Dagmar Wilhelm

Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis

JantinaA Manning, Simon P Windley, Jarrod J Sandow, Sonia S Shah, Patrick Western, Dagmar Wilhelm, Sharad Kumar

Journal article  |  2020  |  Journal of Proteomics

Posttranslational modification by ubiquitination targets proteins for degradation, recycling, stabilization or altered trafficking..

The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice.

Stefan Bagheri-Fam, Huijun Chen, Sean Wilson, Katie Ayers, James Hughes, Frederique Sloan-Bena, Pierre Calvel, Gorjana Robevska, Beatriz Puisac, Kamila Kusz-Zamelczyk, Stefania Gimelli, Anna Spik, Jadwiga Jaruzelska, Alina Warenik-Szymankiewicz, Sultana Faradz, Serge Nef, Juan Pié, Paul Thomas, Andrew Sinclair, Dagmar Wilhelm

Journal article  |  2020  |  PLoS One

Disorders/differences of sex development (DSD) cause profound psychological and reproductive consequences for the affected individ..

A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primordial germ cell-specific genes prior to the sex-determination stage in medaka

Amaury Herpin, Cornelia Schmidt, Susanne Kneitz, Clara Gobe, Martina Regensburger, Aurelie Le Cam, Jerome Montfort, Mateus C Adolfi, Christina Lillesaar, Dagmar Wilhelm, Michael Kraeussling, Brigitte Mourot, Beatrice Porcon, Maelle Pannetier, Eric Pailhoux, Laurence Ettwiller, Dirk Dolle, Yann Guiguen, Manfred Schartl

Journal article  |  2019  |  PLOS BIOLOGY

Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries

Anqi Fu, Sydney M Oberholtzer, Stefan Bagheri-Fam, Raphael H Rastetter, Claire Holdreith, Valeria L Caceres, Steven V John, Sarah A Shaw, Kathleen J Krentz, Xiaoyun Zhang, Chi-chung Hui, Dagmar Wilhelm, Joan S Jorgensen

Journal article  |  2018  |  PLOS GENETICS

The impact of new technologies in our understanding of testis formation and function

Serge Nef, Dagmar Wilhelm

Journal article  |  2018  |  Molecular and Cellular Endocrinology

Mutations in the HMGCS2 gene are associated with disorders of sex development

Stefan Bagheri-Fam, Michelle Wong, Sean Wilson, Katie Ayers, Raphael Rastetter, Paul Thomas, Serge Nef, Paulino Gomez-Puertas, Beatriz Puisac, Mar-A Hernandez-Marcos, Sergio Gil-Clavero, Juan Pie, Andrew Sinclair, Dagmar Wilhelm

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements

Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Yusuke Nagao, Hisashi Hashimoto, Chloe Bertin, Brigitte Mourot, Cornelia Schmidt, Dagmar Wilhelm, Lazaro Centanin, Yann Guiguen, Amaury Herpin

Journal article  |  2018  |  BMC BIOLOGY

Genetic mechanisms of sex determination

D Wilhelm, AJ Pask

Book Chapter  |  2018

Genes and gene defects affecting gonadal development and sex determination

D Wilhelm, S Bagheri-Fam

Book Chapter  |  2018

Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2

Stefan Bagheri-Fam, Anthony D Bird, Liang Zhao, Janelle M Ryan, Meiyun Yong, Dagmar Wilhelm, Peter Koopman, Veraragavan P Eswarakumar, Vincent R Harley

Journal article  |  2017  |  Endocrinology

Testis determination requires the function of a specific FGFR2 isoform

Daniel Bird, Stefan Bagheri-Fam, Li Li, Meiyun Yong, Raymond Lai, Janelle Ryan, Dagmar Wilhelm, Jacob Eswarakumar, Vincent Harley

Conference Proceedings  |  2017  |  Mechanisms of Development

Mice Lacking Hbp1 Function Are Viable and Fertile

Cassy M Spiller, Dagmar Wilhelm, David A Jans, Josephine Bowles, Peter Koopman

Journal article  |  2017  |  PLOS ONE

Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary

M-C De Cian, E Pauper, R Bandiera, VPI Vidal, S Sacco, EP Gregoire, A-A Chassot, C Panzolini, D Wilhelm, E Pailhoux, SA Youssef, A de Bruin, K Teerds, A Schedl, I Gillot, M-C Chaboissier

Journal article  |  2017  |  ONCOGENE

Male Sexual Differentiation

CH Sterling, D Wilhelm, S Bagheri-Fam

Book Chapter  |  2017

WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary

Sonja E Gustin, Kirsten Hogg, Jessica M Stringer, Raphael H Rastetter, Emanuele Pelosi, Denise C Miles, Andrew H Sinclair, Dagmar Wilhelm, Patrick S Western

Journal article  |  2016  |  DEVELOPMENTAL BIOLOGY

Non-coding RNAs and the Reproductive System.

