Abdel Ali Belaidi

Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations

Mark A Greenough, Darius JR Lane, Rachelle Balez, Helena Targa Dias Anastacio, Zhiwen Zeng, Katherine Ganio, Christopher A McDevitt, Karla Acevedo, Abdel Ali Belaidi, Jari Koistinaho, Lezanne Ooi, Scott Ayton, Ashley Bush

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Mutations in presenilin 1 and 2 (PS1 and PS2) cause autosomal dominant familial Alzheimer's disease (FAD). Ferroptosis has been im..

The Neuroinflammatory Acute Phase Response in Parkinsonian-Related Disorders

Scott Ayton, Sara Hall, Shorena Janelidze, Pawel Kalinowski, Sebastian Palmqvist, Abdel A Belaidi, Blaine Roberts, Anne Roberts, Erik Stomrud, Ashley Bush, Oskar Hansson

Journal article  |  2022  |  MOVEMENT DISORDERS

BACKGROUND: Neuroinflammation is implicated in the pathophysiology of Parkinson's disease (PD) and related conditions, yet prior c..

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

Md Jakaria, Abdel Ali Belaidi, Ashley I Bush, Scott Ayton

Journal article  |  2021  |  JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex pathophysiology that is not fully understood. While ..

Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia-Reperfusion Injury

Qing-Zhang Tuo, Shashank Masaldan, Adam Southon, Celeste Mawal, Scott Ayton, Ashley Bush, Peng Lei, Abdel Ali Belaidi

Journal article  |  2021  |  NEUROTHERAPEUTICS

The emergence of ferroptosis as a cell death pathway associated with brain disorders including stroke and neurodegenerative diseas..

Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE epsilon 4, sex and age

Scott Ayton, Shorena Janelidze, Blaine Roberts, Sebastian Palmqvist, Pawel Kalinowski, Ibrahima Diouf, Abdel A Belaidi, Erik Stomrud, Ashley Bush, Oskar Hansson

Journal article  |  2021  |  PROGRESS IN NEUROBIOLOGY

It is unknown how neuroinflammation may feature in the etiology of Alzheimer's disease (AD). We profiled acute phase response (APR..

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan, Ting Zou, Qing-zhang Tuo, Shuo Xu, Hua Li, Abdel Ali Belaidi, Peng Lei

Journal article  |  2021  |  SIGNAL TRANSDUCTION AND TARGETED THERAPY

Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death..

Acute phase markers in CSF reveal inflammatory changes in Alzheimer’s disease that are impacted by APOE ε4, sex and age but not pathology

Scott Ayton, Shorena Janelidze, Blaine R Roberts, Sebastian Palmqvist, Pawel Kalinowski, Ibrahima Diouf, Abdel Ali Belaidi, Erik Stomrud, Ashley I Bush, Oskar Hansson

Journal article  |  2020  |  Alzheimer's & Dementia

Cu-II(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Adam Southon, Kathryn Szostak, Karla M Acevedo, Krista A Dent, Irene Volitakis, Abdel A Belaidi, Kevin J Barnham, Peter J Crouch, Scott Ayton, Paul S Donnelly, Ashley Bush

Journal article  |  2020  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Diacetyl-bis(4-methyl-3-thiosemicarbazonato)copperII (CuII (atsm)) ameliorates neurodegeneration and delay..

Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease

Shashank Masaldan, Abdel Ali Belaidi, Scott Ayton, Ashley Bush

Journal article  |  2019  |  PHARMACEUTICALS

Iron dyshomeostasis is a feature of Alzheimer's disease (AD). The impact of iron on AD is attributed to its interactions with the ..

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Abdel A Belaidi, Adam P Gunn, Bruce X Wong, Scott Ayton, Ambili T Appukuttan, Blaine R Roberts, James A Duce, Ashley I Bush

Journal article  |  2018  |  NEUROTHERAPEUTICS

Proteolytic cleavage of the amyloid precursor protein (APP) into the Aβ peptide has been an extensively researched mechanism for A..