David Williams

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma

Surein Arulananda, Megan O'Brien, Marco Evangelista, Tiffany J Harris, Nikita S Steinohrt, Laura J Jenkins, Marzena Walkiewicz, Robert JJ O'Donoghue, Ashleigh R Poh, Bibhusal Thapa, David S Williams, Trishe Leong, John M Mariadason, Xia Li, Jonathan Cebon, Erinna F Lee, Thomas John, W Douglas Fairlie

Journal article  |  2020  |  CELL DEATH DISCOVERY

Despite having one of the lowest survival rates of all cancers, there have been no new approved treatments for malignant pleural m..

Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer

David S Williams, Dmitri Mouradov, Clare Browne, Michelle Palmieri, Meg J Elliott, Rebecca Nightingale, Catherine G Fang, Rita Li, John M Mariadason, Ian Faragher, Ian T Jones, Leonid Churilov, Niall C Tebbutt, Peter Gibbs, Oliver M Sieber

Journal article  |  2020  |  MODERN PATHOLOGY

TP53 mutations drive colorectal cancer development, with missense mutations frequently leading to accumulation of abnormal TP53 pr..

A case of ANCA-associated vasculitis presenting de novo in pregnancy, successfully treated with rituximab.

A Pefanis, DS Williams, H Skrzypek, A Fung, K Paizis

Journal article  |  2020  |  Obstetric Medicine

Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are rare small vessel vasculitides of unknown cause. The pathogen..

Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation

David S Williams, Dmitri Mouradov, Marsali R Newman, Elham Amini, David K Nickless, Catherine G Fang, Michelle Palmieri, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Iain Skinner, Ian Jones, Peter Gibbs, Oliver M Sieber

Journal article  |  2020  |  MODERN PATHOLOGY

Mucinous colorectal adenocarcinoma (CRC) is conventionally defined by extracellular mucin comprising >50% of the tumour area, whil..

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Mercedes Davalos-Salas, Magdalene K Montgomery, Camilla M Reehorst, Rebecca Nightingale, Irvin Ng, Holly Anderton, Sheren Al-Obaidi, Analia Lesmana, Cameron M Scott, Paul Ioannidis, Hina Kalra, Shivakumar Keerthikumar, Lars Togel, Angela Rigopoulos, Sylvia J Gong, David S Williams, Prusoth Yoganantharaja, Kim Bell-Anderson, Suresh Mathivanan, Yann Gibert, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulati..

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

David K Lau, Dmitri Mouradov, Wiphawan Wasenang, Ian Y Luk, Cameron M Scott, David S Williams, Yvonne H Yeung, Temduang Limpaiboon, George F Iatropoulos, Laura J Jenkins, Camilla M Reehorst, Fiona Chionh, Mehrdad Nikfarjam, Daniel Croagh, Amardeep S Dhillon, Andrew J Weickhardt, Toshihide Muramatsu, Yoshimasa Saito, Niall C Tebbutt, Oliver M Sieber, et al.

Journal article  |  2019  |  ISCIENCE

Biliary tract cancers (BTCs) currently have no approved targeted therapies. Although genomic profiling of primary BTCs has identif..

Impact of universal immunohistochemistry on Lynch syndrome diagnosis in an Australian colorectal cancer cohort.

Zoe Loh, David S Williams, Lucinda Salmon, Eryn Dow, Thomas John

Journal article  |  2019  |  Intern Med J

BACKGROUND: Current guidelines recommend a step-wise screening algorithm for all colorectal carcinomas (CRC) to identify patients ..

Immunosuppressed Returned Traveler With Ulcerating Skin Lesion and Fever

Victoria Hall, Jason A Trubiano, Jason C Kwong, David S Williams, Natasha E Holmes

Journal article  |  2019  |  CLINICAL INFECTIOUS DISEASES

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

David S Williams, Dmitri Mouradov, Robert N Jorissen, Marsali R Newman, Elham Amini, David K Nickless, Julie A Teague, Catherine G Fang, Michelle Palmieri, Marie J Parsons, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Ian Faragher, Ian T Jones, Peter Gibbs, Oliver M Sieber

Journal article  |  2019  |  GUT

OBJECTIVE: Tumour-infiltrating lymphocyte (TIL) response and deficient DNA mismatch repair (dMMR) are determinants of prognosis in..

Ectopic breast cancer in the inguinal region

Zoe Loh, Belinda Yeo, David S Williams, David E Gyorki

Journal article  |  2019  |  BREAST JOURNAL