John Wade

Total Chemical Synthesis of a Nonfibrillating Human Glycoinsulin.

Mohammed Akhter Hossain, Ryo Okamoto, John A Karas, Praveen Praveen, Mengjie Liu, Briony E Forbes, John D Wade, Yasuhiro Kajihara

Journal article  |  2020  |  Journal of the American Chemical Society

Glycosylation is an accepted strategy to improve the therapeutic value of peptide and protein drugs. Insulin and its analogues are..

Coatings Releasing the Relaxin Peptide Analogue B7-33 Reduce Fibrotic Encapsulation

Nicholas G Welch, Shayanti Mukherjee, Mohammed A Hossain, Praveen Praveen, Jerome A Werkmeister, John D Wade, Ross AD Bathgate, David A Winkler, Helmut Thissen

Journal article  |  2019  |  ACS Applied Materials & Interfaces

Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides

Nitin A Patil, John A Karas, John D Wade, Mohammed Akhter Hossain, Julien Tailhades

Journal article  |  2019  |  Chemistry – A European Journal

Robert C. Sheppard (1932-2019)

Eric Atherton, John D Wade

Journal article  |  2019  |  Journal of Peptide Science

Combating bacterial resistance by combination of antibiotics with antimicrobial peptides

Dean E Sheard, Neil M O'Brien-Simpson, John D Wade, Frances Separovic

Journal article  |  2019  |  Pure and Applied Chemistry

Chemical Modification of Cellulose Membranes for SPOT Synthesis

W Li, JD Wade, E Reynolds, NM O'Brien-Simpson

Journal article  |  2019  |  Australian Journal of Chemistry

The 9-Fluorenylmethoxycarbonyl (Fmoc) Group in Chemical Peptide Synthesis-Its Past, Present, and Future

W Li, NM O'Brien-Simpson, MA Hossain, JD Wade

Journal article  |  2019  |  Australian Journal of Chemistry

Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

Nikolaj Kulahin Roed, Cristina M Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R Ganderton, Johan P Turkenburg, Pierre De Meyts, Andrzej M Brzozowski

Journal article  |  2018  |  Nature Communications

Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development

Eszter Ostorhazi, Ralf Hoffmann, Nicole Herth, John D Wade, Carl N Kraus, Laszlo Otvos

Journal article  |  2018  |  Frontiers in Chemistry

Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity

Stephanie Post, Galina Karashchuk, John D Wade, Waseem Sajid, Pierre De Meyts, Marc Tatar

Journal article  |  2018  |  Frontiers in Endocrinology

Covalent conjugation of cationic antimicrobial peptides with a beta-lactam antibiotic core

Wenyi Li, Neil M O'Brien-Simpson, James A Holden, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2018  |  Peptide Science

Editorial: Antimicrobial and Anticancer Peptides

Neil M O'Brien-Simpson, Ralf Hoffmann, CS Brian Chia, John D Wade

Journal article  |  2018  |  Frontiers in Chemistry

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs

Julien Tailhades, Hotake Takizawa, Michael J Gait, Don A Wellings, John D Wade, Yoshitsugu Aoki, Fazel Shabanpoor

Journal article  |  2017  |  Frontiers in Chemistry

Novel Methods for the Chemical Synthesis of Insulin Superfamily Peptides and of Analogues Containing Disulfide Isosteres

Mohammed Akhter Hossain, John D Wade

Journal article  |  2017  |  Accounts of Chemical Research

Relaxin family peptides: structure-activity relationship studies

Nitin A Patil, K Johan Rosengren, Frances Separovic, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2017  |  British Journal of Pharmacology

The Effect of Selective D- or N-alpha-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

Wenyi Li, Zhe Sun, Neil M O'Brien-Simpson, Laszlo Otvos, Eric C Reynolds, Mohammed A Hossain, Frances Separovic, John D Walde

Journal article  |  2017  |  Frontiers in Chemistry

C-Terminal Modification and Multimerization Increase the Efficacy of a Proline-Rich Antimicrobial Peptide

Wenyi Li, Neil M O'Brien-Simpson, Shenggen Yao, Julien Tailhades, Eric C Reynolds, Raymond M Dawson, Laszlo Otvos, Mohammed Akhter Hossain, Frances Separovic, John D Wade

Journal article  |  2017  |  Chemistry - A European Journal

Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2)

Feng Lin, Mohammed Akhter Hossain, Stephanie Post, Galina Karashchuk, Marc Tatar, Pierre De Meyts, John D Wade

Journal article  |  2017  |  Australian Journal of Chemistry

Australasian Peptide Chemistry

Paul F Alewood, John D Wade

Journal article  |  2017  |  Australian Journal of Chemistry

Fluorescent Ion Efflux Screening Assay for Determining Membrane-Active Peptides

Neil M O'Brien-Simpson, Wenyi Li, Namfon Pantarat, Mohammed Akhter Hossain, Frances Separovic, John D Wade, Eric C Reynolds

Journal article  |  2017  |  Australian Journal of Chemistry

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie International Edition

Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

John A Karas, Nitin A Patil, Julien Tailhades, Marc-Antoine Sani, Denis B Scanlon, Briony E Forbes, James Gardiner, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie International Edition

Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

John A Karas, Nitin A Patil, Julien Tailhades, Marc-Antoine Sani, Denis B Scanlon, Briony E Forbes, James Gardiner, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie

Despite recent advances in the treatment of diabetes mellitus, storage of insulin formulations at 4 °C is still necessary to minim..

The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructured

Norelle L Daly, Sunithi Gunasekera, Richard J Clark, Feng Lin, John D Wade, Marilyn A Anderson, David J Craik

Journal article  |  2016  |  Biopolymers

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling

Keiko Hojo, Mohammed Akhter Hossain, Julien Tailhades, Fazel Shabanpoor, Lilian LL Wong, Emma EK Ong-Palsson, Hanna E Kastman, Sherie Ma, Andrew L Gundlach, K Johan Rosengren, John D Wade, Ross AD Bathgate

Journal article  |  2016  |  Journal of Medicinal Chemistry

Direct Measurement of Pore Dynamics and Leakage Induced by a Model Antimicrobial Peptide in Single Vesicles and Cells

Matthew G Burton, Qi M Huang, Mohammed A Hossain, John D Wade, Enzo A Palombo, Michelle L Gee, Andrew HA Clayton

Journal article  |  2016  |  Langmuir

Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers

Wenyi Li, Marc-Antoine Sani, Elaheh Jamasbi, Laszlo Otvos, Mohammed Akhter Hossain, John D Wade, Frances Separovic

Journal article  |  2016  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity

Nitin A Patil, Ross AD Bathgate, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger Summers, Johannes Grosse, Richard A Hughes, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Amino Acids

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

Nitin A Patil, Richard A Hughes, K Johan Rosengren, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger J Summers, Johannes Grosse, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2016  |  Journal of Medicinal Chemistry

Preface

Fernando Albericio, Gregg B Fields, John D Wade

Book  |  2016  |  Letters in Peptide Science

Preface

F Albericio, GB Fields, JD Wade

Journal article  |  2016  |  International Journal of Peptide Research and Therapeutics

Relaxin family peptides: new members, new functions and potential clinical applications

John D Wade

Conference Proceedings  |  2016  |  AMINO ACIDS

Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein

Julien Tailhades, Ashish Sethi, Emma J Petrie, Paul R Gooley, Ross A Bathgate, John D Wade, Mohammed A Hossain

Journal article  |  2016  |  Chemistry - A European Journal

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Mohammed Akhter Hossain, Martina Kocan, Song T Yao, Simon G Royce, Vinojini B Nair, Christopher Siwek, Nitin A Patil, Ian P Harrison, K Johan Rosengren, Stavros Selemidis, Roger J Summers, John D Wade, Ross AD Bathgate, Chrishan S Samuel

Journal article  |  2016  |  Chemical Science

Polyvinyl alcohol nanofiber formulation of the designer antimicrobial peptide APO sterilizes Acinetobacter baumannii-infected skin wounds in mice

Istvan Sebe, Eszter Ostorhazi, Aron Fekete, Krisztian N Kovacs, Romana Zelko, Ilona Kovalszky, Wenyi Li, John D Wade, Dora Szabo, Laszlo Otvos

Journal article  |  2016  |  Amino Acids

Amyloid Beta (A beta) Peptide and Factors that Play Important Roles in Alzheimer's Disease

Elaheh Jamasbi, John D Wade, Frances Separovic, Mohammed A Hossain

Journal article  |  2016  |  Current Medicinal Chemistry

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

Cary Zhang, Berenice E Chua, Annie Yang, Faze Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Craig M Smith, Andrew L Gundlach

Journal article  |  2015  |  Behavioural Brain Research

Site of fluorescent label modifies interaction of melittin with live cells and model membranes

Elaheh Jamasbi, Giuseppe D Ciccotosto, Julien Tailhades, Roy M Robins-Browne, Cathryn L Ugalde, Robyn A Sharples, Nitin Patil, John D Wade, Mohammed Akhter Hossain, Frances Separovic

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane

Wenyi Li, Neil M O'Brien-Simpson, Julien Tailhades, Namfon Pantarat, Raymond M Dawson, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  Chemistry & Biology

Atomic Force Microscopy Reveals the Mechanobiology of Lytic Peptide Action on Bacteria

Anna Mularski, Jonathan J Wilksch, Huabin Wang, Mohammed Akhter Hossain, John D Wade, Frances Separovic, Richard A Strugnell, Michelle L Gee

Journal article  |  2015  |  Langmuir

Optimization of Adiponectin-Derived Peptides for Inhibition of Cancer Cell Growth and Signaling

