Seth Masters

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, et al.

Journal article  |  2020  |  Nature Communications

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a singl..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at si..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (vol 217, e20191421, 2020)

Cynthia Louis, Fernando Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

TBK1 and IKK epsilon Act Redundantly to Mediate STING-Induced NF-kappa B Responses in Myeloid Cells

Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan, Christopher J Burns, Ian P Wicks, Jonathan J Miner, Benjamin T Kile, Seth L Masters, Dominic De Nardo

Journal article  |  2020  |  Cell Reports

Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimm..

Compound Heterozygous Mutations of IL12RB1 in a Patient with Selective Defects in Th17 Differentiation

Ming Liu, Bingtai Lu, Ping Zeng, Bing Huang, Yanhui Xu, Hanquan Liang, Diyuan Yang, Sida Yang, Hai-bin Luo, Andrew M Lew, Seth L Masters, Lanlan Geng, Huasong Zeng, Yuxia Zhang

Journal article  |  2020  |  Journal of Clinical Immunology

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Najoua Lalaoui, Steven E Boyden, Hirotsugu Oda, Geryl M Wood, Deborah L Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E Lawlor, Kristien JM Zaal, Patrycja M Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, et al.

Journal article  |  2020  |  Nature

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post..

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Genevieve Pepin, Dominic De Nardo, Christina L Rootes, Tomalika Ullah, Sumaiah S Al-Asmari, Katherine R Balka, Hong-Mei Li, Kylie M Quinn, Fiona Moghaddas, Stephane Chappaz, Benjamin T Kile, Eric F Morand, Seth L Masters, Cameron R Stewart, Bryan RG Williams, Michael Gantier

Journal article  |  2020  |  mBio

Activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in antiviral responses to many DNA viruses. Sensing of ..

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses

Thomas J Hayman, Alan C Hsu, Tatiana B Kolesnik, Laura F Dagley, Joschka Willemsen, Michelle D Tate, Paul J Baker, Nadia J Kershaw, Lukasz Kedzierski, Andrew Webb, Peter A Wark, Katherine Kedzierska, Seth L Masters, Gabrielle T Belz, Marco Binder, Philip M Hansbro, Nicos A Nicola, Sandra E Nicholson

Journal article  |  2019  |  Immunology & Cell Biology

The innate immune system is our first line of defence against viral pathogens. Host cell pattern recognition receptors (PRRs) sens..

SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm

Tan A Nguyen, Blake RC Smith, Kirstin D Elgass, Sarah J Creed, Shane Cheung, Michelle D Tate, Gabrielle T Belz, Ian P Wicks, Seth L Masters, Ken C Pang

Journal article  |  2019  |  The Journal of Immunology

Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes

Oliver P Skinner, Julie Jurczyluk, Paul J Baker, Seth L Masters, Alicia G Rios Wilks, Misaki S Clearwater, Avril AB Robertson, Kate Schroder, Sam Mehr, Marcia A Munoz, Michael J Rogers

Journal article  |  2019  |  Journal of Allergy and Clinical Immunology

A novel pathogenic NCSTN variant in a large Australian pedigree affected with hidradenitis suppurativa

D Vekic, G Cains, J Woods, F Moghaddas, S Masters

Conference Proceedings  |  2019  |  AUSTRALASIAN JOURNAL OF DERMATOLOGY

TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis

Sian P Cartland, Scott W Genner, Gonzalo J Martinez, Stacy Robertson, Maaike Kockx, Ruby CY Lin, John F O'Sullivan, Yen Chin Koay, Pradeep Manuneedhi Cholan, Melkam A Kebede, Andrew J Murphy, Seth Masters, Martin R Bennett, Wendy Jessup, Leonard Kritharides, Carolyn Geczy, Sanjay Patel, Mary M Kavurma

Journal article  |  2019  |  iScience

The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses

Damien Bierschenk, Mercedes Monteleone, Fiona Moghaddas, Paul J Baker, Seth L Masters, Dave Boucher, Kate Schroder

Journal article  |  2019  |  Journal of Leukocyte Biology

A Demonstration of the Diagnostic and Clinical Utility of Genomic Sequencing in Primary Immunodeficiency Diseases in Australia

Charlotte Slade, Fiona Moghaddas, Sebastian Lunke, Zornitza Stark, Ingrid Winship, Kirsty West, Alison Trainer, Samar Ojaimi, Matthew Hunter, Yael Prawer, Katherine Nicholls, Mittal Patel, Pricilla Auyeung, Kymble Spriggs, Jeremy McComish, Gary Unglik, Joseph De Luca, Samantha Chan, Giulia Valente, Anna Jarmolowicz, et al.

Conference Proceedings  |  2019  |  JOURNAL OF CLINICAL IMMUNOLOGY

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

Franklin L Zhong, Kim Robinson, Daniel Eng Thiam Teo, Kiat-Yi Tan, Chrissie Lim, Cassandra R Harapas, Chien-Hsiung Yu, William H Xie, Radoslaw M Sobota, Veonice Bijin Au, Richard Hopkins, Andrea D'Osualdo, John C Reed, John E Connolly, Seth L Masters, Bruno Reversade

Journal article  |  2018  |  Journal of Biological Chemistry

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface

Fiona Moghaddas, Ping Zeng, Yuxia Zhang, Heike Schuetzle, Sebastian Brenner, Sigrun R Hofmann, Reinhard Berner, Yuanbo Zhao, Bingtai Lu, Xiaoyun Chen, Li Zhang, Suyun Cheng, Stefan Winkler, Kai Lehmberg, Scott W Canna, Peter E Czabotar, Ian P Wicks, Dominic De Nardo, Christian M Hedrich, Huasong Zeng, et al.

