Andrew Deans

Formaldehyde Causes Bone Marrow Failure Linked to Transcriptional Reprogramming or Metabolic Deficiency

Winnie Tan, Andrew J Deans

Journal article  |  2020  |  Molecular Cell

A Structural Guide to the Bloom Syndrome Complex.

Rohan Bythell-Douglas, Andrew J Deans

Journal article  |  2020  |  Structure

The Bloom syndrome complex is a DNA damage repair machine. It consists of several protein components which are functional in isola..

Structural insight into FANCI-FANCD2 monoubiquitination.

Landing Li, Winnie Tan, Andrew J Deans

Journal article  |  2020  |  Essays in Biochemistry

The Fanconi anemia (FA) pathway coordinates a faithful repair mechanism for DNA damage that blocks DNA replication, such as inters..

The ubiquitination machinery of the Fanconi Anemia DNA repair pathway.

Winnie Tan, Andrew J Deans

Journal article  |  2020  |  Progress in Biophysics and Molecular Biology

The Fanconi Anemia (FA) pathway maintains genome stability by preventing DNA damage from occurring when replication is blocked. Ce..

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J Deans, Kum Kum Khanna, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cance..

Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

Michael F Sharp, Vince J Murphy, Sylvie Van Twest, Winnie Tan, Jennii Lui, Kaylene J Simpson, Andrew J Deans, Wayne Crismani

Journal article  |  2020  |  Scientific Reports

DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription...

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI: FANCD2 on DNA in filamentous arrays

Winnie Tan, Sylvie van Twest, Andrew Leis, Rohan Bythell-Douglas, Vincent J Murphy, Michael Sharp, Michael W Parker, Wayne Crismani, Andrew J Deans

Journal article  |  2020  |  eLife

FANCI:FANCD2 monoubiquitination is a critical event for replication fork stabilization by the Fanconi anemia (FA) DNA repair pathw..

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

Winnie Tan, Vincent J Murphy, Aude Charron, Sylvie van Twest, Michael Sharp, Angelos Constantinou, Michael W Parker, Wayne Crismani, Rohan Bythell-Douglas, Andrew J Deans

Journal article  |  2020  |  PLoS One

Site-specific conjugation of ubiquitin onto a range of DNA repair proteins regulates their critical functions in the DNA damage re..

Monoubiquitination by the Fanconi Anemia core complex locks FANCI:FANCD2 on DNA in filamentous arrays

Winnie Tan, Sylvie van Twest, Andrew Leis, Rohan Bythell-Douglas, Vincent Murphy, Michael Sharp, Michael Parker, Wayne Crismani, Andrew Deans

Journal article  |  2019  |  eLife

Abstract FANCI:FANCD2 monoubiquitination is a critical event for replication fork stabilization by the Fanconi anemia (FA) DNA rep..

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT) (vol 10, 2252, 2019)

Robert Lu, Julienne J O'Rourke, Alexander P Sobinoff, Joshua AM Allen, Christopher B Nelson, Christopher G Tomlinson, Michael Lee, Roger R Reddel, Andrew J Deans, Hilda A Pickett

Journal article  |  2019  |  Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.