Prof Natalie Sims

Professor Sims is Head of the Bone Cell Biology and Disease Unit at St. Vincent's Institute of Medical Research, where she is also the Deputy Director, and is a Professorial Fellow at The University of Melbourne.

She completed her PhD at the University of Adelaide in 1995, followed by postdoctoral work at the Garvan Institute (Sydney) and Yale School of Medicine (Connecticut, USA).

Her laboratory studies the cellular interactions responsible for development, maintenance and strength of the skeleton, and has defined the roles of a number of key pathways, including the IL-6 family of cytokines and estrogen receptor isoforms in bone through the use of genetically altered mouse models and in vitro systems.

Her work has been recognised by the American Society of Bone and Mineral Research Fuller Albright Award (2010) and the International Bone and Mineral Society Herbert A Fleisch Award (2013), and was appointed a Fellow of the American Society of Bone and Mineral Research (2018).

She is an Associate Editor of the Journal of Bone and Mineral Research, and at Endocrine Reviews, and she serves on the Editorial Board of the Journal of Biological Chemistry. She is President-Elect of the Australia and New Zealand Bone and Mineral Society.

Find out more about Natalie Sims' experience

Natalie Sims' highlights

FEATURED Journal article

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Natalie Sims' selected work

Novel Mechanisms For Control Of Osteoclastogenesis In Bone And Joint Disease

Research Grant

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanis..

Journal article

Truncating Mutations in Recq14 Cause a Low Bone Mass Phenotype, but Not Osteosarcoma

Conference Proceedings

Truncating Mutations in Recql4 Cause a Low Bone Mass Phenotype, but Not Osteosarcoma

Conference Proceedings

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary..

Journal article

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persisten..

Journal article

Projects

Displaying the most recent project by Natalie Sims.

Novel Mechanisms For Control Of Osteoclastogenesis In Bone And Joint Disease

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Projects

Project Types

Research Grant

Scholarly Works

Displaying the 274 most recent scholarly works by Natalie Sims.

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article | 2020 | eLife

Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, ..

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

Natalie A Sims, T John Martin

Journal article | 2020 | Annual Review of Physiology

Bone remodeling is essential for the repair and replacement of damaged and old bone. The major principle underlying this process i..

Truncating Mutations in Recq14 Cause a Low Bone Mass Phenotype, but Not Osteosarcoma

Wilson Castillo-Tandazo, Monique Smeets, Natalie Sims, Carl Walkley

Conference Proceedings | 2019 | JOURNAL OF BONE AND MINERAL RESEARCH

Truncating Mutations in Recql4 Cause a Low Bone Mass Phenotype, but Not Osteosarcoma

Wilson Castillo-Tandazo, Monique Smeets, Natalie Sims, Carl Walkley

Conference Proceedings | 2019 | JOURNAL OF BONE AND MINERAL RESEARCH

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (vol 10, 3436, 2019)

Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims

Journal article | 2019 | Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

Patricia WM Ho, Audrey S Chan, Nathan J Pavlos, Natalie A Sims, T John Martin

Journal article | 2019 | Biochemical Pharmacology

Parathyroid hormone (PTH)-related protein (PTHrP) (gene name Pthlh) was discovered as the factor responsible for the humoral hyper..

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs

SJ Gauci, SB Golub, L Tatarczuch, E Lee, D Chan, NC Walsh, CB Little, H Stanton, Z Lokmic, NA Sims, EJ Mackie, AJ Fosang

Journal article | 2019 | Matrix Biology

Cartilage remodelling and chondrocyte differentiation are tightly linked to angiogenesis during bone development and endochondral ..

Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling

X Liu, AA D'Cruz, J Hansen, BA Croker, KE Lawlor, NA Sims, IP Wicks

Journal article | 2019 | Osteoarthritis and Cartilage

OBJECTIVE: To investigate the impact of deleting Suppressor of Cytokine Signaling (SOCS)-3 (SOCS3) in chondrocytes during murine s..

Cellular Processes by Which Osteoblasts and Osteocytes Control Bone Mineral Deposition and Maturation Revealed by Stage-Specific EphrinB2 Knockdown.

Martha Blank, Natalie A Sims

Journal article | 2019 | Current Osteoporosis Reports

PURPOSE OF REVIEW: We outline the diverse processes contributing to bone mineralization and bone matrix maturation by describing t..

Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche

Huimin Cao, Benjamin Cao, Chad K Heazlewood, Melanie Domingues, Xuan Sun, Emmanuel Debele, Narelle E McGregor, Natalie A Sims, Shen Y Heazlewood, Susan K Nilsson

Journal article | 2019 | Cells

Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia

Ashleigh King, Nicolas C Hoch, Narelle E McGregor, Natalie A Sims, Ian M Smyth, Jorg Heierhorst

Journal article | 2019 | Human Molecular Genetics

Mutations in subunits of the cilia-specific cytoplasmic Dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs..

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Christina Vrahnas, Martha Blank, Toby A Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwinl, Nguyen Huynh, Mark R Forwood, Yifang Hu, Mika Ikegame, Keith R Bambery, Cyril Petibois, Eleanor J Mackie, Mark J Tobin, Gordon K Smyth, Jonathan S Oakhill, T John Martin, Natalie A Sims

Journal article | 2019 | Nature Communications

Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralizatio..

IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis

Narelle E McGregor, Melissa Murat, Jeevithan Elango, Ingrid J Poulton, Emma C Walker, Blessing Crimeen-Irwin, Patricia WM Ho, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article | 2019 | Journal of Biological Chemistry

Effect of rapamycin on bone mass and strength in the alpha 2(I)-G610C mouse model of osteogenesis imperfecta

John F Bateman, Lisa Sampurno, Antonio Maurizi, Shireen R Lamande, Natalie A Sims, Tegan L Cheng, Aaron Schindeler, David G Little

Journal article | 2019 | Journal of Cellular and Molecular Medicine

Overcoming natural Wnt inhibition to optimize therapy

Natalie A Sims

Journal article | 2019 | Nature Reviews Rheumatology

Local regulators of bone: Interleukin-1, tumor necrosis factor, interferons, the IL-6 family, and additional cytokines

NA Sims, JA Lorenzo

Book Chapter | 2019

Isolation, Purification, Generation, and Culture of Osteocytes.

