Rodney Luwor

Potent and Selective Cytotoxic and Anti-inflammatory Gold(III) Compounds Containing Cyclometalated Phosphine Sulfide Ligands

T Srinivasa Reddy, Deep Pooja, Steven H Priver, Rodney B Luwor, Nedaossadat Mirzadeh, Shwathy Ramesan, Sistla Ramakrishna, Shailaja Karri, Madhusudana Kuncha, Suresh K Bhargava

Journal article  |  2019  |  Chemistry – A European Journal

Krill oil extract suppresses the proliferation of colorectal cancer cells through activation of caspase 3/9

Abilasha Gayani Jayathilake, Elif Kadife, Rodney Brain Luwor, Kulmira Nurgali, Xiao Qun Su

Journal article  |  2019  |  Nutrition & Metabolism

Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma

Rodney Luwor, Andrew P Morokoff, Stephanie Amiridis, Giovanna D'Abaco, Lucia Paradiso, Stanley S Stylli, Hong PT Nguyen, Mark Tarleton, Kelly A Young, Terence J O'Brien, Phillip J Robinson, Megan Chircop, Adam McCluskey, Nigel C Jones

Journal article  |  2019  |  Cancer Investigation

Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer

Elif Kadife, Emily Chan, Rodney Luwor, George Kannourakis, Jock Findlay, Nuzhat Ahmed

Journal article  |  2019  |  Cancers

Cell quiescence correlates with enhanced glioblastoma cell invasion and cytotoxic resistance

Ryan J Atkins, Stanley S Stylli, Natalie Kurganovs, Stefano Mangiola, Cameron J Nowell, Thomas M Ware, Niall M Corcoran, Daniel V Brown, Andrew H Kaye, Andrew Morokoff, Rodney B Luwor, Christopher M Hovens, Theo Mantamadiotis

Journal article  |  2019  |  Experimental Cell Research

Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies

Fiona H Tani, Tracy L Putoczki, Stanley S Stylli, Rodney B Luwor

Journal article  |  2019  |  OncoTargets and Therapy

Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth

Fiona H Tan, Tracy L Putoczki, Jieqiong Lou, Elizabeth Hinde, Frederic Hollande, Julie Giraud, Stanley S Stylli, Lucia Paradiso, Hong-Jian Zhu, Oliver M Sieber, Rodney B Luwor

Journal article  |  2018  |  Cancers

Inhibition of Radiation and Temozolomide-Induced Invadopodia Activity in Glioma Cells Using FDA-Approved Drugs

Clarissa A Whitehead, Hong PT Nguyen, Andrew P Morokoff, Rodney B Luwor, Lucia Paradiso, Andrew H Kaye, Theo Mantamadiotis, Stanley S Stylli

Journal article  |  2018  |  Translational Oncology

Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics

Ruth A Mitchell, Rodney B Luwor, Antony W Burgess

Journal article  |  2018  |  Experimental Cell Research

The role of interleukin-6-STAT3 signalling in glioblastoma

Alice J West, Vanessa Tsui, Stanley S Stylli, Hong PT Nguyen, Andrew P Morokoff, Andrew H Kaye, Rodney B Luwor

Journal article  |  2018  |  Oncology Letters

Enhancement of invadopodia activity in glioma cells by sublethal doses of irradiation and temozolomide

Leon Mao, Clarissa A Whitehead, Lucia Paradiso, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor, Stanley S Stylli

Journal article  |  2018  |  Journal of Neurosurgery

Paclitaxel-Loaded Self-Assembled Lipid Nanoparticles as Targeted Drug Delivery Systems for the Treatment of Aggressive Ovarian Cancer

Jiali Zhai, Rodney B Luwor, Nuzhat Ahmed, Ruth Escalona, Fiona H Tan, Celesta Fong, Julian Ratcliffe, Judith A Scoble, Calum J Drummond, Nhiem Tran

Journal article  |  2018  |  ACS Applied Materials & Interfaces

The emerging use of bioluminescence in medical research

Sana Sharifian, Ahmad Homaei, Roohullah Hemmati, Rodney B Luwor, Khosro Khajeh

Journal article  |  2018  |  Biomedicine & Pharmacotherapy

Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer.

Emily Chan, Rodney Luwor, Christopher Burns, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2018  |  Oncotarget

Despite a good initial response to front-line chemotherapy, majority of the ovarian cancer patients relapse with consecutive phase..

