Geza Berecki

Estimating neuronal conductance model parameters using dynamic action potential clamp

Y Deerasooriya, G Berecki, D Kaplan, IC Forster, S Halgamuge, S Petrou

Journal article  |  2019  |  Journal of Neuroscience Methods

Parameterization of neuronal membrane conductance models relies on data acquired from current clamp (CC) or voltage clamp (VC) rec..

SCN1A gain of function in early infantile encephalopathy

Geza Berecki, Alexander Bryson, Jan Terhag, Snezana Maljevic, Elena Gazina, Sean L Hill, Steven Petrou

Journal article  |  2019  |  Annals of Neurology

Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow

GDC Mendis, G Berecki, E Morrisroe, S Pachernegg, M Li, M Varney, PB Osborne, CA Reid, S Halgamuge, S Petrou

Journal article  |  2019  |  SCIENTIFIC REPORTS

Dynamic action potential clamp predicts functional separation in mild familial and severe de novo forms of SCN2A epilepsy

Geza Berecki, Katherine B Howell, Yadeesha H Deerasooriya, Maria Roberta Cilio, Megan K Oliva, David Kaplan, Ingrid E Scheffer, Samuel F Berkovic, Steven Petrou

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Effects of Linker Sequence Modifications on the Structure, Stability, and Biological Activity of a Cyclic alpha-Conotoxin

Bodil B Carstens, Joakim Swedberg, Geza Berecki, David J Adams, David J Craik, Richard J Clark

Journal article  |  2016  |  Biopolymers

Mechanism of direct Ca(v)2.2 channel block by the kappa-opioid receptor agonist U50488H

Geza Berecki, Leonid Motin, David J Adams

Journal article  |  2016  |  Neuropharmacology

Structure-Activity Studies of Cysteine-Rich -Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif

Bodil B Carstens, Geza Berecki, James T Daniel, Han Siean Lee, Kathryn AV Jackson, Han-Shen Tae, Mahsa Sadeghi, Joel Castro, Tracy O'Donnell, Annemie Deiteren, Stuart M Brierley, David J Craik, David J Adams, Richard J Clark

Journal article  |  2016  |  Angewandte Chemie International Edition

Voltage-Gated R-Type Calcium Channel Inhibition via Human mu-, delta-, and kappa-opioid Receptors Is Voltage-Independently Mediated by G beta gamma Protein Subunits

Geza Berecki, Leonid Motin, David J Adams

Journal article  |  2016  |  Molecular Pharmacology

Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1

Rilei Yu, Victoria AL Seymour, Geza Berecki, Xinying Jia, Muharrem Akcan, David J Adams, Quentin Kaas, David J Craik

Journal article  |  2015  |  Scientific Reports

Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels.

G Berecki, NL Daly, YH Huang, S Vink, DJ Craik, PF Alewood, DJ Adams

Journal article  |  2014  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: ω-Conotoxins CVIE and CVIF (CVIE&F) selectively inhibit Cav2.2 channels and are lead molecules in the deve..

Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Ca-v channels

Julie K Klint, Geza Berecki, Thomas Durek, Mehdi Mobli, Oliver Knapp, Glenn F King, David J Adams, Paul F Alewood, Lachlan D Rash

Journal article  |  2014  |  Biochemical Pharmacology

Differential Ca(v)2.1 and Ca(v)2.3 channel inhibition by baclofen and. alpha-conotoxin Vc1.1 via GABA(B) receptor activation

Geza Berecki, Jeffrey R McArthur, Hartmut Cuny, Richard J Clark, David J Adams

Journal article  |  2014  |  The Journal of General Physiology

Dynamic Clamp as a Tool to Study the Functional Effects of Individual Membrane Currents

Geza Berecki, Arie O Verkerk, Antoni CG van Ginneken, Ronald Wilders

Journal article  |  2014  |  Methods in Molecular Biology

Mechanisms of conotoxin inhibition of N-type (Ca(v)2.2) calcium channels

David J Adams, Geza Berecki

Journal article  |  2013  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes.

