Criselle D'Souza

The efficacy of combination treatment with elotuzumab and lenalidomide is dependent on crosstalk between natural killer cells, monocytes and myeloma cells.

Kelden Richardson, Simon P Keam, Joe Jiang Zhu, Deborah Meyran, Criselle D'Souza, Sean Macdonald, Kerry Campbell, Michael Robbins, Natalie A Bezman, Kirsten Todd, Hang Quach, David S Ritchie, Simon J Harrison, H Miles Prince, Joseph A Trapani, Misty R Jenkins, Paul A Beavis, Phillip K Darcy, Paul J Neeson

Journal article  |  2023  |  Haematologica

Patients with refractory relapsed multiple myeloma respond to combination treatment with elotuzumab and lenalidomide. The mechanis..

CAR-T Plus Radiotherapy: A Promising Combination for Immunosuppressive Tumors

Vicky Mengfei Qin, Nicole M Haynes, Criselle D'Souza, Paul J Neeson, Joe Jiang Zhu

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Radiotherapy (RT) is the standard-of-care treatment for more than half of cancer patients with localized tumors and is also used a..

PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia

Jessica Li, Sarah Whelan, Maya F Kotturi, Deborah Meyran, Criselle D'Souza, Kyle Hansen, Spencer Liang, John Hunter, Joseph A Trapani, Paul J Neeson

Journal article  |  2021  |  HAEMATOLOGICA

This study explored the novel immune checkpoint poliovirus receptor-related immunoglobulin domain-containing (PVRIG) in acute myel..

An Update on the Current Genomic Landscape of Breast Implant-Associated Anaplastic Large Cell Lymphoma

Sean Harrop, Neha Mehta-Shah, Criselle Dsouza, Ella Thompson, Anand Deva, Henry Miles Prince

Journal article  |  2021  |  CANCERS

Breast implant-associated lymphoma (BIA-ALCL) is a rare subtype of anaplastic large-cell lymphoma associated with breast prosthese..

Myeloma natural killer cells are exhausted and have impaired regulation of activation

Criselle D'Souza, Simon P Keam, Han Xian Aw Yeang, Michael Neeson, Kelden Richardson, Andy K Hsu, Rachael Canfield, Natalie Bezman, Michael Robbins, Hang Quach, David S Ritchie, Simon J Harrison, Joseph A Trapani, H Miles Prince, Paul A Beavis, Phillip K Darcy, Paul J Neeson

Journal article  |  2021  |  HAEMATOLOGICA

Not available.

Understanding the Role of T-Cells in the Antimyeloma Effect of Immunomodulatory Drugs

Criselle D'Souza, H Miles Prince, Paul J Neeson

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Immunomodulatory drugs (IMiDs) are effective treatments for patients with multiple myeloma. IMiDs have pleotropic effects includin..

Chimeric Antigen Receptor beyond CAR-T Cells

Vicky Mengfei Qin, Criselle D'Souza, Paul J Neeson, Joe Jiang Zhu

Journal article  |  2021  |  CANCERS

Chimeric antigen receptors (CAR) are genetically engineered receptors that can recognise specific antigens and subsequently activa..

Single-Cell Gene Expression, Clonality, and Feature Barcoding of Melanoma Tumor-Infiltrating Lymphocytes

Angela Pizzolla, Simon P Keam, Criselle D'Souza, Timothy Semple, Paul J Neeson

Journal article  |  2021  |  MELANOMA

We describe here a protocol to measure gene expression, T cell receptor (TCR) sequence, and protein expression by single T cells e..

Using Mass Cytometry to Analyze the Tumor-Infiltrating Lymphocytes in Human Melanoma

Daniela Tantalo, Nguyen Thu, Han Xian Aw Yeang, Joe Zhu, Sean Macdonald, Minyu Wang, Harini de Silva, Criselle D'Souza, Angela Pizzolla, Paul J Neeson

Journal article  |  2021  |  MELANOMA

Here we describe the application of mass cytometry to analyze tumor-infiltrating lymphocytes in human melanoma. Mass cytometry is ..

Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells

Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Hui-Fern Koay, Bronwyn Meehan, Zhe Zhao, Troi Pediongco, Mai Shi, Tianyuan Zhu, Bingjie Wang, Lars Kjer-Nielsen, Sidonia BG Eckle, Jamie Rossjohn, David P Fairlie, Dale I Godfrey, Richard A Strugnell, James McCluskey, Alexandra J Corbett

Journal article  |  2019  |  Current protocols in immunology

This unit describes the utility of various mouse models of infection and immunization for studying mucosal-associated invariant T ..