Susan Northfield

1,3-Dichloroacetone: A Robust Reagent for Preparing Bicyclic Peptides

Qingqing Lin, Denham Hopper, Haoyue Zhang, Jordan Sfyris Qoon, Zihan Shen, John A Karas, Richard A Hughes, Susan E Northfield

Journal article  |  2020  |  ACS Omega

The chemical synthesis of cyclic peptides is a well-established area of research. This has been further expanded by development of..

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

Susan E Northfield, Jerome Wielens, Stephen J Headey, Billy J Williams-Noonan, Mark Mulcair, Martin J Scanlon, Michael W Parker, Philip E Thompson, David K Chalmers

Journal article  |  2018  |  ChemMedChem

Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain

Jessica L Fletcher, Rhiannon J Wood, Jacqueline Nguyen, Eleanor ML Norman, Christine MK Jun, Alexa R Prawdiuk, Melissa Biemond, Huynh TH Nguyen, Susan E Northfield, Richard A Hughes, David G Gonsalvez, Junhua Xiao, Simon S Murray

Journal article  |  2018  |  The Journal of Neuroscience

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold

Conan K Wang, Susan E Northfield, Yen-Hua Huang, Mariana C Ramos, David J Craik

Journal article  |  2016  |  European Journal of Medicinal Chemistry

Effects of Cyclization on Peptide Backbone Dynamics

Conan K Wang, Joakim E Swedberg, Susan E Northfield, David J Craik

Journal article  |  2015  |  The Journal of Physical Chemistry B

Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability

Conan K Wang, Susan E Northfield, Joakim E Swedberg, Barbara Colless, Stephanie Chaousis, David A Price, Spiros Liras, David J Craik

Journal article  |  2015  |  European Journal of Medicinal Chemistry

Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic Peptides

Susan E Northfield, Simon J Mountford, Jerome Wielens, Mengjie Liu, Lei Zhang, Herbert Herzog, Nicholas D Holliday, Martin J Scanlon, Michael W Parker, David K Chalmers, Philip E Thompson

Journal article  |  2015  |  Australian Journal of Chemistry

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

Conan K Wang, Susan E Northfield, Barbara Colless, Stephanie Chaousis, Ingrid Hamernig, Rink-Jan Lohman, Daniel S Nielsen, Christina I Schroeder, Spiros Liras, David A Price, David P Fairlie, David J Craik

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1

Carol M Taylor, Susan E Northfield, Conan K Wang, David J Craik

Journal article  |  2014  |  Tetrahedron

Racemic and Quasi-Racemic X-ray Structures of Cyclic Disulfide-Rich Peptide Drug Scaffolds

Conan K Wang, Gordon J King, Susan E Northfield, Paola G Ojeda, David J Craik

Journal article  |  2014  |  Angewandte Chemie International Edition

Translational Diffusion of Cyclic Peptides Measured Using Pulsed-Field Gradient NMR

Conan K Wang, Susan E Northfield, Joakim E Swedberg, Peta J Harvey, Alan M Mathiowetz, David A Price, Spiros Liras, David J Craik

Journal article  |  2014  |  The Journal of Physical Chemistry B

Disulfide-rich macrocyclic peptides as templates in drug design

Susan E Northfield, Conan K Wang, Christina I Schroeder, Thomas Durek, Meng-Wei Kan, Joakim E Swedberg, David J Craik

Journal article  |  2014  |  European Journal of Medicinal Chemistry

Synthesis of "Difficult" Fluorescence Quenched Substrates of Granzyme C

Susan E Northfield, Kade D Roberts, Simon J Mountford, Richard A Hughes, Dion Kaiserman, Matthew Mangan, Robert N Pike, Phillip I Bird, Philip E Thompson

Journal article  |  2010  |  International Journal of Peptide Research and Therapeutics

7-Azabicyclo[2.2.1]heptane-2-carboxylic acids as peptidomimetic conformational constraints. NK2 antagonists as an example.

S Northfield, M Camerino, H Mulvey, T Ashton, D Chalmers, K Kerr, P Thompson

Conference Proceedings  |  2007

Lipophilicity of beta-adrenocepter antagonists: A new classification scheme for clinical use

SE Northfield, DT Manallack

Journal article  |  2007  |  Journal of Pharmacy Practice and Research

Cyclotide Analysis

Susan E Northfield, Aaron G Poth, Charlotte D'Souza, David J Craik

Book Chapter