Romain Guerillot

Clinical Relevance of Topical Antibiotic Use in Coselecting for Multidrug-Resistant Staphylococcus aureus: Insights from In Vitro and Ex Vivo Models

Yi Nong, George Taiaroa, Shivani Pasricha, Romain Guerillot, Ian R Monk, Sarah L Baines, Glen P Carter, Benjamin P Howden, Deborah A Williamson

Journal article  |  2021  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Topical antibiotic preparations, such as fusidic acid (FA) or mupirocin, are used in the prevention and treatment of superficial s..

Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial

Abdoulie Bojang, Sarah L Baines, Bully Camara, Romain Guerillot, Liam Donovan, Raquel Sanchez Marques, Ousman Secka, Umberto D'Alessandro, Christian Bottomley, Benjamin P Howden, Anna Roca

Journal article  |  2020  |  CLINICAL INFECTIOUS DISEASES

In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers..

Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus

Stefano G Giulieri, Romain Guerillot, Jason C Kwong, Ian R Monk, Ashleigh S Hayes, Diane Daniel, Sarah Baines, Norelle L Sherry, Natasha E Holmes, Peter Ward, Wei Gao, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

Journal article  |  2020  |  MBIO

Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of invasive methicillin-susceptible Stap..

Staphylococcus aureusinduces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes

Maiken Mellergaard, Rikke Illum Hogh, Astrid Lund, Blanca Irene Aldana, Romain Guerillot, Sofie Hedlund Moller, Ashleigh S Hayes, Nafsika Panagiotopoulou, Zofija Frimand, Stine Dam Jepsen, Camilla Hartmann Friis Hansen, Lars Andresen, Anders Rhod Larsen, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden, Helle S Waagepetersen, Dorte Frees, Soren Skov

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcus aureus is among the leading causes of bacterial infections worldwide. The pathogenicity and establishment of S. aur..

Comparative Transcriptomic and Functional Assessments o Linezolid-Responsive Small RNA Genes in Staphylococcus aureus

Wei Gao, Romain Guerillot, Ya Hsun Lin, Jai Tree, Marie Beaume, Patrice Francois, Ian R Monk, Torsten Seemann, Jacques Schrenzel, Benjamin P Howden, Timothy P Stinear

Journal article  |  2020  |  MSYSTEMS

Staphylococcus aureus contains a repertoire of at least 50 and possibly 500 small RNAs (sRNAs). The functions of most sRNAs are no..

Genomic investigation of Staphylococcus aureus recovered from Gambian women and newborns following an oral dose of intra-partum azithromycin

Abdoulie Bojang, Sarah L Baines, Liam Donovan, Romain Guerillot, Kerrie Stevens, Charlie Higgs, Christian Bottomley, Ousman Secka, Mark B Schultz, Anders Goncalves da Silva, Torsten Seemann, Timothy P Stinear, Anna Roca, Benjamin P Howden

Journal article  |  2019  |  JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

BACKGROUND: Oral azithromycin given during labour reduces carriage of bacteria responsible for neonatal sepsis, including Staphylo..

Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification

Jean YH Lee, Glen P Carter, Sacha J Pidot, Romain Guerillot, Torsten Seemann, Anders Goncalves da Silva, Timothy J Foster, Benjamin P Howden, Timothy P Stinear, Ian R Monk

Journal article  |  2019  |  MBIO

Staphylococcus epidermidis is a significant opportunistic pathogen of humans. Molecular studies in this species have been hampered..

Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

Romain Guerillot, Xenia Kostoulias, Liam Donovan, Lucy Li, Glen P Carter, Abderrahman Hachani, Koen Vandelannoote, Stefano Giulieri, Ian R Monk, Mayu Kunimoto, Lora Starrs, Gaetan Burgio, Torsten Seemann, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic and persistent infections despite active ..

Functional genomics reveals extensive diversity in Staphylococcus epidermidis restriction modification systems compared to Staphylococcus aureus

Jean YH Lee, Glen Carter, Sacha Pidot, Romain Guérillot, Torsten Seemann, Anders Gonçalves da Silva, Timothy Foster, Benjamin Howden, Timothy Stinear, Ian Monk

Journal article  |  2019

Staphylococcus epidermidis is a significant opportunistic pathogen of humans. Molecular studies in this species have been hampered..

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

Romain Guerillot, Lucy Li, Sarah Baines, Brian Howden, Mark B Schultz, Torsten Seemann, Ian Monk, Sacha J Pidot, Wei Gao, Stefano Giulieri, Anders Goncalves da Silva, Anthony D'Agata, Takehiro Tomita, Anton Y Peleg, Timothy P Stinear, Benjamin P Howden

Journal article  |  2018  |  GENOME MEDICINE

Mutation acquisition is a major mechanism of bacterial antibiotic resistance that remains insufficiently characterised. Here we pr..