Andrew Deans

Protein truncating variants in FANCM and risk for ER-negative/triple negative breast cancer COMMENT

Paolo Peterlongo, Gisella Figlioli, Andrew J Deans, Fergus J Couch

Journal article  |  2021  |  NPJ BREAST CANCER

The ubiquitination machinery of the Fanconi Anemia DNA repair pathway

Winnie Tan, Andrew J Deans

Journal article  |  2021  |  PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The Fanconi Anemia (FA) pathway maintains genome stability by preventing DNA damage from occurring when replication is blocked. Ce..

A Structural Guide to the Bloom Syndrome Complex

Rohan Bythell-Douglas, Andrew J Deans

Journal article  |  2021  |  STRUCTURE

The Bloom syndrome complex is a DNA damage repair machine. It consists of several protein components which are functional in isola..

Fanconi anemia, put to sleep

Andrew J Deans

Journal article  |  2021  |  BLOOD

In this issue of Blood, Okamoto et al describe how reduced levels of Schlafen protein SLFN11 can rescue the DNA damage sensitivity..

Formaldehyde Causes Bone Marrow Failure Linked to Transcriptional Reprogramming or Metabolic Deficiency

Winnie Tan, Andrew J Deans

Journal article  |  2020  |  MOLECULAR CELL

Two new studies in this issue of Molecular Cell demonstrate that bone marrow failure, in mice and humans, can be induced by formal..

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J Deans, Kum Kum Khanna, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cance..

Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

Michael F Sharp, Vince J Murphy, Sylvie Van Twest, Winnie Tan, Jennii Lui, Kaylene J Simpson, Andrew J Deans, Wayne Crismani

Journal article  |  2020  |  SCIENTIFIC REPORTS

DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription...

Association of clinical severity with FANCB variant type in Fanconi anemia

Moonjung Jung, Ramanagouda Ramanagoudr-Bhojappa, Sylvie van Twest, Rasim Ozgur Rosti, Vincent Murphy, Winnie Tan, Frank X Donovan, Francis P Lach, Danielle C Kimble, Caroline S Jiang, Roger Vaughan, Parinda A Mehta, Filomena Pierri, Carlo Dufour, Arleen D Auerbach, Andrew J Deans, Agata Smogorzewska, Settara C Chandrasekharappa

Journal article  |  2020  |  BLOOD

Fanconi anemia (FA) is the most common genetic cause of bone marrow failure and is caused by inherited pathogenic variants in any ..

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI: FANCD2 on DNA in filamentous arrays

Winnie Tan, Sylvie van Twest, Andrew Leis, Rohan Bythell-Douglas, Vincent J Murphy, Michael Sharp, Michael W Parker, Wayne Crismani, Andrew J Deans

Journal article  |  2020  |  ELIFE

FANCI:FANCD2 monoubiquitination is a critical event for replication fork stabilization by the Fanconi anemia (FA) DNA repair pathw..

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

Winnie Tan, Vincent J Murphy, Aude Charron, Sylvie van Twest, Michael Sharp, Angelos Constantinou, Michael W Parker, Wayne Crismani, Rohan Bythell-Douglas, Andrew J Deans

Journal article  |  2020  |  PLOS ONE

Site-specific conjugation of ubiquitin onto a range of DNA repair proteins regulates their critical functions in the DNA damage re..