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and-7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1 beta Activation

James E Vince, Dominic De Nardo, Wenqing Gao, Angelina J Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M Lindqvist, Philippe Bouillet, Mark A Rizzacasa, Si Ming Man, John Silke, Seth L Masters, Guillaume Lessene, David CS Huang, Daniel HD Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor

Journal article  |  2018  |  Cell Reports

Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes

Natalie J Bitto, Paul J Baker, Jennifer K Dowling, Georgie Wray-McCann, Amanda De Paoli, Son Tran Le, Pak Ling Leung, Katryn J Stacey, Ashley Mansell, Seth L Masters, Richard L Ferrero

Journal article  |  2018  |  Immunology and Cell Biology

A MUTATION OUTSIDE THE DIMERIZATION DOMAIN CAUSING ATYPICAL STING-ASSOCIATED VASCULOPATHY IN INFANCY

Rohit Saldanha, Katherine Balka, Fiona Moghaddas, Sophie Davidson, Dominic De Nardo, Brynn Wainstein, Melanie Wong, Seth Masters, Paul Gray

Conference Proceedings  |  2018  |  INTERNAL MEDICINE JOURNAL

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling

Dominic De Nardo, Katherine R Balka, Yamel Cardona Gloria, Vikram R Rao, Eicke Latz, Seth L Masters

Journal article  |  2018  |  Journal of Biological Chemistry

The classification, genetic diagnosis and modelling of monogenic autoinflammatory disorders

Fiona Moghaddas, Seth L Masters

Journal article  |  2018  |  Clinical Science

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell, et al.

Journal article  |  2018  |  Nature Communications

Ximmer: a system for improving accuracy and consistency of CNV calling from exome data

Simon P Sadedin, Justine A Ellis, Seth L Masters, Alicia Oshlack

Journal article  |  2018  |  GigaScience

A Mutation Outside the Dimerization Domain Causing Atypical STING-Associated Vasculopathy With Onset in Infancy

Rohit G Saldanha, Katherine R Balka, Sophia Davidson, Brynn K Wainstein, Melanie Wong, Rebecca Macintosh, Christine KC Loo, Martin A Weber, Vasanth Kamath, Fiona Moghaddas, Dominic De Nardo, Paul Edgar Gray, Seth Lucian Masters

Journal article  |  2018  |  Frontiers in Immunology

An Update on Autoinflammatory Diseases: Inflammasomopathies

Cassandra R Harapas, Annemarie Steine, Sophia Davidson, Seth L Masters

Journal article  |  2018  |  Current Rheumatology Reports

An Update on Autoinflammatory Diseases: Relopathies

Annemarie Steiner, Cassandra R Harapas, Seth L Masters, Sophia Davidson

Journal article  |  2018  |  Current Rheumatology Reports

An Update on Autoinflammatory Diseases: Interferonopathies

Sophia Davidson, Annemarie Steiner, Cassandra R Harapas, Seth L Masters

Journal article  |  2018  |  Current Rheumatology Reports

Microparticulate Caspase 1 Regulates Gasdermin D and Pulmonary Vascular Endothelial Cell Injury

Srabani Mitra, Matthew Exline, Fabien Habyarimana, Mikhail A Gavrilin, Paul J Baker, Seth L Masters, Mark D Wewers, Anasuya Sarkar

Journal article  |  2018  |  American Journal of Respiratory Cell and Molecular Biology

Caspase substrates won't be defined by a four-letter code

Paul J Baker, Seth L Masters

Journal article  |  2018  |  Journal of Biological Chemistry

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Graeme I Lancaster, Katherine G Langley, Nils Anton Berglund, Helene L Kammoun, Saskia Reibe, Emma Estevez, Jacquelyn Weir, Natalie A Mellett, Gerard Pernes, James RW Conway, Man KS Lee, Paul Timpson, Andrew J Murphy, Seth L Masters, Steve Gerondakis, Nenad Bartonicek, Dominik C Kaczorowski, Marcel E Dinger, Peter J Meikle, Peter J Bond, et al.

Journal article  |  2018  |  Cell Metabolism

The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

Rafid Alhallaf, Zainab Agha, Catherine M Miller, Avril AB Robertson, Javier Sotillo, John Croese, Matthew A Cooper, Seth L Masters, Andreas Kupz, Nicholas C Smith, Alex Loukas, Paul R Giacomin

Journal article  |  2018  |  Cell Reports

Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment

Kyohei Nakamura, Sahar Kassem, Alice Cleynen, Marie-Lorraine Chretien, Camille Guillerey, Eva Maria Putz, Tobias Bald, Irmgard Foerster, Slavica Vuckovic, Geoffrey R Hill, Seth L Masters, Marta Chesi, P Leif Bergsagel, Herve Avet-Loiseau, Ludovic Martinet, Mark J Smyth

Journal article  |  2018  |  Cancer Cell

A Crucial Role for Interleukin-18/IL-18R Signalling Axis in the Development of Renal Inflammation and Elevated Blood Pressure in 1 Kidney/DOCA/Salt-Induced Hypertension

Jordyn Michele Thomas, Yeong Hann Ling, Shalini Murali Krishnan, Dorota Ferens, Seth Masters, Barbara Kemp-Harper, Ashley Mansell, Christopher Sobey, Antony Vinh, Grant Drummond

Conference Proceedings  |  2018  |  FASEB JOURNAL

RECRUITMENT, RANDOMIZATION AND RETENTION: UK EXPERIENCE OF THE '3 RS' IN OSTEOARTHRITIS DRUG TRIALS TARGETING PAIN

S Masters, P Lovegrove, C Pereira, M Goff, G Lang, TL Vincent, K Barker, NK Arden, A Taylor, N Bottomley, W Jackson, A Price, FE Watt

Conference Proceedings  |  2018  |  OSTEOARTHRITIS AND CARTILAGE

Identification of a second binding site on the TRIM25 B30.2 domain

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson

Journal article  |  2018  |  Biochemical Journal

Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice

Chien-Hsiung Yu, Jonas Moecking, Matthias Geyer, Seth L Masters

Journal article  |  2018  |  Journal of Molecular Biology

Generation of Genetic Knockouts in Myeloid Cell Lines Using a Lentiviral CRISPR/Cas9 System.

Paul J Baker, Seth L Masters

Book Chapter  |  2018  |  Methods in Molecular Biology

CRISPR/Cas9-based gene targeting allows deletion of a gene of interest from cultured cell lines. Due to difficulty in transiently ..

