Katharina Hochheiser

Tumor reactivity of CD8( ) T cells favors acquisition of dysfunctional states in human melanoma

Katharina Hochheiser, David E Gyorki, Thomas Gebhardt

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

A recent study by Oliveira et al. provides, in unprecedented detail, novel insights into the relationship between tumorreactivity ..

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation

Katarzyna Jobin, Natascha E Stumpf, Sebastian Schwab, Melanie Eichler, Patrick Neubert, Manfred Rauh, Marek Adamowski, Olena Babyak, Daniel Hinze, Sugirthan Sivalingam, Christina Weisheit, Katharina Hochheiser, Susanne Schmidt, Mirjam Meissner, Natalio Garbi, Zeinab Abdullah, Ulrich Wenzel, Michael Hoelzel, Jonathan Jantsch, Christian Kurts

Journal article  |  2020  |  SCIENCE TRANSLATIONAL MEDICINE

The Western diet is rich in salt, which poses various health risks. A high-salt diet (HSD) can stimulate immunity through the nucl..

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

Journal article  |  2020  |  EMBO JOURNAL

Although adoptive T-cell therapy has shown remarkable clinical efficacy in haematological malignancies, its success in combating s..

Skin colonization with beta papilloma virus drives tissue immunity and resistance to squamous cell cancer

Katharina Hochheiser, David E Gyorki, Thomas Gebhardt

Journal article  |  2019  |  IMMUNOLOGY AND CELL BIOLOGY

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis

Journal article  |  2019

ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article  |  2019  |  IMMUNITY

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

Tissue-resident memory CD8( ) T cells promote melanoma-immune equilibrium in skin

Simone L Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S Wilmott, Richard A Scolyer, Thomas Tueting, Umaimainthan Palendria, David Gyorki, Scott N Mueller, Nicholas D Huntington, Sammy Bedoui, Michael Hoelzel, Laura K Mackay, et al.

Journal article  |  2019  |  NATURE

The immune system can suppress tumour development both by eliminating malignant cells and by preventing the outgrowth and spread o..

Accumulation of CD103( ) CD8( ) T cells in a cutaneous melanoma micrometastasis

Katharina Hochheiser, Han Xian Aw Yeang, Teagan Wagner, Candani Tutuka, Andreas Behren, Jason Waithman, Christopher Angel, Paul J Neeson, Thomas Gebhardt, David E Gyorki

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objective: The immune system can halt cancer progression by suppressing outgrowth of clinically occult micrometastases in a state ..

CRISPR/Cas9: A tool for immunological research

Katharina Hochheiser, Andrew J Kueh, Thomas Gebhardt, Marco J Herold

Journal article  |  2018  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The CRISPR/Cas9-system was originally identified as part of the adaptive immune system in bacteria and has since been adapted for ..