Dagmar Wilhelmm, Pascal Bernard

Journal article  |  2016  |  Advances in experimental medicine and biology

Non-Coding RNA and the Reproductive System

Book  |  2016  |  Advances in Experimental Medicine and Biology

Non-coding RNAs: An Introduction

Jennifer X Yang, Raphael H Rastetter, Dagmar Wilhelm

Book Chapter  |  2016  |  Advances in Experimental Medicine and Biology

Non-coding RNA and the Reproductive System Preface

Dagmar Wilhelm, Pascal Bernard

Book Chapter  |  2016  |  Advances in Experimental Medicine and Biology

The role of non-coding RNAs in male sex determination and differentiation

Raphael H Rastetter, Craig A Smith, Dagmar Wilhelm

Journal article  |  2015  |  REPRODUCTION

ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation

Elanor N Wainwright, Dagmar Wilhelm, Alexander N Combes, Melissa H Little, Peter Koopman

Journal article  |  2015  |  Developmental Biology

FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development

Zhilin Liu, Yi A Ren, Stephanie A Pangas, Jaye Adams, Wei Zhou, Diego H Castrillon, Dagmar Wilhelm, JoAnne S Richards

Journal article  |  2015  |  MOLECULAR ENDOCRINOLOGY

Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary

Katja Hummitzsch, Richard A Anderson, Dagmar Wilhelm, Ji Wu, Evelyn E Telfer, Darryl L Russell, Sarah A Robertson, Raymond J Rodgers

Journal article  |  2015  |  Endocrine Reviews

Signaling Pathways Involved in Mammalian Sex Determination and Gonad Development

Simon P Windley, Dagmar Wilhelm

Journal article  |  2015  |  SEXUAL DEVELOPMENT

Genes and Gene Defects Affecting Gonad Development and Primary Sex Determination☆

Dagmar Wilhelm, Marie-Christine Chaboissier, Serge Nef

Book Chapter  |  2015

Marker genes identify three somatic cell types in the fetal mouse ovary

Raphael H Rastetter, Pascal Bernard, James S Palmer, Anne-Amandine Chassot, Huijun Chen, Patrick S Western, Robert G Ramsay, Marie-Christine Chaboissier, Dagmar Wilhelm

Journal article  |  2014  |  Developmental Biology

Development of mammalian ovary

Peter Smith, Dagmar Wilhelm, Raymond J Rodgers

Journal article  |  2014  |  Journal of Endocrinology

Loss of Function Mutation in the Palmitoyl-Transferase HHAT Leads to Syndromic 46,XY Disorder of Sex Development by Impeding Hedgehog Protein Palmitoylation and Signaling

Patrick Callier, Pierre Calvel, Armine Matevossian, Periklis Makrythanasis, Pascal Bernard, Hiroshi Kurosaka, Anne Vannier, Christel Thauvin-Robinet, Christelle Borel, Verine Mazaud-Guittot, Antoine Rolland, Christele Desdoits-Lethimonier, Michel Guipponi, Celine Zimmermann, Isabelle Stevant, Francoise Kuhne, Beatrice Conne, Federico Santoni, Sandy Lambert, Frederic Huet, et al.

Journal article  |  2014  |  PLOS GENETICS

Anatomical and Molecular Analyses of XY Ovaries from the African Pygmy Mouse Mus minutoides

Massilva Rahmoun, Julie Perez, Paul A Saunders, Brigitte Boizet-BonhoureB, Dagmar Wilhelm, Francis Poulat, Frederic Veyrunes

Journal article  |  2014  |  Sexual Development

Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a

Shunsuke Kuroki, Shogo Matoba, Mika Akiyoshi, Yasuko Matsumura, Hitoshi Miyachi, Nathan Mise, Kuniya Abe, Atsuo Ogura, Dagmar Wilhelm, Peter Koopman, Masami Nozaki, Yoshiakira Kanai, Yoichi Shinkai, Makoto Tachibana

Journal article  |  2013  |  Science

SOX9 Regulates MicroRNA miR-202-5p/3p Expression During Mouse Testis Differentiation

Elanor N Wainwright, Joan S Jorgensen, Youngha Kim, Truong Vy, Stefan Bagheri-Fam, Tara Davidson, Terje Svingen, Selene L Fernandez-Valverde, Kathryn S McClelland, Ryan J Taft, Vincent R Harley, Peter Koopman, Dagmar Wilhelm

Journal article  |  2013  |  Biology of Reproduction

MicroRNAs-140-5p/140-3p Modulate Leydig Cell Numbers in the Developing Mouse Testis

