Rodney Luwor

The Interleukin-11/IL-11 Receptor Promotes Glioblastoma Survival and Invasion under Glucose-Starved Conditions through Enhanced Glutaminolysis

Sarah F Stuart, Ayenachew Bezawork-Geleta, Zammam Areeb, Juliana Gomez, Vanessa Tsui, Ahmad Zulkifli, Lucia Paradiso, Jordan Jones, Hong PT Nguyen, Tracy L Putoczki, Paul V Licciardi, George Kannourakis, Andrew P Morokoff, Adrian A Achuthan, Rodney B Luwor

Journal article  |  2023  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glioblastoma cells adapt to changes in glucose availability through metabolic plasticity allowing for cell survival and continued ..

Blocking Muscarinic Receptor 3 Attenuates Tumor Growth and Decreases Immunosuppressive and Cholinergic Markers in an Orthotopic Mouse Model of Colorectal Cancer

Nyanbol Kuol, Majid Davidson, Jimsheena Karakkat, Rhiannon T Filippone, Margaret Veale, Rodney Luwor, Sarah Fraser, Vasso Apostolopoulos, Kulmira Nurgali

Journal article  |  2023  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor cells have evolved to express immunosuppressive molecules allowing their evasion from the host's immune system. These molecu..

The comparative anti-cancer effects of krill oil and oxaliplatin in an orthotopic mouse model of colorectal cancer

Abilasha Gayani Jayathilake, Majid Hassanzadeganroudsari, Valentina Jovanovska, Rodney Brain Luwor, Kulmira Nurgali, Xiao Qun Su

Journal article  |  2022  |  NUTRITION & METABOLISM

BACKGROUND: Our in vitro studies demonstrated that krill oil (KO) has anti-cancer potential. This study aimed to compare the anti-..

Extracellular Vesicles Secreted by Glioma Stem Cells Are Involved in Radiation Resistance and Glioma Progression

Chenkai Ma, Hong PT Nguyen, Jordan J Jones, Stanley S Stylli, Clarissa A Whitehead, Lucy Paradiso, Rodney B Luwor, Zammam Areeb, Eric Hanssen, Ellie Cho, Ulrich Putz, Andrew H Kaye, Andrew P Morokoff

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glioblastoma is the most aggressive brain tumour with short survival, partly due to resistance to conventional therapy. Glioma ste..

Cortical tension initiates the positive feedback loop between cadherin and F-actin

Qilin Yu, William R Holmes, Jean P Thiery, Rodney B Luwor, Vijay Rajagopal

Journal article  |  2022  |  BIOPHYSICAL JOURNAL

Adherens junctions physically link two cells at their contact interface via extracellular binding between cadherin molecules and i..

Krill oil supplementation reduces the growth of CT-26 orthotopic tumours in Balb/c mice

Abilasha Gayani Jayathilake, Elif Kadife, Nyanbol Kuol, Rodney Brain Luwor, Kulmira Nurgali, Xiao Qun Su

Journal article  |  2022  |  BMC COMPLEMENTARY MEDICINE AND THERAPIES

BACKGROUND: We have previously reported that the free fatty acid extract (FFAE) of krill oil (KO) significantly inhibits the proli..

The effects of the dietary compound L-sulforaphane against respiratory pathogens

Nadia Mazarakis, Rachel A Higgins, Jeremy Anderson, Zheng Quan Toh, Rodney B Luwor, Kenneth J Snibson, Tom C Karagiannis, Lien Anh Ha Do, Paul Licciardi

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

L-sulforaphane (LSF) is an isothiocyanate derived from cruciferous vegetables that has long been known for its anticarcinogenic, a..

Carfilzomib Promotes the Unfolded Protein Response and Apoptosis in Cetuximab-Resistant Colorectal Cancer

Ahmad Zulkifli, Fiona H Tan, Zammam Areeb, Sarah F Stuart, Juliana Gomez, Lucia Paradiso, Rodney B Luwor

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cetuximab is a common treatment option for patients with wild-type K-Ras colorectal carcinoma. However, patients often display int..

Dinuclear orthometallated gold(I)-gold(III) anticancer complexes with potent in vivo activity through an ROS-dependent mechanism

Nedaossadat Mirzadeh, Srinivasa Reddy Telukutla, Rodney Luwor, Steven Priver, Ganga Reddy Velma, Ranjith Kumar Jakku, Stephens N Andrew, Magdalena Plebanski, Hartinger Christian, Suresh Bhargava

Journal article  |  2021  |  METALLOMICS

Increasingly explored over the last decade, gold complexes have shown great promise in the field of cancer therapeutics. A major o..

EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism

Juliana Gomez, Zammam Areeb, Sarah F Stuart, Hong PT Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K Montgomery, Hui K Gan, Andrew M Scott, Jordan Jones, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor

Journal article  |  2021  |  CANCERS

Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiol..