Michael Gorman

Temporal organization of pineal melatonin signaling in mammals.

Michael R Gorman

Journal article  |  2020  |  Molecular and Cellular Endocrinology

In mammals, the pineal gland is the sole endocrine source of melatonin, which is secreted according to daily and seasonal patterns..

The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function.

Erica C Pandolfi, Joseph A Breuer, Viet Anh Nguyen Huu, Tulasi Talluri, Duong Nguyen, Jessica Sora Lee, Rachael Hu, Kapil Bharti, Dorota Skowronska-Krawczyk, Michael R Gorman, Pamela L Mellon, Hanne M Hoffmann

Journal article  |  2020  |  Molecular Neurobiology

The brain's primary circadian pacemaker, the suprachiasmatic nucleus (SCN), is required to translate day-length and circadian rhyt..

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Jessica Koach, Jessica K Holien, Hassina Massudi, Daniel R Carter, Olivia C Ciampa, Mika Herath, Taylor Lim, Janith A Seneviratne, Giorgio Milazzo, Jayne E Murray, Joshua A McCarroll, Bing Liu, Chelsea Mayoh, Bryce Keenan, Brendan W Stevenson, Michael A Gorman, Jessica L Bell, Larissa Doughty, Stefan Huettelmaier, Andre Oberthuer, et al.

Journal article  |  2019  |  Cancer Research

MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN pro..

Physiological, behavioral and environmental factors influence bifurcated circadian entrainment in mice.

Thijs J Walbeek, Deborah AM Joye, Ila Mishra, Michael R Gorman

Journal article  |  2019  |  Physiology & Behavior

Under permissive conditions, mice and hamsters exposed to a polyphasic light regime consisting of two light and two dark phases ev..

No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis.

Michael McCann, Michael Gorman, Barry McKeown

Journal article  |  2019  |  The Journal of Emergency Medicine

BACKGROUND: Infective endocarditis is associated with significant morbidity and mortality, despite advances in diagnosis and treat..

Why Should We Abolish Daylight Saving Time?

Till Roenneberg, Anna Wirz-Justice, Debra J Skene, Sonia Ancoli-Israel, Kenneth P Wright, Derk-Jan Dijk, Phyllis Zee, Michael R Gorman, Eva C Winnebeck, Elizabeth B Klerman

Journal article  |  2019  |  Journal of Biological Rhythms

Local and national governments around the world are currently considering the elimination of the annual switch to and from Dayligh..

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

Kristin R Wade, Sara L Lawrence, Allison J Farrand, Eileen M Hotze, Michael J Kuiper, Michael A Gorman, Michelle P Christie, Santosh Panjikar, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2019  |  MBIO

The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebra..

Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations

Maryam Molakarimi, Michael A Gorman, Ammar Mohseni, Zaiddodine Pashandi, Majid Taghdir, Hossein Naderi-Manesh, Reza H Sajedi, Michael W Parker

Journal article  |  2019  |  Journal of Biological Chemistry

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

Sarah C Atkinson, Con Dogovski, Kathleen Wood, Michael DW Griffin, Michael A Gorman, Lilian Hor, Cyril F Reboul, Ashley M Buckle, Joachim Wuttke, Michael W Parker, Renwick Cj Dobson, Matthew A Perugini

Journal article  |  2018  |  Structure

QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins

Maryam Molakarimi, Ammar Mohseni, Majid Taghdir, Zaiddodine Pashandi, Michael A Gorman, Michael W Parker, Hossein Naderi-Manesh, Reza H Sajedi

Journal article  |  2017  |  PLOS ONE

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Mara Dottore, Barbara J McClure, Urmi Dhagat, Houng Taing, Michael A Gorman, Jack King-Scott, Angel F Lopez, Michael W Parker

Journal article  |  2016  |  Structure

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

Christopher G Langendorf, Kevin RW Ngoei, John W Scott, Naomi XY Ling, Sam MA Issa, Michael A Gorman, Michael W Parker, Kei Sakamoto, Jonathan S Oakhill, Bruce E Kemp

Journal article  |  2016  |  NATURE COMMUNICATIONS

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

Sara L Lawrence, Susanne C Feil, Craig J Morton, Allison J Farrand, Terrence D Mulhern, Michael A Gorman, Kristin R Wade, Rodney K Tweten, Michael W Parker

Journal article  |  2015  |  SCIENTIFIC REPORTS

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

Jesse I Mobbs, Ann Koay, Alex Di Paolo, Michael Bieri, Emma J Petrie, Michael A Gorman, Larissa Doughty, Michael W Parker, David I Stapleton, Michael DW Griffin, Paul R Gooley

Journal article  |  2015  |  Biochemical Journal

Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health

Michael A Gorman, Christine A Seers, Belinda J Michell, Susanne C Feil, N Laila Huq, Keith J Cross, Eric C Reynolds, Michael W Parker

Journal article  |  2015  |  Protein Science

From Knock-Out Phenotype to Three-Dimensional Structure of a Promising Antibiotic Target from Streptococcus pneumoniae

Con Dogovski, Michael A Gorman, Natalia E Ketaren, Judy Praszkier, Leanne M Zammit, Haydyn D Mertens, Gary Bryant, Ji Yang, Michael DW Griffin, F Grant Pearce, Juliet A Gerrard, Geoffrey B Jameson, Michael W Parker, Roy M Robins-Browne, Matthew A Perugini

Journal article  |  2013  |  PLoS One

Crystal structure of the Leishmania major MIX protein: A scaffold protein that mediates protein-protein interactions