A comprehensive meta-analysis of circulation miRNAs in glioma as potential diagnostic biomarker

Chenkai Ma, Hong PT Nguyen, Rodney B Luwor, Stanley S Stylli, Andrew Gogos, Lucia Paradiso, Andrew H Kaye, Andrew P Morokoff

Journal article  |  2018  |  PLOS ONE

Effects of EphB4 receptor expression on colorectal cancer cells, tumor growth, vascularization and composition

Elif Kadife, Thomas Michael Benjamin Ware, Rodney Brian Luwor, Steven Tuck Foo Chan, Kulmira Nurgali, Paul Senior Vincent

Journal article  |  2018  |  Acta Oncologica

Cancer exosomes in cerebrospinal fluid

Clarissa A Whitehead, Rodney B Luwor, Andrew P Morokoff, Andrew H Kaye, Stanley S Stylli

Journal article  |  2017  |  Translational Cancer Research

STAT3 signaling mediates tumour resistance to EGFR targeted therapeutics

Ahmad A Zulkifli, Fiona H Tan, Tracy L Putoczki, Stanley S Stylli, Rodney B Luwor

Journal article  |  2017  |  Molecular and Cellular Endocrinology

Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

Chantel Samardzija, David W Greening, Ruth Escalona, Maoshan Chen, Maree Bilandzic, Rodney Luwor, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2017  |  Scientific Reports

miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage

Stanley S Stylli, Alexios A Adamides, Rachel M Koldej, Rodney B Luwor, David S Ritchie, James Ziogas, Andrew H Kaye

Journal article  |  2017  |  Journal of Neurosurgery

The emergent role of exosomes in glioma

J Gourlay, AP Morokoff, RB Luwor, HJ Zhu, AH Kaye, SS Stylli

Journal article  |  2017  |  Journal of Clinical Neuroscience

PREOPERATIVE SERUM microRNA PROFILING AS A DIAGNOSTIC TOOL IN GLIOMA

Andrew Morokoff, Iwan Bennett, Lucy Paradiso, Rod Luwor, Michael Wong, Rachel Koldej, Jason Li, Chenkai Ma, Kate Drummond, Stanley Stylli, Andrew Kaye, Tali Siegal

Conference Proceedings  |  2016  |  NEURO-ONCOLOGY

Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth

Linna Guo, Olga Zaysteva, Zuqin Nie, Naomi C Mitchell, Jue Er Amanda Lee, Thomas Ware, Linda Parsons, Rodney Luwor, Gretchen Poortinga, Ross D Hannan, David L Levens, Leonie M Quinn

Journal article  |  2016  |  Nucleic Acids Research

Coalition of Oct4A and beta 1 integrins in facilitating metastasis in ovarian cancer

Chantel Samardzija, Rodney B Luwor, Michael A Quinn, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2016  |  BMC Cancer

Frontiers in Clinical Drug Research - Anti-Cancer Agents

Book Chapter  |  2016

Inhibition of glioblastoma cell proliferation, migration and invasion by the proteasome antagonist carfilzomib

Zammam Areeb, Stanley S Stylli, Thomas MB Ware, Nicole C Harris, Lipi Shukla, Ramin Shayan, Lucia Paradiso, Bo Li, Andrew P Morokoff, Andrew H Kaye, Rodney B Luwor

Journal article  |  2016  |  Medical Oncology

Tumor Resistance Mechanisms to Inhibitors Targeting the Epidermal Growth Factor Receptor – Part II: Intracellular Molecules

R Luwor

Book Chapter  |  2016

Tumor resistance to agents targeting the Epidermal Growth Factor Receptor (EGFR) is common, and well recognised as a major challen..

MicroRNA as potential biomarkers in Glioblastoma

Zammam Areeb, Stanley S Stylli, Rachel Koldej, David S Ritchie, Tali Siegal, Andrew P Morokoff, Andrew H Kaye, Rodney B Luwor

Journal article  |  2015  |  Journal of Neuro-Oncology

The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells

Jared Ching, Stephanie Amiridis, Stanley S Stylli, Andrew R Bjorksten, Nicole Kountouri, Thomas Zheng, Lucy Paradiso, Rodney B Luwor, Andrew P Morokoff, Terence J O'Brien, Andrew H Kaye

Journal article  |  2015  |  Oncotarget

A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer

Chantel Samardzija, Rodney B Luwor, Mila Volchek, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2015  |  Molecular Cancer

SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-beta Signaling Pathway Targeting the Type II Receptor

Sheng Liu, Thao Nheu, Rodney Luwor, Sandra E Nicholson, Hong-Jian Zhu

Journal article  |  2015  |  Journal of Biological Chemistry

Using bioluminescence imaging in glioma research

Rodney B Luwor, Stanley S Stylli, Andrew H Kaye

Journal article  |  2015  |  Journal of Clinical Neuroscience

Mouse models of glioma

Stanley S Stylli, Rodney B Luwor, Thomas MB Ware, Fiona Tan, Andrew H Kaye

Journal article  |  2015  |  Journal of Clinical Neuroscience

Single live cell TGF-beta signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-beta-Smad3 activity

Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson, Hong-Jian Zhu

Journal article  |  2015  |  Molecular Cancer

Enhanced activation of STAT3 in ascites-derived recurrent ovarian tumors: inhibition of cisplatin-induced STAT3 activation reduced tumorigenicity of ovarian cancer by a loss of cancer stem cell-like characteristics

Khalid Abubaker, Ardian Latifi, Emily Chan, Rodney B Luwor, Christopher J Burns, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2015  |  Journal of Cancer Stem Cell Research

Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NF kappa B-mediated induction of MMP2

Maree Bilandzic, Yao Wang, Nuzhat Ahmed, Rodney B Luwor, Hong Jian Zhu, Jock K Findlay, Kaye L Stenvers

Journal article  |  2014  |  Cancer Letters

Expression of the adaptor protein Tks5 in human cancer: Prognostic potential

Stanley S Stylli, Rodney B Luwor, Andrew H Kaye, TT Stacey, Christopher M Hovens, Peter Lock

Journal article  |  2014  |  Oncology Reports

Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

Khalid Abubaker, Rodney B Luwor, Hongjian Zhu, Orla McNally, Michael A Quinn, Christopher J Burns, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2014  |  BMC Cancer

Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity

Nelson Ung, Tracy L Putoczki, Stanley S Stylli, Irvin Ng, John M Mariadason, Timothy A Chan, Hong-Jian Zhu, Rodney B Luwor

Journal article  |  2014  |  Cancer Biology & Therapy

Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-beta signalling

FangFang Zhou, Yvette Drabsch, Tim JA Dekker, Amaya Garcia de Vinuesa, Yihao Li, Lukas JAC Hawinkels, Kelly-Ann Sheppard, Marie-Jose Goumans, Rodney B Luwor, Carlie J de Vries, Wilma E Mesker, Rob AEM Tollenaar, Peter Devilee, Chris X Lu, Hongjian Zhu, Long Zhang, Peter ten Dijke

Journal article  |  2014  |  Nature Communications

Targeted disruption of the JAK2/STAT3 pathway in combination with systemic administration of paclitaxel inhibits the priming of ovarian cancer stem cells leading to a reduced tumor burden

Khalid Abubaker, Rodney B Luwor, Ruth Escalona, Orla McNally, Michael A Quinn, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2014  |  Frontiers in Oncology

The Role of STAT3 Signaling in Mediating Tumor Resistance to Cancer Therapy

Fiona H Tan, Tracy L Putoczki, Stanley S Stylli, Rodney B Luwor

Journal article  |  2014  |  Current Drug Targets

Glycogen synthase kinase-3 beta (GSK-3 beta) and its dysregulation in glioblastoma multiforme

RJ Atkins, SS Stylli, RB Luwor, AH Kaye, CM Hovens

Journal article  |  2013  |  Journal of Clinical Neuroscience

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

Tracy L Putoczki, Stefan Thiem, Andrea Loving, Rita A Busutti, Nicholas J Wilson, Paul K Ziegler, Paul M Nguyen, Adele Preaudet, Ryan Farid, Kirsten M Edwards, Yeliz Boglev, Rodney B Luwor, Andrew Jarnicki, David Horst, Alex Boussioutas, Joan K Heath, Oliver M Sieber, Irina Pleines, Benjamin T Kile, Andrew Nash, et al.

