine Brady, SJ Curnow, John Gordon, Nicholas M Barnes

Conference Proceedings  |  2020  |  Immunology

CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome.

Alexander Roberts, Gillian Grafton, Andrew D Powell, Kristian Brock, Chunlin Chen, Dejian Xie, Jinkun Huang, Shuang Liu, Alison J Cooper, Catherine A Brady, Omar Qureshi, Zania Stamataki, David D Manning, Nicholas A Moore, Bruce J Sargent, Peter R Guzzo, Nicholas M Barnes

Journal article  |  2020  |  Journal of Pharmacology and Experimental Therapeutics

The 5-hydroxytryptamine (5-HT) (serotonin) 5-HT3 receptor represents a clinical target for antagonists to deliver symptomatic reli..

Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4 T Cell Engulfment Process.

Scott P Davies, Gary M Reynolds, Alex L Wilkinson, Xiaoyan Li, Rebecca Rose, Maanav Leekha, Yuxin S Liu, Ratnam Gandhi, Emma Buckroyd, Joe Grove, Nicholas M Barnes, Robin C May, Stefan G Hubscher, David H Adams, Yuehua Huang, Omar Qureshi, Zania Stamataki

Journal article  |  2019  |  Cell Reports

CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate th..

5-HT3 receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Nicholas M Barnes, Tim G Hales, Sarah CR Lummis, Beate Niesler, John A Peters

Journal article  |  2019  |  IUPHAR/BPS Guide to Pharmacology CITE

The 5-HT3 receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-Hydroxytryptamine (serotonin) receptors [66]) is a l..