Renata Rehak, Theodore M Bartoletti, Jordan DT Engbers, Geza Berecki, Ray W Turner, Gerald W Zamponi

Journal article  |  2013  |  PLoS ONE

Calcium-activated potassium channels of the KCa1.1 class are known to regulate repolarization of action potential discharge throug..

gamma-Aminobutyric Acid Type B (GABA(B)) Receptor Expression Is Needed for Inhibition of N-type (Ca(v)2.2) Calcium Channels by Analgesic alpha-Conotoxins

Hartmut Cuny, Andrew de Faoite, Thuan G Huynh, Takahiro Yasuda, Geza Berecki, David J Adams

Journal article  |  2012  |  Journal of Biological Chemistry

Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels

David J Adams, Brid Callaghan, Geza Berecki

Journal article  |  2012  |  BRITISH JOURNAL OF PHARMACOLOGY

Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels (Molecular Pharmacology (2010) 77, (139-148))

G Berecki, L Motin, A Haythornthwaite, S Vink, P Bansal, R Drinkwater, CI Wang, M Moretta, J Lewis, PF Alewood, MJ Christie, DJ Adams

Journal article  |  2011  |  Molecular Pharmacology

Re-evaluation of the action potential upstroke velocity as a measure of the Na current in cardiac myocytes at physiological conditions.

Géza Berecki, Ronald Wilders, Berend de Jonge, Antoni CG van Ginneken, Arie O Verkerk

Journal article  |  2010  |  PLoS ONE

BACKGROUND: The SCN5A encoded sodium current (I(Na)) generates the action potential (AP) upstroke and is a major determinant of AP..

Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels.

G Berecki, L Motin, A Haythornthwaite, S Vink, P Bansal, R Drinkwater, CI Wang, M Moretta, RJ Lewis, PF Alewood, MJ Christie, DJ Adams

Journal article  |  2010  |  Molecular Pharmacology

Neuronal (N)-type Ca(2+) channel-selective omega-conotoxins have emerged as potential new drugs for the treatment of chronic pain...

Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.

Brid Callaghan, Alison Haythornthwaite, Géza Berecki, Richard J Clark, David J Craik, David J Adams

Journal article  |  2008  |  Journal of Neuroscience

alpha-Conotoxins Vc1.1 and Rg1A are peptides from the venom of marine Conus snails that are currently in development as a treatmen..

Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure"

HM Den Ruijter, G Berecki, AO Verkerk, D Bakker, A Baartscheer, CA Schumacher, CNW Belterman, JWT Fiolet, R Coronel, N De Jonge, IA Brouwer

Journal article  |  2008  |  Circulation

Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure.

Hester M Den Ruijter, Géza Berecki, Arie O Verkerk, Diane Bakker, Antonius Baartscheer, Cees A Schumacher, Charly NW Belterman, Nicolaas de Jonge, Jan WT Fiolet, Ingeborg A Brouwer, Ruben Coronel

Journal article  |  2008  |  Circulation

BACKGROUND: Fish oil reduces sudden death in patients with prior myocardial infarction. Sudden death in heart failure may be due t..

Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes.

Géza Berecki, Hester M Den Ruijter, Arie O Verkerk, Cees A Schumacher, Antonius Baartscheer, Diane Bakker, Bastiaan J Boukens, Antoni CG van Ginneken, Jan WT Fiolet, Tobias Opthof, Ruben Coronel

Journal article  |  2007  |  Heart Rhythm

BACKGROUND: Fish oil reduces the incidence of sudden cardiac death in postmyocardial infarction patients. Triggered activity is th..

Pro- and antiarrhythmic properties of a diet rich in fish oil.

Hester M Den Ruijter, Géza Berecki, Tobias Opthof, Arie O Verkerk, Peter L Zock, Ruben Coronel

Journal article  |  2007  |  Cardiovascular Research

Increased consumption of fish rich in omega-3 polyunsaturated fatty acids (omega3-PUFAs) is associated with decreased incidence of..

