Hadi Lioe

Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques

Amy K Searle, Yung-Chih Chen, Maria Wallert, James D McFadyen, Ana C Maluenda, Jonathan Noonan, Peter Kanellakis, Maria TK Zaldivia, Angela Huang, Hadi Lioe, Mark Biondo, Marc W Nolte, Paolo Rossato, Alex Bobik, Con Panousis, Xiaowei Wang, Hamid Hosseini, Karlheinz Peter

Journal article  |  2022  |  THROMBOSIS AND HAEMOSTASIS

BACKGROUND: 3F7 is a monoclonal antibody targeting the enzymatic pocket of activated factor XII (FXIIa), thereby inhibiting its ca..

Synthesis and gas-phase uni- and bi-molecular reactivity of bisphosphine ligated gold clusters, [AuxLy](n )

Peter SD Robinson, Tich-Lam Nguyen, Hadi Lioe, Richard AJ O'Hair, George N Khairallah

Journal article  |  2012  |  INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

The condensed phase synthesis of bis-phosphine Ph2P(CH 2)nPPh2 (Ln) (n = 3-6) protected gold clusters containing 6-11 gold core at..

Gold-Mediated C-I Bond Activation of Iodobenzene

Peter SD Robinson, George N Khairallah, Gabriel da Silva, Hadi Lioe, Richard AJ O'Hair

Journal article  |  2012  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controversy resolved! A combination of gas-phase ion-molecule reactions and theoretical studies confirm bisligated mononuclear Au(..

The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture.

Andrew J Baldwin, Hadi Lioe, Gillian R Hilton, Lindsay A Baker, John L Rubinstein, Lewis E Kay, Justin LP Benesch

Journal article  |  2011  |  Structure

We report structural models for the most abundant oligomers populated by the polydisperse molecular chaperone αB-crystallin. Subun..

Quaternary dynamics of αB-crystallin as a direct consequence of localised tertiary fluctuations in the C-terminus.

Andrew J Baldwin, Gillian R Hilton, Hadi Lioe, Claire Bagnéris, Justin LP Benesch, Lewis E Kay

Journal article  |  2011  |  J Mol Biol

The majority of proteins exist in vivo within macromolecular assemblies whose functions are dependent on dynamical processes spann..

αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics.

Andrew J Baldwin, Hadi Lioe, Carol V Robinson, Lewis E Kay, Justin LP Benesch

Journal article  |  2011  |  J Mol Biol

The inherent heterogeneity of many protein assemblies complicates characterization of their structure and dynamics, as most biophy..

Preference for bridging versus terminal ligands in magnesium dimers

Hadi Lioe, Jonathan M White, Richard AJ O'Hair

Journal article  |  2011  |  JOURNAL OF MOLECULAR MODELING

Magnesium dimers play important roles in inorganic and organometallic chemistry. This study evaluates the inherent bridging abilit..

How Does Acetylcholine Lose Trimethylamine? A Density Functional Theory Study of Four Competing Mechanisms

Hadi Lioe, Christopher K Barlow, Richard AJ O'Hair

Journal article  |  2009  |  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Low-energy collision-induced dissociation (CID) of acetylcholine (ACh) yields only two fragment ions: the dominant C(4)H(7)O(2)(+)..

A novel salt bridge mechanism highlights the need for nonmobile proton conditions to promote disulfide bond cleavage in protonated peptides under low-energy collisional activation

Hadi Lioe, Richard AJ O'Hair

Journal article  |  2007  |  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The gas-phase fragmentation mechanisms of small models for peptides containing intermolecular disulfide links have been studied us..

Can metal ions be used as gas-phase disulfide bond cleavage reagents? A survey of coinage metal complexes of model peptides containing an intermolecular disulfide bond

Hadi Lioe, Mubing Duan, Richard AJ O'Hair

Journal article  |  2007  |  RAPID COMMUNICATIONS IN MASS SPECTROMETRY

The role that a metal ion can have in promoting disulfide bond cleavage has been assessed by surveying the tandem mass spectra of ..