Liam Fearnley

A founder event causing a dominant childhood epilepsy survives 800 years through weak selective pressure

Bronwyn E Grinton, Erandee Robertson, Liam G Fearnley, Ingrid E Scheffer, Anthony G Marson, Terence J O'Brien, W Owen Pickrell, Mark Rees, Sanjay M Sisodiya, David J Balding, Mark F Bennett, Melanie Bahlo, Samuel F Berkovic, Karen L Oliver

Journal article  |  2022  |  AMERICAN JOURNAL OF HUMAN GENETICS

Genetic epilepsy with febrile seizures plus (GEFS+) is an autosomal dominant familial epilepsy syndrome characterized by distincti..

Multi-level remodelling of chromatin underlying activation of human T cells

Naiara G Bediaga, Hannah D Coughlan, Timothy M Johanson, Alexandra L Garnham, Gaetano Naselli, Jan Schroeder, Liam G Fearnley, Esther Bandala-Sanchez, Rhys S Allan, Gordon K Smyth, Leonard C Harrison

Journal article  |  2021  |  SCIENTIFIC REPORTS

Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage develop..

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Artika P Nath, Scott C Ritchie, Sean G Byars, Liam G Fearnley, Aki S Havulinna, Anni Joensuu, Antti J Kangas, Pasi Soininen, Annika Wennerstrom, Lili Milani, Andres Metspalu, Satu Mannisto, Peter Wurtz, Johannes Kettunen, Emma Raitoharju, Mika Kahonen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, et al.

Journal article  |  2017  |  GENOME BIOLOGY

BACKGROUND: Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene n..

Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks

Liam G Fearnley, Michael Inouye

Journal article  |  2016  |  INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Metabolomics is becoming feasible for population-scale studies of human disease. In this review, we survey epidemiological studies..

A Scalable Permutation Approach Reveals Replication and Preservation Patterns of Network Modules in Large Datasets

Scott C Ritchie, Stephen Watts, Liam G Fearnley, Kathryn E Holt, Gad Abraham, Michael Inouye

Journal article  |  2016  |  CELL SYSTEMS

Network modules-topologically distinct groups of edges and nodes-that are preserved across datasets can reveal common features of ..

The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection

Scott C Ritchie, Peter Wurtz, Artika P Nath, Gad Abraham, Aki S Havulinna, Liam G Fearnley, Antti-Pekka Sarin, Antti J Kangas, Pasi Soininen, Kristiina Aalto, Ilkka Seppala, Emma Raitoharju, Marko Salmi, Mikael Maksimow, Satu Mannisto, Mika Kahonen, Markus Juonala, Samuli Ripatti, Terho Lehtimaki, Sirpa Jalkanen, et al.

Journal article  |  2015  |  CELL SYSTEMS

The biomarker glycoprotein acetylation (GlycA) has been shown to predict risk of cardiovascular disease and all-cause mortality. H..

Extracting reaction networks from databases-opening Pandora's box

Liam G Feamley, Melissa J Davis, Mark A Ragan, Lars K Nielsen

Journal article  |  2014  |  BRIEFINGS IN BIOINFORMATICS

Large quantities of information describing the mechanisms of biological pathways continue to be collected in publicly available da..

Honey Production and Compositional Parameters

L FEARNLEY

Book Chapter  |  2014

This book presents information key to understanding how antioxidants change during production of a wide variety of food products, ..

Towards a Large Integrated Model of Signal Transduction and Gene Regulation Events in Mammalian Cells

Liam G Fearnley, Mark A Ragan, Lars K Nielsen

Conference Proceedings  |  2014  |  BIOINFORMATICS 2014: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON BIOINFORMATICS MODELS, METHODS AND ALGORITHMS

PATHLOGIC-S: A Scalable Boolean Framework for Modelling Cellular Signalling

Liam G Fearnley, Lars K Nielsen

Journal article  |  2012  |  PLOS ONE

Curated databases of signal transduction have grown to describe several thousand reactions, and efficient use of these data requir..