Seth Masters

Ten things to know about NLRP10.

Seth L Masters

Journal article  |  2023  |  Nat Immunol

Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1 beta release in X-linked inhibitor of apoptosis (XIAP) deficiency

Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, et al.

Journal article  |  2023  |  EMBO JOURNAL

Genetic lesions in X-linked inhibitor of apoptosis (XIAP) pre-dispose humans to cell death-associated inflammatory diseases, altho..

Inflammasome sensor NLRP1 disease variant M1184V promotes autoproteolysis and DPP9 complex formation by stabilizing the FIIND domain.

Jonas Moecking, Pawat Laohamonthonkul, Kubilay Meşe, Gregor Hagelueken, Annemarie Steiner, Cassandra R Harapas, Jarrod J Sandow, Jonathan D Graves, Seth L Masters, Matthias Geyer

Journal article  |  2022  |  J Biol Chem

The inflammasome sensor NLRP1 (nucleotide-binding oligomerization domain-like receptor containing a pyrin domain 1) detects a vari..

DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.

Cassandra R Harapas, Kim S Robinson, Kenneth Lay, Jasmine Wong, Ricardo Moreno Traspas, Nasrin Nabavizadeh, Annick Rass-Rothschild, Bertrand Boisson, Scott B Drutman, Pawat Laohamonthonkul, Devon Bonner, Jingwei Rachel Xiong, Mark D Gorrell, Sophia Davidson, Chien-Hsiung Yu, Mark D Fleming, Jonas Gudera, Jerry Stein, Miriam Ben-Harosh, Emily Groopman, et al.

Journal article  |  2022  |  Sci Immunol

Dipeptidyl peptidase 9 (DPP9) is a direct inhibitor of NLRP1, but how it affects inflammasome regulation in vivo is not yet establ..

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.

Kim S Robinson, Gee Ann Toh, Pritisha Rozario, Rae Chua, Stefan Bauernfried, Zijin Sun, Muhammad Jasrie Firdaus, Shima Bayat, Rhea Nadkarni, Zhi Sheng Poh, Khek Chian Tham, Cassandra R Harapas, Chrissie K Lim, Werncui Chu, Celest WS Tay, Kiat Yi Tan, Tianyun Zhao, Carine Bonnard, Radoslaw Sobota, John E Connolly, et al.

Journal article  |  2022  |  Science

Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin and a..

Deficiency in coatomer complex I causes aberrant activation of STING signalling

Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F Dagley, Michael J Mlodzianoski, Kelly L Rogers, Thomas Zillinger, Gunther Hartmann, Michael P Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L Masters

Journal article  |  2022  |  NATURE COMMUNICATIONS

Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the endoplasmic reticulum (ER) and within Golgi ..

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3 ' UTR protect against ALS

Chen Eitan, Aviad Siany, Elad Barkan, Tsviya Olender, Kristel R van Eijk, Matthieu Moisse, Sali MK Farhan, Yehuda M Danino, Eran Yanowski, Hagai Marmor-Kollet, Natalia Rivkin, Nancy Sarah Yacovzada, Shu-Ting Hung, Johnathan Cooper-Knock, Chien-Hsiung Yu, Cynthia Louis, Seth L Masters, Kevin P Kenna, Rick AA van der Spek, William Sproviero, et al.

Journal article  |  2022  |  NATURE NEUROSCIENCE

The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association..

Organellar homeostasis and innate immune sensing

Cassandra R Harapas, Elina Idiiatullina, Mahmoud Al-Azab, Katja Hrovat-Schaale, Thomas Reygaerts, Annemarie Steiner, Pawat Laohamonthonkul, Sophia Davidson, Chien-Hsiung Yu, Lee Booty, Seth L Masters

Journal article  |  2022  |  NATURE REVIEWS IMMUNOLOGY

A cell is delimited by numerous borders that define specific organelles. The walls of some organelles are particularly robust, suc..

Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24

Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frederic Ebstein, Paul J Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Kong, Dale J Calleja, Cassandra R Harapas, Katherine R Balka, Jacob Mitchell, Jacob T Jackson, Niall D Geoghegan, Fiona Moghaddas, Kelly L Rogers, Katrin D Mayer-Barber, Adriana A De Jesus, Dominic De Nardo, et al.

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signalin..

Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus

Annemarie Steiner, Thomas Reygaerts, Alessandra Pontillo, Isabella Ceccherini, Jonas Moecking, Fiona Moghaddas, Sophia Davidson, Francesco Caroli, Alice Grossi, Fabio Fernandes Morato Castro, Jorge Kalil, Florian N Gohr, Florian Schmidt, Eva Bartok, Thomas Zillinger, Gunther Hartmann, Matthias Geyer, Marco Gattorno, Leonardo Oliveira Mendonca, Seth L Masters

Journal article  |  2021  |  JOURNAL OF CLINICAL IMMUNOLOGY

PURPOSE: NLRC4-associated autoinflammatory disease (NLRC4-AID) is an autosomal dominant condition presenting with a range of clini..