John Wade

Chemical Synthesis and Characterization of a Nonfibrillating Glycoglucagon.

Mengjie Liu, Peishen Zhao, Md Hemayet Uddin, Wenyi Li, Feng Lin, Chaitra Chandrashekar, Yuji Nishiuchi, Yasuhiro Kajihara, Briony E Forbes, Denise Wootten, John D Wade, Mohammed Akhter Hossain

Journal article  |  2021  |  Bioconjug Chem

The current commercially available glucagon formulations for the treatment of severe hypoglycemia must be reconstituted immediatel..

Leptin antagonism inhibits prostate cancer xenograft growth and progression

Lisa K Philp, Anja Rockstroh, Martin C Sadowski, Atefeh Taherian Fard, Melanie Lehman, Gregor Tevz, Michelle S Liberio, Charles L Bidgood, Jennifer H Gunter, Stephen McPherson, Nenad Bartonicek, John D Wade, Laszlo Otvos, Colleen C Nelson

Journal article  |  2021  |  ENDOCRINE-RELATED CANCER

Hyperleptinaemia is a well-established therapeutic side effect of drugs inhibiting the androgen axis in prostate cancer (PCa), inc..

The Chemical Synthesis of Insulin: An Enduring Challenge

John A Karas, John D Wade, Mohammed Akhter Hossain

Journal article  |  2021  |  CHEMICAL REVIEWS

The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential for glycemic control and is used as a..

Chemically modified and conjugated antimicrobial peptides against superbugs

Wenyi Li, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2021  |  CHEMICAL SOCIETY REVIEWS

Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050, will lead to more deaths from bacteri..

Chemical Glycosylation and Its Application to Glucose Homeostasis-Regulating Peptides

Chaitra Chandrashekar, Mohammed Akhter Hossain, John D Wade

Journal article  |  2021  |  FRONTIERS IN CHEMISTRY

Peptides and proteins are attractive targets for therapeutic drug development due to their exquisite target specificity and low to..

Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria

Da'san MM Jaradat, Nehaya Al-Karablieh, Basmah HM Zaarer, Wenyi Li, Khalil KY Saleh, Anas J Rasras, Saeid Abu-Romman, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2021  |  BIOLOGICAL CHEMISTRY

Increasing antibiotic resistance in Gram-negative bacteria has mandated the development of both novel antibiotics and alternative ..

De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications

Shuimu Lin, John D Wade, Shouping Liu

Journal article  |  2021  |  ACCOUNTS OF CHEMICAL RESEARCH

The alarming rate at which pathogens are developing resistance to conventional antibiotics represents one of the major global chal..

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

Mengjie Liu, Emily A Whitfield, Linda J Fothergill, John B Furness, John D Wade, Sebastian GB Furness, Mohammed Akhter Hossain

Journal article  |  2020  |  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human ghrelin receptor (GHSR) is a recognized prospective target in the diagnosis and therapy of multiple cancer types. To gain a ..

(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

Nicholas G Welch, Wenyi Li, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2020  |  FRONTIERS IN CHEMISTRY

As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AM..

Adiponectin receptor activation inhibits prostate cancer xenograft growth

Lisa K Philp, Anja Rockstroh, Melanie Lehman, Martin C Sadowski, Nenad Bartonicek, John D Wade, Laszlo Otvos, Colleen C Nelson

Journal article  |  2020  |  ENDOCRINE-RELATED CANCER

Adiponectin is an adipokine originally identified as dysregulated in obesity, with a key role in insulin sensitisation and in main..