Colleen Elso

Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes

Kriti Joshi, Colleen Elso, Ali Motazedian, Tanya Labonne, Jacqueline V Schiesser, Fergus Cameron, Stuart I Mannering, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2019  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. ..

Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetes.

Stuart I Mannering, Anthony R Di Carluccio, Colleen M Elso

Journal article  |  2019  |  Diabetologia

Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of pancreatic insulin-producing beta cells. The epi..

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes.

Colleen M Elso, Nicholas A Scott, Lina Mariana, Emma I Masterman, Andrew PR Sutherland, Helen E Thomas, Stuart I Mannering

Journal article  |  2019  |  PLoS One

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-o..

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes

Michelle So, Colleen M Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja, John M Wentworth, Leonard C Harrison, Balasubramanian Krishnamurthy, Helen E Thomas, Christine Rodda, Fergus J Cameron, Jacinta McMahon, Thomas WH Kay, Stuart I Mannering

Journal article  |  2018  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells, found within the islets of Langerhans in the..

Autoimmune-diseaseprone NOD mice help to reveal a new genetic locus for reducing pulmonary disease caused by Mycoplasma pulmonis

NK Wawegama, PF Markham, CM Elso, A Kanci, MS Marenda, GF Browning, TC Brodnicki

Journal article  |  2018  |  Infection and Immunity (Online)

© 2018 American Society for Microbiology. Mycoplasmas are bacterial pathogens of a range of animals, including humans, and are a c..

Shuffling peptides to create T-cell epitopes: does the immune system play cards?

Stuart I Mannering, Michelle So, Colleen M Elso, Thomas WH Kay

Journal article  |  2018  |  IMMUNOLOGY AND CELL BIOLOGY

For a long time, immunologists have believed that classical CD4+ and CD8+ T cells recognize peptides (referred to as epitopes), de..

Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility

Edward PF Chu, Colleen M Elso, Abigail H Pollock, May A Alsayb, Leanne Mackin, Helen E Thomas, Thomas WH Kay, Pablo A Silveira, Ashley S Mansell, Katharina Gaus, Thomas C Brodnicki

Journal article  |  2017  |  MOLECULAR IMMUNOLOGY

During immune cell activation, serine-derived lipids such as phosphatidylserine and sphingolipids contribute to the formation of p..

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

Thomas Delong, Timothy A Wiles, Rocky L Baker, Brenda Bradley, Gene Barbour, Richard Reisdorph, Michael Armstrong, Roger L Powell, Nichole Reisdorph, Nitesh Kumar, Colleen M Elso, Megan DeNicola, Rita Bottino, Alvin C Powers, David M Harlan, Sally C Kent, Stuart I Mannering, Kathryn Haskins

Journal article  |  2016  |  SCIENCE

T cell-mediated destruction of insulin-producing β cells in the pancreas causes type 1 diabetes (T1D). CD4 T cell responses play a..

Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes

Colleen M Elso, Edward PF Chu, May A Alsayb, Leanne Mackin, Sean T Ivory, Michelle P Ashton, Stefan Broeer, Pablo A Silveira, Thomas C Brodnicki

Journal article  |  2015  |  G3-GENES GENOMES GENETICS

A number of different strategies have been used to identify genes for which genetic variation contributes to type 1 diabetes (T1D)..

A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues.

C Chase Bolt, Colleen M Elso, Xiaochen Lu, Fuming Pan, Andreas Kispert, Lisa Stubbs

Journal article  |  2014  |  Dev Biol

The vertebrate T-box transcription factor gene Tbx18 performs a vital role in development of multiple organ systems. Tbx18 insuffi..