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Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal n..
Dynamic action potential clamp predicts functional separation in mild familial and severe ..
Effects of Linker Sequence Modifications on the Structure, Stability, and Biological Activ..
Displaying the most recent project by Geza Berecki.
Displaying the 36 most recent scholarly works by Geza Berecki.
Estimating neuronal conductance model parameters using dynamic action potential clamp
Y Deerasooriya, G Berecki, D Kaplan, IC Forster, S Halgamuge, S Petrou
Journal article | 2019 | Journal of Neuroscience Methods
Parameterization of neuronal membrane conductance models relies on data acquired from current clamp (CC) or voltage clamp (VC) rec..
Dynamic action potential clamp predicts functional separation in mild familial and severe de novo forms of SCN2A epilepsy
Geza Berecki, Katherine B Howell, Yadeesha H Deerasooriya, Maria Roberta Cilio, Megan K Oliva, David Kaplan, Ingrid E Scheffer, Samuel F Berkovic, Steven Petrou
Journal article | 2018 | Proceedings of the National Academy of Sciences
Structure-Activity Studies of Cysteine-Rich -Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif
Bodil B Carstens, Geza Berecki, James T Daniel, Han Siean Lee, Kathryn AV Jackson, Han-Shen Tae, Mahsa Sadeghi, Joel Castro, Tracy O'Donnell, Annemie Deiteren, Stuart M Brierley, David J Craik, David J Adams, Richard J Clark
Journal article | 2016 | Angewandte Chemie International Edition
Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels.
G Berecki, NL Daly, YH Huang, S Vink, DJ Craik, PF Alewood, DJ Adams
Journal article | 2014 | British Journal of Pharmacology
BACKGROUND AND PURPOSE: ω-Conotoxins CVIE and CVIF (CVIE&F) selectively inhibit Cav2.2 channels and are lead molecules in the deve..
Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Ca-v channels
Julie K Klint, Geza Berecki, Thomas Durek, Mehdi Mobli, Oliver Knapp, Glenn F King, David J Adams, Paul F Alewood, Lachlan D Rash
Journal article | 2014 | Biochemical Pharmacology
Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes.
Renata Rehak, Theodore M Bartoletti, Jordan DT Engbers, Geza Berecki, Ray W Turner, Gerald W Zamponi
Journal article | 2013 | PLoS ONE
Calcium-activated potassium channels of the KCa1.1 class are known to regulate repolarization of action potential discharge throug..
gamma-Aminobutyric Acid Type B (GABA(B)) Receptor Expression Is Needed for Inhibition of N-type (Ca(v)2.2) Calcium Channels by Analgesic alpha-Conotoxins
Hartmut Cuny, Andrew de Faoite, Thuan G Huynh, Takahiro Yasuda, Geza Berecki, David J Adams
Journal article | 2012 | Journal of Biological Chemistry
Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels (Molecular Pharmacology (2010) 77, (139-148))
G Berecki, L Motin, A Haythornthwaite, S Vink, P Bansal, R Drinkwater, CI Wang, M Moretta, J Lewis, PF Alewood, MJ Christie, DJ Adams
Journal article | 2011 | Molecular Pharmacology
Re-evaluation of the action potential upstroke velocity as a measure of the Na current in cardiac myocytes at physiological conditions.
Géza Berecki, Ronald Wilders, Berend de Jonge, Antoni CG van Ginneken, Arie O Verkerk
Journal article | 2010 | PLoS ONE
BACKGROUND: The SCN5A encoded sodium current (I(Na)) generates the action potential (AP) upstroke and is a major determinant of AP..
Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels.
G Berecki, L Motin, A Haythornthwaite, S Vink, P Bansal, R Drinkwater, CI Wang, M Moretta, RJ Lewis, PF Alewood, MJ Christie, DJ Adams
Journal article | 2010 | Molecular Pharmacology
Neuronal (N)-type Ca(2+) channel-selective omega-conotoxins have emerged as potential new drugs for the treatment of chronic pain...
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.
Brid Callaghan, Alison Haythornthwaite, Géza Berecki, Richard J Clark, David J Craik, David J Adams
Journal article | 2008 | Journal of Neuroscience
alpha-Conotoxins Vc1.1 and Rg1A are peptides from the venom of marine Conus snails that are currently in development as a treatmen..
Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure"
HM Den Ruijter, G Berecki, AO Verkerk, D Bakker, A Baartscheer, CA Schumacher, CNW Belterman, JWT Fiolet, R Coronel, N De Jonge, IA Brouwer
Journal article | 2008 | Circulation
Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure.
