John Wade

De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications

Shuimu Lin, John D Wade, Shouping Liu

Journal article  |  2021  |  Accounts of Chemical Research

ConspectusThe alarming rate at which pathogens are developing resistance to conventional antibiotics represents one of the major g..

Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria

DMM Jaradat, N Al-Karablieh, BHM Zaarer, W Li, KKY Saleh, AJ Rasras, S Abu-Romman, NM O'Brien-Simpson, JD Wade

Journal article  |  2021  |  Biological Chemistry

Abstract Increasing antibiotic resistance in Gram-negative bacteria has mandated the development of both novel anti..

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

Mengjie Liu, Emily A Whitfield, Linda J Fothergill, John B Furness, John D Wade, Sebastian GB Furness, Mohammed Akhter Hossain

Journal article  |  2020  |  Biochemical and Biophysical Research Communications

Human ghrelin receptor (GHSR) is a recognized prospective target in the diagnosis and therapy of multiple cancer types. To gain a ..

Adiponectin receptor activation inhibits prostate cancer xenograft growth.

Lisa K Philp, Anja Rockstroh, Melanie Lehman, Martin C Sadowski, Nenad Bartonicek, John D Wade, Laszlo Otvos, Colleen C Nelson

Journal article  |  2020  |  Endocrine Related Cancer

Adiponectin is an adipokine originally identified as dysregulated in obesity, with a key role in insulin sensitisation and in main..

(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

Nicholas G Welch, Wenyi Li, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2020  |  Frontiers in Chemistry

As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AM..

Effects of C-Terminal B-Chain Modifications in a Relaxin 3 Agonist Analogue

Praveen Praveen, Julien Tailhades, K Johan Rosengren, Mengjie Liu, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2020  |  ACS Medicinal Chemistry Letters

The receptor for the neuropeptide relaxin 3, relaxin family peptide 3 (RXFP3) receptor, is an attractive pharmacological target fo..

Total Chemical Synthesis of a Nonfibrillating Human Glycoinsulin

Mohammed Akhter Hossain, Rio Okamoto, John A Karas, Praveen Praveen, Mengjie Liu, Briony E Forbes, John D Wade, Yasuhiro Kajihara

Journal article  |  2020  |  Journal of the American Chemical Society

Glycosylation is an accepted strategy to improve the therapeutic value of peptide and protein drugs. Insulin and its analogues are..

Professor Paul Alewood

Edouard C Nice, John D Wade

Journal article  |  2020  |  Australian Journal of Chemistry

Chemical Modification of Cellulose Membranes for SPOT Synthesis

Wenyi Li, John Wade, Eric Reynolds, Neil M O'Brien-Simpson

Journal article  |  2020  |  Australian Journal of Chemistry

Since the development of solid-phase peptide synthesis in the 1960s, many laboratories have modified the technology for the produc..

Traceable Peptidic Ligands that Target Ghrelin Receptors

Mengjie Liu, John Wade, Mohammed Akhter Hossain

Journal article  |  2020  |  Current Protein and Peptide Science

Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes...