Rodney Luwor

Dinuclear orthometallated gold(I)-gold(III) anticancer complexes with potent in vivo activity through an ROS-dependent mechanism.

Nedaossadat Mirzadeh, Srinivasa Reddy Telukutla, Rodney Luwor, Steven Privér, Ganga Reddy Velma, Ranjith Kumar Jakku, Stephens Andrew N, Magdalena Plebanski, Hartinger Christian, Suresh Bhargava

Journal article  |  2021  |  Metallomics

Increasingly explored over the last decade, gold complexes have shown great promise in the field of cancer therapeutics. A major o..

Carfilzomib Promotes the Unfolded Protein Response and Apoptosis in Cetuximab-Resistant Colorectal Cancer

Ahmad Zulkifli, Fiona H Tan, Zammam Areeb, Sarah F Stuart, Juliana Gomez, Lucia Paradiso, Rodney B Luwor

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cetuximab is a common treatment option for patients with wild-type K-Ras colorectal carcinoma. However, patients often display int..

Elucidating the role of long intergenic non-coding RNA 339 in human endometrium and endometriosis

Sarah J Holdsworth-Carson, Molly Churchill, Jacqueline F Donoghue, Sally Mortlock, Jenny N Fung, Clare Sloggett, Jessica Chung, Leonie Cann, Wan Tinn Teh, Katie-Rose Campbell, Rodney Luwor, Martin Healey, Grant Montgomery, Jane E Girling, Peter AW Rogers

Journal article  |  2021  |  MOLECULAR HUMAN REPRODUCTION

Endometriosis is a complex disease, influenced by genetic factors. Genetic markers associated with endometriosis exist at chromoso..

EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism

Juliana Gomez, Zammam Areeb, Sarah F Stuart, Hong PT Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K Montgomery, Hui K Gan, Andrew M Scott, Jordan Jones, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor

Journal article  |  2021  |  CANCERS

Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiol..

Examination of Novel Immunomodulatory Effects of L-Sulforaphane

Nadia Mazarakis, Jeremy Anderson, Zheng Quan Toh, Rachel A Higgins, Lien Anh Ha Do, Rodney B Luwor, Kenneth J Snibson, Tom C Karagiannis, Paul Licciardi

Journal article  |  2021  |  NUTRIENTS

The dietary isothiocyanate L-sulforaphane (LSF), derived from cruciferous vegetables, is reported to have several beneficial biolo..

Krill oil extract inhibits the migration of human colorectal cancer cells and down-regulates EGFR signalling and PD-L1 expression

Abilasha G Jayathilake, Margaret F Veale, Rodney Brain Luwor, Kulmira Nurgali, Xiao Q Su

Journal article  |  2020  |  BMC COMPLEMENTARY MEDICINE AND THERAPIES

BACKGROUND: The currently available treatments for colorectal cancer (CRC) are often associated with serious side-effects. Therefo..

Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma

Zammam Areeb, Sarah F Stuart, Alice J West, Juliana Gomez, Hong PT Nguyen, Lucia Paradiso, Ahmad Zulkifli, Jordan Jones, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor

Journal article  |  2020  |  SCIENTIFIC REPORTS

Despite aggressive treatment with temozolomide and radiotherapy and extensive research into alternative therapies there has been l..

Serum microRNA is a biomarker for post-operative monitoring in glioma

Andrew Morokoff, Jordan Jones, Hong Nguyen, Chenkai Ma, Arian Lasocki, Frank Gaillard, Iwan Bennett, Rod Luwor, Stanley Stylli, Lucia Paradiso, Rachel Koldej, Iddo Paldor, Ramyar Molania, Terence P Speed, Andrew Webb, Guiseppe Infusini, Jason Li, Charles Malpas, Tomas Kalincik, Katharine Drummond, et al.

Journal article  |  2020  |  JOURNAL OF NEURO-ONCOLOGY

PURPOSE: A circulating biomarker has potential to provide more accurate information for glioma progression post treatment, however..

In Vitro and In Vivo Toxicity and Biodistribution of Paclitaxel-Loaded Cubosomes as a Drug Delivery Nanocarrier: A Case Study Using an A431 Skin Cancer Xenograft Model

Jiali Zhai, Fiona H Tan, Rodney B Luwor, T Srinivasa Reddy, Nuzhat Ahmed, Calum J Drummond, Nhiem Tran

Journal article  |  2020  |  ACS APPLIED BIO MATERIALS

Cubosomes with an internal three-dimensional (3D) periodic and porous particulate nanostructure have emerged as a promising drug d..

Novel additive for sperm cryopreservation media: Holotheria parva coelomic cavity extract protects human spermatozoa against oxidative stress-A pilot study

Zahra Khashavi, Ahmad Homaei, Fahimeh Koohnavard, Ehsan Kamrani, Marcella Spinaci, Rodney B Luwor, Mahsa Archang, Ashok Agarwal, Ralf Henkel

Journal article  |  2020  |  ANDROLOGIA

Cryopreservation is the most effective method for preserving semen for a long period of time. However, during the freeze-thaw proc..