Laszlo Otvos, Ilona Kovalszky, Julia Olah, Roberta Coroniti, Daniel Knappe, Friederike I Nollmann, Ralf Hoffmann, John D Wade, Sandor Lovas, Eva Surmacz

Journal article  |  2015  |  Biopolymers

Solution Structure, Aggregation Behavior, and Flexibility of Human Relaxin-2

Linda M Haugaard-Kedstrom, Mohammed Akhter Hossain, Norelle L Daly, Ross AD Bathgate, Ernst Rinderknecht, John D Wade, David J Craik, K Johan Rosengren

Journal article  |  2015  |  ACS Chemical Biology

Intramolecular acyl transfer in peptide and protein ligation and synthesis

Julien Tailhades, Nitin A Patil, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  Journal of Peptide Science

C-Terminal Modifications Broaden Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

Wenyi Li, Julien Tailhades, M Akhter Hossain, Neil M O'Brien-Simpson, Eric C Reynolds, Laszlo Otvos, Frances Separovic, John D Wade

Journal article  |  2015  |  Australian Journal of Chemistry

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B Nair, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  BioMed Research International

Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins

Nitin A Patil, Julien Tailhades, Richard Anthony Hughes, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2015  |  International Journal of Molecular Sciences

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

Mohammed Akhter Hossain, Linda M Haugaard-Kedstroem, K Johan Rosengren, Ross AD Bathgate, John D Wade

Journal article  |  2015  |  Organic & Biomolecular Chemistry

Melittin peptides exhibit different activity on different cells and model membranes

Elaheh Jamasbi, Steven Batinovic, Robyn A Sharples, Marc-Antoine Sani, Roy Michael Robins-Browne, John D Wade, Frances Separovic, Mohammed Akhter Hossain

Journal article  |  2014  |  Amino Acids

Synthetic relaxins

Mohammed Akhter Hossain, John D Wade

Journal article  |  2014  |  Current Opinion in Chemical Biology

Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy. III: Racemization studies and water-based synthesis of histidine-containing peptides

Keiko Hojo, Natsuki Shinozaki, Koushi Hidaka, Yuko Tsuda, Yoshinobu Fukumori, Hideki Ichikawa, John D Wade

Journal article  |  2014  |  Amino Acids

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

Wenyi Li, Julien Tailhades, Neil M O'Brien-Simpson, Frances Separovic, Laszlo Otvos, M Akhter Hossain, John D Wade

Journal article  |  2014  |  Amino Acids

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

Johannes Grosse, Helen Heffron, Keith Burling, Mohammed Akhter Hossain, Abdella M Habib, Gareth J Rogers, Paul Richards, Rachel Larder, Debra Rimmington, Alice A Adriaenssens, Laura Parton, Justin Powell, Matteo Binda, William H Colledge, Joanne Doran, Yukio Toyoda, John D Wade, Samuel Aparicio, Mark BL Carlton, Anthony P Coll, et al.

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin

John A Karas, Denis B Scanlon, Briony E Forbes, Irina Vetter, Richard J Lewis, James Gardiner, Frances Separovic, John D Wade, Mohammed A Hossain

Journal article  |  2014  |  Chemistry - A European Journal

Mapping Key Regions of the RXFP2 Low-Density Lipoprotein Class-A Module That Are Involved in Signal Activation

Roy CK Kong, Ross AD Bathgate, Shoni Bruell, John D Wade, Paul R Gooley, Emma J Petrie

Journal article  |  2014  |  Biochemistry

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice

Craig M Smith, Berenice E Chua, Cary Zhang, Andrew W Walker, Mouna Haidar, David Hawkes, Fazel Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Andrew L Gundlach

Journal article  |  2014  |  Behavioural Brain Research

Signalling profiles of H3 relaxin, H2 relaxin and R3(B.23-27) R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

M Kocan, M Sarwar, MA Hossain, JD Wade, RJ Summers

Journal article  |  2014  |  British Journal of Pharmacology

The Designer Proline-rich Antibacterial Peptide A3-APO Prevents Bacillus anthracis Mortality by Deactivating Bacterial Toxins

Laszlo Otvos, Helen Flick-Smith, Marc Fox, Eszter Ostorhazi, Raymond M Dawson, John D Wade

Journal article  |  2014  |  Protein and Peptide Letters

The designer leptin antagonist peptide Allo-aca compensates for short serum half-life with very tight binding to the receptor

Laszlo Otvos, Stefan W Vetter, Mohit Koladia, Daniel Knappe, Rico Schmidt, Eszter Ostorhazi, Ilona Kovalszky, Nina Bionda, Predrag Cudic, Eva Surmacz, John D Wade, Ralf Hoffmann

Journal article  |  2014  |  Amino Acids

Susceptibility of Intracellular Coxiella burnetii to Antimicrobial Peptides in Mouse Fibroblast Cells

Nathan B Unsworth, Raymond M Dawson, John D Wade, Chun-Qiang Liu

Journal article  |  2014  |  Protein & Peptide Letters

Development of second generation peptides modulating cellular adiponectin receptor responses

Laszlo Otvos, Daniel Knappe, Ralf Hoffmann, Ilona Kovalszky, Julia Olah, Tim D Hewitson, Roma Stawikowska, Maciej Stawikowski, Predrag Cudic, Feng Lin, John D Wade, Eva Surmacz, Sandor Lovas

Journal article  |  2014  |  Frontiers in Chemistry

Current challenges in peptide-based drug discovery

Laszlo Otvos, John D Wade

Journal article  |  2014  |  Frontiers in Chemistry

Relaxin and its role in fibrotic diseases

Linda Jiaying Chan, Chrishan S Samuel, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Book Chapter  |  2014  |  Amino Acids, Peptides and Proteins

Relaxin-3/RXFP3 system regulates alcohol-seeking

Philip J Ryan, Hanna E Kastman, Elena V Krstew, K Johan Rosengren, Mohammed Akhter Hossain, Leonid Churilov, John D Wade, Andrew L Gundlach, Andrew J Lawrence

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Minimum Active Structure of Insulin-like Peptide 5

Alessia Begi, Ross AD Bathgate, Martina Kocan, Nitin Patil, Suode Zhang, Geoffrey W Tregear, John D Wade, Mohammed Akhter Hossain

Journal article  |  2013  |  Journal of Medicinal Chemistry

C-Terminus of the B-Chain of Relaxin-3 Is Important for Receptor Activity

Fazel Shabanpoor, Ross AD Bathgate, John D Wade, Mohammed Akhter Hossain

Journal article  |  2013  |  PLoS One

Rapid systemic and local treatments with the antibacterial peptide dimer A3-APO and its monomeric metabolite eliminate bacteria and reduce inflammation in intradermal lesions infected with Propionibacterium acnes and meticillin-resistant Staphylococcus aureus

Eszter Ostorhazi, Elvira Voros, Eva Nemes-Nikodem, Dora Pinter, Palma Sillo, Balazs Mayer, John D Wade, Laszlo Otvos

Journal article  |  2013  |  International Journal of Antimicrobial Agents

Long-Time-Scale Interaction Dynamics between a Model Antimicrobial Peptide and Giant Unilamellar Vesicles

Matthew G Burton, Qi M Huang, Mohammed A Hossain, John D Wade, Andrew HA Clayton, Michelle L Gee

Journal article  |  2013  |  Langmuir

Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium

Victoria Carter, Ann Underhill, Ibrahima Baber, Lakamy Sylla, Mounirou Baby, Isabelle Larget-Thiery, Agnes Zettor, Catherine Bourgouin, Ulo Langel, Ingrid Faye, Laszlo Otvos, John D Wade, Mamadou B Coulibaly, Sekou F Traore, Frederic Tripet, Paul Eggleston, Hilary Hurd

Journal article  |  2013  |  PLoS Pathogens

INSL3 as a Biomarker of Leydig Cell Functionality

Richard Ivell, John D Wade, Ravinder Anand-Ivell

Journal article  |  2013  |  Biology of Reproduction

Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity

Serena Beccari, Ilona Kovalszky, John D Wade, Laszlo Otvos, Eva Surmacz

Journal article  |  2013  |  Peptides

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

Mohammed Akhter Hossain, Craig M Smith, Philip J Ryan, Elena Buechler, Ross AD Bathgate, Andrew L Gundlach, John D Wade

Journal article  |  2013  |  Amino Acids

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat

Philip J Ryan, Elena Buechler, Fazel Shabanpoor, Mohammed Akhter Hossain, John D Wade, Andrew J Lawrence, Andrew L Gundlach

Journal article  |  2013  |  Behavioural Brain Research

Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production

Claire Glister, Leanne Satchell, Ross AD Bathgate, John D Wade, Yanzhenzi Dai, Richard Ivell, Ravinder Anand-Ivell, Raymond J Rodgers, Philip G Knight

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies

Anna Blasiak, Tomasz Blasiak, Marian H Lewandowski, Mohammed Akhter Hossain, John D Wade, Andrew L Gundlach

Journal article  |  2013  |  European Journal of Neuroscience

Imaging the action of antimicrobial peptides on living bacterial cells

Michelle L Gee, Matthew Burton, Alistair Grevis-James, Mohammed Akhter Hossain, Sally McArthur, Enzo A Palombo, John D Wade, Andrew HA Clayton

Journal article  |  2013  |  Scientific Reports

The Importance of Tryptophan B28 in H2 Relaxin for RXFP2 Binding and Activation

Linda J Chan, John D Wade, Frances Separovic, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2013  |  International Journal of Peptide Research and Therapeutics

Editorial for the Special Issue for the 3rd Modern Solid Phase Peptide Synthesis and its Applications Symposium

Neil M O'Brien-Simpson, John D Wade

Journal article  |  2013  |  International Journal of Peptide Research and Therapeutics

Preliminary Structure-Function Relationship Studies on Insulin-Like Peptide 5 (INSL5)

Alessia Belgi, Ross AD Bathgate, Geoffrey W Tregear, John D Wade, Mohammed Akhter Hossain

Journal article  |  2013  |  International Journal of Peptide Research and Therapeutics

Sequential formation of regioselective disulfide bonds in synthetic peptides with multiple disulfide bonds

F Shabanpoor, MA Hossain, F Lin, JD Wade

Journal article  |  2013  |  Methods in Molecular Biology

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization

Linda J Chan, Craig M Smith, Berenice E Chua, Feng Lin, Ross AD Bathgate, Frances Separovic, Andrew L Gundlach, Mohammed Akhter Hossain, John D Wade

Journal article  |  2013  |  Frontiers in Chemistry

Total chemical synthesis of a heterodimeric interchain bis-lactam-linked Peptide: application to an analogue of human insulin-like Peptide 3.