Joanna Rakoczy, Selene L Fernandez-Valverde, Evgeny A Glazov, Elanor N Wainwright, Tempei Sato, Shuji Takada, Alexander N Combes, Darren J Korbie, David Miller, Sean M Grimmond, Melissa H Little, Hiroshi Asahara, John S Mattick, Ryan J Taft, Dagmar Wilhelm

Journal article  |  2013  |  Biology of Reproduction

Sex Determination, Mouse

JS Palmer, D Wilhelm

Book Chapter  |  2013

A New Model of Development of the Mammalian Ovary and Follicles

Katja Hummitzsch, Helen F Irving-Rodgers, Nicholas Hatzirodos, Wendy Bonner, Laetitia Sabatier, Dieter P Reinhardt, Yoshikazu Sado, Yoshifumi Ninomiya, Dagmar Wilhelm, Raymond J Rodgers

Journal article  |  2013  |  PLOS ONE

Signaling through the TGF Beta-Activin Receptors ALK4/5/7 Regulates Testis Formation and Male Germ Cell Development

Denise C Miles, Stephanie I Wakeling, Jessica M Stringer, Jocelyn A van den Bergen, Dagmar Wilhelm, Andrew H Sinclair, Patrick S Western

Journal article  |  2013  |  PLOS ONE

Insulin and IGF1 Receptors Are Essential for XX and XY Gonadal Differentiation and Adrenal Development in Mice

Jean-Luc Pitetti, Pierre Calvel, Yannick Romero, Beatrice Conne, Truong Vy, Marilena D Papaioannou, Olivier Schaad, Mylene Docquier, Pedro Luis Herrera, Dagmar Wilhelm, Serge Nef

Journal article  |  2013  |  PLOS GENETICS

Novel PCR Assay for Determining the Genetic Sex of Mice

L McFarlane, V Truong, JS Palmer, D Wilhelm

Journal article  |  2013  |  Sexual Development

Mammalian Sex Determination and Gonad Development

Dagmar Wilhelm, Jennifer X Yang, Paul Thomas

Journal article  |  2013  |  Current Topics in Developmental Biology

Three-Dimensional Imaging of Prox1-EGFP Transgenic Mouse Gonads Reveals Divergent Modes of Lymphangiogenesis in the Testis and Ovary

Terje Svingen, Mathias Francois, Dagmar Wilhelm, Peter Koopman

Journal article  |  2012  |  PLOS ONE

Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes

Dennis K Gascoigne, Seth W Cheetham, Pierre B Cattenoz, Michael B Clark, Paulo P Amaral, Ryan J Taft, Dagmar Wilhelm, Marcel E Dinger, John S Mattick

Journal article  |  2012  |  Bioinformatics

Identification of Novel Markers of Mouse Fetal Ovary Development

Huijun Chen, James S Palmer, Rathi D Thiagarajan, Marcel E Dinger, Emmanuelle Lesieur, Hansheng Chiu, Alexandra Schulz, Cassy Spiller, Sean M Grimmond, Melissa H Little, Peter Koopman, Dagmar Wilhelm

Journal article  |  2012  |  PLOS ONE

Excess DAX1 Leads to XY Ovotesticular Disorder of Sex Development (DSD) in Mice by Inhibiting Steroidogenic Factor-1 (SF1) Activation of the Testis Enhancer of SRY-box-9 (Sox9)

Louisa M Ludbrook, Pascal Bernard, Stefan Bagheri-Fam, Janelle Ryan, Ryohei Sekido, Dagmar Wilhelm, Robin Lovell-Badge, Vincent R Harley

Journal article  |  2012  |  Endocrinology

Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice

Yuko Katoh-Fukui, Kanako Miyabayashi, Tomoko Komatsu, Akiko Owaki, Takashi Baba, Yuichi Shima, Tomohide Kidokoro, Yoshiakira Kanai, Andreas Schedl, Dagmar Wilhelm, Peter Koopman, Yasushi Okuno, Ken-ichirou Morohashi

Journal article  |  2012  |  Endocrinology

Expansion of the Ago gene family in the teleost clade

Lindsey McFarlane, Terje Svingen, Ingo Braasch, Peter Koopman, Manfred Schartl, Dagmar Wilhelm

Journal article  |  2011  |  Development Genes and Evolution

Expression of distinct RNAs from 3 ' untranslated regions

Tim R Mercer, Dagmar Wilhelm, Marcel E Dinger, Giulia Solda, Darren J Korbie, Evgeny A Glazov, Truong Vy, Maren Schwenke, Cas Simons, Klaus I Matthaei, Robert Saint, Peter Koopman, John S Mattick

