Susan Northfield

The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation

Lin Hsin, Nithya A Fernandopulle, Jie Ding, Chris Lumb, Nicholas Veldhuis, John A Karas, Susan E Northfield, Graham A Mackay

Journal article  |  2022  |  PHARMACOLOGY RESEARCH & PERSPECTIVES

The tachykinin neuropeptide substance P (SP) is the canonical agonist peptide for the neurokinin 1 receptor (NK1 R). More recently..

Esterase-Mediated Sustained Release of Peptide-Based Therapeutics from a Self-Assembled Injectable Hydrogel

Ketav Kulkarni, Rachel L Minehan, Tanesh Gamot, Harold A Coleman, Simon Bowles, Qingqing Lin, Denham Hopper, Susan E Northfield, Richard A Hughes, Robert E Widdop, Marie-Isabel Aguilar, Helena C Parkington, Mark P Del Borgo

Journal article  |  2021  |  ACS APPLIED MATERIALS & INTERFACES

A synthetic strategy for conjugating small molecules and peptide-based therapeutics, via a cleavable ester bond, to a lipidated β3..

TNFSF14-Derived Molecules as a Novel Treatment for Obesity and Type 2 Diabetes

Mark Agostino, Jennifer Rooney, Lakshini Herat, Jennifer Matthews, Allyson Simonds, Susan E Northfield, Denham Hopper, Markus P Schlaich, Vance B Matthews

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with glucose intolerance and ..

1,3-Dichloroacetone: A Robust Reagent for Preparing Bicyclic Peptides

Qingqing Lin, Denham Hopper, Haoyue Zhang, Jordan Sfyris Qoon, Zihan Shen, John A Karas, Richard A Hughes, Susan E Northfield

Journal article  |  2020  |  ACS OMEGA

The chemical synthesis of cyclic peptides is a well-established area of research. This has been further expanded by development of..

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

Susan E Northfield, Jerome Wielens, Stephen J Headey, Billy J Williams-Noonan, Mark Mulcair, Martin J Scanlon, Michael W Parker, Philip E Thompson, David K Chalmers

Journal article  |  2018  |  CHEMMEDCHEM

The p75 splice variant of lens epithelium-derived growth factor (LEDGF) is a 75 kDa protein, which is recruited by the human immun..

Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain

Jessica L Fletcher, Rhiannon J Wood, Jacqueline Nguyen, Eleanor ML Norman, Christine MK Jun, Alexa R Prawdiuk, Melissa Biemond, Huynh TH Nguyen, Susan E Northfield, Richard A Hughes, David G Gonsalvez, Junhua Xiao, Simon S Murray

Journal article  |  2018  |  JOURNAL OF NEUROSCIENCE

Methods to promote myelin regeneration in response to central myelin loss are essential to prevent the progression of clinical dis..

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold

Conan K Wang, Susan E Northfield, Yen-Hua Huang, Mariana C Ramos, David J Craik

Journal article  |  2016  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Disulfide-rich macrocyclic peptides are emerging as versatile scaffolds for the development of stable biochemical tools. This pote..

Effects of Cyclization on Peptide Backbone Dynamics

Conan K Wang, Joakim E Swedberg, Susan E Northfield, David J Craik

Journal article  |  2015  |  JOURNAL OF PHYSICAL CHEMISTRY B

Despite the widespread use of cyclization as a structure optimization tool in peptide chemistry, little is known about the effect ..

Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability

Conan K Wang, Susan E Northfield, Joakim E Swedberg, Barbara Colless, Stephanie Chaousis, David A Price, Spiros Liras, David J Craik

Journal article  |  2015  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An increasing number of macrocyclic peptides that cross biological membranes are being reported, suggesting that it might be possi..

Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic Peptides

Susan E Northfield, Simon J Mountford, Jerome Wielens, Mengjie Liu, Lei Zhang, Herbert Herzog, Nicholas D Holliday, Martin J Scanlon, Michael W Parker, David K Chalmers, Philip E Thompson

Journal article  |  2015  |  AUSTRALIAN JOURNAL OF CHEMISTRY

The use of the click reaction for the introduction of conjugate groups, such as affinity or fluorescent labels, to a peptide for t..