John Karas, Fazel Shabanpoor, Mohammed Akhter Hossain, James Gardiner, Frances Separovic, John D Wade, Denis B Scanlon

Journal article  |  2013  |  International Journal of Peptides

Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary confor..

Amino Acids, Peptides and Proteins

Book Chapter  |  2013

Sequential Formation of Regioselective Disulfide Bonds in Synthetic Peptides with Multiple Disulfide Bonds

Fazel Shabanpoor, Mohammed Akhter Hossain, Feng Lin, John D Wade

Book  |  2013  |  Methods in Molecular Biology

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules.

Shoni Bruell, Roy CK Kong, Emma J Petrie, Brad Hoare, John D Wade, Daniel J Scott, Paul R Gooley, Ross AD Bathgate

Journal article  |  2013  |  Frontiers in Endocrinology

Relaxin family peptide (RXFP) receptors 1 and 2 are unique G-protein coupled receptors in that they contain an N-terminal low-dens..

Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.

Craig M Smith, Ihaia T Hosken, Natalie L Downer, Berenice E Chua, Mohammad Akhter Hossain, John D Wade, Andrew L Gundlach

Journal article  |  2013  |  Italian Journal of Anatomy and Embryology

The neuropeptide relaxin-3 and its cognate G-protein-coupled receptor, RXFP3, have been implicated in the control of feeding behav..

Chemical synthesis and biological evaluation of an antimicrobial peptide gonococcal growth inhibitor

John D Wade, Feng Lin, Mohammed Akhter Hossain, Raymond M Dawson

Journal article  |  2012  |  Amino Acids

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Linda J Chan, K Johan Rosengren, Sharon L Layfield, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed A Hossain, John D Wade

Journal article  |  2012  |  Journal of Biological Chemistry

Human relaxin-2: historical perspectives and role in cancer biology

Vinojini B Nair, Chrishan S Samuel, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2012  |  Amino Acids

Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies

Wei-Jie Zhang, Xiao Luo, Ya-Li Liu, Xiao-Xia Shao, John D Wade, Ross AD Bathgate, Zhan-Yun Guo

Journal article  |  2012  |  Amino Acids

Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin

Mohammed Akhter Hossain, John D Wade, Ross AD Bathgate

Journal article  |  2012  |  Peptides

Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone

Fazel Shabanpoor, Ross AD Bathgate, Alessia Belgi, Linda J Chan, Vinojini B Nair, John D Wade, Mohammed Akhter Hossain

Journal article  |  2012  |  Biochemical and Biophysical Research Communications

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Fazel Shabanpoor, Mohammad Alchter Hossain, Philip J Ryan, Alessia Belgi, Sharon Layfield, Martina Kocan, Suode Zhang, Chrishan S Samuel, Andrew L Gundlach, Ross AD Bathgate, Frances Separovic, John D Wade

Journal article  |  2012  |  Journal of Medicinal Chemistry

Slow Insertion Kinetics during Interaction of a Model Antimicrobial Peptide with Unilamellar Phospholipid Vesicles

Zubaidah Ningsih, Mohammed Akhter Hossain, John D Wade, Andrew HA Clayton, Michelle L Gee

Journal article  |  2012  |  Langmuir

The structural determinants of insulin-like Peptide 3 activity.

Ross AD Bathgate, Soude Zhang, Richard A Hughes, K Johan Rosengren, John D Wade

Journal article  |  2012  |  Frontiers in Endocrinology

Insulin-like peptide 3 (INSL3) is a hormone and/or paracrine factor which is a member of the relaxin peptide family. It has key ro..

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

F Shabanpoor, M Hossain, PJ Ryan, A Belgi, SL Layfield, undefined Kocan, undefined Zhang, C Samuel, AL Gundlach, R Bathgate, F Separovic, JD Wade

Journal article  |  2012  |  Journal of Medicinal Chemistry

The Minimal Active Structure of Human Relaxin-2

Mohammed Akhter Hossain, K Johan Rosengren, Chrishan S Samuel, Fazel Shabanpoor, Linda J Chan, Ross AD Bathgate, John D Wade

Journal article  |  2011  |  Journal of Biological Chemistry

Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

Laszlo Otvos, Eva Haspinger, Francesca La Russa, Federica Maspero, Patrizia Graziano, Ilona Kovalszky, Sandor Lovas, Kaushik Nama, Ralf Hoffmann, Daniel Knappe, Marco Cassone, John Wade, Eva Surmacz

Journal article  |  2011  |  BMC Biotechnology

Structure and Function Relationship of Murine Insulin-like Peptide 5 (INSL5): Free C-Terminus Is Essential for RXFP4 Receptor Binding and Activation

Alessia Begi, Mohammed A Hossain, Fazel Shabanpoor, Linda Chan, Suode Zhang, Ross AD Bathgate, Geoffrey W Tregear, John D Wade

Journal article  |  2011  |  Biochemistry

Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis

Laszlo Otvos, Wen-Hai Shao, Anne S Vanniasinghe, Michael A Amon, Marianna Csilla Holub, Ilona Kovalszkyg, John D Wade, Michelle Doll, Philip L Cohen, Nicholas Manolios, Eva Surmacz

Journal article  |  2011  |  Peptides

Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer

Laszlo Otvos, Ilona Kovalszky, Mirko Riolfi, Rita Ferla, Julia Olah, Andras Sztodola, Kaushik Nama, Annamaria Molino, Quirino Piubello, John D Wade, Eva Surmacz

Journal article  |  2011  |  European Journal of Cancer

Broad-spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved

Eszter Ostorhazi, Marianna Csilla Holub, Rozgonyi Ferenc, Harmos Ferenc, Marco Cassone, John D Wade, Laszlo Otvos

Journal article  |  2011  |  International Journal of Antimicrobial Agents

Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3

Linda M Haugaard-Kedstrom, Fazel Shabanpoor, Mohammed Akhter Hossain, Richard J Clark, Philip J Ryan, David J Craik, Andrew L Gundlach, John D Wade, Ross AD Bathgate, K Johan Rosengren

Journal article  |  2011  |  Journal of the American Chemical Society

Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa

Mohammed Akhter Hossain, Laure Guilhaudis, Agnes Sonnevend, Samir Attoub, Bianca J van Lierop, Andrea J Robinson, John D Wade, J Michael Conlon

Journal article  |  2011  |  European Biophysics Journal

Structural Dynamics of a Lytic Peptide Interacting with a Supported Lipid Bilayer

Andrew C Rapson, Mohammed Akhter Hossain, John D Wade, Edouard C Nice, Trevor A Smith, Andrew HA Clayton, Michelle L Gee

Journal article  |  2011  |  Biophysical Journal

H3 Relaxin Demonstrates Antifibrotic Properties via the RXFP1 Receptor

Mohammed Akhter Hossain, Bryna Chow Suet Man, Chongxin Zhao, Qi Xu, Xiao-Jun Du, John D Wade, Chrishan S Samuel

Journal article  |  2011  |  Biochemistry

General method for selective labelling of double-chain cysteine-rich peptides with a lanthanide chelate via solid-phase synthesis

Fazel Shabanpoor, Frances Separovic, John D Wade

Journal article  |  2011  |  Journal of Peptide Science

The severe short stature in two siblings with a heterozygous IGF1 mutation is not caused by a dominant negative effect of the putative truncated protein

HA van Duyvenvoorde, J van Doorn, J Koenig, L Gauguin, W Oostdijk, JD Wade, M Karperien, CAL Ruivenkamp, M Losekoot, PA van Setten, MJE Walenkamp, C Noordam, P De Meyts, JM Wit

Journal article  |  2011  |  Growth Hormone & IGF Research

Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity

Giuseppe D Ciccotosto, Deborah J Tew, Simon C Drew, Danielle G Smith, Timothy Johanssen, Varsha Lal, Tong-Lay Lau, Keyla Perez, Cyril C Curtain, John D Wade, Frances Separovic, Colin L Masters, Jeffrey P Smith, Kevin J Barnham, Roberto Cappai

Journal article  |  2011  |  Neurobiology of Aging

The chemical synthesis of insulin: From the past to the present

A Belgi, MA Hossain, GW Tregear, JD Wade

Journal article  |  2011  |  Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry

Design and Development of Analogues of Dimers of Insulin-like Peptide 3 B-Chain as High-Affinity Antagonists of the RXFP2 Receptor

Fazel Shabanpoor, Suode Zhang, Richard A Hughes, Mohammed Akhter Hossain, Sharon Layfield, Tania Ferraro, Ross AD Bathgate, Frances Separovic, John D Wade

