Andrew Deans

Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal

Charlotte Hodson, Sylvie van Twest, Malgorzata Dylewska, Julienne J O'Rourke, Winnie Tan, Vincent J Murphy, Mannu Walia, Lara Abbouche, Jadwiga Nieminuszczy, Elyse Dunn, Rohan Bythell-Douglas, Jorg Heierhorst, Wojciech Niedzwiedz, Andrew J Deans

Journal article  |  2022  |  CELL REPORTS

Co-transcriptional R loops arise from stalling of RNA polymerase, leading to the formation of stable DNA:RNA hybrids. Unresolved R..

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

Charlotte Hodson, Jason KK Low, Sylvie van Twest, Samuel E Jones, Paolo Swuec, Vincent Murphy, Kaima Tsukada, Matthew Fawkes, Rohan Bythell-Douglas, Adelina Davies, Jessica K Holien, Julienne J O'Rourke, Benjamin L Parker, Astrid Glaser, Michael W Parker, Joel P Mackay, Andrew N Blackford, Alessandro Costa, Andrew J Deans

Journal article  |  2022  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the "Bloom syndrome c..

Childhood acute myeloid leukemia shows a high level of germline predisposition.

Saumya E Samaraweera, Paul PS Wang, Ka Leung Li, Debora A Casolari, Jinghua Feng, Mark Pinese, Kyaw Ze Ya Maung, Paul Leo, Mark Cowley, Kelly Perkins, Amanda M Smith, Jonathan Ellis, Amilia Wee, Devendra K Hiwase, Hamish S Scott, Andreas W Schreiber, Anna L Brown, Andrew J Deans, David M Ross, Andrew S Moore, et al.

Journal article  |  2021  |  Blood

Protein truncating variants in FANCM and risk for ER-negative/triple negative breast cancer COMMENT

Paolo Peterlongo, Gisella Figlioli, Andrew J Deans, Fergus J Couch

Journal article  |  2021  |  NPJ BREAST CANCER

FANCM protein truncating variants (PTVs) are emerging as risk factors for ER-negative and triple negative breast cancer. Here, we ..

Cyclin-Dependent Kinase-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

Juan A Cantres-Velez, Justin L Blaize, David A Vierra, Rebecca A Boisvert, Jada L Garzon, Benjamin Piraino, Winnie Tan, Andrew J Deans, Niall G Howlett

Journal article  |  2021  |  MOLECULAR AND CELLULAR BIOLOGY

Fanconi anemia (FA) is a rare genetic disease characterized by increased risk for bone marrow failure and cancer. The FA proteins ..

The Fanconi anemia ubiquitin E3 ligase complex as an anti-cancer target

Michael F Sharp, Rohan Bythell-Douglas, Andrew J Deans, Wayne Crismani

Journal article  |  2021  |  MOLECULAR CELL

Agents that induce DNA damage can cure some cancers. However, the side effects of chemotherapy are severe because of the indiscrim..

The ubiquitination machinery of the Fanconi Anemia DNA repair pathway

Winnie Tan, Andrew J Deans

Journal article  |  2021  |  PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The Fanconi Anemia (FA) pathway maintains genome stability by preventing DNA damage from occurring when replication is blocked. Ce..

A Structural Guide to the Bloom Syndrome Complex

Rohan Bythell-Douglas, Andrew J Deans

Journal article  |  2021  |  STRUCTURE

The Bloom syndrome complex is a DNA damage repair machine. It consists of several protein components which are functional in isola..

Fanconi anemia, put to sleep

Andrew J Deans

Journal article  |  2021  |  BLOOD

Formaldehyde Causes Bone Marrow Failure Linked to Transcriptional Reprogramming or Metabolic Deficiency

Winnie Tan, Andrew J Deans

Journal article  |  2020  |  MOLECULAR CELL

Two new studies in this issue of Molecular Cell demonstrate that bone marrow failure, in mice and humans, can be induced by formal..