Cardiac channelopathies studied with the dynamic action potential-clamp technique.

Géza Berecki, Jan G Zegers, Ronald Wilders, Antoni CG Van Ginneken

Journal article  |  2007  |  Methods in molecular biology (Clifton, N.J.)

The cardiac long QT syndrome (LQTS) is characterized by a delayed repolarization of the ventricular myocytes, resulting in prolong..

Why the Brugada syndrome is not yet a disease: syndromes, diseases, and genetic causality.

Ruben Coronel, Géza Berecki, Tobias Opthof

Journal article  |  2006  |  Cardiovascular Research

Dietary fish oil reduces the occurrence of early afterdepolarizations in pig ventricular myocytes.

Hester M Den Ruijter, Arie O Verkerk, Géza Berecki, Diane Bakker, Antoni CG van Ginneken, Ruben Coronel

Journal article  |  2006  |  Journal of Molecular and Cellular Cardiology

Fish oil reduces sudden cardiac death in post myocardial infarction patients. Life-threatening arrhythmias in heart failure are as..

Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials.

Arie O Verkerk, Antoni CG van Ginneken, Géza Berecki, Hester M den Ruijter, Cees A Schumacher, Marieke W Veldkamp, Antonius Baartscheer, Simona Casini, Tobias Opthof, Robert Hovenier, Jan WT Fiolet, Peter L Zock, Ruben Coronel

Journal article  |  2006  |  Cardiovascular Research

BACKGROUND: Omega-3 polyunsaturated fatty acids (omega3-PUFAs) from fish oil reduce the risk of sudden death presumably by prevent..

Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique.

Géza Berecki, Jan G Zegers, Zahurul A Bhuiyan, Arie O Verkerk, Ronald Wilders, Antoni CG van Ginneken

Journal article  |  2006  |  The Journal of Physiology

Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, we used the 'dynamic action po..

HERG channel (dys)function revealed by dynamic action potential clamp technique.

Géza Berecki, Jan G Zegers, Arie O Verkerk, Zahurul A Bhuiyan, Berend de Jonge, Marieke W Veldkamp, Ronald Wilders, Antoni CG van Ginneken

Journal article  |  2005  |  Biophysical Journal

The human ether-a-go-go-related gene (HERG) encodes the rapid component of the cardiac delayed rectifier potassium current (I(Kr))..

Tonoplast anion channel activity modulation by pH in Chara corallina.

G Berecki, M Eijken, F Van Iren, B Van Duijn

Journal article  |  2001  |  Journal of Membrane Biology

The patch-clamp technique was used to investigate regulation of anion channel activity in the tonoplast of Chara corallina in resp..

Membrane orientation of droplets prepared from Chara corallina internodal cells.

G Berecki, M Eijken, F Van Iren, B Van Duijn

Journal article  |  2001  |  Protoplasma

It is generally accepted that the membrane surrounding droplets from characean cells originates from the tonoplast, but there is s..

The presence and subcellular localization of caspase 3-like proteinases in plant cells.

HA Korthout, G Berecki, W Bruin, B van Duijn, M Wang

Journal article  |  2000  |  FEBS Letters

Caspases play a very important role in initiating and executing apoptotic processes in animal cells. In this study we show that pl..

Anion channels in chara corallina tonoplast membrane: calcium dependence and rectification.

G Berecki, Z Varga, F Van Iren, B Van Duijn

Journal article  |  1999  |  Journal of Membrane Biology

Tonoplast K(+) channels of Chara corallina are well characterized but only a few reports mention anion channels, which are likely ..

Peripheral blood lymphocytes display reduced K channel activity in aged humans.

G Panyi, G Berecki, R Gáspár, I Seres, T Fülöp, S Damjanovich

Journal article  |  1994  |  Biochemical and Biophysical Research Communications

Steady-state parameters of whole-cell K+ current have been determined in human peripheral blood lymphocytes of young (20-50 y.) an..