Journal article  |  2013  |  Cancer Cell

The role of Stat3 in glioblastoma multiforme

Rodney B Luwor, Stanley S Stylli, Andrew H Kaye

Journal article  |  2013  |  Journal of Clinical Neuroscience

Targeting Stat3 and Smad7 to restore TGF-beta cytostatic regulation of tumor cells in vitro and in vivo

RB Luwor, B Baradaran, LE Taylor, J Iaria, TV Nheu, N Amiry, CM Hovens, B Wang, AH Kaye, H-J Zhu

Journal article  |  2013  |  Oncogene

Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden

Khalid Abubaker, Ardian Latifi, Rod Luwor, Simon Nazaretian, Hongjian Zhu, Michael A Quinn, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2013  |  Molecular Cancer

Isolation and Characterization of Tumor Cells from the Ascites of Ovarian Cancer Patients: Molecular Phenotype of Chemoresistant Ovarian Tumors

Ardian Latifi, Rodney B Luwor, Maree Bilandzic, Simon Nazaretian, Kaye Stenvers, Jan Pyman, Hongjian Zhu, Erik W Thompson, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2012  |  PLoS One

Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation

Rodney B Luwor, Xiaowen Chin, Andrew B McGeachie, Phillip J Robinson, Hong-Jian Zhu

Journal article  |  2012  |  Growth Factors

New reagents for improved in vitro and in vivo examination of TGF-beta signalling

Rodney B Luwor, Bo Wang, Thao V Nheu, Josephine Iaria, Evelyn Tsantikos, Margaret L Hibbs, Oliver M Sieber, Hong-Jian Zhu

Journal article  |  2011  |  Growth Factors

Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib

Rodney B Luwor, Yang Lu, Xinqun Li, Ke Liang, Zhen Fan

Journal article  |  2011  |  Cancer Letters

The EGFRvIII variant in glioblastoma multiforme

Hui K Gan, Andrew H Kaye, Rodney B Luwor

Journal article  |  2009  |  Journal of Clinical Neuroscience

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Thomas PJ Garrett, Antony W Burgess, Hui K Gan, Rod B Luwor, Glenn Cartwright, Francesca Walker, Suzanne G Orchard, Andrew HA Clayton, Edouard C Nice, Julie Rothacker, Bruno Catimel, Webster K Cavenee, Lloyd J Old, Elisabeth Stockert, Gerd Ritter, Timothy E Adams, Peter A Hoyne, K Dane Wittrup, Ginger Chao, Jennifer R Cochran, et al.

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Transforming growth factor-beta (TGF-beta) and brain tumours

Rodney B Luwor, Andrew H Kaye, Hong-Han Zhu

Journal article  |  2008  |  Journal of Clinical Neuroscience

Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the Anti-EGFR monoclonal antibody cetuximab

Yang Lu, Xinqun Li, Ke Liang, Rodney Luwor, Zahid H Siddik, Gordon B Nuiis, John Mendelsohn, Zhen Fan

Journal article  |  2007  |  Cancer Research

Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells

X Li, R Luwor, Y Lu, K Liang, Z Fan

Journal article  |  2006  |  Oncogene

Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity

RM Perera, Y Narita, FB Furnari, HK Gan, C Murone, M Ahikvist, RB Luwor, AW Burgess, E Stockert, AA Jungbluth, LJ Old, WK Cavenee, AM Scott, TG Johns

Journal article  |  2005  |  Clinical Cancer Research

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

RB Luwor, Y Lu, XQ Li, J Mendelsohn, Z Fan

Journal article  |  2005  |  Oncogene

The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR

RB Luwor, HJ Zhu, F Walker, AA Vitali, RM Perera, AW Burgess, AM Scott, TG Johns

Journal article  |  2004  |  Oncogene

Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478

TG Johns, RB Luwor, C Murone, F Walker, J Weinstock, AA Vitali, RM Perera, AA Jungbluth, E Stockert, LJ Old, EC Nice, AW Burgess, AM Scott

Journal article  |  2003  |  Proceedings of the National Academy of Sciences of the United States of America

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR

RB Luwor, TG Johns, C Murone, HJS Huang, WK Cavenee, G Ritter, LJ Old, AW Burgess, AM Scott

Journal article  |  2001  |  Cancer Research

Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor

K Mishima, TG Johns, RB Luwor, AM Scott, E Stockert, AA Jungbluth, XD Ji, P Suvarna, JR Voland, LJ Old, HJS Huang, WK Cavenee

Journal article  |  2001  |  Cancer Research

Peripheral biomarkers in glioblastoma patients—is it all just HOTAIR?

Hong PT Nguyen, Andrew P Morokoff, Stanley S Stylli, Andrew H Kaye, Rodney B Luwor

Journal article  |  Non-coding RNA Investigation