Jonathan H Gooi, Ling Yeong Chia, Christina Vrahnas, Natalie A Sims

Journal article | 2019 | Methods in molecular biology (Clifton, N.J.)

Osteocytes reside within bone matrix and produce both paracrine and endocrine factors that influence the skeleton and other tissue..

Coupling of bone formation and resorption

NA Sims, TJ Martin

Book Chapter | 2019

Paracrine parathyroid hormone-related protein in bone: Physiology and pharmacology

TJ Martin, NA Sims

Book Chapter | 2019

The osteoblast lineage: Its actions and communication mechanisms

NA Sims, TJ Martin

Book Chapter | 2019

Retinoic Acid Receptor gamma Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis

Alanna C Green, Victoria Rudolph-Stringer, Lenny Straszkowski, Gavin Tjin, Blessing Crimeen-Irwin, Mannu Walia, T John Martin, Natalie A Sims, Louise E Purton

Journal article | 2018 | Journal of Bone and Mineral Research

Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits

Christina Vrahnas, Pascal R Buenzli, Thomas A Pearson, Brenda L Pennypacker, Mark J Tobin, Keith R Bambery, Le T Duong, Natalie A Sims

Journal article | 2018 | Calcified Tissue International

The C-terminal domain of PTHrP limits PTH receptor-mediated changes in gene expression in osteocytes

Yao Sun, Patricia WM Ho, Rachelle W Johnson, T John Martin, Natalie A Sims

Conference Proceedings | 2018 | JOURNAL OF BONE AND MINERAL RESEARCH

Oncostatin M is a key effector of heterotopic ossification following spinal cord injuries

Hsu-Wen Tseng, Kylie Alexander, Irina Kulina, Marjorie Salga, Beulah Jose, Francois Genet, Frederic Torossian, Bernadette Guerton, Adrienne Anginot, Whitney Fleming, Susan Millard, Allison Pettit, Natalie Sims, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdiles, Jean Pierre Levesque

Conference Proceedings | 2018 | JOURNAL OF BONE AND MINERAL RESEARCH

Bone corticalisation requires suppression of glycoprotein 130 signalling in osteocytes, and occurs by region-specific imbalances in bone formation and resorption

Emma Walker, Kim Truong, Narelle Mcgregor, T John Martin, Natalie A Sims

Conference Proceedings | 2018 | JOURNAL OF BONE AND MINERAL RESEARCH

Bone strength and mineralization are regulated independently of bone mass by ephrinB2-dependent autophagic processes in osteocytes

Vrahnas Christina, Toby Dite, Yifang Hu, Nguyen Huynh, Mark R Forwood, Keith R Bambery, Mark J Tobin, Gordon K Smyth, T John Martin, Natalie A Sims

Conference Proceedings | 2018 | JOURNAL OF BONE AND MINERAL RESEARCH

IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy

Leah Lazzaro, Brett A Tonkin, Ingrid J Poulton, Narelle E McGregor, Walter Ferlin, Natalie A Sims

Journal article | 2018 | Bone

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease

Evelyn Tsantikos, Maverick Lau, Cassandra MN Castelino, Mhairi J Maxwell, Samantha L Passey, Michelle J Hansen, Narelle E McGregor, Natalie A Sims, Daniel P Steinfort, Louis B Irving, Gary P Anderson, Margaret L Hibbs

Journal article | 2018 | Journal of Clinical Investigation

Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner

Rachelle W Johnson, Yao Sun, Patricia WM Ho, Audrey SM Chan, Jasmine A Johnson, Nathan J Pavlos, Natalie A Sims, T John Martin

Journal article | 2018 | FRONTIERS IN ENDOCRINOLOGY

Biomechanical testing of the calcified metacarpal articular surface and its association with subchondral bone microstructure in Thoroughbred racehorses

AJ Williamson, NA Sims, CDL Thomas, PVS Lee, MA Stevenson, RC Whitton

Journal article | 2018 | Equine Veterinary Journal

Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms

Jean-Pierre Levesque, Natalie A Sims, Allison R Pettit, Kylie A Alexander, Hsu-Wen Tseng, Frederic Torossian, Francois Genet, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdiles

Journal article | 2018 | Journal of Bone and Mineral Research

Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice

Steven Maltby, Alyssa J Lochrin, Bianca Bartlett, Hock L Tay, Jessica Weaver, Ingrid J Poulton, Maximilian W Plank, Helene F Rosenberg, Natalie A Sims, Paul S Foster

Journal article | 2018 | The Journal of Immunology

Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post-lactation Bone Recovery in Cyp27b1 Null Mice

Brittany R Gillies, Brittany A Ryan, Brett A Tonkin, Ingrid J Poulton, Yue Ma, Beth J Kirby, Rene St-Arnaud, Natalie A Sims, Christopher S Kovacs

Journal article | 2018 | Journal of Bone and Mineral Research

Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein

Niloufar Ansari, Patricia WM Ho, Blessing Crimeen-Irwin, Ingrid J Poulton, Athena R Brunt, Mark R Forwood, Paola Divieti Pajevic, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article | 2018 | Journal of Bone and Mineral Research

Integrating Endocrine and Paracrine Influences on Bone; Lessons From Parathyroid Hormone and Parathyroid Hormone-Related Protein

T John Martin, NA Sims

Book Chapter | 2018

Adolescent Inhalant Abuse Results in Adrenal Dysfunction and a Hypermetabolic Phenotype with Persistent Growth Impairments

Rose Crossin, Zane B Andrews, Natalie A Sims, Terence Pang, Michael Mathai, Jonathan H Gooi, Aneta Stefanidis, Brian J Oldfield, Andrew J Lawrence, Jhodie R Duncan

Journal article | 2018 | Neuroendocrinology

Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications

Frederic Torossian, Bernadette Guerton, Adrienne Anginot, Kylie A Alexander, Christophe Desterke, Sabrina Soave, Hsu-Wen Tseng, Nassim Arouche, Laetitia Boutin, Irina Kulina, Marjorie Salga, Beulah Jose, Allison R Pettit, Denis Clay, Nathalie Rochet, Erica Vlachos, Guillaume Genet, Charlotte Debaud, Philippe Denormandie, Francois Genet, et al.