Journal article  |  2011  |  Biopolymers

Peptide-Based leptin Receptor Antagonists for Cancer Treatment and Appetite Regulation

Laszlo Otvos, Ilona Kovalszky, Laura Scolaro, Andras Sztodola, Julia Olah, Marco Cassone, Daniel Knappe, Ralf Hoffmann, Sandor Lovas, Marcus PD Hatfield, Gabriella Beko, Suode Zhang, John D Wade, Eva Surmacz

Journal article  |  2011  |  Biopolymers

Intramuscularly Administered Peptide A3-APO Is Effective Against Carbapenem-Resistant Acinetobacter baumannii in Mouse Models of Systemic Infections

Eszter Ostorhazi, Ferenc Rozgonyi, Dora Szabo, Annegret Binas, Marco Cassone, John D Wade, Oliver Nolte, Christopher R Bethel, Robert A Bonomo, Laszlo Otvos

Journal article  |  2011  |  Biopolymers

The Relaxin Peptide Family-Structure, Function and Clinical Applications

Linda Jiaying Chan, Mohammed Akhter Hossain, Chrishan S Samuel, Frances Separovic, John D Wade

Journal article  |  2011  |  Protein and Peptide Letters

The Roles of the A- and B-Chains of Human Relaxin-2 and-3 on Their Biological Activity

Mohammed Akhter Hossain, John D Wade

Journal article  |  2010  |  Current Protein & Peptide Science

Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections

Eszter Ostorhazi, Ferenc Rozgonyi, Andras Sztodola, Ferenc Harmos, Ilona Kovalszky, Dora Szabo, Daniel Knappe, Ralf Hoffmann, Marco Cassone, John D Wade, Robert A Bonomo, Laszlo Otvos

Journal article  |  2010  |  Journal of Antimicrobial Chemotherapy

Design and recombinant expression of insulin-like peptide 5 precursors and the preparation of mature human INSL5

Xiao Luo, Ross AD Bathgate, Wei-Jie Zhang, Ya-Li Liu, Xiao-Xia Shao, John D Wade, Zhan-Yun Guo

Journal article  |  2010  |  Amino Acids

A simple approach for the preparation of mature human relaxin-3

Xiao Luo, Ya-Li Liu, Sharon Layfield, Xiao-Xia Shao, Ross AD Bathgate, John D Wade, Zhan-Yun Guo

Journal article  |  2010  |  Peptides

Short Stature Associated with a Novel Heterozygous Mutation in the Insulin-Like Growth Factor 1 Gene

HA van Duyvenvoorde, PA van Setten, MJE Walenkamp, J van Doorn, J Koenig, L Gauguin, W Oostdijk, CAL Ruivenkamp, M Losekoot, JD Wade, P De Meyts, M Karperien, C Noordam, JM Wit

Journal article  |  2010  |  Journal of Clinical Endocrinology & Metabolism

A3 APO a proline-rich antibacterial peptide in burn infections

Eszter Ostorhazi, Ferenc Harmos, Ilona Kovalszky, Dora Szabo, Ferenc Rozgonyi, Daniel Knappe, Rali Hofimann, Marco Cassone, John D Wade, Laszlo Oetvoes

Conference Proceedings  |  2010  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2

Suode Zhang, Richard A Hughes, Ross AD Bathgate, Fazel Shabanpoor, M Akhter Hossain, Feng Lin, Bianca van Lierop, Andrea J Robinson, John D Wade

Journal article  |  2010  |  Peptides

Solid Phase Synthesis of an Analogue of Insulin, A0:R glargine, That Exhibits Decreased Mitogenic Activity

Seon-Yeong Kwak, Briony E Forbes, Yoon-Sik Lee, Alessia Belgi, John D Wade, Mohammed Akhter Hossain

Journal article  |  2010  |  International Journal of Peptide Research and Therapeutics

Editorial for the Special Issue on the 2nd Modern Solid Phase Peptide Synthesis and its Applications Symposium

Neil M O'Brien-Simpson, John D Wade

Journal article  |  2010  |  International Journal of Peptide Research and Therapeutics

The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist

Mohammed Akhter Hossain, Chrishan S Samuel, Claudia Binder, Tim D Hewitson, Geoffrey W Tregear, John D Wade, Ross AD Bathgate

Journal article  |  2010  |  Amino Acids

H2 Relaxin Is a Biased Ligand Relative to H3 Relaxin at the Relaxin Family Peptide Receptor 3 (RXFP3)

Emma T van der Westhuizen, Arthur Christopoulos, Patrick M Sexton, John D Wade, Roger J Summers

Journal article  |  2010  |  Molecular Pharmacology

The designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models

Dora Szabo, Eszter Ostorhazi, Annegret Binas, Ferenc Rozgonyi, Bela Kocsis, Marco Cassone, John D Wade, Oliver Nolte, Laszlo Otvos

Journal article  |  2010  |  International Journal of Antimicrobial Agents

Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3

Fazel Shabanpoor, Richard A Hughes, Suode Zhang, Ross AD Bathgate, Sharon Layfield, Mohammed Akhter Hossain, Geoffrey W Tregear, Frances Separovic, John D Wade

Journal article  |  2010  |  Amino Acids

Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus

Sherie Ma, Francisco E Olucha-Bordonau, M Akhter Hossain, Feng Lin, Chester Kuei, Changlu Liu, John D Wade, Steven W Sutton, Angel Nunez, Andrew L Gundlach

Journal article  |  2009  |  Learning and memory

Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy

Eleni Giannakis, Chrishan S Samuel, Tim D Hewitson, Wee-Ming Boon, Mary Macris, Shane Reeve, Josie Lawrence, A Ian Smith, Geoffrey W Tregear, John D Wade

Journal article  |  2009  |  Proteomics - Clinical Applications

The Antibacterial Effect of a Proline-Rich Antibacterial Peptide A3-APO

F Rozgonyi, D Szabo, B Kocsis, E Ostorhazi, G Abbadessa, M Cassone, JD Wade, L Otvos

Journal article  |  2009  |  Current Medicinal Chemistry

RELAXIN-3 INNERVATION AND MODULATION OF THE INTERGENICULATE LEAFLET OF THE RAT THALAMUS

A Blasiak, T Blasiak, MA Hossain, JD Wade, AL Gundlach, MH Lewandowski

Conference Proceedings  |  2009  |  NEUROPEPTIDES

Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3

Xiao Luo, Ross AD Bathgate, Ya-Li Liu, Xiao-Xia Shao, John D Wade, Zhan-Yun Guo

Journal article  |  2009  |  FEBS Journal

Use of a Temporary "Solubilizing" Peptide Tag for the Fmoc Solid-Phase Synthesis of Human Insulin Glargine via Use of Regioselective Disulfide Bond Formation

Mohammed Akhter Hossain, Alessia Belgi, Feng Lin, Suode Zhang, Fazel Shabanpoor, Linda Chan, Chris Belyea, Hue-Trung Truong, Amy R Blair, Sof Andrikopoulos, Geoffrey W Tregear, John D Wade

Journal article  |  2009  |  Bioconjugate Chemistry

Induced Resistance to the Designer Proline-rich Antimicrobial Peptide A3-APO does not Involve Changes in the Intracellular Target DnaK

Marco Cassone, Nikea Frith, Paraskevi Vogiatzi, John D Wade, Laszlo Otvos

Journal article  |  2009  |  International Journal of Peptide Research and Therapeutics

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework

Linda M Haugaard-Jonsson, Mohammed Akhter Hossain, Norelle L Daly, David J Craik, John D Wade, K Johan Rosengren

Journal article  |  2009  |  Biochemical Journal

Relaxin Family Peptide Receptor (RXFP1) Coupling to G alpha(i3) Involves the C-Terminal Arg(752) and Localization within Membrane Raft Microdomains

Michelle L Halls, Emma T van der Westhuizen, John D Wade, Bronwyn A Evans, Ross AD Bathgate, Roger J Summers

Journal article  |  2009  |  Molecular Pharmacology

Roles of the Receptor, the Ligand, and the Cell in the Signal Transduction Pathways Utilized by the Relaxin Family Peptide Receptors 1-3

Roger J Summers, Ross AD Bathgate, John D Wade, Emma T van der Westhuizen, Michelle L Halls

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

INSL3/RXFP2 Signaling in Testicular Descent Mice and Men

Shu Feng, Alberto Ferlin, Anne Truong, Ross Bathgate, John D Wade, Sean Corbett, Shuo Han, Mounia Tannour-Louet, Dolores J Lamb, Carlo Foresta, Alexander I Agoulnik

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

THE HUMAN INSULIN SUPERFAMILY OF POLYPEPTIDE HORMONES

Fazel Shabanpoor, Frances Separovic, John D Wade

Book Chapter  |  2009  |  Vitamins and Hormones: Advances in Research and Applications

Synergy Between a Lead Proline-rich Antibacterial Peptide Derivative and Small Molecule Antibiotics

Laszlo Otvos, Marco Cassone, Vanessa de Olivier Inacio, Paul Noto, John J Rux, John D Wade, Predrag Cudic

Conference Proceedings  |  2009  |  Advances in experimental medicine and biology

Structural Properties of Relaxin Chimeras NMR Characterization of the R3/I5 Relaxin Peptide

Linda M Haugaard-Jonsson, Mohammed Akhter Hossain, Norelle L Daly, Ross AD Bathgate, John D Wade, David J Craik, K Johan Rosengren

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

Probing the Functional Domains of Relaxin-3 and the Creation of a Selective Antagonist for RXFP3/GPCR135 over Relaxin Receptor RXFP1/LGR7

Changlu Liu, Chester Kuei, Steven Sutton, Jonathan Shelton, Jessica Zhu, Diane Nepomuceno, Mohammed Akhter Hossain, John D Wade, Ross AD Bathgate, Pascal Bonaventure, Timothy Lovenberg

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

RXFP1 Couples to the G alpha(i3)-G beta gamma-PI3K-PKC zeta Pathway via the Final 10 Amino Acids of the Receptor C-terminal Tail

Michelle L Halls, Maria Papaioannou, John D Wade, Bronwyn A Evans, Ross AD Bathgate, Roger J Summers

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

De Novo Design and Synthesis of Cyclic and Linear Peptides to Mimic the Binding Cassette of Human Relaxin

Mohammed Akhter Hossain, Ross AD Bathgate, Geoffery Tregear, John D Wade

Journal article  |  2009  |  Annals of the New York Academy of Sciences

The chemistry and biology of insulin-like peptide 3, a novel member of the insulin superfamily.

