Natalie Sims

Transient Polycomb activity represses developmental genes in growing oocytes.

Ellen G Jarred, Zhipeng Qu, Tesha Tsai, Ruby Oberin, Sigrid Petautschnig, Heidi Bildsoe, Stephen Pederson, Qing-Hua Zhang, Jessica M Stringer, John Carroll, David K Gardner, Maarten Van den Buuse, Natalie A Sims, William T Gibson, David L Adelson, Patrick S Western

Journal article  |  2022  |  Clin Epigenetics

BACKGROUND: Non-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programmin..

Sexing Bones: Improving Transparency of Sex Reporting to Address Bias Within Preclinical Studies

Aikta Sharma, Lysanne Michels, Andrew A Pitsillides, Julie Greeves, Lillian Plotkin, Valentina Cardo, Natalie A Sims, Claire E Clarkin

Journal article  |  2022  |  JOURNAL OF BONE AND MINERAL RESEARCH

Despite knowledge that sexually dimorphic mechanisms regulate bone homeostasis, sex often remains unreported and unconsidered in p..

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance (vol 14, pg 684, 2011)

Kim Loh, Atsushi Fukushima, Xinmei Zhang, Sandra Galic, Dana Briggs, Pablo J Enriori, Stephanie Simonds, Florian Wiede, Alexander Reichenbach, Christine Hauser, Natalie A Sims, Kendra K Bence, Sheng Zhang, Zhong-Yin Zhang, Barbara B Kahn, Benjamin G Neel, Zane B Andrews, Michael A Cowley, Tony Tiganis

Journal article  |  2022  |  CELL METABOLISM

(Cell Metabolism 14, 684–699; November 2, 2011) We regret to inform that a mistake was made when preparing Figure 4A. In the figur..

Calcitriol-Dependent and -Independent Regulation of Intestinal Calcium Absorption, Osteoblast Function, and Skeletal Mineralization during Lactation and Recovery in Mice

Brittany A Ryan, Narelle E McGregor, Beth J Kirby, Abdelkhayoum Al-Tilissi, Ingrid J Poulton, Natalie A Sims, Christopher S Kovacs

Journal article  |  2022  |  JOURNAL OF BONE AND MINERAL RESEARCH

Recovery from lactation-induced bone loss appears to be calcitriol-independent, since mice lacking 1-alpha-hydroxylase or vitamin ..

Leptin receptor in osteocytes promotes cortical bone consolidation in female mice

Natalie KY Wee, Thaisa FC de Lima, Narelle E McGregor, Emma C Walker, Ingrid J Poulton, Martha Blank, Natalie A Sims

Journal article  |  2022  |  JOURNAL OF ENDOCRINOLOGY

Bone strength is partially determined during cortical bone consolidation, a process comprising coalescence of peripheral trabecula..

Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries

Larissa K Dill, Natalie A Sims, Ali Shad, Chidozie Anyaegbu, Andrew Warnock, Yilin Mao, Melinda Fitzgerald, Bridgette D Semple

Journal article  |  2022  |  SCIENTIFIC REPORTS

While it is well-established that bone responds dynamically to mechanical loading, the effects of mild traumatic brain injury (mTB..

G-CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes

Tsuyoshi Isojima, Emma C Walker, Ingrid J Poulton, Narelle E McGregor, Ian P Wicks, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2022  |  JOURNAL OF BONE AND MINERAL RESEARCH

Bone strength is determined by the structure and composition of its thickened outer shell (cortical bone), yet the mechanisms cont..

The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 ( /p.G610C)) mice

Martha Blank, Narelle E McGregor, Lynn Rowley, Louise HW Kung, Blessing Crimeen-Irwin, Ingrid J Poulton, Emma C Walker, Jonathan H Gooi, Shireen R Lamande, Natalie A Sims, John F Bateman

Journal article  |  2022  |  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The inherited brittle bone disease osteogenesis imperfecta (OI) is commonly caused by COL1A1 and COL1A2 mutations that disrupt the..

EphrinB2 in osteocytes is essential for lysosome formation and collagen arrangement

Martha Blank, Blessing Crimeen-Irwin, Mriga Dutt, Benjamin L Parker, Cameron J Nowell, T John Martin, Natalie A Sims

Journal article  |  2022  |  Bone Reports

Unsuppressed STAT3 signalling in osteocytes exaggerates cortical bone response to mechanical load

Emma McGowan, Narelle McGregor, Audrey Chan, Ingrid Poulton, Sara Windahl, Natalie A Sims

Conference Proceedings  |  2022  |  JOURNAL OF BONE AND MINERAL RESEARCH