Journal article | 2017 | JCI Insight

Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6

Dae-Chul Cho, Holly J Brennan, Rachelle W Johnson, Ingrid J Poulton, Jonathan H Gooi, Brett A Tonkin, Narelle E McGregor, Emma C Walker, David J Handelsman, TJ Martin, Natalie A Sims

Journal article | 2017 | NATURE COMMUNICATIONS

High dose dietary vitamin D3 increases bone mass and strength in mice.

Liam Williamson, Alan Hayes, Erik D Hanson, Peter Pivonka, Natalie A Sims, Jonathan H Gooi

Journal article | 2017 | Bone Rep

Vitamin D plays a critical role in skeletal homeostasis. Vitamin D supplementation is used worldwide to maintain optimal bone heal..

Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation

Christina Vrahnas, Thomas A Pearson, Athena R Brunt, Mark R Forwood, Keith R Bambery, Mark J Tobin, T John Martin, Natalie A Sims

Journal article | 2016 | Bone

Senescent Osteocytes: Do They Cause Damage and Can They Be Targeted to Preserve the Skeleton?

Natalie A Sims

Journal article | 2016 | Journal of Bone and Mineral Research

Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass

Emma C Walker, Rachelle W Johnson, Yifang Hu, Holly J Brennan, Ingrid J Poulton, Jian-Guo Zhang, Brendan J Jenkins, Gordon K Smyth, Nicos A Nicola, Natalie A Sims

Journal article | 2016 | Journal of Biological Chemistry

Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption

Natalie A Sims

Journal article | 2016 | The International Journal of Biochemistry & Cell Biology

Response to "Letter to the Editor. On osteocyte density in the human body"

Pascal R Buenzli, Natalie A Sims

Journal article | 2016 | Bone

Prepubertal Di-n-Butyl Phthalate Exposure Alters Sertoli and Leydig Cell Function and Lowers Bone Density in Adult Male Mice

Amanda Bielanowicz, Rachelle W Johnson, Hoey Goh, Sarah C Moody, Ingrid J Poulton, Nic Croce, Kate L Loveland, Mark P Hedger, Natalie A Sims, Catherine Itman

Journal article | 2016 | Endocrinology

VPS35: Two Ways to Recycle the Parathyroid Hormone Receptor (PTH1R) in Osteoblasts

Natalie A Sims

Journal article | 2016 | EBIOMEDICINE

Does anti-sclerostin therapy promote inflammation in rheumatoid arthritis?

Natalie A Sims

Journal article | 2016 | Nature Reviews Endocrinology

Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification

Stephen Tonna, Ingrid J Poulton, Farzin Taykar, Patricia WM Ho, Brett Tonkin, Blessing Crimeen-Irwin, Liliana Tatarczuch, Narelle E McGregor, Eleanor J Mackie, T John Martin, Natalie A Sims

Journal article | 2016 | Development

Loss of G(s)alpha in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy

Partha Sinha, Piia Aarnisalo, Rhiannon Chubb, Ingrid J Poulton, Jun Guo, Gregory Nachtrab, Takaharu Kimura, Srilatha Swami, Hamid Saeed, Min Chen, Lee S Weinstein, Ernestina Schipani, Natalie A Sims, Henry M Kronenberg, Joy Y Wu

Journal article | 2016 | Journal of Biological Chemistry

The effect of sex steroids on osteoclast function

K Henriksen, NA Sims, LB Tankó, MA Karsdal

Book Chapter | 2016

Coupling: The Influences of Immune and Bone Cells

Natalie A Sims, John Martin, Julian MW Quinn

Book Chapter | 2016

Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection (vol 89, pg 581, 2015)

Weiqiang Chen, Suan-Sin Foo, Adam Taylor, Aleksei Lulla, Andres Merits, Linda Hueston, Mark R Forwood, Nicole C Walsh, Natalie A Sims, Lara J Herrero, Suresh Mahalingam

Journal article | 2015 | Journal of Virology

Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone

Rachelle W Johnson, Narelle E McGregor, Holly J Brennan, Blessing Crimeen-Irwin, Ingrid J Poulton, T John Martin, Natalie A Sims

Journal article | 2015 | Bone

EphrinB2 Signalling in Osteoblast Differentiation, Bone Formation and Endochondral Ossification

Christina Vrahnas, Natalie A Sims

Journal article | 2015 | Current Molecular Biology Reports

Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?

Natalie A Sims, Evange Romas

Journal article | 2015 | ARTHRITIS RESEARCH & THERAPY

Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders

Natalie A Sims

Journal article | 2015 | Cytokine & Growth Factor Reviews

Quantifying the osteocyte network in the human skeleton

Pascal R Buenzli, Natalie A Sims

Journal article | 2015 | Bone

RAR gamma is a negative regulator of osteoclastogenesis

Alanna C Green, Ingrid J Poulton, Christina Vrahnas, Karl D Haeusler, Carl R Walkley, Joy Y Wu, T John Martin, Matthew T Gillespie, Roshantha AS Chandraratna, Julian MW Quinn, Natalie A Sims, Louise E Purton

Journal article | 2015 | The Journal of Steroid Biochemistry and Molecular Biology