Michael A Gorman, Alex D Uboldi, Peter J Walsh, Kher Shing Tan, Guido Hansen, Trevor Huyton, Hong Ji, Joan Curtis, Lukasz Kedzierski, Anthony T Papenfuss, Con Dogovski, Matthew A Perugini, Richard J Simpson, Emanuela Handman, Michael W Parker

Journal article  |  2011  |  Protein Science

Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase

Natalie J Gunn, Michael A Gorman, Renwick CJ Dobson, Michael W Parker, Terrence D Mulhern

Journal article  |  2011  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Recognition and Detoxification of the Insecticide DDT by Drosophila melanogaster Glutathione S-Transferase D1

Wai Yee Low, Susanne C Feil, Hooi Ling Ng, Michael A Gorman, Craig J Morton, James Pyke, Malcolm J McConville, Michael Bieri, Yee-Foong Mok, Charles Robin, Paul R Gooley, Michael W Parker, Philip Batterham

Journal article  |  2010  |  Journal of Molecular Biology

Proteins Membrane Binding and Pore Formation Introduction

Susanne C Feil, Galina Polekhina, Michael A Gorman, Michael W Parker

Book Chapter  |  2010  |  Advances in Experimental Medicine and Biology

Advances in Experimental Medicine and Biology: Introduction

SC Feil, G Polekhina, MA Gorman, MW Parker

Book  |  2010  |  Advances in Experimental Medicine and Biology

Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

Sudhir Dommaraju, Michael A Gorman, Con Dogovski, F Grant Pearce, Juliet A Gerrard, Renwick CJ Dobson, Michael W Parker, Matthew A Perugini

Journal article  |  2010  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae

Natalia E Sibarani, Michael A Gorman, Con Dogovski, Michael W Parker, Matthew A Perugini

Journal article  |  2010  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Crystallization and preliminary X-ray analysis of glutathione transferases from cyanobacteria

Susanne C Feil, Julian Tang, Guido Hansen, Michael A Gorman, Eric Wiktelius, Gun Stenberg, Michael W Parker

Journal article  |  2009  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate

Sarah C Atkinson, Renwick CJ Dobson, Janet M Newman, Michael A Gorman, Con Dogovski, Michael W Parker, Matthew A Perugini

Journal article  |  2009  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum

Renwick CJ Dobson, Sarah C Atkinson, Michael A Gorman, Janet M Newman, Michael W Parker, Matthew A Perugini

Journal article  |  2008  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Structure of the Janus protein human CLIC2

Brett A Cromer, Michael A Gorman, Guido Hansen, Julian J Adams, Marjorie Coggan, Dene R Littler, Louise J Brown, Michele Mazzanti, Samuel N Breit, Paul MG Curmi, Angela F Dulhunty, Philip G Board, Michael W Parker

Journal article  |  2007  |  Journal of Molecular Biology

Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2)

Brett A Cromer, Michael A Gorman, Guido Hansen, Julian J Adams, Marjorie Coggan, Philip G Board, Michael W Parker

Journal article  |  2007  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Crystal structure of the mitochondrial chaperone TIM9 center dot 10 reveals a six-bladed alpha-propeller

CT Webb, MA Gorman, M Lazarou, MT Ryan, JM Gulbis

Journal article  |  2006  |  Molecular Cell

Structure of the AAA ATPase p97.

X Zhang, A Shaw, PA Bates, RH Newman, B Gowen, E Orlova, MA Gorman, H Kondo, P Dokurno, J Lally, G Leonard, H Meyer, M van Heel, PS Freemont

Journal article  |  2000  |  Molecular Cell

p97, an abundant hexameric ATPase of the AAA family, is involved in homotypic membrane fusion. It is thought to disassemble SNARE ..

Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.

DG Rothwell, B Hang, MA Gorman, PS Freemont, B Singer, ID Hickson

Journal article  |  2000  |  Nucleic Acids Research

HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells. Previous structural studies ha..

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.

MA Gorman, S Morera, DG Rothwell, E de La Fortelle, CD Mol, JA Tainer, ID Hickson, PS Freemont

Journal article  |  1997  |  The EMBO Journal

The structure of the major human apurinic/ apyrimidinic endonuclease (HAP1) has been solved at 2.2 A resolution. The enzyme consis..

Effects of pancreatic spasmolytic Polypeptide (PSP) on epithelial cell function.

WR Otto, J Rao, HM Cox, E Kotzian, CY Lee, RA Goodlad, A Lane, M Gorman, PA Freemont, HF Hansen, D Pappin, NA Wright

Journal article  |  1996  |  European Journal of Biochemistry

Trefoil peptides are expressed near endodermal ulcerations and may modulate epithelial repair. The trefoil pancreatic spasmolytic ..

Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors.

A De, DG Brown, MA Gorman, M Carr, MR Sanderson, PS Freemont

Journal article  |  1994  |  Proceedings of the National Academy of Sciences

Porcine pancreatic spasmolytic polypeptide (PSP) belongs to a large family of homologous growth factor-like polypeptides character..

Crystallization and preliminary X-ray diffraction studies of pancreatic spasmolytic polypeptide.

MA Gorman, A De, PS Freemont

Journal article  |  1992  |  Journal of Molecular Biology

Pancreatic spasmolytic polypeptide (PSP) isolated from porcine pancreas has been crystallized by the hanging drop vapour diffusion..

Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells.

J Edgeworth, M Gorman, R Bennett, P Freemont, N Hogg

Journal article  |  1991  |  Journal of Biological Chemistry

In this report we describe the biochemical characterization of neutrophil and monocyte p8 and p14. Together the two proteins compr..