My current research focuses on T-cell mediated immune responses in peripheral tissues, which I am highly interested in because knowledge about the molecular mechanisms might be translated into treatment of a great variety of diseases. I am especially interested in the development and function of Tissue Resident Memory T cells, which remain in tissues after infection and have been shown to play a major role in protective but also harmful immune responses.
My PhD was carried out under the supervision of Prof. Christian Kurts in Bonn, Germany, and focused on Dendritic Cells in the kidney.
I characterized DCs from different compartments of the kidney in the steady state and in different nephritis models and demonstrated the dependence of effector T cell responses on the presence of mature DCs.
In November 2014 I joined the lab of Assoc. Prof. Thomas Gebhardt at the University of Melbourne, who is an expert on memory T cells and shares my interest in immune cell functions in peripheral tissues. My research now focuses on T cell immunity in the skin. Using mouse models of skin infection, autoimmunity and melanoma in combination with gene editing techniques such as ectopic expression and CRISPR/Cas9 mediated knockout, I investigate the development and function of Tissue Resident Memory T cells and their role in different skin diseases.
In collaboration with Dr. David Gyorki, who is a surgeon at the Peter MacCallum Cancer Centre, we have recently started to work with human samples. Applying multiplex immunohistochemistry, we are investigating whether we can translate findings from our animal models into the clinic.
Find out more about Katharina Hochheiser's experience
Katharina Hochheiser's highlights
Katharina Hochheiser's selected work
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficac..
Skin colonization with beta papilloma virus drives tissue immunity and resistance to squam..
PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid t..
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activat..
Displaying the most recent project by Katharina Hochheiser.
Displaying the 22 most recent scholarly works by Katharina Hochheiser.
A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation
Katarzyna Jobin, Natascha E Stumpf, Sebastian Schwab, Melanie Eichler, Patrick Neubert, Manfred Rauh, Marek Adamowski, Olena Babyak, Daniel Hinze, Sugirthan Sivalingam, Christina Weisheit, Katharina Hochheiser, Susanne Schmidt, Mirjam Meissner, Natalio Garbi, Zeinab Abdullah, Ulrich Wenzel, Michael Hoelzel, Jonathan Jantsch, Christian Kurts
Journal article | 2020 | Science Translational Medicine
The Western diet is rich in salt, which poses various health risks. A high-salt diet (HSD) can stimulate immunity through the nucl..
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours
Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis
Journal article | 2020 | The EMBO Journal
PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours
Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis
Journal article | 2019
ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells
Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.
Journal article | 2019 | Immunity
Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..
Tissue-resident memory CD8( ) T cells promote melanoma-immune equilibrium in skin
Simone L Park, Anthony Buzzai, Jai Rautela, Jyh Liang Hor, Katharina Hochheiser, Maike Effern, Nathan McBain, Teagan Wagner, Jarem Edwards, Robyn McConville, James S Wilmott, Richard A Scolyer, Thomas Tueting, Umaimainthan Palendria, David Gyorki, Scott N Mueller, Nicholas D Huntington, Sammy Bedoui, Michael Hoelzel, Laura K Mackay, et al.
Journal article | 2019 | Nature
Accumulation of CD103( ) CD8( ) T cells in a cutaneous melanoma micrometastasis
Katharina Hochheiser, Han Xian Aw Yeang, Teagan Wagner, Candani Tutuka, Andreas Behren, Jason Waithman, Christopher Angel, Paul J Neeson, Thomas Gebhardt, David E Gyorki
Journal article | 2019 | Clinical & Translational Immunology
Objective: The immune system can halt cancer progression by suppressing outgrowth of clinically occult micrometastases in a state ..
Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells
Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui
Journal article | 2018 | Journal of Virology
Selective Dependence of Kidney Dendritic Cells on CX3CR1--Implications for Glomerulonephritis Therapy.
Katharina Hochheiser, Christian Kurts
Journal article | 2015 | Advances in Experimental Medicine and Biology
As central regulators of the adaptive immune response, dendritic cells (DCs) are found in virtually all lymphatic and non-lymphati..
Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression.
Katharina Hochheiser, Christoph Heuser, Torsten A Krause, Simon Teteris, Anissa Ilias, Christina Weisheit, Florian Hoss, André P Tittel, Percy A Knolle, Ulf Panzer, Daniel R Engel, Pierre-Louis Tharaux, Christian Kurts
Journal article | 2013 | Journal of Clinical Investigation
DCs and macrophages both express the chemokine receptor CX3CR1. Here we demonstrate that its ligand, CX3CL1, is highly expressed i..
Ligand-specific binding and activation of the human adenosine A(2B) receptor.
Dominik Thimm, Anke C Schiedel, Farag F Sherbiny, Sonja Hinz, Katharina Hochheiser, Daniela CG Bertarelli, Astrid Maass, Christa E Müller
Journal article | 2013 | Biochemistry
Adenosine A(2B) receptors, which play a role in inflammation and cancer, are of considerable interest as novel drug targets. To ga..
Isolation of functional dendritic cells from murine kidneys for immunological characterization.
Simon Alexander Teteris, Katharina Hochheiser, Christian Kurts
Journal article | 2012 | Nephrology
AIM: The kidney is a complex organ, requiring the contributions of multiple cell types to perform its various functions. Within th..
Kidney dendritic cells in acute and chronic renal disease.
Katharina Hochheiser, André Tittel, Christian Kurts
Journal article | 2011 | International Journal of Experimental Pathology
Dendritic cells are not only the master regulators of adaptive immunity, but also participate profoundly in innate immune response..
Endogenous foxp3( ) T-regulatory cells suppress anti-glomerular basement membrane nephritis.
Joshua D Ooi, Sarah L Snelgrove, Daniel R Engel, Katharina Hochheiser, Isis Ludwig-Portugall, Yuji Nozaki, Kim M O'Sullivan, Michael J Hickey, Stephen R Holdsworth, Christian Kurts, A Richard Kitching
Journal article | 2011 | Kidney International
Foxp3(+) T-regulatory cells (Tregs) may suppress pathogenic inflammation; however, although transferred Tregs lessen glomeruloneph..
Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria.
Katharina Hochheiser, Daniel R Engel, Linda Hammerich, Felix Heymann, Percy A Knolle, Ulf Panzer, Christian Kurts
Journal article | 2011 | Journal of the American Society of Nephrology
It is unclear why kidney dendritic cells attenuate some models of kidney disease but aggravate others. Kidney dendritic cells amel..
Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs
Verena Semmling, Veronika Lukacs-Kornek, Christoph A Thaiss, Thomas Quast, Katharina Hochheiser, Ulf Panzer, Jamie Rossjohn, Patrick Perlmutter, Jia Cao, Dale I Godfrey, Paul B Savage, Percy A Knolle, Waldemar Kolanus, Irmgard Foerster, Christian Kurts
Journal article | 2010 | Nature Immunology
Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments.
Sven Burgdorf, Verena Schuette, Verena Semmling, Katharina Hochheiser, Veronika Lukacs-Kornek, Percy A Knolle, Christian Kurts
Journal article | 2010 | Proceedings of the National Academy of Sciences
Honours, Awards and Fellowships
RJS Thomas Translational Research Prize
NOTINLIST - Not in List
NOTINLIST - Not in List
NOTINLIST - Not in List
Senior Research Officer
Microbiology And Immunology
Australasian Society For Immunology
Australasian Society for Immunology
German Society For Immunology
German Society for Immunology
Dr. rer. nat.
University of Bonn