RANKL/OPG; Critical role in bone physiology

T John Martin, Natalie A Sims

Journal article | 2015 | Reviews in Endocrine and Metabolic Disorders

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle

Francois Genet, Irina Kulina, Cedryck Vaquette, Frederic Torossian, Susan Millard, Allison R Pettit, Natalie A Sims, Adrienne Anginot, Bernadette Guerton, Ingrid G Winkler, Valerie Barbier, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdiles, Dietmar W Hutmacher, Jean-Pierre Levesque

Journal article | 2015 | The Journal of Pathology

Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model

Q Liu, J Zhao, R Tan, H Zhou, Z Lin, M Zheng, E Romas, J Xu, NA Sims

Journal article | 2015 | Scandinavian Journal of Rheumatology

Ubiquitous expression of the Pik3ca(H1047R) mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly

Kathryn M Kinross, Karen G Montgomery, Salvatore P Mangiafico, Lauren M Hare, Margarete Kleinschmidt, Megan J Bywater, Ingrid J Poulton, Christina Vrahnas, Holger Henneicke, Jordane Malaterre, Paul M Waring, Carleen Cullinane, Natalie A Sims, Grant A McArthur, Sofianos Andrikopoulos, Wayne A Phillips

Journal article | 2015 | FASEB JOURNAL

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

Alvin JM Ng, Mannu K Walia, Monique F Smeets, Anthony J Mutsaers, Natalie A Sims, Louise E Purton, Nicole C Walsh, T John Martin, Carl R Walkley

Journal article | 2015 | PLOS GENETICS

Coupling signals between the osteoclast and osteoblast how are messages transmitted between these temporary visitors to the bone surface?

Natalie A Sims, T John Martin

Journal article | 2015 | FRONTIERS IN ENDOCRINOLOGY

Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes

Ling Yeong Chia, Nicole C Walsh, T John Martin, Natalie A Sims

Journal article | 2015 | Bone

Calcitonin Physiology, Saved by a Lysophospholipid

T John Martin, Natalie A Sims

Journal article | 2015 | Journal of Bone and Mineral Research

Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

Weiqiang Chen, Suan-Sin Foo, Adam Taylor, Aleksei Lulla, Andres Merits, Linda Hueston, Mark R Forwood, Nicole C Walsh, Natalie A Sims, Lara J Herrero, Suresh Mahalingam

Journal article | 2015 | Journal of Virology

Arthritogenic alphaviruses: new insights into arthritis and bone pathology.

Weiqiang Chen, Suan-Sin Foo, Natalie A Sims, Lara J Herrero, Nicole C Walsh, Suresh Mahalingam

Journal article | 2015 | Trends in Microbiology

Arthritogenic alphaviral infection begins as a febrile illness and often progresses to joint pain and rheumatic symptoms that are ..

Arthritogenic alphaviruses: new insights into arthritis and bone pathology

Weiqiang Chen, Suan-Sin Foo, Natalie A Sims, Lara J Herrero, Nicole C Walsh, Suresh Mahalingam

Journal article | 2015 | TRENDS IN MICROBIOLOGY

Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts

Natalie A Sims, Christina Vrahnas

Journal article | 2014 | Archives of Biochemistry and Biophysics

gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation

Therese Standal, Rachelle W Johnson, Narelle E McGregor, Ingrid J Poulton, Patricia WM Ho, T John Martin, Natalie A Sims

Journal article | 2014 | Journal of Endocrinology

EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis

Stephen Tonna, Farzin M Takyar, Christina Vrahnas, Blessing Crimeen-Irwin, Patricia WM Ho, Ingrid J Poulton, Holly J Brennan, Narelle E McGregor, Elizabeth H Allan, Huynh Nguyen, Mark R Forwood, Liliana Tatarczuch, Eleanor J Mackie, T John Martin, Natalie AZ Sims

Journal article | 2014 | The FASEB Journal

Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts

Benoit Le Goff, Sofie Singbrant, Brett A Tonkin, T John Martin, Evange Romas, Natalie A Sims, Nicole C Walsh

Journal article | 2014 | Cytokine

Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation

Rachelle W Johnson, Jason D White, Emma C Walker, T John Martin, Natalie A Sims

Journal article | 2014 | Bone

UThe Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation

Rachelle W Johnson, Holly J Brennan, Christina Vrahnas, Ingrid J Poulton, Narelle E McGregor, Therese Standal, Emma C Walker, Thuan-Tzen Koh, Huynh Nguyen, Nicole C Walsh, Mark R Forwood, T John Martin, Natalie A Sims

Journal article | 2014 | Journal of Bone and Mineral Research

Decline in calcitonin receptor expression in osteocytes with age

Jonathan H Gooi, Ling Yeong Chia, Nicole C Walsh, Morten A Karsdal, Julian MW Quinn, T John Martin, Natalie A Sims

Journal article | 2014 | JOURNAL OF ENDOCRINOLOGY

Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss

Weiqiang Chen, Suan-Sin Foo, Nestor E Rulli, Adam Taylor, Kuo-Ching Sheng, Lara J Herrero, Belinda L Herring, Brett A Lidbury, Rachel W Li, Nicole C Walsh, Natalie A Sims, Paul N Smith, Suresh Mahalingam

Journal article | 2014 | Proceedings of the National Academy of Sciences

OSTEOCYTE CELL DEATH IN SUBCHONDRAL BONE FOLLOWING JOINT INJURY CORRELATES WITH THE SEVERITY OF AGGRECAN LOSS IN OVERLYING CARTILAGE

BA Tonkin, N Jansz, E Romas, NA Sims, NC Walsh

Conference Proceedings | 2014 | Osteoarthritis and Cartilage

MICE LACKING ONCOSTATIN M RECEPTOR EXPRESSION SHOW REDUCED SYNOVIAL INFLAMMATION AND CARTILAGE DAMAGE, BUT INCREASED BONE LOSS IN RESPONSE TO JOINT INJURY

BA Tonkin, N Jansz, J Johnson, E Romas, NA Sims, NC Walsh

Conference Proceedings | 2014 | Osteoarthritis and Cartilage

Implications of Osteoblast-Osteoclast Interactions in the Management of Osteoporosis by Antiresorptive Agents Denosumab and Odanacatib

Natalie A Sims, Kong Wah Ng

Journal article | 2014 | Current Osteoporosis Reports

Deletion of ephrinB2 in osteocytes leads to increased trabecular bone mass, but reduced bone strength.

