Yannick Alexandre

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Brigette C Duckworth, Fanny Lafouresse, Verena C Wimmer, Benjamin J Broomfield, Lennard Dalit, Yannick O Alexandre, Amania A Sheikh, Raymond Z Qin, Carolina Alvarado, Lisa A Mielke, Marc Pellegrini, Scott N Mueller, Thomas Boudier, Kelly L Rogers, Joanna R Groom

Journal article  |  2021  |  Nature Immunology

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we d..

Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

Yannick O Alexandre, Sapna Devi, Simone L Park, Laura K Mackay, William R Heath, Scott N Mueller

Journal article  |  2020  |  Cell Reports

Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered..

Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo

Raphael Mattiuz, Christian Wohn, Sonia Ghilas, Marc Ambrosini, Yannick O Alexandre, Cindy Sanchez, Anissa Fries, Vu Manh Thien-Phong, Bernard Malissen, Marc Dalod, Karine Crozat

Journal article  |  2018  |  Frontiers in Immunology

Type 1 conventional DCs (cDC1) excel in the cross-priming of CD8+ T cells, which is crucial for orchestrating efficient immune res..

Stromal cell networks coordinate immune response generation and maintenance

Yannick O Alexandre, Scott N Mueller

Journal article  |  2018  |  Immunological Reviews

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay

Journal article  |  2018  |  Nature Immunology

Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

Julia L Gregory, Anne Walter, Yannick O Alexandre, Jyh Liang Hor, Ruijie Liu, Joel Z Ma, Sapna Devi, Nobuko Tokuda, Yuji Owada, Laura K Mackay, Gordon K Smyth, William R Heath, Scott N Mueller

Journal article  |  2017  |  Cell Reports

Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery.

Laurence Ardouin, Hervé Luche, Rabie Chelbi, Sabrina Carpentier, Alaa Shawket, Frédéric Montanana Sanchis, Camille Santa Maria, Pierre Grenot, Yannick Alexandre, Claude Grégoire, Anissa Fries, Thien-Phong Vu Manh, Samira Tamoutounour, Karine Crozat, Elena Tomasello, Audrey Jorquera, Even Fossum, Bjarne Bogen, Hiroaki Azukizawa, Marc Bajenoff, et al.

Journal article  |  2016  |  Immunity

Dendritic cells (DCs) are instrumental in the initiation of T cell responses, but how thymic and peripheral tolerogenic DCs differ..

XCR1( ) dendritic cells promote memory CD8( ) T cell recall upon secondary infections with Listeria monocytogenes or certain viruses

Yannick O Alexandre, Sonia Ghilas, Cindy Sanchez, Agnes Le Bon, Karine Crozat, Marc Dalod

Journal article  |  2016  |  Journal of Experimental Medicine

Naive CD8(+) T cell priming during tumor development or many primary infections requires cross-presentation by XCR1(+) dendritic c..

Deciphering the role of DC subsets in MCMV infection to better understand immune protection against viral infections

Yannick O Alexandre, Clement D Cocita, Sonia Ghilas, Marc Dalod

Journal article  |  2014  |  Frontiers in Microbiology

Infection of mice with murine cytomegalovirus (MCMV) recapitulates many physiopathological characteristics of human CMV infection ..

Plasmacytoid, conventional, and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation.

Thien-Phong Vu Manh, Yannick Alexandre, Thomas Baranek, Karine Crozat, Marc Dalod

Journal article  |  2013  |  European Journal of Immunology

DCs express receptors sensing microbial, danger or cytokine signals, which when triggered in combination drive DC maturation and f..