Natalie Sims

Physiological and Pharmacological Roles of PTH and PTHrP in Bone Using Their Shared Receptor, PTH1R.

T John Martin, Natalie A Sims, Ego Seeman

Journal article  |  2021  |  Endocr Rev

Parathyroid hormone (PTH) and the paracrine factor, PTH-related protein (PTHrP), have preserved in evolution sufficient identities..

Cortical bone development, maintenance and porosity: genetic alterations in humans and mice influencing chondrocytes, osteoclasts, osteoblasts and osteocytes

Tsuyoshi Isojima, Natalie A Sims

Journal article  |  2021  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Cortical bone structure is a crucial determinant of bone strength, yet for many years studies of novel genes and cell signalling p..

Dmp1Cre-directed knockdown of parathyroid hormone-related protein (PTHrP) in murine decidua is associated with a life-long increase in bone mass, width, and strength in male progeny

Niloufar Ansari, Tsuyoshi Isojima, Blessing Crimeen-Irwin, Ingrid J Poulton, Narelle E McGregor, Patricia WM Ho, Mark R Forwood, Christopher S Kovacs, Evdokia Dimitriadis, Jonathan H Gooi, T John Martin, Natalie A Sims

Journal article  |  2021  |  JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid hormone-related protein (PTHrP, gene name Pthlh) is a pleiotropic regulator of tissue homeostasis. In bone, Dmp1Cre-ta..

Editorial Peer Reviewers as Shepherds, Rather Than Gatekeepers

Joel D Boerckel, Lilian Plotkin, Natalie A Sims

Journal article  |  2021  |  JOURNAL OF BONE AND MINERAL RESEARCH

The journals of the American Society for Bone and Mineral Research (the Journal of Bone and Mineral Research [JBMR] and its sister..

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice.

Audrey SM Chan, Narelle E McGregor, Ingrid J Poulton, Justin P Hardee, Ellie H-J Cho, T John Martin, Paul Gregorevic, Natalie A Sims, Gordon S Lynch

Journal article  |  2021  |  JBMR Plus

The development of the musculoskeletal system and its maintenance depends on the reciprocal relationship between muscle and bone. ..

Rothmund-Thomson Syndrome-Like RECQL4 Truncating Mutations Cause a Haploinsufficient Low-Bone-Mass Phenotype in Mice

Wilson Castillo-Tandazo, Ann E Frazier, Natalie A Sims, Monique F Smeets, Carl R Walkley

Journal article  |  2021  |  MOLECULAR AND CELLULAR BIOLOGY

Rothmund-Thomson Syndrome (RTS) is an autosomal recessive disorder characterized by defects in the skeletal system such as bone hy..

Bone loss markers in the earliest Pacific Islanders

Justyna J Miszkiewicz, Frederique Valentin, Christina Vrahnas, Natalie A Sims, Jitraporn Vongsvivut, Mark J Tobin, Geoffrey Clark

Journal article  |  2021  |  SCIENTIFIC REPORTS

Kingdom of Tonga in Polynesia is one of the most obese nations where metabolic conditions, sedentary lifestyles, and poor quality ..

Measuring Bone Volume at Multiple Densities by Micro-computed Tomography

Emma C Walker, Narelle E McGregor, Audrey SM Chan, Natalie A Sims

Journal article  |  2021  |  BIO-PROTOCOL

Bone strength is controlled by both bone mass, and the organization and quality of the bone material. The current standard method ..

Asymmetric midshaft femur remodeling in an adult male with left sided hip joint ankylosis, Metal Period Nagsabaran, Philippines

Justyna J Miszkiewicz, Claire Rider, Shimona Kealy, Christina Vrahnas, Natalie A Sims, Jitraporn Vongsvivut, Mark J Tobin, Mary Jane Louise A Bolunia, Alexandra S De Leon, Antonio L Penalosa, Pablo S Pagulayan, Adan V Soriano, Ruth Page, Marc F Oxenham

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF PALEOPATHOLOGY

OBJECTIVE: This study investigated microstructural changes of the right and left midshaft femur in an archaeological individual af..

Interaction between osteocyte SOCS3-dependent signaling and the bone marrow microenvironment maintains cortical bone integrity

Tsuyoshi Isojima, Emma C Walker, Blessing Crimeen-Irwin, Ingrid J Poulton, Narelle E McGregor, Jonathan H Gooi, T John Martin, Natalie A Sims

Conference Proceedings  |  2020  |  JOURNAL OF BONE AND MINERAL RESEARCH