Christina Vrahnas, Stephen Tonna, Nguyen Huynh, Mark Forwood, T John Martin, Natalie Sims

Conference Proceedings | 2014 | JOURNAL OF BONE AND MINERAL RESEARCH

Subchondral Bone Health is Compromised in Post-Traumatic Osteoarthritis.

Brett Tonkin, Natasha Jansz, Evange Romas, Natalie Sims, Nicole Walsh

Conference Proceedings | 2014 | JOURNAL OF BONE AND MINERAL RESEARCH

Isolation of a hematopoietic cell-free preparation of highly purified DMP1-GFP osteocytes using fluorescence activated cell sorting (FACS)

Ling Yeong Chia, Nicole Walsh, T John Martin, Natalie Sims

Conference Proceedings | 2014 | JOURNAL OF BONE AND MINERAL RESEARCH

Prolonging JAK/STAT signaling by deletion of osteocytic SOCS3 results in a profound sex-divergent change in trabecular bone mass

Holly Brennan, Rachelle Johnson, Emma Walker, Gordon Smyth, Nicos Nicola, T John Martin, Natalie Sims

Conference Proceedings | 2014 | JOURNAL OF BONE AND MINERAL RESEARCH

Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit.

Natalie A Sims, T John Martin

Journal article | 2014 | BoneKEy Reports

Coupling between bone formation and bone resorption refers to the process within basic multicellular units in which resorption by ..

Erratum to: Cell–Cell Signaling: Broadening Our View of the Basic Multicellular Unit (Calcif Tissue Int, 10.1007/s00223-013-9766-y)

N Sims, R Civitelli

Journal article | 2014 | Calcified Tissue International

Osteoimmunology: oncostatin M as a pleiotropic regulator of bone formation and resorption in health and disease.

Natalie A Sims, Julian MW Quinn

Journal article | 2014 | BoneKEy Reports

Bone remodeling in health and disease is carried out by osteoblasts and osteoclasts, which respectively produce bone matrix and re..

Cell-Cell Signaling: Broadening Our View of the Basic Multicellular Unit

Natalie A Sims, Roberto Civitelli

Journal article | 2014 | Calcified Tissue International

Talking among Ourselves: Paracrine Control of Bone Formation within the Osteoblast Lineage

Stephen Tonna, Natalie A Sims

Journal article | 2014 | Calcified Tissue International

Ciliary Neurotrophic Factor Inhibits Bone Formation and Plays a Sex-Specific Role in Bone Growth and Remodeling (vol 86, pg 261, 2010)

Narelle E McGregor, Ingrid J Poulton, Emma C Walker, Sueli Pompolo, Julian MW Quinn, T John Martin, Natalie A Sims

Journal article | 2013 | Calcified Tissue International

EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone

Farzin M Takyar, Stephen Tonna, Patricia WM Ho, Blessing Crimeen-Irwin, Emma K Baker, T John Martin, Natalie A Sims

Journal article | 2013 | Journal of Bone and Mineral Research

EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair

Agnieszka Arthur, Romana A Panagopoulos, Lachlan Cooper, Danijela Menicanin, Ian H Parkinson, John D Codrington, Kate Vandyke, Andrew CW Zannettino, Simon A Koblar, Natalie A Sims, Koichi Matsuo, Stan Gronthos

Journal article | 2013 | Journal of Bone and Mineral Research

Lactating Ctcgrp Nulls Lose Twice the Normal Bone Mineral Content due to Fewer Osteoblasts and More Osteoclasts, Whereas Bone Mass Is Fully Restored After Weaning in Association With Up-Regulation of Wnt Signaling and Other Novel Genes

Jillian N Collins, Beth J Kirby, Janine P Woodrow, Robert F Gagel, Clifford J Rosen, Natalie A Sims, Christopher S Kovacs

Journal article | 2013 | Endocrinology

FOCAL CHANGES IN TIBIAL BONE STRUCTURE AND OSTEOCYTE INTEGRITY IN A MOUSE SURGICAL MODEL OF OSTEOARTHRITIS

BA Tonkin, N Jansz, E Romas, NA Sims, NC Walsh

Conference Proceedings | 2013 | Osteoarthritis and Cartilage

Deletion of gp130 in Osteocytes Blocks PTH Anabolic Effect

Therese Standal, Therese Standal, Rachelle Johnson, Narelle McGregor, T John Martin, Natalie Sims

Conference Proceedings | 2013 | JOURNAL OF BONE AND MINERAL RESEARCH

EphrinB2 reverse signaling in osteoblasts is required for normal bone material strength and increased bone formation in response to parathyroid hormone (PTH)

Farzin Takyar, Christina Vrahnas, Stephen Tonna, Blessing Crimeen-Irwin, Patricia Ho, TJ Martin, Natalie Sims

Conference Proceedings | 2013 | JOURNAL OF BONE AND MINERAL RESEARCH

Deletion of the Glycoprotein130 Co-Receptor in Osteoclasts Reduces Cortical Bone Formation

Rachelle Johnson, Narelle McGregor, Holly Brennan, Ingrid Poulton, T John Martin, Natalie Sims

Conference Proceedings | 2013 | JOURNAL OF BONE AND MINERAL RESEARCH

EphrinB2/EphB4 control of osteoclast formation is mediated by the osteoblast lineage

Stephen Tonna, Farzin Takyar, Blessing Crimeen-Irwin, Patricia Ho, T John Martin, Natalie Sims

Conference Proceedings | 2013 | JOURNAL OF BONE AND MINERAL RESEARCH

Intermittent PTH Increases Bone Formation but Not Bone Mass in Osteopenic Mice Lacking Gsa in Osteoblasts