F SHABANPOOR, R HUGHES, F SEPAROVIC, J WADE

Book Chapter  |  2009

Structure and Activity in the Relaxin Family of Peptides

Geoffrey W Tregear, Ross AD Bathgate, Mohammed Akhter Hossain, Feng Lin, Suode Zhang, Fazel Shabanpoor, Daniel J Scott, Sherie Ma, Andrew L Gundlach, Chrishan S Samuel, John D Wade

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Evaluation of Relaxin's Antifibrotic Action by SELDI-TOF Mass Spectrometry-Based Profiling of Relaxin Knockout Mice, a Model of Progressive Fibrosis

Eleni Giannakis, Mary Macris, Linda Chan, Geoffrey W Tregear, Chrishan S Samuel, John D Wade

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Dimerization and Negative Cooperativity in the Relaxin Family Peptide Receptors

Angela Manegold Svendsen, Milka Vrecl, Louise Knudsen, Anders Heding, John D Wade, Ross AD Bathgate, Pierre De Meyts, Jane Nohr

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

Relaxin Family Peptides and Receptors in Mammalian Brain Anatomical Insights and Diverse Functional Possibilities

Andrew L Gundlach, Sherie Ma, Qian Sang, Pei-Juan Shen, Loretta Piccenna, Katayoun Sedaghat, Craig M Smith, Ross AD Bathgate, Andrew J Lawrence, Geoffrey W Tregear, John D Wade, David I Finkelstein, Pascal Bonaventure, Changlu Liu, Timothy W Lovenberg, Steve W Sutton

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Agonists and Partial Antagonists Acting on the Leptin - Leptin Receptor Interface

Laszlo Otvos, Marco Cassone, Marianna Terrasi, Sandra Cascio, George D Mateo, Daniel Knappe, Ralf Hoffman, Predrag Cudic, John D Wade, Eva Surmacz

Journal article  |  2009  |  Advances in experimental medicine and biology

The Chemical Synthesis of Relaxin and Related Peptides A Historical Perspective

John D Wade, Feng Lin, M Akhter Hossain, Fazel Shabanpoor, Suode Zhang, Geoffrey W Tregear

Journal article  |  2009  |  Annals of The New York Academy of Sciences

Addition of a Carboxy-Terminal Green Fluorescent Protein Does Not Alter the Binding and Signaling Properties of Relaxin Family Peptide Receptor 3

Emma T van der Westhuizen, John D Wade, Patrick M Sexton, Roger J Summers

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

Mohammed Akhter Hossain, K Johan Rosengren, Suode Zhang, Ross AD Bathgate, Geoffrey W Tregear, Bianca J van Lierop, Andrea J Robinson, John D Wade

Journal article  |  2009  |  Organic & Biomolecular Chemistry

SELDI-TOF mass spectrometry-based protein profiling of kidney tissue.

Eleni Giannakis, Chrishan S Samuel, Wee-Ming Boon, Mary Macris, Tim D Hewitson, John D Wade

Book Chapter  |  2009  |  Methods in Molecular Biology

Protein profiling has numerous applications in renal research including the detection of protein biomarkers with aberrant expressi..

Development of Lanthanide-Labeled Human INSL3 as an Alternative Probe to Radioactively Labeled INSL3 for Use in Bioassays

Fazel Shabanpoor, Richard A Hughes, Ross AD Bathgate, Frances Separovic, John D Wade

Book Chapter  |  2009  |  Annals of the New York Academy of Sciences

Structural Insights into the Function of Relaxins

K Johan Rosengren, Ross AD Bathgate, David J Craik, Norelle L Daly, Linda M Haugaard-Jonsson, Mohammed Akhter Hossain, John D Wade

Conference Proceedings  |  2009  |  Annals of the New York Academy of Sciences

The Structural and Functional Role of the B-chain C-terminal Arginine in the Relaxin-3 Peptide Antagonist, R3(B Delta 23-27)R/I5

Mohammed Akhter Hossain, Ross AD Bathgate, K Johan Rosengren, Fazel Shabanpoor, Suode Zhang, Feng Lin, Geoffrey W Tregear, John D Wade

Journal article  |  2009  |  Chemical Biology and Drug Design

Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1

Angela Manegold Svendsen, Anna Zalesko, Julie Konig, Milka Vrecl, Anders Heding, Jesper Boggild Kristensen, John D Wade, Ross AD Bathgate, Pierre De Meyts, Jane Nohr

Conference Proceedings  |  2008  |  Molecular and Cellular Endocrinology

Simultaneous Post-cysteine(S-Acm) Group Removal Quenching of Iodine and Isolation of Peptide by One Step Ether Precipitation

Suode Zhang, Feng Lin, Mohammed Akhter Hossain, Fazel Shabanpoor, Geoffrey W Tregear, John D Wade

Conference Proceedings  |  2008  |  International Journal of Peptide Research and Therapeutics

Modern Solid Phase Peptide Synthesis and its Applications

Neil M O'Brien-Simpson, Nicholas J Ede, John D Wade

Journal article  |  2008  |  International Journal of Peptide Research and Therapeutics

Amyloid-beta Peptide (A beta) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A beta Dimers and Trimers Correlate with Neurotoxicity

Lin Wai Hung, Giuseppe D Ciccotosto, Eleni Giannakis, Deborah J Tew, Keyla Perez, Colin L Masters, Roberto Cappai, John D Wade, Kevin J Barnham

Journal article  |  2008  |  Journal of Neuroscience

Analysis of Abeta interactions using ProteinChip technology.

E Giannakis, LW Hung, KP Camacaro, DP Smith, KJ Barnham, JD Wade

Journal article  |  2008  |  Methods in molecular biology (Clifton, N.J.)

Scope and limitations of the designer proline-rich antibacterial peptide dimer, A3-APO, alone or in synergy with conventional antibiotics

Marco Cassone, Paraskevi Vogiatzi, Raffaele La Montagna, Vanessa De Olivier Inacio, Predrag Cudic, John D Wade, Laszlo Otvos

Journal article  |  2008  |  Peptides

Development of a pharmacologically improved peptide agonist of the leptin receptor

Laszlo Otvos, Marianna Terrasi, Sandra Cascio, Marco Cassone, Giovanni Abbadessa, Francesco De Pascali, Laura Scolaro, Daniel Knappe, Maciej Stawikowski, Predrag Cudic, John D Wade, Ralf Hoffmann, Eva Surmacz

Journal article  |  2008  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist

Linda M Haugaard-Jonsson, Mohammed Akhter Hossain, Norelle L Daly, Ross AD Bathgate, John D Wade, David J Craik, K Johan Rosengren

Journal article  |  2008  |  Journal of Biological Chemistry

The proline-rich antimicrobial peptide dimer A3-APO and its single-chain in vivo metabolite represent a new paradigm in microbiology, pharmacology and drug development

Marco Cassone, Paraskevi Vogiatzi, John D Wade, Ferenc Rozgonyi, Dora Szabp, Bela Kocsis, Laszlo Otvos

Conference Proceedings  |  2008  |  JOURNAL OF PEPTIDE SCIENCE

Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5)

Mohammed Akhter Hossain, Ross AD Bathgate, Chze K Kong, Fazel Shabanpoor, Suode Zhang, Linda M Haugaard-Jonsson, K Johan Rosengren, Geoffrey W Tregear, John D Wade

Journal article  |  2008  |  ChemBioChem

Solid-phase synthesis of europium-labeled human INSL3 as a novel probe for the study of ligand-receptor interactions

Fazel Shabanpoor, Richard A Hughes, Ross AD Bathgate, Suode Zhang, Denis B Scanlon, Feng Lin, Mohammed Akhter Hossain, Frances Separovic, John D Wade

Journal article  |  2008  |  Bioconjugate Chemistry

Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo

Paul Bart Noto, Giovanni Abbadessa, Marco Cassone, George D Mateo, Alexis Agelan, John D Wade, Dora Szabo, Bela Kocsis, Karoly Nagy, Ferenc Rozgonyi, Laszlo Otvos

Journal article  |  2008  |  Protein Science

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors

Mohammed Akhter Hossain, K Johan Rosengren, Linda M Haugaard-Joensson, Soude Zhang, Sharon Layfield, Tania Ferraro, Norelle L Daly, Geoffrey W Tregear, John D Wade, Ross AD Bathgate

Journal article  |  2008  |  Journal of Biological Chemistry

Dimeric structures of alpha-synuclein bind preferentially to lipid membranes

Eleni Giannakis, Jessica Pacifico, David P Smith, Lin Wai Hung, Colin L Masters, Roberto Cappai, John D Wade, Kevin J Barnhain

Journal article  |  2008  |  Biochimica et Biophysica Acta-Biomembranes

Cooperative binding of insulin-like peptide 3 to a dimeric relaxin family peptide receptor 2

Angela Manegold Svendsen, Milka Vrecl, Tina M Ellis, Anders Heding, Jesper Boggild Kristensen, John D Wade, Ross AD Bathgate, Pierre De Meyts, Jane Nohr

Journal article  |  2008  |  Endocrinology

Metal effects on the membrane interactions of amyloid-beta peptides

John D Gehman, Caitlin C O'Brien, Fazel Shabanpoor, John D Wade, Frances Separovic

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: Pore formation mechanism in various lipid compositions

Seong-Cheol Park, Mi-Hyun Kim, Mohammed Akhter Hossain, Song Yub Shin, Yangmee Kim, Lorenzo Stella, John D Wade, Yoonkyung Park, Kyung-Soo Hahm

Journal article  |  2008  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Analysis of Abeta interactions using ProteinChip technology.