A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever

Fiona Moghaddas, Rafael Llamas, Dominic De Nardo, Helios Martinez-Banaclocha, Juan J Martinez-Garcia, Pablo Mesa-del-Castillo, Paul J Baker, Vanessa Gargallo, Anna Mensa-Vilaro, Scott Canna, Ian P Wicks, Pablo Pelegrin, Juan I Arostegui, Seth L Masters

Journal article  |  2017  |  Annals of the Rheumatic Diseases

NOD1 triggers epithelial intrinsic processing of pro-interleukin-18 to protect the gastric mucosa from pre-cancerous changes induced by chronic Helicobacter pylori infection

Le Son Tran, Hassan Chaudhry, Kimberley D'costa, Amanda De Paoli, Julia Como, Jennifer Dowling, Jonathan Ferrand, Ashley Mansell, Ben A Croker, Ueli Nachbur, Seth L Masters, Richard L Ferrero

Conference Proceedings  |  2017  |  CYTOKINE

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

Paul JBaker, Dave Boucher, Natalie J Bitto, Damien Bierschenk, Christina Tebartz, Paul G Whitney, Sammy Bedoui, Kate Schroder, Richard L Ferrero, Seth L Masters

Conference Proceedings  |  2017  |  CYTOKINE

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Tan A Nguyen, Blake RC Smith, Michelle D Tate, Gabrielle T Belz, Marilou H Barrios, Kirstin D Elgass, Alexandra S Weisman, Paul J Baker, Simon P Preston, Lachlan Whitehead, Alexandra Garnham, Rachel J Lundie, Gordon K Smyth, Marc Pellegrini, Meredith O'Keeffe, Ian P Wicks, Seth L Masters, Craig P Hunter, Ken C Pang

Journal article  |  2017  |  Immunity

POSTTRANSLATIONAL MODIFICATION AS A CRITICAL DETERMINANT OF CYTOPLASMIC INNATE IMMUNE RECOGNITION

Paul J Baker, Dominic De Nardo, Fiona Moghaddas, Son Tran Le, Annabell Bachem, Nguyen Tan, Thomas Hayman, Hazel Tye, James E Vince, Sammy Bedoui, Richard L Ferrero, Seth L Masters

Journal article  |  2017  |  Physiological Reviews

A Helicobacter pylori Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization

Melanie L Hutton, Kimberley D'Costa, Amanda E Rossiter, Lin Wang, Lorinda Turner, David L Steer, Seth L Masters, Ben A Croker, Maria Kaparakis-Liaskos, Richard L Ferrero

Journal article  |  2017  |  Frontiers in Cellular and Infection Microbiology

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

Viola Neudecker, Moritz Haneklaus, Owen Jensen, Ludmila Khailova, Joanne C Masterson, Hazel Tye, Kathryn Biette, Paul Jedlicka, Kelley S Brodsky, Mark E Gerich, Matthias Mack, Avril AB Robertson, Matthew A Cooper, Glenn T Furuta, Charles A Dinarello, Luke A O'Neill, Holger K Eltzschig, Seth L Masters, Eoin N McNamee

Journal article  |  2017  |  Journal of Experimental Medicine

Intercellular communication for innate immunity

Tan A Nguyen, Ken C Pang, Seth L Masters

Journal article  |  2017  |  Molecular Immunology

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Auvro R Mridha, Alexander Wree, Avril AB Robertson, Matthew M Yeh, Casey D Johnson, Derrick M Van Rooyen, Fahrettin Haczeyni, Narci C-H Teoh, Christopher Savard, George N Ioannou, Seth L Masters, Kate Schroder, Matthew A Cooper, Ariel E Feldstein, Geoffrey C Farrell

Journal article  |  2017  |  Journal of Hepatology

The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome

Moritz Haneklaus, John D O'Neil, Andrew R Clark, Seth L Masters, Luke AJ O'Neill

Journal article  |  2017  |  Journal of Biological Chemistry

Interleukin-18 is Crucial for the Development of Renal Inflammation and Elevated Blood Pressure in a Mouse Model of Hypertension

Yeong Hann Ling, Jordyn Thomas, Shalini Murali Krishnan, Dorota Ferens, Seth Masters, Barbara Kemp-Harper, Ashley Mansell, Christopher Sobey, Grant Drummond

Conference Proceedings  |  2017  |  FASEB JOURNAL

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Jaclyn S Pearson, Cristina Giogha, Sabrina Muhlen, Ueli Nachbur, Chi LL Pham, Ying Zhang, Joanne M Hildebrand, Clare V Oates, Tania Wong Fok Lung, Danielle Ingle, Laura F Dagley, Aleksandra Bankovacki, Emma J Petrie, Gunnar N Schroeder, Valerie F Crepin, Gad Frankel, Seth L Masters, James Vince, James M Murphy, Margaret Sunde, et al.

Journal article  |  2017  |  Nature Microbiology

Homeostasis-altering molecular processes as mechanisms of inflammasome activation

Adrian Liston, Seth L Masters

Journal article  |  2017  |  Nature Reviews Immunology

Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin

Mary Speir, Adam Vogrin, Azadeh Seidi, Gilu Abraham, Stephane Hunot, Qingqing Han, Gerald W Dorn, Seth L Masters, Richard A Flavell, James E Vince, Thomas Naderer

Journal article  |  2017  |  Frontiers in Cellular and Infection Microbiology

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Stephanie A Conos, Kaiwen W Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Nunez, Seth L Masters, James M Murphy, Kate Schroder, David L Vaux, Kate E Lawlor, Lisa M Lindqvist, James E Vince

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Protective Effect of Inflammasome Activation by Hydrogen Peroxide in a Mouse Model of Septic Shock

Olivier Huet, Raelene J Pickering, Chris Tikellis, Celine Latouche, Fenella Long, Bronwyn Kingwell, Bryan Dickinson, Chris J Chang, Seth Masters, Fabienne Mackay, Mark E Cooper, Judy B de Haan

Journal article  |  2017  |  Critical Care Medicine

OBJECTIVES: To study the effect of a lack of antioxidant defenses during lethal pneumonia induced by Klebsiella pneumonia, compare..

