Dagmar Wilhelm

TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

Moira Rossitto, Stephanie Dejardin, Chris M Rands, Stephanie Le Gras, Roberta Migale, Mahmoud-Reza Rafiee, Yasmine Neirijnck, Alain Pruvost, Anvi Laetitia Nguyen, Guillaume Bossis, Florence Cammas, Lionel Le Gallic, Dagmar Wilhelm, Robin Lovell-Badge, Brigitte Boizet-Bonhoure, Serge Nef, Francis Poulat

Journal article  |  2022  |  NATURE COMMUNICATIONS

Gonadal sexual fate in mammals is determined during embryonic development and must be actively maintained in adulthood. In the mou..

beta-hydroxybutyrate reduces blastocyst viability via trophectoderm-mediated metabolic aberrations in mice

Emma G Whatley, Thi T Truong, Dagmar Wilhelm, Alexandra J Harvey, David K Gardner

Journal article  |  2022  |  HUMAN REPRODUCTION

STUDY QUESTION: What is the effect of the ketone β-hydroxybutyrate (βOHB) on preimplantation mouse embryo development, metabolism,..

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.

Chloé Mayère, Violaine Regard, Aitana Perea-Gomez, Corey Bunce, Yasmine Neirijnck, Cyril Djari, Natividad Bellido-Carreras, Pauline Sararols, Richard Reeves, Simon Greenaway, Michelle Simon, Pam Siggers, Diana Condrea, Françoise Kühne, Ivana Gantar, Furong Tang, Isabelle Stévant, Laura Batti, Norbert B Ghyselinck, Dagmar Wilhelm, et al.

Journal article  |  2022  |  Sci Adv

Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the dif..

Loss of NEDD4 causes complete XY gonadal sex reversal in mice

Simon P Windley, Chloe Mayere, Alice E McGovern, Natasha L Harvey, Serge Nef, Quenten Schwarz, Sharad Kumar, Dagmar Wilhelm

Journal article  |  2022  |  CELL DEATH & DISEASE

Gonadogenesis is the process wherein two morphologically distinct organs, the testis and the ovary, arise from a common precursor...

Heterozygous deletion of Sox9 in mouse mimics the gonadal sex reversal phenotype associated with campomelic dysplasia in humans

Stefan Bagheri-Fam, Alexander N Combes, Cheuk K Ling, Dagmar Wilhelm

Journal article  |  2020  |  HUMAN MOLECULAR GENETICS

Heterozygous mutations in the human SOX9 gene cause the skeletal malformation syndrome campomelic dysplasia which in 75% of 46, XY..

Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis

JantinaA Manning, Simon P Windley, Jarrod J Sandow, Sonia S Shah, Patrick Western, Dagmar Wilhelm, Sharad Kumar

Journal article  |  2020  |  JOURNAL OF PROTEOMICS

Posttranslational modification by ubiquitination targets proteins for degradation, recycling, stabilization or altered trafficking..

The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice.

Stefan Bagheri-Fam, Huijun Chen, Sean Wilson, Katie Ayers, James Hughes, Frederique Sloan-Bena, Pierre Calvel, Gorjana Robevska, Beatriz Puisac, Kamila Kusz-Zamelczyk, Stefania Gimelli, Anna Spik, Jadwiga Jaruzelska, Alina Warenik-Szymankiewicz, Sultana Faradz, Serge Nef, Juan Pié, Paul Thomas, Andrew Sinclair, Dagmar Wilhelm

Journal article  |  2020  |  PLoS One

Disorders/differences of sex development (DSD) cause profound psychological and reproductive consequences for the affected individ..

A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primordial germ cell-specific genes prior to the sex-determination stage in medaka

Amaury Herpin, Cornelia Schmidt, Susanne Kneitz, Clara Gobe, Martina Regensburger, Aurelie Le Cam, Jerome Montfort, Mateus C Adolfi, Christina Lillesaar, Dagmar Wilhelm, Michael Kraeussling, Brigitte Mourot, Beatrice Porcon, Maelle Pannetier, Eric Pailhoux, Laurence Ettwiller, Dirk Dolle, Yann Guiguen, Manfred Schartl

Journal article  |  2019  |  PLOS BIOLOGY

Dmrt1 is a highly conserved transcription factor, which is critically involved in regulation of gonad development of vertebrates. ..

Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries

Anqi Fu, Sydney M Oberholtzer, Stefan Bagheri-Fam, Raphael H Rastetter, Claire Holdreith, Valeria L Caceres, Steven V John, Sarah A Shaw, Kathleen J Krentz, Xiaoyun Zhang, Chi-chung Hui, Dagmar Wilhelm, Joan S Jorgensen

Journal article  |  2018  |  PLOS GENETICS

Women and other mammalian females are born with a finite supply of oocytes that determine their reproductive lifespan. During feta..

The impact of new technologies in our understanding of testis formation and function

Serge Nef, Dagmar Wilhelm

Journal article  |  2018  |  MOLECULAR AND CELLULAR ENDOCRINOLOGY