Eleni Giannakis, Lin-Wai Hung, Keyla Perez Camacaro, David P Smith, Kevin J Barnham, John D Wade

Journal article  |  2008  |  Methods in Molecular Biology

Abeta peptides are now acknowledged to play a central role in the pathogenesis of Alzheimer's disease. Their generation results fr..

Cholesterol and Clioquinol modulation of A beta(1-42) interaction with phospholipid bilayers and metals

Tong-Lay Lau, John D Gehman, John D Wade, Colin L Masters, Kevin J Barnham, Frances Separovic

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

Overview of solid phase synthesis of "difficult peptide" sequences.

Anna K Tickler, John D Wade

Journal article  |  2007  |  Current Protocols in Protein Science

Solid-phase peptide synthesis has contributed immeasurably to the understanding of the chemistry and biology of peptides by enabli..

Membrane interactions and the effect of metal ions of the amyloidogenic fragment A beta(25-35) in comparison to A beta(1-42)

Tong-Lay Lau, John D Gehman, John D Wade, Keyla Perez, Colin L Masters, Kevin J Barnham, Frances Separovic

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

R3(B Delta 23-27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7 - In vitro and in vivo characterization

Chester Kuei, Steven Sutton, Pascal Bonaventure, Cindy Pudiak, Jonathan Shelton, Jessica Zhu, Diane Nepomuceno, Jiejun Wu, Jingcai Chen, Fredrik Kamme, Mark Seierstad, Michael D Hack, Ross AD Bathgate, Mohammed Akhter Hossain, John D Wade, John Atack, Timothy W Lovenberg, Changlu Liu

Journal article  |  2007  |  Journal of Biological Chemistry

Defining the LGR8 residues involved in binding insulin-like peptide 3

Daniel J Scott, Tracey N Wilkinson, Suode Zhang, Tania Ferraro, John D Wade, Geoffrey W Tregear, Ross AD Bathgate

Journal article  |  2007  |  Molecular Endocrinology

Untitled

Fernando Alberico, Gregg Fields, John Wade

Journal article  |  2007  |  International Journal of Peptide Research and Therapeutics

Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin

Chrishan S Samuel, Feng Lin, Mohammed Akhter Hossain, Chongxin Zhao, Tania Ferraro, Ross AD Bathgate, Geoffrey W Tregear, John D Wade

Journal article  |  2007  |  Biochemistry

A structural core within apolipoprotein C-II amyloid fibrils identified using hydrogen exchange and proteolysis

Leanne M Wilson, Yee-Foong Mok, Katrina J Binger, Michael DW Griffin, Haydyn DT Mertens, Feng Lin, John D Wade, Paul R Gooley, Geoffrey J Howlett

Journal article  |  2007  |  Journal of Molecular Biology

Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain

Fazel Shabanpoor, Ross AD Bathgate, Mohammed Akhter Hossain, Eleni Giannakis, John D Wade, Richard A Hughes

Journal article  |  2007  |  Journal of Peptide Science

The conserved N-terminal repeat of the plant cyclotides does not assist folding of cyclotide precursor in vitro

S Gunasekera, NL Daly, RJ Clark, SM Simonsen, FM Foley, I Saska, F Lin, JD Wade, MA Anderson, DJ Craik

Conference Proceedings  |  2007  |  BIOPOLYMERS

The structure and function of relaxins: effect of sequential truncation at the N-terminal end of the A-chains of human relaxins-2 and -3 on their GPCR binding and activation.

MA Hossain, RAD Bathgate, JD Wade

Conference Proceedings  |  2007  |  BIOPOLYMERS

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase (vol 116, pg 2828, 2006)

Luigi Puglielli, Avi L Friedlich, Kenneth DR Setchell, Seiichi Nagano, Carlos Opazo, Robert A Cherny, Kevin J Barnham, John D Wade, Simon Melov, Dora M Kovacs, Ashley I Bush

Journal article  |  2006  |  Journal of Clinical Investigation

Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3

K Johan Rosengren, Suode Zhang, Feng Lin, Norelle L Daly, Daniel J Scott, Richard A Hughes, Ross AD Bathgate, David J Craik, John D Wade

Journal article  |  2006  |  Journal of Biological Chemistry

Regioselective disulfide solid phase synthesis, chemical characterization and in vitro receptor binding activity of equine relaxin

Mohammed Akhter Hossain, Feng Lin, Soude Zhang, Tania Ferraro, Ross A Bathgate, Geoffrey W Tregear, John D Wade

Conference Proceedings  |  2006  |  International Journal of Peptide Research and Therapeutics

Prior antibacterial peptide-mediated inhibition of protein folding in bacteria mutes resistance enzymes

Laszlo Otvos, Vanessa de Olivier Inacio, John D Wade, Predrag Cudic

Journal article  |  2006  |  Antimicrobial Agents and Chemotherapy

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

David P Smith, Danielle G Smith, Cyril C Curtain, John F Boas, John R Pilbrow, Giuseppe D Ciccotosto, Tong-Lay Lau, Deborah J Tew, Keyla Perez, John D Wade, Ashley I Bush, Simon C Drew, Frances Separovic, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2006  |  Journal of Biological Chemistry

Analogs of insulin-like peptide 3 (INSL3) B-chain are LGR8 antagonists in vitro and in vivo

MP Del Borgo, RA Hughes, RAD Bathgate, F Lin, K Kawamura, JD Wade

Journal article  |  2006  |  Journal of Biological Chemistry

Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation

P Fu, P-J Shen, C-X Zhao, DJ Scott, CS Samuel, JD Wade, GW Tregear, RAD Bathgate, AL Gundlach

Journal article  |  2006  |  Journal of Endocrinology

High density lipoproteins bind A beta and apolipoprotein C-II amyloid fibrils

LM Wilson, CLL Pham, AJ Jenkins, JD Wade, AF Hill, MA Perugini, GJ Howlett

Journal article  |  2006  |  Journal of Lipid Research

Acetylated tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32

R Berro, K Kehn, C de la Fuente, A Pumfery, R Adair, J Wade, AM Colberg-Poley, J Hiscott, F Kashanchi

Journal article  |  2006  |  Journal of Virology

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3

KJ Rosengren, F Lin, RAD Bathgate, GW Tregear, NL Daly, JD Wade, DJ Craik

Journal article  |  2006  |  Journal of Biological Chemistry

Inhibition of HIV-1 virus replication using small soluble Tat peptides

E Agbottah, NG Zhang, S Dadgar, A Pumfery, JD Wade, Z Chen, F Kashanchi

Journal article  |  2006  |  Virology

Relaxin-3: Improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo

RAD Bathgate, F Lin, NF Hanson, L Otvos, A Guidolin, C Giannakis, S Bastiras, SL Layfield, T Ferraro, S Ma, CX Zhao, AL Gundlach, CS Samuel, GW Tregear, JD Wade

Journal article  |  2006  |  Biochemistry

An automated peptide and protein thiazolidine coupling chemistry for biosensor immobilization giving a unique N-terminal orientation

JD Wade, K Hojo, K Kawasaki, TG Johns, B Catimel, J Rothacker, EC Nice

Journal article  |  2006  |  Analytical Biochemistry

Conformationally constrained single-chain peptide mimics of relaxin B-chain secondary structure

MP Del Borgo, RA Hughes, JD Wade

Journal article  |  2005  |  Journal of Peptide Science

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase

L Puglielli, AL Friedlich, KDR Setchell, S Nagano, C Opazo, RA Cherny, KJ Barnham, JD Wade, S Melov, DM Kovacs, AI Bush

Journal article  |  2005  |  Journal of Clinical Investigation

Designer antibacterial peptides kill fluoroquinolone-resistant clinical isolates

L Otvos, JD Wade, F Lin, BA Condie, J Hanrieder, R Hoffmann

Journal article  |  2005  |  Journal of Medicinal Chemistry

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

V Pham, MQ Dong, JD Wade, LJ Miller, CJ Morton, H Ng, MW Parker, PM Sexton

Journal article  |  2005  |  Journal of Biological Chemistry

The role of A beta peptides in Alzheimer's disease

AK Tickler, JD Wade, F Separovic

Journal article  |  2005  |  Protein and Peptide Letters

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutaselike structures and inhibition of neurotoxicity

AK Tickler, DG Smith, GD Ciccotosto, DJ Tew, CC Curtain, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, JD Wade, KJ Barnham

Journal article  |  2005  |  Journal of Biological Chemistry

Chimeric antimicrobial peptides exhibit multiple modes of action

L Otvos, C Snyder, B Condie, P Bulet, JD Wade

Journal article  |  2005  |  International Journal of Peptide Research and Therapeutics

