Abdel Belaidi

Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE epsilon 4, sex and age

Scott Ayton, Shorena Janelidze, Blaine Roberts, Sebastian Palmqvist, Pawel Kalinowski, Ibrahima Diouf, Abdel A Belaidi, Erik Stomrud, Ashley Bush, Oskar Hansson

Journal article  |  2021  |  Progress in Neurobiology

It is unknown how neuroinflammation may feature in the etiology of Alzheimer's disease (AD). We profiled acute phase response (APR..

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan, Ting Zou, Qing-zhang Tuo, Shuo Xu, Hua Li, Abdel Ali Belaidi, Peng Lei

Journal article  |  2021  |  Signal Transduction and Targeted Therapy

Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death..

Acute phase markers in CSF reveal inflammatory changes in Alzheimer’s disease that are impacted by APOE ε4, sex and age but not pathology

Scott Ayton, Shorena Janelidze, Blaine R Roberts, Sebastian Palmqvist, Pawel Kalinowski, Ibrahima Diouf, Abdel Ali Belaidi, Erik Stomrud, Ashley I Bush, Oskar Hansson

Journal article  |  2020  |  Alzheimer's & Dementia

Cu-II(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Adam Southon, Kathryn Szostak, Karla M Acevedo, Krista A Dent, Irene Volitakis, Abdel A Belaidi, Kevin J Barnham, Peter J Crouch, Scott Ayton, Paul S Donnelly, Ashley Bush

Journal article  |  2020  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Diacetyl-bis(4-methyl-3-thiosemicarbazonato)copperII (CuII (atsm)) ameliorates neurodegeneration and delay..

Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease

Shashank Masaldan, Abdel Ali Belaidi, Scott Ayton, Ashley Bush

Journal article  |  2019  |  PHARMACEUTICALS

Iron dyshomeostasis is a feature of Alzheimer's disease (AD). The impact of iron on AD is attributed to its interactions with the ..

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Abdel A Belaidi, Adam P Gunn, Bruce X Wong, Scott Ayton, Ambili T Appukuttan, Blaine R Roberts, James A Duce, Ashley I Bush

Journal article  |  2018  |  Neurotherapeutics

Proteolytic cleavage of the amyloid precursor protein (APP) into the Aβ peptide has been an extensively researched mechanism for A..

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency

Avadh Kumar, Borislav Dejanovic, Florian Hetsch, Marcus Semtner, Debora Fusca, Sita Arjune, Jose Angel Santamaria-Araujo, Aline Winkelmann, Scott Ayton, Ashley I Bush, Peter Kloppenburg, Jochen C Meier, Guenter Schwarz, Abdel Ali Belaidi

Journal article  |  2017  |  JOURNAL OF CLINICAL INVESTIGATION

Molybdenum cofactor deficiency (MoCD) is an autosomal recessive inborn error of metabolism characterized by neurodegeneration and ..

Targeting Transition Metals for Neuroprotection in Alzheimer's Disease

S Ayton, AA Belaidi, P Lei, AI Bush

Book Chapter  |  2017

Alzheimer's disease (AD) is a prevalent, devastating, and therapeutically intractable disease of the elderly. Amyloid beta and tau..

The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update

Laura Mahoney-Sanchez, Abdel Ali Belaidi, Ashley I Bush, Scott Ayton

Journal article  |  2016  |  JOURNAL OF MOLECULAR NEUROSCIENCE

Apolipoprotein E (ApoE) plays a crucial role in the homeostatic control of lipids in both the periphery and the central nervous sy..

Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study

Bernd C Schwahn, Francjan J Van Spronsen, Abdel A Belaidi, Stephen Bowhay, John Christodoulou, Terry G Derks, Julia B Hennermann, Elisabeth Jameson, Kai Koenig, Tracy L McGregor, Esperanza Font-Montgomery, Jose A Santamaria-Araujo, Saikat Santra, Mamta Vaidya, Anne Vierzig, Evangeline Wassmer, Ilona Weis, Flora Y Wong, Alex Veldman, Guenter Schwarz

Journal article  |  2015  |  The Lancet

BACKGROUND: Molybdenum cofactor deficiency (MoCD) is characterised by early, rapidly progressive postnatal encephalopathy and intr..