Seth Masters

NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity.

Jonas Moecking, Pawat Laohamonthonkul, Katelyn Chalker, Marquitta J White, Cassandra R Harapas, Chien-Hsiung Yu, Sophia Davidson, Katja Hrovat Schaale, Donglei Hu, Celeste Eng, Scott Huntsman, Dale J Calleja, Jay C Horvat, Phil M Hansbro, Robert JJ O'Donoghue, Jenny P Ting, Esteban G Burchard, Matthias Geyer, Motti Gerlic, Seth L Masters

Journal article  |  2020  |  Journal of Allergy and Clinical Immunology

BACKGROUND: NLRP1 is an innate immune sensor that can form cytoplasmic inflammasome complexes. Polymorphisms in NLRP1 are linked t..

Pharmacological validation of targets regulating CD14 during macrophage differentiation.

Gisela Jimenez-Duran, Rosario Luque-Martin, Meghana Patel, Emma Koppe, Sharon Bernard, Catriona Sharp, Natalie Buchan, Ceara Rea, Menno PJ de Winther, Nil Turan, Davina Angell, Christine A Wells, Rick Cousins, Palwinder K Mander, Seth L Masters

Journal article  |  2020  |  EBioMedicine

The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflamma..

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, et al.

Journal article  |  2020  |  Cell

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a ..

Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development.

Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L Masters, Andrew M Lew, Sitang Gong, Fan Bai, et al.

Journal article  |  2020  |  Journal of Allergy and Clinical Immunology

BACKGROUND: Very-early-onset inflammatory bowel disease (VEOIBD) is a chronic inflammatory disease of the gastrointestinal tract o..

Constitutive immune mechanisms: mediators of host defence and immune regulation

Sren R Paludan, Thomas Pradeu, Seth L Masters, Trine H Mogensen

Journal article  |  2020  |  Nature Reviews Immunology

The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked th..

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, et al.

Journal article  |  2020  |  Nature Communications

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a singl..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at si..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (vol 217, e20191421, 2020)

Cynthia Louis, Fernando Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

TBK1 and IKK epsilon Act Redundantly to Mediate STING-Induced NF-kappa B Responses in Myeloid Cells

Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan, Christopher J Burns, Ian P Wicks, Jonathan J Miner, Benjamin T Kile, Seth L Masters, Dominic De Nardo

Journal article  |  2020  |  Cell Reports

Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimm..

Compound Heterozygous Mutations of IL12RB1 in a Patient with Selective Defects in Th17 Differentiation

Ming Liu, Bingtai Lu, Ping Zeng, Bing Huang, Yanhui Xu, Hanquan Liang, Diyuan Yang, Sida Yang, Hai-bin Luo, Andrew M Lew, Seth L Masters, Lanlan Geng, Huasong Zeng, Yuxia Zhang

Journal article  |  2020  |  Journal of Clinical Immunology