Turgut Aktepe

Liquid Chalk Is an Antiseptic against SARS-CoV-2 and Influenza A Respiratory Viruses.

Julie L McAuley, Joshua M Deerain, William Hammersla, Turgut E Aktepe, Damian FJ Purcell, Jason M Mackenzie

Journal article  |  2021  |  mSphere

The COVID-19 pandemic has impacted and enforced significant restrictions within our societies, including the attendance of public ..

A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication

Andrea Mikulasova, Leah K Gillespie, Rebecca L Ambrose, Turgut E Aktepe, Alice M Trenerry, Susann Liebscher, Jason M Mackenzie

Journal article  |  2021  |  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Flavivirus replication is intimately associated with re-organized cellular membranes. These virus-induced changes in membrane arch..

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface expression, is used by many viruses to evade ..

Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2 alpha Axis

Svenja Fritzlar, Turgut E Aktepe, Yi-Wei Chao, Nathan D Kenney, Michael R McAllaster, Craig B Wilen, Peter A White, Jason M Mackenzie

Journal article  |  2019  |  MBIO

The integrated stress response (ISR) is a cellular response system activated upon different types of stresses, including viral inf..

Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8( ) T Cell Recognition and Activation

Svenja Fritzlar, Sinthujan Jegaskanda, Turgut Esad Aktepe, Julia Emiley Prier, Lauren Elise Holz, Peter A White, Jason M Mackenzie

Journal article  |  2018  |  JOURNAL OF VIROLOGY

Human noroviruses are highly infectious single-stranded RNA (ssRNA) viruses and the major cause of nonbacterial gastroenteritis wo..

Shaping the flavivirus replication complex: It is curvaceous!

Turgut E Aktepe, Jason M Mackenzie

Journal article  |  2018  |  CELLULAR MICROBIOLOGY

Flavivirus replication is intimately involved with remodelled membrane organelles that are compartmentalised for different functio..

Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus

Susann Liebscher, Rebecca L Ambrose, Turgut E Aktepe, Andrea Mikulasova, Julia E Prier, Leah K Gillespie, Adam J Lopez-Denman, Thusitha WT Rupasinghe, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie

Journal article  |  2018  |  PLOS PATHOGENS

Positive-sense RNA virus intracellular replication is intimately associated with membrane platforms that are derived from host org..

The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling

Turgut E Aktepe, Susann Liebscher, Julia E Prier, Cameron P Simmons, Jason M Mackenzie

Journal article  |  2017  |  CELL REPORTS

Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and ..

Hijacking to use and abuse: the role of host factors during West Nile and Dengue virus replication and membrane mophogenesis

Turgut Esad Aktepe

Thesis / Dissertation  |  2017

Flaviviruses such as West Nile virus and Dengue virus are enveloped, +ssRNA virus from the Flaviviridae family causing infection i..

Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus

Turgut E Aktepe, Helen Pham, Jason M Mackenzie

Journal article  |  2015  |  VIROLOGY

It is well established that +ssRNA viruses manipulate cellular lipid homoeostasis and distribution to facilitate efficient replica..