Inflammasome Priming in Sterile Inflammatory Disease

Meghana N Patel, Richard G Carroll, Silvia Galvan-Pena, Evanna L Mills, Robin Olden, Martha Triantafilou, Amaya I Wolf, Clare E Bryant, Kathy Triantafilou, Seth L Masters

Journal article  |  2017  |  Trends in Molecular Medicine

Remote Inflammation Triggers Autoimmune Arthritis through Th17 Distribution

Nina Chevalier, Jian Tan, Linda Mason, Remy Robert, Craig McKenzie, Seth Masters, Charles Mackay

Conference Proceedings  |  2016  |  ARTHRITIS & RHEUMATOLOGY

The modern interleukin-1 superfamily: Divergent roles in obesity

Man KS Lee, Laurent Yvan-Charvet, Seth L Masters, Andrew J Murphy

Journal article  |  2016  |  Seminars in Immunology

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

Franklin L Zhong, Ons Mamai, Lorenzo Sborgi, Lobna Boussofara, Richard Hopkins, Kim Robinson, Ildiko Szeverenyi, Takuya Takeichi, Reshmaa Balaji, Aristotle Lau, Hazel Tye, Keya Roy, Carine Bonnard, Patricia J Ahl, Leigh Ann Jones, Paul J Baker, Lukas Lacina, Atsushi Otsuka, Pierre R Fournie, Francois Malecaze, et al.

Journal article  |  2016  |  Cell

Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges

Nina Chevalier, Jian K Tan, Linda J Mason, Remy Robert, Craig I McKenzie, Florence Lim, Connie H Wong, Laurence Macia, Alison N Thorburn, Brendan E Russ, Seth L Masters, Charles R Mackay

Journal article  |  2016  |  Journal of Autoimmunity

A endogenous retroviral noncoding RNA is highly enriched in dendritic cell exosomes and transferred to recipient cells in vitro and in vivo

M Barrios, A Garnham, M Wakefileld, BJ Scicluna, N Huntington, S Masters, KC Pang

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Familial autoinflammation with neutrophilic dermatosis reveals a novel regulatory mechanism of pyrin activation

PJ Baker, V Lagou, I Jeru, L Van Eyck, DA Parry, D Lawless, D De Nardo, JE Garcia-Perez, LF Dagley, C Holley, J Dooley, P-Y Jeandel, R Sciot, D Lyras, A Webb, SE Nicholson, L De Somer, E van Niewenhove, J Ruuth-Praz, B Copin, et al.

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

GLYCOGEN SYNTHASE KINASE-3 IS HYPERPHOSPHORYLATED IN SLE AND PROVIDES A FEEDBACK MECHANISM FOR THE GENERATION OF REGULATORY B CELLS

A Clarke, A Harin, S Masters, B Rhodes, T Vyse, K Simon

Conference Proceedings  |  2016  |  CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Granzyme M has a critical role in providing innate immune protection in ulcerative colitis

F Souza-Fonseca-Guimaraes, Y Krasnova, T Putoczki, K Miles, KP MacDonald, L Town, W Shi, GC Gobe, L McDade, LA Mielke, H Tye, SL Masters, GT Belz, ND Huntington, G Radford-Smith, MJ Smyth

Journal article  |  2016  |  Cell Death & Disease

VASCULAR ENDOTHELIAL GROWTH FACTOR AS AN AID TO DIAGNOSIS OF GIANT CELL ARTERITIS

N Goodfellow, J Morlet, A Floris, S Singh, A Sabokbar, A Hutchings, V Sharma, J Vaskova, S Masters, R Luqmani

Conference Proceedings  |  2016  |  Annals of the Rheumatic Diseases

Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan

Yifan Zhan, Kevin V Chow, Priscilla Soo, Zhen Xu, Jamie L Brady, Kate E Lawlor, Seth L Masters, Meredith O'keeffe, Ken Shortman, Jian-Guo Zhang, Andrew M Lew

Journal article  |  2016  |  Scientific Reports

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

Seth L Masters, Vasiliki Lagou, Isabelle Jeru, Paul J Baker, Lien Van Eyck, David A Parry, Dylan Lawless, Dominic De Nardo, Josselyn E Garcia-Perez, Laura F Dagley, Caroline L Holley, James Dooley, Fiona Moghaddas, Emanuela Pasciuto, Pierre-Yves Jeandel, Raf Sciot, Dena Lyras, Andrew I Webb, Sandra E Nicholson, Lien De Somer, et al.

Journal article  |  2016  |  Science Translational Medicine

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

Andrew J Murphy, Michael J Kraakman, Helene L Kammoun, Dragana Dragoljevic, Man KS Lee, Kate E Lawlor, John M Wentworth, Ajithkumar Vasanthakumar, Motti Gerlic, Lachlan W Whitehead, Ladina DiRago, Louise Cengia, Rachael M Lane, Donald Metcalf, James E Vince, Leonard C Harrison, Axel Kallies, Benjamin T Kile, Ben A Croker, Mark A Febbraio, et al.