Hester M Den Ruijter, Géza Berecki, Arie O Verkerk, Diane Bakker, Antonius Baartscheer, Cees A Schumacher, Charly NW Belterman, Nicolaas de Jonge, Jan WT Fiolet, Ingeborg A Brouwer, Ruben Coronel
Journal article | 2008 | Circulation
BACKGROUND: Fish oil reduces sudden death in patients with prior myocardial infarction. Sudden death in heart failure may be due t..
Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes.
Géza Berecki, Hester M Den Ruijter, Arie O Verkerk, Cees A Schumacher, Antonius Baartscheer, Diane Bakker, Bastiaan J Boukens, Antoni CG van Ginneken, Jan WT Fiolet, Tobias Opthof, Ruben Coronel
Journal article | 2007 | Heart Rhythm
BACKGROUND: Fish oil reduces the incidence of sudden cardiac death in postmyocardial infarction patients. Triggered activity is th..
Pro- and antiarrhythmic properties of a diet rich in fish oil.
Hester M Den Ruijter, Géza Berecki, Tobias Opthof, Arie O Verkerk, Peter L Zock, Ruben Coronel
Journal article | 2007 | Cardiovascular Research
Increased consumption of fish rich in omega-3 polyunsaturated fatty acids (omega3-PUFAs) is associated with decreased incidence of..
Cardiac channelopathies studied with the dynamic action potential-clamp technique.
Géza Berecki, Jan G Zegers, Ronald Wilders, Antoni CG Van Ginneken
Journal article | 2007 | Methods in molecular biology (Clifton, N.J.)
The cardiac long QT syndrome (LQTS) is characterized by a delayed repolarization of the ventricular myocytes, resulting in prolong..
Dietary fish oil reduces the occurrence of early afterdepolarizations in pig ventricular myocytes.
Hester M Den Ruijter, Arie O Verkerk, Géza Berecki, Diane Bakker, Antoni CG van Ginneken, Ruben Coronel
Journal article | 2006 | Journal of Molecular and Cellular Cardiology
Fish oil reduces sudden cardiac death in post myocardial infarction patients. Life-threatening arrhythmias in heart failure are as..
Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials.
Arie O Verkerk, Antoni CG van Ginneken, Géza Berecki, Hester M den Ruijter, Cees A Schumacher, Marieke W Veldkamp, Antonius Baartscheer, Simona Casini, Tobias Opthof, Robert Hovenier, Jan WT Fiolet, Peter L Zock, Ruben Coronel
Journal article | 2006 | Cardiovascular Research
BACKGROUND: Omega-3 polyunsaturated fatty acids (omega3-PUFAs) from fish oil reduce the risk of sudden death presumably by prevent..
Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique.
Géza Berecki, Jan G Zegers, Zahurul A Bhuiyan, Arie O Verkerk, Ronald Wilders, Antoni CG van Ginneken
Journal article | 2006 | The Journal of Physiology
Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, we used the 'dynamic action po..
HERG channel (dys)function revealed by dynamic action potential clamp technique.
Géza Berecki, Jan G Zegers, Arie O Verkerk, Zahurul A Bhuiyan, Berend de Jonge, Marieke W Veldkamp, Ronald Wilders, Antoni CG van Ginneken
Journal article | 2005 | Biophysical Journal
The human ether-a-go-go-related gene (HERG) encodes the rapid component of the cardiac delayed rectifier potassium current (I(Kr))..
Tonoplast anion channel activity modulation by pH in Chara corallina.
G Berecki, M Eijken, F Van Iren, B Van Duijn
Journal article | 2001 | Journal of Membrane Biology
The patch-clamp technique was used to investigate regulation of anion channel activity in the tonoplast of Chara corallina in resp..
The presence and subcellular localization of caspase 3-like proteinases in plant cells.
HA Korthout, G Berecki, W Bruin, B van Duijn, M Wang
Journal article | 2000 | FEBS Letters
Caspases play a very important role in initiating and executing apoptotic processes in animal cells. In this study we show that pl..
Anion channels in chara corallina tonoplast membrane: calcium dependence and rectification.
G Berecki, Z Varga, F Van Iren, B Van Duijn
Journal article | 1999 | Journal of Membrane Biology
Tonoplast K(+) channels of Chara corallina are well characterized but only a few reports mention anion channels, which are likely ..
Peripheral blood lymphocytes display reduced K channel activity in aged humans.
G Panyi, G Berecki, R Gáspár, I Seres, T Fülöp, S Damjanovich
Journal article | 1994 | Biochemical and Biophysical Research Communications
Steady-state parameters of whole-cell K+ current have been determined in human peripheral blood lymphocytes of young (20-50 y.) an..
Florey Department Of Neuroscience And Mental Health
Florey Department Of Neuroscience And Mental Health