Hongdo Do

A Synthetic DNA Construct to Evaluate the Recovery Efficiency of Cell-Free DNA Extraction and Bisulfite Modification

Su Kah Goh, Daniel RA Cox, Boris Ka Leong Wong, Ashan Musafer, Tom Witkowski, Hongdo Do, Vijayaragavan Muralidharan, Alexander Dobrovic

Journal article  |  2021  |  CLINICAL CHEMISTRY

BACKGROUND: Despite improvements in the genetic and epigenetic analysis of cell-free DNA (cfDNA), there has been limited focus on ..

Cerebrospinal fluid liquid biopsy for detecting somatic mosaicism in brain

Zimeng Ye, Zac Chatterton, Jahnvi Pflueger, John A Damiano, Lara McQuillan, Anthony Simon Harvey, Stephen Malone, Hongdo Do, Wirginia Maixner, Amy Schneider, Bernadette Nolan, Martin Wood, Wei Shern Lee, Greta Gillies, Kate Pope, Michael Wilson, Paul J Lockhart, Alexander Dobrovic, Ingrid E Scheffer, Melanie Bahlo, et al.

Journal article  |  2021  |  BRAIN COMMUNICATIONS

Brain somatic mutations are an increasingly recognized cause of epilepsy, brain malformations and autism spectrum disorders and ma..

NTRK and ALK rearrangements in malignant pleural mesothelioma, pulmonary neuroendocrine tumours and non-small cell lung cancer

Jose Luis Leal, Geoffrey Peters, Marcin Szaumkessel, Trishe Leong, Khashayar Asadi, Gareth Rivalland, Hongdo Do, Clare Senko, Paul L Mitchell, Chai Zi Quing, Alexander Dobrovic, Bibhusal Thapa, Thomas John

Journal article  |  2020  |  LUNG CANCER

OBJECTIVES: Gene rearrangements involving NTRK1, NTRK2, NTRK3, ROS1 and ALK have been identified in many types of cancer, includin..

A case-control study of constitutional BRCA1 methylation in a mammographically screened cohort

Basant Ebaid, Hongdo Do, Jia Min Pang, Lisa Devereux, Alexander Dobrovic

Conference Proceedings  |  2019  |  CANCER RESEARCH

Abstract Introduction: Over 90% of breast cancers occur sporadically with no obvious hereditary factors at play, th..

Adapting an Established Clinical Chemistry Quality Control Measure for Droplet Generation Performance in Digital PCR

Su Kah Goh, Boris Ka Leong Wong, Vijayaragavan Muralidharan, Christopher Christophi, Hongdo Do, Alexander Dobrovic

Journal article  |  2018  |  CLINICAL CHEMISTRY

NTRK and ALK rearrangements in mesothelioma and lung carcinoid.

Geoffrey David Peters, Marcin Szaumkessel, Trishe Leong, Marzena Walkiewicz, Hongdo Do, Alexander Dobrovic, Gareth Rivalland, Bibhusal Thapa, Thomas John

Conference Proceedings  |  2018  |  JOURNAL OF CLINICAL ONCOLOGY

In Reply to Leone.

Hongdo Do, Surein Arulananda, Thomas John, Alexander Dobrovic

Journal article  |  2018  |  J Thorac Oncol

GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly

Daniel L Cameron, Jan Schroder, Jocelyn Sietsma Penington, Hongdo Do, Ramyar Molania, Alexander Dobrovic, Terence P Speed, Anthony T Papenfuss

Journal article  |  2017  |  GENOME RESEARCH

The identification of genomic rearrangements with high sensitivity and specificity using massively parallel sequencing remains a m..

EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma

Timothy D Clay, Prudence A Russell, Hongdo Do, Vijaya Sundararajan, Matthew Conron, Gavin M Wright, Benjamin Solomon, Alexander Dobrovic, Sue-Anne McLachlan, Melissa M Moore

Journal article  |  2017  |  MEDICAL ONCOLOGY

Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) against EGFR mutant lung adenocarcinoma de..

Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase

Hongdo Do, Ramyar Molania, Paul L Mitchell, Rita Vaiskunaite, John D Murdoch, Alexander Dobrovic

Journal article  |  2017  |  CLINICAL CHEMISTRY

BACKGROUND: False-positive EGFR T790M mutations have been reported in formalin-fixed lung tumors, but the cause of the false posit..