Journal article  |  2016  |  Cell Metabolism

Regulation of Starch Stores by a Ca2 -Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii

Alessandro D Uboldi, James M McCoy, Martin Blume, Motti Gerlic, David JP Ferguson, Laura F Dagley, Cherie T Beahan, David I Stapleton, Paul R Gooley, Antony Bacic, Seth L Masters, Andrew I Webb, Malcolm J McConville, Christopher J Tonkin

Journal article  |  2015  |  Cell Host & Microbe

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David JP Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin

Journal article  |  2015  |  eLife

ATF3 Is a Key Regulator of Macrophage IFN Responses

Larisa I Labzin, Susanne V Schmidt, Seth L Masters, Marc Beyer, Wolfgang Krebs, Kathrin Klee, Rainer Stahl, Dieter Luetjohann, Joachim L Schultze, Eicke Latz, Dominic De Nardo

Journal article  |  2015  |  The Journal of Immunology

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

Paul J Baker, Dave Boucher, Damien Bierschenk, Christina Tebartz, Paul G Whitney, Damian B D'Silva, Maria C Tanzer, Mercedes Monteleone, Avril AB Robertson, Matthew A Cooper, Silvia Alvarez-Diaz, Marco J Herold, Sammy Bedoui, Kate Schroder, Seth L Masters

Journal article  |  2015  |  European Journal of Immunology

A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and Virulence

Martin Blume, Richard Nitzsche, Ulrich Sternberg, Motti Gerlic, Seth L Masters, Nishith Gupta, Malcolm J McConville

Journal article  |  2015  |  Cell Host & Microbe

Monogenic autoinflammatory diseases: Cytokinopathies

Fiona Moghaddas, Seth L Masters

Journal article  |  2015  |  Cytokine

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

David P Sester, Vitaliya Sagulenko, Sara J Thygesen, Jasmyn A Cridland, Yen Siew Loi, Simon O Cridland, Seth L Masters, Ulrich Genske, Veit Hornung, Christopher E Andoniou, Matthew J Sweet, Mariapia A Degli-Esposti, Kate Schroder, Katryn J Stacey

Journal article  |  2015  |  The Journal of Immunology

Broadening the definition of autoinflammation

Seth L Masters

Journal article  |  2015  |  Seminars in Immunopathology

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1 beta

Man Lyang Kim, Jae Jin Chae, Yong Hwan Park, Dominic De Nardo, Roslynn A Stirzaker, Hyun-Ja Ko, Hazel Tye, Louise Cengia, Ladina DiRago, Donald Metcalf, Andrew W Roberts, Daniel L Kastner, Andrew M Lew, Dena Lyras, Benjamin T Kile, Ben A Croker, Seth L Masters

Journal article  |  2015  |  Journal of Experimental Medicine

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C Coll, Avril AB Robertson, Jae Jin Chae, Sarah C Higgins, Raul Munoz-Planillo, Marco C Inserra, Irina Vetter, Lara S Dungan, Brian G Monks, Andrea Stutz, Daniel E Croker, Mark S Butler, Moritz Haneklaus, Caroline E Sutton, Gabriel Nunez, Eicke Latz, Daniel L Kastner, Kingston HG Mills, Seth L Masters, Kate Schroder, et al.

Journal article  |  2015  |  Nature Medicine

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells

Ajithkumar Vasanthakumar, Kazuyo Moro, Annie Xin, Yang Liao, Renee Gloury, Shimpei Kawamoto, Sidonia Fagarasan, Lisa A Mielke, Shoukat Afshar-Sterle, Seth L Masters, Susumu Nakae, Hirohisa Saito, John M Wentworth, Peng Li, Wei Liao, Warren J Leonard, Gordon K Smyth, Wei Shi, Stephen L Nutt, Shigeo Koyasu, et al.

Journal article  |  2015  |  Nature Immunology

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A Croker, Akshay A D'Cruz, Cathrine Hall, Sukhdeep Kaur Spall, Holly Anderton, Seth L Masters, Maryam Rashidi, Ian P Wicks, Warren S Alexander, Yasuhiro Mitsuuchi, Christopher A Benetatos, Stephen M Condon, W Wei-Lynn Wong, John Silke, David L Vaux, James E Vince

Journal article  |  2015  |  Nature Communications

Fas regulates neutrophil lifespan during viral and bacterial infection

Joanne A O'Donnell, Catherine L Kennedy, Marc Pellegrini, Cameron J Nowell, Jian-Guo Zhang, Lorraine A O'Reilly, Louise Cengia, Stuart Dias, Seth L Masters, Elizabeth L Hartland, Andrew W Roberts, Motti Gerlic, Ben A Croker

Journal article  |  2015  |  Journal of Leukocyte Biology

Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets

Jibran A Wali, Esteban N Gurzov, Stacey Fynch, Lorraine Elkerbout, Thomas W Kay, Seth L Masters, Helen E Thomas

Journal article  |  2014  |  PLoS ONE

Inflammasome activation due to polymerized actin triggers an autoinflammatory disease that is dependent on IL-18, not IL-1 beta

Man Lyang Kim, Jae Jin Chae, Ros A Stirzaker, Hyun-Ja Ko, Andrew W Roberts, Daniel L Kastner, Ben T Kile, Ben A Croker, Seth L Masters

Conference Proceedings  |  2014  |  Cytokine

Critical role for post-transcriptional regulation of the gene encoding the key inflammasome protein NLRP3

Moritz Haneklaus, Seth L Masters, Luke AJ O'Neill

Conference Proceedings  |  2014  |  Cytokine

Modulation of innate immune responses by ATF3

Dominic De Nardo, Larisa I Labzin, Susanne Schmidt, Seth L Masters, Rainer Stahl, Joachim Schultze, Eicke Latz

Conference Proceedings  |  2014  |  Cytokine

MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseases

Rebecca C Coll, Avril AB Robertson, Jae Jin Chae, Sarah C Higgins, Lara S Dungan, Raul Munoz-Planillo, Brian G Monks, Daniel E Croker, Caroline E Sutton, Andrea Stutz, Gabriel Nunez, Eicke Latz, Daniel L Kastner, Kingston HG Mills, Seth L Masters, Kate Schroder, Matt A Cooper, Luke AJ O'Neill

Conference Proceedings  |  2014  |  Cytokine

Internalisation of Toxoplasma A healthy appetite for Toxoplasma at the cellular level

Motti Gerlic, Seth L Masters

Journal article  |  2014  |  Immunology & Cell Biology

What causes Kupffer cell activation in NAFLD? HMGB1, TLR4, crystals and NLRP3 inflammasome link free cholesterol to inhibitable pro-inflammatory pathways in NASH

LT Gan, DM Van Rooyen, M Cooper, A Robertson, S Masters, N Teoh, G Farrell

Conference Proceedings  |  2014  |  Journal of Gastroenterology and Hepatology

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K Spall, Toby J Phesse, Helen E Abud, Louise H Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst, et al.

