Seth Masters

The role of PLC gamma 2 in immunological disorders, cancer, and neurodegeneration

Jacob T Jackson, Elisabeth Mulazzani, Stephen L Nutt, Seth L Masters

Journal article  |  2021  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule activated downstream from a variety of ce..

NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity

Jonas Moecking, Pawat Laohamonthonkul, Katelyn Chalker, Marquitta J White, Cassandra R Harapas, Chien-Hsiung Yu, Sophia Davidson, Katja Hrovat-Schaale, Donglei Hu, Celeste Eng, Scott Huntsman, Dale J Calleja, Jay C Horvat, Phil M Hansbro, Robert JJ O'Donoghue, Jenny P Ting, Esteban G Burchard, Matthias Geyer, Motti Gerlic, Seth L Masters

Journal article  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BACKGROUND: NLRP1 is an innate immune sensor that can form cytoplasmic inflammasome complexes. Polymorphisms in NLRP1 are linked t..

Differential recognition of HIV-stimulated IL-1 beta and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages

Kathy Triantafilou, Christopher JK Ward, Magdalena Czubala, Robert G Ferris, Emma Koppe, Curt Haffner, Vincent Piguet, Vipulkumar K Patel, Heather Amrine-Madsen, Louise Modis, Seth L Masters, Martha Triantafilou

Journal article  |  2021  |  PLOS PATHOGENS

Macrophages are important drivers of pathogenesis and progression to AIDS in HIV infection. The virus in the later phases of the i..

Constitutive immune mechanisms: mediators of host defence and immune regulation

Soren R Paludan, Thomas Pradeu, Seth L Masters, Trine H Mogensen

Journal article  |  2021  |  NATURE REVIEWS IMMUNOLOGY

The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked th..

JEM career launchpad

Anna Bigas, Ivan Zanoni, Matthew R Hepworth, Stephanie C Eisenbarth, Seth Lucian Masters, Jonathan Kipnis, Carola G Vinuesa, Kim L Good-Jacobson, Stuart G Tangye, Sayuri Yamazaki, Claire Hivroz, Elia Tait Wojno, Ziv Shulman, Marco Colonna

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

JEM has been a launching pad for scientific careers since its inception. Here is a collection of testimonials attesting to the div..

Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development

Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L Masters, Andrew M Lew, Sitang Gong, Fan Bai, et al.

Journal article  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BACKGROUND: Very-early-onset inflammatory bowel disease (VEOIBD) is a chronic inflammatory disease of the gastrointestinal tract o..

Small extracellular vesicle enrichment of a retrotransposon-derived double-stranded rna: A means to avoid autoinflammation?

MH Barrios, AL Garnham, AD Foers, L Cheng-Sim, SL Masters, KC Pang

Journal article  |  2021  |  Biomedicines

Small extracellular vesicles (SEVs) such as exosomes are released by multiple cell types. Originally believed to be a mechanism fo..

Pharmacological validation of targets regulating CD14 during macrophage differentiation

Gisela Jimenez-Duran, Rosario Luque-Martin, Meghana Patel, Emma Koppe, Sharon Bernard, Catriona Sharp, Natalie Buchan, Ceara Rea, Menno PJ de Winther, Nil Turan, Davina Angell, Christine A Wells, Rick Cousins, Palwinder K Mander, Seth L Masters

Journal article  |  2020  |  EBIOMEDICINE

The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflamma..

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, et al.

Journal article  |  2020  |  CELL

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a ..

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a singl..