Rhiannon Chubb, Partha Sinha, Piia Aarnisalo, Rachelle Johnson, Ingrid Poulton, Min Chen, Lee Weinstein, Natalie Sims, Henry Kronenberg, Joy Wu

Conference Proceedings | 2013 | JOURNAL OF BONE AND MINERAL RESEARCH

Prospective Histomorphometric and DXA Evaluation of Bone Remodeling in Imatinib-Treated CML Patients: Evidence for Site-Specific Skeletal Effects

Kate Vandyke, Stephen Fitter, Jenny Drew, Seiji Fukumoto, Christopher G Schultz, Natalie A Sims, David T Yeung, Timothy P Hughes, Andrew CW Zannettino

Journal article | 2013 | The Journal of Clinical Endocrinology & Metabolism

Delayed development of specific thyroid hormone-regulated events in transthyretin null mice

Julie A Monk, Natalie A Sims, Katarzyna M Dziegielewska, Roy E Weiss, Robert G Ramsay, Samantha J Richardson

Journal article | 2013 | American Journal of Physiology - Endocrinology and Metabolism

Integrating Endocrine and Paracrine Influences on Bone: Lessons from Parathyroid Hormone and Parathyroid Hormone-related Protein

T John Martin, Natalie A Sims

Book Chapter | 2013

Basic Principles of Bone Cell Biology

T John Martin, Kong Wah Ng, Natalie A Sims

Book Chapter | 2013

Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis

Brett A Tonkin, Evange Romas, Natalie A Sims, Nicole C Walsh

Conference Proceedings | 2012 | ARTHRITIS AND RHEUMATISM

Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation

IG Winkler, AR Pettit, LJ Raggatt, RN Jacobsen, CE Forristal, V Barbier, B Nowlan, A Cisterne, LJ Bendall, NA Sims, J-P Levesque

Journal article | 2012 | Leukemia

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance (vol 14, pg 684, 2011)

Kim Loh, Atsushi Fukushima, Xinmei Zhang, Sandra Galic, Dana Briggs, Pablo J Enriori, Stephanie Simonds, Florian Wiede, Alexander Reichenbach, Christine Hauser, Natalie A Sims, Kendra K Bence, Sheng Zhang, Zhong-Yin Zhang, Barbara B Kahn, Benjamin G Neel, Zane B Andrews, Michael A Cowley, Tony Tiganis

Journal article | 2012 | Cell Metabolism

Intercellular Cross-Talk Among Bone Cells: New Factors and Pathways

Natalie A Sims, Nicole C Walsh

Journal article | 2012 | Current Osteoarthritis Reports

Regulation of sclerostin expression by paracrine and endocrine factors

NA Sims, LY Chia

Journal article | 2012 | Clinical Reviews in Bone and Mineral Metabolism

Sclerostin, a secreted protein encoded by the SOST gene, has been identified as a key regulator of bone formation by studies in hu..

Strain-Dependent Differences in Bone Development, Myeloid Hyperplasia, Morbidity and Mortality in Ptpn2-Deficient Mice

Florian Wiede, Sock Hui Chew, Catherine van Vliet, Ingrid J Poulton, Konstantinos Kyparissoudis, Tedjo Sasmono, Kim Loh, Michel L Tremblay, Dale I Godfrey, Natalie A Sims, Tony Tiganis

Journal article | 2012 | PLOS ONE

MICRO-CT QUANTITATION OF CHANGES IN TIBIAL BONE STRUCTURE IN A MOUSE SURGICAL MODEL OF OSTEOARTHRITIS

B Tonkin, E Romas, N Sims, N Walsh

Conference Proceedings | 2012 | INTERNAL MEDICINE JOURNAL

Sustained RANKL Response to Parathyroid Hormone in Oncostatin M Receptor-Deficient Osteoblasts Converts Anabolic Treatment to a Catabolic Effect In Vivo

Emma C Walker, Ingrid J Poulton, Narelle E McGregor, Patricia WM Ho, Elizabeth H Allan, Julie M Quach, T John Martin, Natalie A Sims

Journal article | 2012 | Journal of Bone and Mineral Research

Leukemia inhibitory factor: A paracrine mediator of bone metabolism

Natalie A Sims, Rachelle W Johnson

Journal article | 2012 | Growth Factors

Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair

SR Georgy, CN Pagel, A Ghasem-Zadeh, RMD Zebaze, RN Pike, NA Sims, EJ Mackie

Journal article | 2012 | Bone

Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization

Ingrid J Poulton, Narelle E McGregor, Sueli Pompolo, Emma C Walker, Natalie A Sims

Journal article | 2012 | Journal of Bone and Mineral Research

Mobilizing Agents G-CSF, Cyclophosphamide or AMD3100 (Plerixafor) Have Distinct Effects on Osteoblasts, Hematopoietic Stem Cell Niches, and B-Lymphopoiesis

Jean-Pierre Levesque, Linda J Bendall, Allison R Pettit, Liza Raggatt, Rebecca Jacobsen, Valerie Barbier, Bianca Nowlan, Yi Shen, Natalie A Sims, Ingrid G Winkler

Conference Proceedings | 2011 | BLOOD

Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

Kim Henriksen, Carmen Flores, Jesper S Thomsen, Anne-Marie Bruel, Christian S Thudium, Anita V Neutzsky-Wulff, Geerling EJ Langenbach, Natalie Sims, Maria Askmyr, Thomas J Martin, Vincent Everts, Morten A Karsdal, Johan Richter

Journal article | 2011 | PLOS ONE

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Journal article | 2011 | Cell Metabolism

Oncostatin M Is a Potent Regulator of Interleukin-6 and RANKL Expression in Mouse Synovial Fibroblasts and Synergises with Interleukin-1.