Journal article  |  2014  |  Cell

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

Prabhakara R Nagareddy, Michael Kraakman, Seth L Masters, Roslynn A Stirzaker, Darren J Gorman, Ryan W Grant, Dragana Dragoljevic, Eun Shil Hong, Ahmed Abdel-Latif, Susan S Smyth, Sung Hee Choi, Judith Korner, Karin E Bornfeldt, Edward A Fisher, Vishwa Deep Dixit, Alan R Tall, Ira J Goldberg, Andrew J Murphy

Journal article  |  2014  |  Cell Metabolism

NLRP1a Expression in Srebp-1a-Deficient Mice

Motti Gerlic, Ben A Croker, Louise H Cengia, Mahtab Moayeri, Benjamin T Kile, Seth L Masters

Journal article  |  2014  |  Cell Metabolism

The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages

Nathalie Uwamahoro, Jiyoti Verma-Gaur, Hsin-Hui Shen, Yue Qu, Rowena Lewis, Jingxiong Lu, Keith Bambery, Seth L Masters, James E Vince, Thomas Naderer, Ana Traven

Journal article  |  2014  |  MBIO

Innate immunity

Seth L Masters, Dominic De Nardo

Journal article  |  2014  |  Current Opinion in Immunology

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

Gezahegn Gorfu, Kimberly M Cirelli, Mariane B Melo, Katrin Mayer-Barber, Devorah Crown, Beverly H Koller, Seth Masters, Alan Sher, Stephen H Leppla, Mahtab Moayeri, Jeroen PJ Saeij, Michael E Grigg

Journal article  |  2014  |  mBio

Necroptotic Death Of RIPK1-Deficient HSC Compromises Hematopoiesis

Ben A Croker, O'Donnell A Joanne, Donald Metcalf, Rickard James, Joseph Evans, Seth L Masters, Andrew W Roberts, Motti Gerlic, John Silke

Conference Proceedings  |  2013  |  Blood

Critical role for the 3 ' UTR in the post-transcriptional regulation of the gene encoding the key inflammasome protein NLRP3

Moritz Haneklaus, Seth L Masters, Luke AJ O'Neill

Conference Proceedings  |  2013  |  Cytokine

miR-223: infection, inflammation and cancer

M Haneklaus, M Gerlic, LAJ O'Neill, SL Masters

Journal article  |  2013  |  Journal of Internal Medicine

Specific inflammasomes in complex diseases

Seth L Masters

Journal article  |  2013  |  Clinical Immunology

Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha

GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, AF McGettrick, G Goel, C Frezza, NJ Bernard, B Kelly, NH Foley, L Zheng, A Gardet, Z Tong, SS Jany, SC Corr, M Haneklaus, BE Caffrey, K Pierce, S Walmsley, FC Beasley, et al.

Journal article  |  2013  |  Nature

Transcriptional analysis of the three Nlrp1 paralogs in mice

Inka Sastalla, Devorah Crown, Seth L Masters, Andrew McKenzie, Stephen H Leppla, Mahtab Moayeri

Journal article  |  2013  |  BMC Genomics

Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP.

Clara Westwell-Roper, Aisling Dunne, Man Lyang Kim, C Bruce Verchere, Seth L Masters

Journal article  |  2013  |  Methods in Molecular Biology

In addition to several other extracellular substances, phagocytosis of amyloid-forming peptides can perturb cellular homeostasis, ..

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

Seth L Masters, Motti Gerlic, Donald Metcalf, Simon Preston, Marc Pellegrini, Joanne A O'Donnell, Kate McArthur, Tracey M Baldwin, Stephane Chevrier, Cameron J Nowell, Louise H Cengia, Katya J Henley, Janelle E Collinge, Daniel L Kastner, Lionel Feigenbaum, Douglas J Hilton, Warren S Alexander, Benjamin T Kile, Ben A Croker

Journal article  |  2012  |  Immunity

Activation of the NLRP1 Inflammasome Induces the Pyroptotic Death of Hematopoietic Progenitor Cells

Seth L Masters, Mordechay Gerlic, Donald Metcalf, Simon P Preston, Marc Pellegrini, Joanne A O'Donnell, Kate McArthur, Tracey M Baldwin, Stephane Chevrier, Cameron J Nowell, Louise H Cengia, Katya J Henley, Janelle E Collinge, Daniel L Kastner, Lionel Feigenbaum, Douglas J Hilton, Warren S Alexander, Ben A Croker, Benjamin T Kile

Conference Proceedings  |  2012  |  Blood

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1 beta Production

Moritz Haneklaus, Motti Gerlic, Mariola Kurowska-Stolarska, Ashleigh-Ann Rainey, Dagmar Pich, Iain B McInnes, Wolfgang Hammerschmidt, Luke AJ O'Neill, Seth L Masters

Journal article  |  2012  |  The Journal of Immunology

Regulation of Microrna 223 Expression in a Gouty Arthritis

Gianina Statache, Ashleigh-Ann Rainey, Seth Masters, Andra Balanescu, Iain B McInnes, Mariola Kurowska-Stolarska

Conference Proceedings  |  2012  |  ARTHRITIS AND RHEUMATISM

Regulation of microRNA 223 expression in a gouty arthritis

G Statache, A Rainey, L Crawford, S Masters, A Balanescu, I McInnes, M Kurowska-Stolarska

Conference Proceedings  |  2012  |  IMMUNOLOGY

miR-223 TARGETS IL-1 beta PRODUCTION AND IS DECREASED IN SYNOVIAL FLUID MONOCYTES FROM ARTHRITIS PATIENTS

M Haneklaus, M Gerlic, M Kurowska-Stolarska, A Rainey, D Pitch, W Hammerschmidt, L O'Neill, S Masters

Conference Proceedings  |  2012  |  INTERNAL MEDICINE JOURNAL

New chemistry of 1,2-closo-P2B10H10 and 1,2-closo-As2B10H10; in silico and gas electron diffraction structures, and new metalladiphospha- and metalladiarsaboranes

