Michael Gorman

A structural view of PA2G4 isoforms with opposing functions in cancer

Brendan W Stevenson, Michael A Gorman, Jessica Koach, Belamy B Cheung, Glenn M Marshall, Michael W Parker, Jessica K Holien

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The role of proliferation-associated protein 2G4 (PA2G4), alternatively known as ErbB3-binding protein 1 (EBP1), in cancer has bec..

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Jessica Koach, Jessica K Holien, Hassina Massudi, Daniel R Carter, Olivia C Ciampa, Mika Herath, Taylor Lim, Janith A Seneviratne, Giorgio Milazzo, Jayne E Murray, Joshua A McCarroll, Bing Liu, Chelsea Mayoh, Bryce Keenan, Brendan W Stevenson, Michael A Gorman, Jessica L Bell, Larissa Doughty, Stefan Huettelmaier, Andre Oberthuer, et al.

Journal article  |  2019  |  CANCER RESEARCH

MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN pro..

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

Kristin R Wade, Sara L Lawrence, Allison J Farrand, Eileen M Hotze, Michael J Kuiper, Michael A Gorman, Michelle P Christie, Santosh Panjikar, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2019  |  MBIO

The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebra..

Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations

Maryam Molakarimi, Michael A Gorman, Ammar Mohseni, Zaiddodine Pashandi, Majid Taghdir, Hossein Naderi-Manesh, Reza H Sajedi, Michael W Parker

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Bioluminescence of a variety of marine organisms, mostly cnidarians and ctenophores, is carried out by Ca2+-dependent photoprotein..

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

Sarah C Atkinson, Con Dogovski, Kathleen Wood, Michael DW Griffin, Michael A Gorman, Lilian Hor, Cyril F Reboul, Ashley M Buckle, Joachim Wuttke, Michael W Parker, Renwick Cj Dobson, Matthew A Perugini

Journal article  |  2018  |  STRUCTURE

Protein dynamics manifested through structural flexibility play a central role in the function of biological molecules. Here we ex..

QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins

Maryam Molakarimi, Ammar Mohseni, Majid Taghdir, Zaiddodine Pashandi, Michael A Gorman, Michael W Parker, Hossein Naderi-Manesh, Reza H Sajedi

Journal article  |  2017  |  PLOS ONE

Photoproteins are responsible for light emission in a variety of marine ctenophores and coelenterates. The mechanism of light emis..

The GM-CSF Receptor - mechanisms for affinity conversion and signalling

Sophie Elizabeth Broughton, Timothy Hercus, Tracy Nero, Mara Dottore, Barbara McClure, Urmi Dhagat, Houng Taing, Michael Gorman, Angel F Lopez, Michael W Parker

Conference Proceedings  |  2017  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Mara Dottore, Barbara J McClure, Urmi Dhagat, Houng Taing, Michael A Gorman, Jack King-Scott, Angel F Lopez, Michael W Parker

Journal article  |  2016  |  STRUCTURE

The GM-CSF, IL-3, and IL-5 receptors constitute the βc family, playing important roles in inflammation, autoimmunity, and cancer. ..

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

Christopher G Langendorf, Kevin RW Ngoei, John W Scott, Naomi XY Ling, Sam MA Issa, Michael A Gorman, Michael W Parker, Kei Sakamoto, Jonathan S Oakhill, Bruce E Kemp

Journal article  |  2016  |  NATURE COMMUNICATIONS

The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to en..

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

Sara L Lawrence, Susanne C Feil, Craig J Morton, Allison J Farrand, Terrence D Mulhern, Michael A Gorman, Kristin R Wade, Rodney K Tweten, Michael W Parker

Journal article  |  2015  |  SCIENTIFIC REPORTS

Pore-forming proteins are weapons often used by bacterial pathogens to breach the membrane barrier of target cells. Despite their ..