Michael Gorman

Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography

Catherine G Fitzgerald Dickmann, Alexander FF McDonald, Nhi Huynh, Angela Rigopoulos, Zhanqi Liu, Nancy Guo, Laura DD Osellame, Michael AA Gorman, Michael WW Parker, Hui KK Gan, Andrew MM Scott, Uwe Ackermann, Ingrid JG Burvenich, Jonathan MM White

Journal article  |  2023  |  CHEMICAL COMMUNICATIONS

Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. ..

A structural view of PA2G4 isoforms with opposing functions in cancer

Brendan W Stevenson, Michael A Gorman, Jessica Koach, Belamy B Cheung, Glenn M Marshall, Michael W Parker, Jessica K Holien

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The role of proliferation-associated protein 2G4 (PA2G4), alternatively known as ErbB3-binding protein 1 (EBP1), in cancer has bec..

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Jessica Koach, Jessica K Holien, Hassina Massudi, Daniel R Carter, Olivia C Ciampa, Mika Herath, Taylor Lim, Janith A Seneviratne, Giorgio Milazzo, Jayne E Murray, Joshua A McCarroll, Bing Liu, Chelsea Mayoh, Bryce Keenan, Brendan W Stevenson, Michael A Gorman, Jessica L Bell, Larissa Doughty, Stefan Huettelmaier, Andre Oberthuer, et al.

Journal article  |  2019  |  CANCER RESEARCH

MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN pro..

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

Kristin R Wade, Sara L Lawrence, Allison J Farrand, Eileen M Hotze, Michael J Kuiper, Michael A Gorman, Michelle P Christie, Santosh Panjikar, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2019  |  MBIO

The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebra..

Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations

Maryam Molakarimi, Michael A Gorman, Ammar Mohseni, Zaiddodine Pashandi, Majid Taghdir, Hossein Naderi-Manesh, Reza H Sajedi, Michael W Parker

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Bioluminescence of a variety of marine organisms, mostly cnidarians and ctenophores, is carried out by Ca2+-dependent photoprotein..

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

Sarah C Atkinson, Con Dogovski, Kathleen Wood, Michael DW Griffin, Michael A Gorman, Lilian Hor, Cyril F Reboul, Ashley M Buckle, Joachim Wuttke, Michael W Parker, Renwick Cj Dobson, Matthew A Perugini

Journal article  |  2018  |  STRUCTURE

Protein dynamics manifested through structural flexibility play a central role in the function of biological molecules. Here we ex..

QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins

Maryam Molakarimi, Ammar Mohseni, Majid Taghdir, Zaiddodine Pashandi, Michael A Gorman, Michael W Parker, Hossein Naderi-Manesh, Reza H Sajedi

Journal article  |  2017  |  PLOS ONE

Photoproteins are responsible for light emission in a variety of marine ctenophores and coelenterates. The mechanism of light emis..

The GM-CSF Receptor - mechanisms for affinity conversion and signalling

Sophie Elizabeth Broughton, Timothy Hercus, Tracy Nero, Mara Dottore, Barbara McClure, Urmi Dhagat, Houng Taing, Michael Gorman, Angel F Lopez, Michael W Parker

Conference Proceedings  |  2017  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Mara Dottore, Barbara J McClure, Urmi Dhagat, Houng Taing, Michael A Gorman, Jack King-Scott, Angel F Lopez, Michael W Parker

Journal article  |  2016  |  STRUCTURE

The GM-CSF, IL-3, and IL-5 receptors constitute the βc family, playing important roles in inflammation, autoimmunity, and cancer. ..

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

Christopher G Langendorf, Kevin RW Ngoei, John W Scott, Naomi XY Ling, Sam MA Issa, Michael A Gorman, Michael W Parker, Kei Sakamoto, Jonathan S Oakhill, Bruce E Kemp

Journal article  |  2016  |  NATURE COMMUNICATIONS

The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to en..