R McLellan, NM Boag, K Dodds, D Ellis, SA Macgregor, D McKay, SL Masters, R Noble-Eddy, NP Platt, DWH Rankin, HE Robertson, GM Rosair, AJ Welch

Journal article  |  2011  |  Dalton Transactions

The Inflammasome in Atherosclerosis and Type 2 Diabetes

Seth L Masters, Eicke Latz, Luke AJ O'Neill

Journal article  |  2011  |  Science Translational Medicine

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

Seth L Masters, Luke AJ O'Neill

Journal article  |  2011  |  Trends in Molecular Medicine

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1 beta in type 2 diabetes

Seth L Masters, Aisling Dunne, Shoba L Subramanian, Rebecca L Hull, Gillian M Tannahill, Fiona A Sharp, Christine Becker, Luigi Franchi, Eiji Yoshihara, Zhe Chen, Niamh Mullooly, Lisa A Mielke, James Harris, Rebecca C Coll, Kingston HG Mills, K Hun Mok, Philip Newsholme, Gabriel Nunez, Junji Yodoi, Steven E Kahn, et al.

Journal article  |  2010  |  Nature Immunology

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

Zhihe Kuang, Rowena S Lewis, Joan M Curtis, Yifan Zhan, Bernadette M Saunders, Jeffrey J Babon, Tatiana B Kolesnik, Andrew Low, Seth L Masters, Tracy A Willson, Lukasz Kedzierski, Shenggen Yao, Emanuela Handman, Raymond S Norton, Sandra E Nicholson

Journal article  |  2010  |  The Journal of Cell Biology

Clinical features and functional significance of the P369S/R408Q variant in pyrin, the familial Mediterranean fever protein

JG Ryan, SL Masters, MG Booty, N Habal, JD Alexander, BK Barham, EF Remmers, KS Barron, DL Kastner, I Aksentijevich

Journal article  |  2010  |  Annals of the Rheumatic Diseases

Release of the mitochondrial endosymbiont helps explain sterile inflammation

Seth L Masters, Patrick T Walsh

Journal article  |  2010  |  Proceedings of the National Academy of Sciences

Pyrin Modulates the Intracellular Distribution of PSTPIP1

Andrea L Waite, Philip Schaner, Neil Richards, Banu Balci-Peynircioglu, Seth L Masters, Susannah D Brydges, Michelle Fox, Arthur Hong, Engin Yilmaz, Daniel L Kastner, Ellis L Reinherz, Deborah L Gumucio

Journal article  |  2009  |  PLoS ONE

An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist

Ivona Aksentijevich, Seth L Masters, Polly J Ferguson, Paul Dancey, Joost Frenkel, Annet van Royen-Kerkhoff, Ron Laxer, Ulf Tedgard, Edward W Cowen, Tuyet-Hang Pham, Matthew Booty, Jacob D Estes, Netanya G Sandler, Nicole Plass, Deborah L Stone, Maria L Turner, Suvimol Hill, John A Butman, Rayfel Schneider, Paul Babyn, et al.

Journal article  |  2009  |  New England Journal of Medicine

Familial Mediterranean Fever With a Single MEFV Mutation Where Is the Second Hit?

Matthew G Booty, Jae Jin Chae, Seth L Masters, Elaine F Remmers, Beverly Barham, Julie M Le, Karyl S Barron, Steve M Holland, Daniel L Kastner, Ivona Aksentijevich

Journal article  |  2009  |  Arthritis & Rheumatism

SPRY Domain-Containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding

Z Kuang, S Yao, Y Xu, RS Lewis, A Low, SL Masters, TA Willson, TB Kolesnik, SE Nicholson, TJP Garrett, RS Norton

Journal article  |  2009  |  Journal of Molecular Biology

The four mammalian SPRY (a sequence repeat in dual-specificity kinase splA and ryanodine receptors) domain-containing suppressor o..

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

Seth L Masters, Anna Simon, Ivona Aksentijevich, Daniel L Kastner

Book  |  2009  |  Annual Review of Immunology

Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders

A Laurence, SL Masters, J O'Shea

Book Chapter  |  2008

Mutations in the interleulkin-1 receptor antagonist cause a new autoinflammatory disease

Seth L Masters, Ivona Aksentijevich, Polly J Ferguson, Matthew G Booty, Arian Laurence, Hang Pham, Deborah L Stone, Edward W Cowen, Nicole Plass, Xinyu Bing, Gillian I Clarke, Kamal Ohson, Hatem I Ei-Shanti, Annet van Royen, Joost Frenk

Conference Proceedings  |  2008  |  Cytokine

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappa B through its N-terminal fragment

Jae Jin Chae, Geryl Wood, Katharina Richard, Howard Jaffe, Nona T Colburn, Seth L Masters, Deborah L Gumucio, Nitza G Shoham, Daniel L Kastner

Journal article  |  2008  |  Blood

Characterization of mice deficient for Pstpip1, the gene mutated in PAPA syndrome

Seth L Masters, Susannah Brydges, Sophia Y Cleland, Richard M Siegel, Daniel L Kastner

Conference Proceedings  |  2008  |  ARTHRITIS AND RHEUMATISM

Clinical and functional significance of P369S and R408Q variants in the familial Mediterranean fever-associated gene MEFV

John G Ryan, Matthew G Booty, Beverly Barham, Elaine F Remmers, Karyl Barron, Daniel L Kastner, Ivona Aksentijevich, Seth L Masters

Conference Proceedings  |  2008  |  ARTHRITIS AND RHEUMATISM

A variant truncation form of ASC has a reduced pro-inflammatory profile

S Masters, M Booty, J Chae, I Aksentijevich, D Kastner

Conference Proceedings  |  2008  |  CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

Elaine F Remmers, Robert M Plenge, Annette T Lee, Robert R Graham, Geoffrey Hom, Timothy W Behrens, Paul IW de Bakker, Julie M Le, Hye-Soon Lee, Franak Batliwalla, Wentian Li, Seth L Masters, Matthew G Booty, John P Carulli, Leonid Padyukov, Lars Alfredsson, Lars Klareskog, Wei V Chen, Christopher I Amos, Lindsey A Criswell, et al.