Preface

F Albericio, G Fields, J Wade

Journal article  |  2005  |  International Journal of Peptide Research and Therapeutics

Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney

P Fu, PJ Shen, CX Zhao, DJ Scott, CS Samuel, JD Wade, GW Tregear, RAD Bathgate, AL Gundlach

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

The chemistry and biology of human relaxin-3

GW Tregear, RA Bathgate, S Layfield, T Ferraro, A Gundlach, S Ma, F Lin, NF Hanson, RJ Summers, J Rosengren, DJ Craik, JD Wade

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

Structure and neurofunction of relaxin-3, the ancestral relaxin

JD Wade, F Lin, J Rosengren, D Craik, L Otvos, R Bathgate, GW Tregear

Conference Proceedings  |  2005  |  BIOPOLYMERS

Insulin-relaxin family peptide signaling and receptors in mouse brain membranes and neuronal cells

S Ortinau, F Lin, JD Wade, GW Tregear, RAD Bathgate, AL Gundlach

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

Relaxin research in the postgenomic era

K Kawamura, S Sudo, J Kumagai, M Pisarska, SYT Hsu, R Bathgate, J Wade, AJW Hsueh

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

Studies on soluble ectodomain proteins of relaxin (LGR7) and insulin 3 (LGR8) receptors

Y Yan, J Cai, P Fu, S Layfield, T Ferraro, J Kumagai, S Sudo, JG Tang, E Giannakis, GW Tregear, JD Wade, RAD Bathgate

Conference Proceedings  |  2005  |  Annals of The New York Academy of Sciences

Insulin-like peptide 3, a novel member of the insulin superfamily, is a direct regulator of germ cell maturation and fertility

M Del Borgo, R Bathgate, F Lin, K Kawamura, RA Hughes, JD Wade

Conference Proceedings  |  2005  |  BIOPOLYMERS

Serotonergic mechanism of the lateral parabrachial nucleus and relaxin-induced sodium intake

JV Menani, SP Barbosa, MJ McKinley, JD Wade, LA De Luca

Journal article  |  2004  |  Brain Research

Amyloid-beta as a "difficult sequence" in solid phase peptide synthesis

AK Tickler, AB Clippingdale, JD Wade

Journal article  |  2004  |  Protein and Peptide Letters

Physiological and pathophysiological influences on thirst

MJ McKinley, MJ Cairns, DA Denton, G Egan, ML Mathai, A Uschakov, JD Wade, RS Weisinger, BJ Oldfield

Journal article  |  2004  |  Physiology & Behavior

Paracrine regulation of mammalian oocyte maturation and male germ cell survival

K Kawamura, J Kumagai, S Sudo, SY Chun, M Pisarska, H Morita, J Toppari, P Fu, JD Wade, RAD Bathgate, AJW Hsueh

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

Synthetic human insulin 4 does not activate the G-protein-coupled receptors LGR7 or LGR8

F Lin, L Otvos, J Kumagai, GW Tregear, RAD Bathgate, JD Wade

Journal article  |  2004  |  Journal of Peptide Science

Vasopressin secretion: Osmotic and hormonal regulation by the lamina terminalis

MJ McKinley, ML Mathai, RM McAllen, RC McClear, RR Miselis, GL Pennington, L Vivas, JD Wade, BJ Oldfield

Journal article  |  2004  |  Journal of Neuroendocrinology

Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor

V Pham, JD Wade, BW Purdue, PM Sexton

Journal article  |  2004  |  Journal of Biological Chemistry

Synthesis, conformation, receptor binding and biological activities of monobiotinylated human insulin-like peptide 3

P Fu, S Layfield, T Ferraro, H Tomiyama, J Hutson, L Otvos, GW Tregear, RAD Bathgate, JD Wade

Journal article  |  2004  |  Journal of Peptide Research

Paracrine regulation of mammalian oocyte maturation and male germ cell survival.

K Kawamura, J Kumagai, S Sudo, SY Chun, P Fu, JD Wade, RAD Bathgate, AJW Hsueh

Conference Proceedings  |  2004  |  BIOLOGY OF REPRODUCTION

Relaxin 3, a novel member of the insulin superfamily of peptide hormones

Ross A Bathgate, Nicky F Hanson, Feng Lin, Geoffrey W Tregear, John D Wade

Conference Proceedings  |  2004  |  PEPTIDE REVOLUTION: GENOMICS, PROTEOMICS & THERAPEUTICS

IMPROVED REGIOSELECTIVE DISULFIDE BOND SYNTHESIS OF HUMAN RELAXIN 3, A NOVEL BRAIN-SPECIFIC MEMBER OF THE INSULIN SUPERFAMILY

F Lin, GW Tregear, JD Wade

Conference Proceedings  |  2004  |  JOURNAL OF PEPTIDE SCIENCE

Design, synthesis and analysis of single chain mimetics of relaxin and relaxin-like factor (INSL3)

Mark P Del Borgo, Richard A Hughes, John D Wade

Conference Proceedings  |  2004  |  Peptide Revolution: Genomics, Proteomics & Therapeutics

BIOSENSOR-BASED BIOMOLECULAR INTERACTION ANALYSIS: THE USE OF 2-[PHENYL(METHYL)SULFONIOLETHYLOXYCARBONYL] (PMS)-SERINE AS A NOVEL REAGENT FOR SURFACE DERIVATISATION

E Nice, J Rothacker, K Kawasaki, JD Wade

Conference Proceedings  |  2004  |  JOURNAL OF PEPTIDE SCIENCE

Identification of a direct interaction between calcitonin peptide and its receptor

Vi Pham, John A Wade, Brooke W Purdue, Patrick M Sexton

Conference Proceedings  |  2004  |  Peptide Revolution: Genomics, Proteomics & Therapeutics

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

KJ Barnham, GD Ciccotosto, AK Tickler, FE Ali, DG Smith, NA Williamson, YH Lam, D Carrington, D Tew, G Kocak, I Volitakis, F Separovic, CJ Barrow, JD Wade, CL Masters, RA Cherny, CC Curtain, AI Bush, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Chromatin remodeling and modification during HIV-1 tat-activated transcription

A Pumfery, LW Deng, A Maddukuri, C de la Fuente, H Li, JD Wade, P Lambert, A Kumar, F Kashanchi

Journal article  |  2003  |  Current HIV Research

Human gene 2 relaxin chain combination and folding

JG Tang, ZH Wang, GW Tregear, JD Wade

Journal article  |  2003  |  Biochemistry

Design, synthesis and analysis of single chain relaxin mimetics

M Del Borgo, RA Hughes, JD Wade

Conference Proceedings  |  2003  |  BIOPOLYMERS

Relaxin 3, a novel member of the insulin superfamily of peptide hormones

RA Bathgate, N Hanson, F Lin, GW Tregear, JD Wade

Conference Proceedings  |  2003  |  BIOPOLYMERS

Application of photoaffinity crosslinking in determining the interaction between calcitonin and its receptor

V Pham, JD Wade, PM Sexton

Journal article  |  2003  |  Letters in Peptide Science

Walking the fine line between intracellular and membrane activities of antibacterial peptides

MA Bower, M Cudic, W Campbell, JD Wade, L Otvos

Journal article  |  2003  |  Letters in Peptide Science

Insulin 3: From chemical synthesis to biological function

P Fu, RAD Bathgate, GW Tregear, JD Wade

Conference Proceedings  |  2003  |  Letters in Peptide Science

Relaxin 3, a novel member of the insulin superfamily of peptide hormones.

RA Bathgate, N Hanson, F Lin, GW Tregear, JD Wade

Conference Proceedings  |  2003  |  BIOPOLYMERS

Design, synthesis and analysis of single chain relaxin mimetics

M Del Borgo, RA Hughes, JD Wade

Conference Proceedings  |  2003  |  BIOPOLYMERS

Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria

YY Tan, NF Dawson, AR Kompa, CP Bond, A Claasz, JD Wade, GW Tregear, RJ Summers

Journal article  |  2002  |  European Journal of Pharmacology

Relaxin-like bioactivity of ovine Insulin 3 (INSL3) analogues

AA Claasz, CP Bond, RA Bathgate, L Otvos, NF Dawson, RJ Summers, GW Tregear, JD Wade

Journal article  |  2002  |  European Journal of Biochemistry

INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent

J Kumagai, SY Hsu, H Matsumi, JS Roh, P Fu, JD Wade, RAD Bathgate, AJW Hsueh

Journal article  |  2002  |  Journal of Biological Chemistry

Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene - Novel members of the relaxin peptide family

RAD Bathgate, CS Samuel, TCD Burazin, S Layfield, AA Claasz, IGT Reytomas, NF Dawson, CX Zhao, C Bond, RJ Summers, LJ Parry, JD Wade, GW Tregear

Journal article  |  2002  |  Journal of Biological Chemistry

Relaxin 3, a novel member of the insulin/relaxin superfamily of peptide hormones.