Benoit Le Goff, Brett A Tonkin, Sofie Singbrant, T John Martin, Evange Romas, Natalie A Sims, Nicole C Walsh

Conference Proceedings | 2011 | ARTHRITIS AND RHEUMATISM

THE ROLE OF EPHB/EPHRINB MOLECULES IN FRACTURE REPAIR

A Arthur, R Panagopoulos, L Cooper, A Zannettino, SA Koblar, NA Sims, K Matsuo, S Gronthos

Conference Proceedings | 2011 | OSTEOPOROSIS INTERNATIONAL

ONCOSTATIN M POTENTLY INDUCES IL-6 AND RANKL EXPRESSION IN MOUSE SYNOVIAL FIBROBLASTS AND SYNERGISES WITH IL-1

B Le Goff, BA Tonkin, S Singbrant, TJ Martin, E Romas, NA Sims, NC Walsh

Conference Proceedings | 2011 | OSTEOPOROSIS INTERNATIONAL

OSTEOBLASTIC SUPPORT OF OSTEOCLASTS: THE ROLE OF GP130 SIGNALLING

NA Sims

Conference Proceedings | 2011 | OSTEOPOROSIS INTERNATIONAL

ONCOSTATIN M POTENTLY INDUCES IL-6 AND RANKL EXPRESSION IN MOUSE SYNOVIAL FIBROBLASTS AND SIGNIFICANTLY ENHANCES THE EFFECTS OF IL-1 AND TNF

B Le Goff, BA Tonkin, S Singbrant, TJ Martin, E Romas, NA Sims, NC Walsh

Conference Proceedings | 2011 | Osteoarthritis and Cartilage

EPHRINB2 SIGNALLING IN OSTEOBLASTS IS REQUIRED FOR NORMAL OSTEOBLAST DIFFERENTIATION AND OSTEOCLAST MATURATION

S Tonna, F Takyar, IJ Poulton, PWM Ho, NE McGregor, TJ Martin, NA Sims

Conference Proceedings | 2011 | OSTEOPOROSIS INTERNATIONAL

INHIBITING EPHRINB2/EPHB4 BINDING PREVENTS PROGRESSION OF OSTEOBLAST DIFFERENTIATION AND ENHANCES OSTEOCLASTOGENIC FACTORS

PWM Ho, S Tonna, FM Takyar, NA Sims, TJ Martin

Conference Proceedings | 2011 | OSTEOPOROSIS INTERNATIONAL

G(s)alpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice

Joy Y Wu, Piia Aarnisalo, Murat Bastepe, Partha Sinha, Keertik Fulzele, Martin K Selig, Min Chen, Ingrid J Poulton, Louise E Purton, Natalie A Sims, Lee S Weinstein, Henry M Kronenberg

Journal article | 2011 | Journal of Clinical Investigation

Skeletal Recovery After Weaning Does Not Require PTHrP

Beth J Kirby, Laleh Ardeshirpour, Janine P Woodrow, John J Wysolmerski, Natalie A Sims, Andrew C Karaplis, Christopher S Kovacs

Journal article | 2011 | Journal of Bone and Mineral Research

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

Sofie Singbrant, Megan R Russell, Tanja Jovic, Brian Liddicoat, David J Izon, Louise E Purton, Natalie A Sims, T John Martin, Vijay G Sankaran, Carl R Walkley

Journal article | 2011 | Blood

Vaginally Administered PEGylated LIF Antagonist Blocked Embryo Implantation and Eliminated Non-Target Effects on Bone in Mice

Ellen Menkhorst, Jian-Guo Zhang, Natalie A Sims, Phillip O Morgan, Priscilla Soo, Ingrid J Poulton, Donald Metcalf, Estella Alexandrou, Melissa Gresle, Lois A Salamonsen, Helmut Butzkueven, Nicos A Nicola, Evdokia Dimitriadis

Journal article | 2011 | PLOS ONE

Excessive resorption of mineralised cartilage at the growth plate and impaired bone formation in remodelling in the absence of leukemia inhibitory factor

IJ Poulton, S Pompolo, EC Walker, NE McGregor, NA Sims

Conference Proceedings | 2011 | Bone

Osteoblastic ephrinB2 is required for normal osteoblast and osteoclast differentiation

FM Takyar, B Crimeen-Irwin, TJ Martin, NA Sims

Conference Proceedings | 2011 | Bone

ONCOSTATIN M ALONE, AND IN SYNERGY WITH IL-1, IS A POTENT REGULATOR OF INTERLEUKIN-6 AND RANKL EXPRESSION IN MOUSE SYNOVIAL FIBROBLASTS

B Le Goff, B Tonkin, T Martin, E Romas, N Sims, N Walsh

Conference Proceedings | 2011 | INTERNAL MEDICINE JOURNAL

EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation

Agnieszka Arthur, Andrew Zannettino, Romana Panagopoulos, Simon A Koblar, Natalie A Sims, Con Stylianou, Koichi Matsuo, Stan Gronthos

Journal article | 2011 | Bone

Zinc Finger Protein 467 Is a Novel Regulator of Osteoblast and Adipocyte Commitment

Julie M Quach, Emma C Walker, Elizabeth Allan, Melissa Solano, Atsushi Yokoyama, Shigeaki Kato, Natalie A Sims, Matthew T Gillespie, T John Martin

Journal article | 2011 | Journal of Biological Chemistry

Interactions Among Osteoblasts, Osteoclasts, and Other Cells in Bone

T John Martin, Natalie A Sims, Julian MW Quinn

Book Chapter | 2011

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Ingrid G Winkler, Natalie A Sims, Allison R Pettit, Valerie Barbier, Bianca Nowlan, Falak Helwani, Ingrid J Poulton, Nico van Rooijen, Kylie A Alexander, Liza J Raggatt, Jean-Pierre Levesque

Journal article | 2010 | Blood

Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Regulates Hematopoiesis and Bone Formation In Vivo

Yi Shen, Ingrid G Winkler, Valerie Barbier, Natalie A Sims, Jean Hendy, Jean-Pierre Levesque