Journal article  |  2007  |  New England Journal of Medicine

Parthenolide, a sesquiterpene lactone from the medicinal plant, feverfew, inhibits I kappa B kinase, nuclear factor-kappa B activation and inflammatory response in CF cell lines and mice

A Saadane, S Masters, J DiDonato, J Li, M Berger

Conference Proceedings  |  2007  |  Journal of Allergy and Clinical Immunology

Recent advances in the molecular pathogenesis of hereditary recurrent fevers

Seth L Masters, Adrian A Lobito, JaeJin Chae, Daniel L Kastner

Journal article  |  2006  |  Current Opinion in Allergy and Clinical Immunology

Dynamics of the SPRY domain-containing SOCS box protein 2: Flexibility of key functional loops

Shenggen Yao, Ming S Liu, Seth L Masters, Jian-Guo Zhang, Jeffrey J Babon, Nicos A Nicola, Sandra E Nicholson, Raymond S Norton

Journal article  |  2006  |  Protein Science

Structural analysis of the pyrin B30.2 domain and its interaction with caspase-1 - the consequences of FMF mutations.

Seth L Masters, Jae Jin Chae, Shenggen Yao, Nicos A Nicola, Raymond S Norton, Sandra E Nicholson, Brian J Smith, Daniel L Kastner

Conference Proceedings  |  2006  |  ARTHRITIS AND RHEUMATISM

The familial mediterranean fever protein, pyrin, modulates Il-1 beta production by C-terminal interaction with caspase-1, and activates Nf-kappa B through its N-terminal cleaved fragment.

Jae Jin Chae, Geryl Wood, Katharina Richard, Seth Masters, Howard Jaffe, Nona Colburn, Deborah L Gumucio, Nitza G Shoham, Daniel L Kastner

Conference Proceedings  |  2006  |  ARTHRITIS AND RHEUMATISM

Structural analysis of the pyrin B30.2 domain and its interaction with caspase-1 - The consequences of FMF mutations.

Seth L Masters, Jae Jin Chae, Shenggen Yao, Nicos A Nicola, Raymond S Norton, Sandra E Nicholson, Brian J Smith, Daniel L Kastner

Conference Proceedings  |  2006  |  ARTHRITIS AND RHEUMATISM

The familial mediterranean fever protein, pyrin, modulates IL-1 beta production by C-terminal interaction with caspase-1, and activates Nf-kappa B through its n-terminal cleaved fragment.

Jae Jin Chae, Geryl Wood, Katharina Richard, Seth Masters, Howard Jaffe, Nona Colburn, Deborah L Gumucio, Nitza G Shoham, Daniel L Kastner

Conference Proceedings  |  2006  |  ARTHRITIS AND RHEUMATISM

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1 beta production

Jae Jin Chae, Geryl Wood, Seth L Masters, Katharina Richard, Grace Park, Brian J Smith, Daniel L Kastner

Journal article  |  2006  |  Proceedings of the National Academy of Sciences

The ankyrin repeat and SOCS box-containing protein Asb-9 targets creatine kinase B for degradation

MA Debrincat, JG Zhang, TA Willson, BT Kile, SL Masters, LM Connolly, RJ Simpson, HM Martin, NA Nicola, DJ Hilton

Conference Proceedings  |  2006  |  FEBS JOURNAL

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

SL Masters, SG Yao, TA Willson, JG Zhang, KR Palmer, BJ Smith, JJ Babon, NA Nicola, RS Norton, SE Nicholson

Journal article  |  2006  |  Nature Structural & Molecular Biology

Biochemical, structural and physiological analysis of the SPRY domain-containing SOCS box protein 2 (SSB-2)

SL Masters, S Yao, KR Palmer, JG Zhang, NS Sprigg, NA Nicola, RS Norton, SE Nicholson

Conference Proceedings  |  2005  |  FEBS JOURNAL

Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia

SL Masters, KR Palmer, WS Stevenson, D Metcalf, EM Viney, NS Sprigg, WS Alexander, NA Nicola, SE Nicholson

Journal article  |  2005  |  Molecular and Cellular Biology

Backbone H-1, C-13 and N-15 assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2)

SG Yao, S Masters, JG Zhang, K Palmer, J Babon, N Nicola, S Nicholson, R Norton

Journal article  |  2005  |  Journal of Biomolecular NMR

The medical profession and the pharmaeutical industry: when will we open our eyes?

S Masters

Journal article  |  2004  |  The Medical journal of Australia

16th Lorne Cancer Conference, 12-15 February 2004

R Columbus, S Masters

Conference Proceedings  |  2004  |  Cancer Forum

Characteristics and service packages of adults with intellectual disabilities (ID) who offend

J McBrien, S Masters

Conference Proceedings  |  2004  |  JOURNAL OF INTELLECTUAL DISABILITY RESEARCH

Adenoviral gene therapy using an anti-proliferative mutant of PTHrP completely prevents arterial re-stenosis.

NM Fiaschi-Taesch, KK Takane, S Masters, AF Stewart

Conference Proceedings  |  2002  |  JOURNAL OF BONE AND MINERAL RESEARCH

New treatments for advanced cancer: an approach to prioritization

JSJ Ferguson, M Summerhayes, S Masters, S Schey, IE Smith

Journal article  |  2000  |  British Journal of Cancer

Changes of brain water and cerebral blood flow in a hyperammonemic model of brain edema.

S Masters, J Gottstein, AT Blei

Conference Proceedings  |  1998  |  HEPATOLOGY

Residual peroxide measurement - An important parameter for monitoring and controlling the peroxide bleaching process

TJL Gustavsson, GH Fladda, S Masters

Conference Proceedings  |  1998  |  52ND APPITA ANNUAL GENERAL CONFERENCE, 1998 PROCEEDINGS, VOLS 1 AND 2