RA Bathgate, D Scott, CS Samuel, TCD Burazin, S Layfield, AA Claasz, NF Dawson, S Ma, C Bond, RJ Summers, JD Wade, GW Tregear

Journal article  |  2002  |  BIOLOGY OF REPRODUCTION

Fmoc-solid phase peptide thioester synthesis: Optimization of base conditions for reduction of side reaction

AB CLIPPINGDALE, CJ BARROW, GW TREGEAR, M MATHIEU, JDC WADE

Conference Proceedings  |  2002  |  Pepties. Biology and Chemistry. Proceedings of the 200 Chinese Peptide Symposium

The use of coiled-coil interactions for the analysis and micropreparative isolation of adenomatous polyposis coli protein complexes

B Catimel, MC Faux, M Nerrie, J Rothacker, L Otvos, JD Wade, EC Nice, AW Burgess

Journal article  |  2001  |  Journal of Peptide Research

Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA

LW Deng, D Wang, C de la Fuente, L Wang, H Li, CG Lee, R Donnelly, JD Wade, P Lambert, F Kashanchi

Journal article  |  2001  |  Virology

Chemical synthesis and biological activity of rat INSL3

KJ Smith, JD Wade, AA Claasz, L Otvos, C Temelcos, Y Kubota, JM Hutson, GW Tregear, RA Bathgate

Journal article  |  2001  |  Journal of Peptide Science

Improved preparation of amyloid-beta peptides using DBU as N-alpha-Fmoc deprotection reagent

AK Tickler, CJ Barrow, JD Wade

Journal article  |  2001  |  Journal of Peptide Science

Structural and biosensor analyses of a synthetic biotinylated peptide probe for the isolation of adenomatous polyposis coli tumor suppressor protein complexes

JD Wade, B Catimel, MC Faux, AW Burgess, E Nice, L Otvos

Journal article  |  2001  |  Journal of Peptide Research

Synthesis of a disulfide-linked octameric peptide construct carrying three different antigenic determinants

G Kragol, L Otvos, JQ Feng, W Gerhard, JD Wade

Journal article  |  2001  |  Bioorganic and Medicinal Chemistry Letters

Editorial peptides - From discovery to therapeutics

M Aguilar, E Nice, J Wade

Conference Proceedings  |  2001  |  Letters in Peptide Science

The amyloid-beta peptide and its role in Alzheimer's disease

AB Clippingdale, JD Wade, CJ Barrow

Journal article  |  2001  |  Journal of Peptide Science

Synthesis, conformational studies and biological activity of N-alpha-mono-biotinylated rat relaxin

MN Mathieu, JD Wade, B Catimel, CP Bond, EC Nice, RJ Summers, L Otvos, GW Tregear

Journal article  |  2001  |  Journal of Peptide Research

The Relaxin-Like Factor (Insulin 3) is highly expressed in the ruminant ovary: A putative ruminant relaxin?

RAD Bathgate, N Moniac, B Bartlick, A Claasz, N Dawson, YY Tan, JD Wade, GW Tregear, R Ivell

Conference Proceedings  |  2001  |  RELAXIN 2000

Fmoc solid phase synthesis of peptide thioesters: Stability of mercaptropropionic acid linker to DBU base.

AB CLIPPINGDALE, CJ BARROW, JDC WADE

Conference Proceedings  |  2001  |  Peptides 2000. Proceedings of the Twenty-Sixty European Peptide Symposium.

Structure-activity relationships of relaxin and relaxin-like factor/Insulin 3

YY Tan, NF Dawson, AR Kompa, C Bond, A Claasz, JD Wade, GW Tregear, RJ Summers

Conference Proceedings  |  2001  |  Relaxin 200. Proceedings of the Third International Conference on Relaxin and Related Peptides.

Human relaxin chain combination and folding.

JG TANG, GW TREGEAR, JDC WADE

Conference Proceedings  |  2001  |  Peptides: The Wave of the Future.

Synthesis and biological activity of biotinylated rat relaxin.

M MATHIEU, JDC WADE, GW TREGEAR

Conference Proceedings  |  2001  |  Peptides 2000. Proceedings of the Twenty-Sixth European Peptide Symposium.

Bioassays for relaxin and relaxin-related peptides

YY Tan, CP Bond, JD Wade, GW Tregear, RJ Summers

Conference Proceedings  |  2001  |  Relaxin 2000. Proceedings of the Third International Conference on Relaxin and Related Peptides.

Chemical synthesis and relaxin activity of analogues of ovine insulin 3 containing specific B-chain residue replacements

AA Claasz, RA Bathgate, NF Dawson, RJ Summers, L Otvos, GW Tregear, JD Wade

Conference Proceedings  |  2001  |  Relaxin 2000. Proceedings of the Third International Conference on Relaxin and Related Peptides.

The relaxin-like factor (RLF, Insl3) is highly expressed in the ruminant ovary.

R BATHGATE, N MONIAC, B BARTLICK, AA CLAASZ, N DAWSON, YY TAN, JDC WADE, GW TREGEAR, R IVELL

Conference Proceedings  |  2001  |  Relaxin 2000. Proceedings of the 3rd International Conference on Relaxin & Related Peptides. A putative ruminant relaxin?

Synthesis and conformational analysis of template-assembled mimetics of relaxin.

M MATHIEU, JDC WADE, GW TREGEAR

Conference Proceedings  |  2001  |  Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries. Peptids, Proteins and Nucleic Acis. Small Molecule Organic Chemical Diversity 2000.

Chemical synthesis and relaxin activity of rat insulin 3

KJ Smith, RA Bathgate, AA Claasz, NF Dawson, L Otvos, GW Tregear, JD Wade

Conference Proceedings  |  2001  |  RELAXIN 2000

Improved Fmoc-solid phase synthesis of Beta-amyloid peptides using DBU as Nalpha-deprotection reagent.

AK TICKLER, CJ BARROW, JDC WADE

Conference Proceedings  |  2001  |  Peptides: The Wave of the Future.

Solid phase syntheses of rat prorelaxin C-peptides (1-73) and (76-101)

NF Dawson, YY Tan, RJ Summers, M Macris, L Otvos, GW Tregear, JD Wade

Conference Proceedings  |  2001  |  Relaxin 2000. Proceedings of the Third International Conference on Relaxin and Related Peptides.

The use of biosensor technology to search for orphan biomolecules: towards the relaxin receptor

E Nice, B Catimel, J Rothacker, RA Bathgate, M Mathieu, AA Claasz, GW Tregear, JD Wade

Conference Proceedings  |  2001  |  Relaxin 2000. Proceedings of the Third International Conference on Relaxin and Related Peptides.

Using solid phase synthesis to elucidate the role of relaxin in mammalian physiology.

JDC WADE, GW TREGEAR

Conference Proceedings  |  2001  |  Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries.

The use of a synthetic biotinylaged peptide probe for the isolation of adenoatous polyposis coli (APC) tumur suppressor protein complexes.

BL CATIMEL, JDC WADE, M FAUX, AW BURGESS, L OTVOS, EC NICE

Conference Proceedings  |  2001  |  Peptides. The Wave of the Future.

Chemical synthesis of relaxin analogues: Current status and future developments

GW Tregear, MN Mathieu, NF Dawson, KJ Smith, AA Claasz, AB Clippingdale, P Fu, JD Wade

Conference Proceedings  |  2001  |  Relaxin 2000. Proceedings of the Third International Conference on Relaxin and Related Peptides.

The formation of amyloid fibrils by relaxin.

CE MACPHEE, CM DOBSON, JDC WADE

Conference Proceedings  |  2001  |  Relaxin 2000. Proceedings of the Third International Conference on Relaxin and Related Peptides.

Design and synthesis of a mini-prorelaxin model.

M MATHIEU, N DAWSON, JDC WADE, GW TREGEAR

Conference Proceedings  |  2001  |  Peptides. The Wave of the Future.

Use of thiazolidine-mediated ligation for site specific biotinylation of mouse EGF for biosensor immobilisation

JD Wade, T Domagala, J Rothacker, B Catimel, E Nice

Conference Proceedings  |  2001  |  Letters in Peptide Science

Design, synthesis and biological activity of template-assembled peptidic mimetics of rat relaxin

MN Mathieu, JD Wade, YY Tan, RJ Summers, GW Tregear

Conference Proceedings  |  2001  |  RELAXIN 2000

N-alpha-mono-biotinylated rat relaxin: synthesis and activity

MN Mathieu, CP Bond, JD Wade, RJ Summers, GW Tregear

Conference Proceedings  |  2001  |  RELAXIN 2000

Chemical synthesis and biological activity of ovine insulin 3, a relaxin structural homologue

NF Dawson, M Macris, RJ Summers, YY Tan, GW Tregear, JD Wade

Conference Proceedings  |  2001  |  RELAXIN 2000

Three-dimensional structure of RK-1: A novel alpha-defensin peptide

AM McManus, NF Dawson, JD Wade, LE Carrington, DJ Winzor, DJ Craik

Journal article  |  2000  |  Biochemistry

Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones

LW Deng, C de la Fuente, P Fu, L Wang, R Donnelly, JD Wade, P Lambert, H Li, CG Lee, F Kashanchi

Journal article  |  2000  |  Virology

Convenient synthesis of a head-to-tail cyclic peptide containing an expanded ring

M Cudic, JD Wade, L Otvos

Journal article  |  2000  |  Tetrahedron Letters

Identification of initiation sites for T4 lysozyme folding using CD and NMR spectroscopy of peptide fragments

LV Najbar, DJ Craik, JD Wade, MJ McLeish

Journal article  |  2000  |  Biochemistry

Novel strategy for the synthesis of template-assembled analogues of rat relaxin

MN Mathieu, JD Wade, YY Tan, RJ Summers, GW Tregear

Journal article  |  2000  |  Journal of Peptide Science

Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation

AB Clippingdale, CJ Barrow, JD Wade

Journal article  |  2000  |  Journal of Peptide Science

Insect peptides with improved protease-resistance protect mice against bacterial infection

L Otvos, K Bokonyi, I Varga, BI Otvos, R Hoffmann, HCJ Ertl, JD Wade, AM McManus, D Craik, P Bulet

Journal article  |  2000  |  Protein Science