Journal article | 2010 | PLOS ONE

EPHs and ephrins: Many pathways to regulate osteoblasts and osteoclasts

Natalie A Sims

Journal article | 2010 | IBMS BoneKEy

GP130 cytokines and bone remodelling in health and disease

Natalie A Sims, Nicole C Walsh

Journal article | 2010 | BMB Reports

Severe developmental bone phenotype in ClC-7 deficient mice

AV Neutzsky-Wulff, NA Sims, C Supanchart, U Kornak, D Felsenberg, IJ Poulton, TJ Martin, MA Karsdal, K Henriksen

Journal article | 2010 | Developmental Biology

Development of a vaginally applied, non-hormonal contraceptive: the contraceptive efficacy and impact on bone turnover of PEGLA, a long-acting LIF antagonist

E Menkhorst, JG Zhang, PO Morgan, IJ Poulton, D Metcalf, LA Salamonsen, NA Sims, NA Nicola, E Dimitriadis

Conference Proceedings | 2010 | Journal of Reproductive Immunology

The Tyrosine Kinase Inhibitor Dasatinib Dysregulates Bone Remodeling Through Inhibition of Osteoclasts In Vivo

Kate Vandyke, Andrea L Dewar, Peter Diamond, Stephen Fitter, Christopher G Schultz, Natalie A Sims, Andrew CW Zannettino

Journal article | 2010 | Journal of Bone and Mineral Research

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes

JH Gooi, S Pompolo, MA Karsdal, NH Kulkarni, I Kalajzic, SHM McAhren, B Han, JE Onyia, PWM Ho, MT Gillespie, NC Walsh, LY Chia, JMW Quinn, TJ Martin, NA Sims

Journal article | 2010 | BONE

Adverse effects of valproate on bone: Defining a model to investigate the pathophysiology

Susan M Senn, Susan Kantor, Ingrid J Poulton, Margaret J Morris, Natalie A Sims, Terence J O'Brien, John D Wark

Journal article | 2010 | Epilepsia

Lack of Sustained Response to Teriparatide in a Patient with Adult Hypophosphatasia

Claudia Gagnon, Natalie A Sims, Steven Mumm, Sybil A McAuley, Caroline Jung, Ingrid J Poulton, Kong Wah Ng, Peter R Ebeling

Journal article | 2010 | Journal of Clinical Endocrinology & Metabolism

Identifying epigenetic targets in osteosarcoma and differentiating osteoblasts

Emma Baker, Carl Walkley, Natalie Sims, Louise Purton, T John Martin

Conference Proceedings | 2010 | Bone

Endocrine and paracrine regulation of osteoblasts, osteoclasts and osteocytes

Natalie A Sims

Conference Proceedings | 2010 | ENDOCRINE JOURNAL

Ciliary Neurotrophic Factor Inhibits Bone Formation and Plays a Sex-Specific Role in Bone Growth and Remodeling

Narelle E McGregor, Ingrid J Poulton, Emma C Walker, Sueli Pompolo, Julian MW Quinn, T John Martin, Natalie A Sims

Journal article | 2010 | Calcified Tissue International

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

Emma C Walker, Narelle E McGregor, Ingrid J Poulton, Melissa Solano, Sueli Pompolo, Tania J Fernandes, Matthew J Constable, Geoff C Nicholson, Jian-Guo Zhang, Nicos A Nicola, Matthew T Gillespie, John Martin, Natalie A Sims

Journal article | 2010 | Journal of Clinical Investigation

Building Bone With a SOST-PTH Partnership

Natalie A Sims

Journal article | 2010 | Journal of Bone and Mineral Research

Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling

Peter Pivonka, Jan Zimak, David W Smith, Bruce S Gardiner, Colin R Dunstan, Natalie A Sims, T John Martin, Gregory R Mundy

Journal article | 2010 | Journal of Theoretical Biology

Communication Between EphrinB2 and EphB4 Within the Osteoblast Lineage

TJ Martin, EH Allan, PWM Ho, JH Gooi, JMW Quinn, MT Gillespie, V Krasnoperov, NA Sims

Journal article | 2010 | Advances in Experimental Medicine and Biology

Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function

Julian MW Quinn, Shanna Tam, Natalie A Sims, Hasnawati Saleh, Narelle E McGregor, Ingrid J Poulton, John W Scott, Matthew T Gillespie, Bruce E Kemp, BJW van Denderen

Journal article | 2010 | FASEB Journal

How Cells Communicate in the Bone Remodelling Process

Thomas J Martin, Natalie A Sims

Journal article | 2010 | Journal of Korean Endocrine Society

gp130 signaling in bone cell biology: Multiple roles revealed by analysis of genetically altered mice

Natalie A Sims

Journal article | 2009 | Molecular and Cellular Endocrinology

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

Lauren S Whyte, Erik Ryberg, Natalie A Sims, Susan A Ridge, Ken Mackie, Peter J Greasley, Ruth A Ross, Michael J Rogers

Journal article | 2009 | Proceedings of the National Academy of Sciences of the United States of America

ENDOSTEAL MACROPHAGES MAINTAIN THE HEMATOPOIETIC STEM CELL (HSC) NICHE AND PARTICIPATE IN HSC MOBILIZATION INDUCED BY G-CSF OR CHEMOTHERAPY

JP Levesque, LJ Raggatt, AR Pettit, NA Sims, LJ Bendall, F Helwani, IG Winkler

Conference Proceedings | 2009 | EXPERIMENTAL HEMATOLOGY

What is the true nature of the osteoblastic hematopoietic stem cell niche?

Maria Askmyr, Natalie A Sims, T John Martin, Louise E Purton

Journal article | 2009 | Trends in Endocrinology & Metabolism

Parathyroid hormone exposure to human articular osteoarthritic chondrocytes results in collagen and proteoglycan synthesis: May parathyroid hormone be a possible anabolic treatment opportunity for osteoarthritis?

B Sondergaard, SH Madsen, A Bay-Jensen, T Christensen, C Chrtiansen, N Schultz, NA Sims, JH Gooi, MA Karsdal