Dr Ellen Menkhorst leads the Decidual Biology team in the Embryo Implantation Laboratory. Ellen is passionate about the importance of the intrauterine environment for a healthy pregnancy and lifelong health of the child and mother.
Dr Menkhorst has established a research program to investigate the role of the decidua during implantation and placentation. By understanding the mechanisms which underlie implantation and early placentation, she aims to identify factors which can be used as biomarkers or therapeutic targets to treat infertility, recurrent pregnancy loss or placental insufficiency leading to diseases including preeclampsia/intrauterine growth restriction.
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Ellen Menkhorst's highlights
Ellen Menkhorst's selected work
Decidual-Secreted miRs: Essential Mediators of Maternal-Fetal Dialogue during Early Pregna..
Displaying the 3 most recent projects by Ellen Menkhorst.
Displaying the 51 most recent scholarly works by Ellen Menkhorst.
Mouse double minute homologue 2 (MDM2) downregulation by miR-661 impairs human endometrial epithelial cell adhesive capacity
Amy Winship, Amanda Ton, Michelle Van Sinderen, Ellen Menkhorst, Katarzyna Rainczuk, Meaghan Griffiths, Carly Cuman, Evdokia Dimitriadis
Journal article | 2018 | Reproduction, Fertility and Development
An Electrical Impedance-Based Assay to Examine Functions of Various Placental Cell Types In Vitro
Tejasvy Chollangi, Helene Clabault, Andree-Anne Hudon Thibeault, Hannah EJ Yong, Shagun Narula, Ellen Menkhorst, J Thomas Sanderson, Cathy Vaillancourt, Padma Murthi
Book Chapter | 2018 | Methods in Molecular Biology
Soluble Delta-like ligand 1 alters human endometrial epithelial cell adhesive capacity
Michelle Van Sinderen, Jennifer Oyanedel, Ellen Menkhorst, Carly Cuman, Katarzyna Rainczuk, Amy Winship, Lois Salamonsen, Tracey Edgell, Evdokia Dimitriadis
Journal article | 2017 | Reproduction, Fertility and Development
Interleukin-11 alters placentation and causes preeclampsia features in mice
Amy L Winship, Kaori Koga, Ellen Menkhorst, Michelle Van Sinderen, Katarzyna Rainczuk, Miwako Nagai, Carly Cuman, Joanne Yap, Jian-Guo Zhang, David Simmons, Morag J Young, Evdokia Dimitriadis
Journal article | 2015 | Proceedings of the National Academy of Sciences
Blocking Endogenous Leukemia Inhibitory Factor During Placental Development in Mice Leads to Abnormal Placentation and Pregnancy Loss
Amy Winship, Jeanne Correia, Tara Krishnan, Ellen Menkhorst, Carly Cuman, Jian-Guo Zhang, Nicos A Nicola, Evdokia Dimitriadis
Journal article | 2015 | Scientific Reports
Effects of Gefitinib, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth
Ulrika W Nilsson, Terrance G Johns, Tania Wilmann, Tu'uhevaha Kaitu'u-Lino, Clare Whitehead, Eva Dimitriadis, Ellen Menkhorst, Burcu Saglam, Yane Gao, Sameer A Greenall, Andrew W Horne, Stephen Tong
Journal article | 2013 | Obstetrics and Gynecology
Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to IVF success
C Cuman, EM Menkhorst, LJ Rombauts, S Holden, D Webster, M Bilandzic, T Osianlis, E Dimitriadis
Journal article | 2013 | Human Reproduction
Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua
Tu'uhevaha J Kaitu'u-Lino, Louie Ye, Laura Tuohey, Evdokia Dimitriadis, Judith Bulmer, Peter Rogers, Ellen Menkhorst, Michelle Van Sinderen, Jane E Girling, Natalie Hannan, Stephen Tong
Journal article | 2013 | Human Reproduction
Decidual-Secreted Factors Alter Invasive Trophoblast Membrane and Secreted Proteins Implying a Role for Decidual Cell Regulation of Placentation
Ellen Melaleuca Menkhorst, Natalie Lane, Amy Louise Winship, Priscilla Li, Joanne Yap, Katie Meehan, Adam Rainczuk, Andrew Stephens, Evdokia Dimitriadis
Journal article | 2012 | PLoS ONE
Vaginally Administered PEGylated LIF Antagonist Blocked Embryo Implantation and Eliminated Non-Target Effects on Bone in Mice
Ellen Menkhorst, Jian-Guo Zhang, Natalie A Sims, Phillip O Morgan, Priscilla Soo, Ingrid J Poulton, Donald Metcalf, Estella Alexandrou, Melissa Gresle, Lois A Salamonsen, Helmut Butzkueven, Nicos A Nicola, Evdokia Dimitriadis
Journal article | 2011 | PLoS One
IFPA Meeting 2010 Workshops Report II: Placental pathology; Trophoblast invasion; Fetal sex; Parasites and the placenta; Decidua and embryonic or fetal loss; Trophoblast differentiation and syncytialisation
A Al-Khan, IL Aye, I Barsoum, A Borbelyd, E Cebral, G Cerchi, VL Clifton, S Collins, T Cotechini, A Davey, J Flores-Martin, T Fournier, AM Franchi, RE Fretes, CH Graham, G Godbole, SR Hansson, PL Headley, C Ibarra, A Jawerbaum, et al.
Journal article | 2011 | Placenta
Development of a vaginally applied, non-hormonal contraceptive: the contraceptive efficacy and impact on bone turnover of PEGLA, a long-acting LIF antagonist
E Menkhorst, JG Zhang, PO Morgan, IJ Poulton, D Metcalf, LA Salamonsen, NA Sims, NA Nicola, E Dimitriadis
Conference Proceedings | 2010 | Journal of Reproductive Immunology
Research Fellow In Reproductive Biology
Obstetrics And Gynaecology Royal Women'S Hospital/Mercy
Australian and New Zealand Placental Research Association
Doctorate of Philosophy
University of Melbourne