Simon Willis

An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway.

Stephanie Trezise, Isabella Y Kong, Edwin D Hawkins, Marco J Herold, Simon N Willis, Stephen L Nutt

Journal article  |  2023  |  Front Immunol

BACKGROUND: Humoral immunity depends on the differentiation of B cells into antibody secreting cells (ASCs). Excess or inappropria..

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

Isabella Y Kong, Stephanie Trezise, Amanda Light, Izabela Todorovski, Gisela Mir Arnau, Sreeja Gadipally, David Yoannidis, Kaylene J Simpson, Xueyi Dong, Lachlan Whitehead, Jessica C Tempany, Anthony J Farchione, Amania A Sheikh, Joanna R Groom, Kelly L Rogers, Marco J Herold, Vanessa L Bryant, Matthew E Ritchie, Simon N Willis, Ricky W Johnstone, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

High-throughput methodologies are the cornerstone of screening approaches to identify novel compounds that regulate immune cell fu..

OBF1 and Oct factors control the germinal center transcriptional program

Shuang Song, Chun Cao, Mohamed-Amin Choukrallah, Fengyuan Tang, Gerhard Christofori, Hubertus Kohler, Fabian Wu, Barna D Fodor, Mathias Frederiksen, Simon N Willis, Jacob T Jackson, Stephen L Nutt, Stefan Dirnhofer, Michael B Stadler, Patrick Matthias

Journal article  |  2021  |  BLOOD

OBF1 is a specific coactivator of the POU family transcription factors OCT1 and OCT2. OBF1 and OCT2 are B cell-specific and indisp..

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

Pasquale L Fedele, Yang Liao, Jia-nan Gong, Yuan Yao, Mark F van Delft, Michael SY Low, Lin Tai, Marco J Herold, Jacob T Jackson, Charis E Teh, Tania Tan, Lorraine A O'Reilly, Julie Tellier, George Grigoriadis, David CS Huang, Wei Shi, Stephen L Nutt, Simon N Willis

Journal article  |  2020  |  LEUKEMIA

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

Michael Sze Yuan Low, Erica J Brodie, Pasquale L Fedele, Yang Liao, George Grigoriadis, Andreas Strasser, Axel Kallies, Simon N Willis, Julie Tellier, Wei Shi, Sarah Gabriel, Kristy O'Donnell, Catherine Pitt, Stephen L Nutt, David Tarlinton

Journal article  |  2019  |  CELL REPORTS

The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasm..

New players in the gene regulatory network controlling late B cell differentiation

Simon N Willis, Stephen L Nutt

Journal article  |  2019  |  CURRENT OPINION IN IMMUNOLOGY

The differentiation of B cells into antibody-secreting plasma cells is associated with profound changes in morphology, lifespan, a..

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos

Pasquale L Fedele, Simon N Willis, Yang Liao, Michael S Low, Jai Rautela, David H Segal, Jia-Nan Gong, Nicholas D Huntington, Wei Shi, David CS Huang, George Grigoriadis, Julie Tellier, Stephen L Nutt

Journal article  |  2018  |  BLOOD

Recent studies have demonstrated that the immunomodulatory drugs (IMiDs) lead to the degradation of the transcription factors Ikar..

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

Stephanie Trezise, Alexander Karnowski, Pasquale L Fedele, Sridurga Mithraprabhu, Yang Liao, Kathy D'Costa, Andrew J Kueh, Matthew P Hardy, Catherine M Owczarek, Marco J Herold, Andrew Spencer, Wei Shi, Simon N Willis, Stephen L Nutt, Lynn M Corcoran

Journal article  |  2018  |  International Journal of Molecular Sciences

Antibody Secreting Cells (ASCs) are a fundamental component of humoral immunity, however, deregulated or excessive antibody produc..

A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets

Francisca F Almeida, Sara Tognarelli, Antoine Marcais, Andrew J Kueh, Miriam E Friede, Yang Liao, Simon N Willis, Kylie Luong, Fabrice Faure, Francois E Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zoeller, et al.

Journal article  |  2018  |  ONCOIMMUNOLOGY

NKp46 (CD335) is a surface receptor shared by both human and mouse natural killer (NK) cells and innate lymphoid cells (ILCs) that..

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

Simon N Willis, Julie Tellier, Yang Liao, Stephanie Trezise, Amanda Light, Kristy O'Donnell, Lee Ann Garrett-Sinha, Wei Shi, David M Tarlinton, Stephen L Nutt

Journal article  |  2017  |  NATURE COMMUNICATIONS

Humoral immunity requires B cells to respond to multiple stimuli, including antigen, membrane and soluble ligands, and microbial p..