Journal article  |  2011  |  NUCLEIC ACIDS RESEARCH

Analysis of Gene Function in Cultured Embryonic Mouse Gonads Using Nucleofection

J Ryan, L Ludbrook, D Wilhelm, A Sinclair, P Koopman, P Bernard, VR Harley

Journal article  |  2011  |  Sexual Development

FOXL2 and BMP2 Act Cooperatively to Regulate Follistatin Gene Expression during Ovarian Development

Kenichi Kashimada, Emanuele Pelosi, Huijun Chen, David Schlessinger, Dagmar Wilhelm, Peter Koopman

Journal article  |  2011  |  Endocrinology

SRY, Sex Determination and Gonadal Differentiation

P Koopman, D WILHELM

Book Chapter  |  2011

Insights into the Aetiology of Ovotesticular DSD from Studies of Mouse Ovotestes

Peter Koopman, Dagmar Wilhelm

Journal article  |  2011  |  Advances in Experimental Medicine and Biology

A Male-Specific Role for p38 Mitogen-Activated Protein Kinase in Germ Cell Sex Differentiation in Mice

Katherine Ewen, Andrew Jackson, Dagmar Wilhelm, Peter Koopman

Journal article  |  2010  |  Biology of Reproduction

Molecular Characterization of the Bidder's Organ in the Cane Toad (Bufo marinus)

John Abramyan, Dagmar Wilhelm, Peter Koopman

Journal article  |  2010  |  Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

An 'Anti-Testis' Effect of DAX1-Antagonism of the Testis-Specific Enhancer of SOX9.

LM Ludbrook, P Bernard, R Sekido, D Wilhelm, S Bagheri-Fam, R Lovell-Badge, VR Harley

Conference Proceedings  |  2010  |  ENDOCRINE REVIEWS

Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development

Juan Carlos Polanco, Dagmar Wilhelm, Tara-Lynne Davidson, Deon Knight, Peter Koopman

Journal article  |  2010  |  Human Molecular Genetics

Retinoblastoma 1 Protein Modulates XY Germ Cell Entry into G(1)/G(0) Arrest During Fetal Development in Mice

Cassy M Spiller, Dagmar Wilhelm, Peter Koopman

Journal article  |  2010  |  Biology of Reproduction

Non-Coding RNAs in Mammalian Sexual Development

L McFarlane, D Wilhelm

Journal article  |  2010  |  Sexual Development

Gonadal defects in Cited2 -mutant mice indicate a role for SF1 in both testis and ovary differentiation

Alexander N Combes, Cassy M Spiller, Vincent R Harley, Andrew H Sinclair, Sally L Dunwoodie, Dagmar Wilhelm, Peter Koopman

Journal article  |  2010  |  International Journal of Developmental Biology

THE GAME PLAN: CELLULAR AND MOLECULAR MECHANISMS OF MAMMALIAN TESTIS DEVELOPMENT

Elanor N Wainwright, Dagmar Wilhelm

Journal article  |  2010  |  Current Topics in Developmental Biology

Global Survey of Protein Expression during Gonadal Sex Determination in Mice

Katherine Ewen, Mark Baker, Dagmar Wilhelm, R John Aitken, Peter Koopman

Journal article  |  2009  |  Molecular & Cellular Proteomics

Cell cycle analysis of fetal germ cells during sex differentiation in mice

Cassy Spiller, Dagmar Wilhelm, Peter Koopman

Journal article  |  2009  |  BIOLOGY OF THE CELL

A cell-autonomous role for WT1 in regulating Sry in vivo

Stephen T Bradford, Dagmar Wilhelm, Roberto Bandiera, Valerie Vidal, Andreas Schedl, Peter Koopman

Journal article  |  2009  |  Human Molecular Genetics

Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

Debora Bogani, Pam Siggers, Rachel Brixey, Nick Warr, Sarah Beddow, Jessica Edwards, Debbie Williams, Dagmar Wilhelm, Peter Koopman, Richard A Flavell, Hongbo Chi, Harry Ostrer, Sara Wells, Michael Cheeseman, Andy Greenfield

Journal article  |  2009  |  PLOS BIOLOGY

Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice

Brett Hosking, Mathias Francois, Dagmar Wilhelm, Fabrizio Orsenigo, Andrea Caprini, Terje Svingen, Desmond Tutt, Tara Davidson, Catherine Browne, Elisabetta Dejana, Peter Koopman

Journal article  |  2009  |  Development

The Cerebellin 4 Precursor Gene Is a Direct Target of SRY and SOX9 in Mice

Stephen T Bradford, Ryuji Hiramatsu, Madhavi P Maddugoda, Pascal Bernard, Marie-Christine Chaboissier, Andrew Sinclair, Andreas Schedl, Vincent Harley, Yoshiakira Kanai, Peter Koopman, Dagmar Wilhelm

Journal article  |  2009  |  Biology of Reproduction

Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice

Dagmar Wilhelm, Linda L Washburn, Vy Truong, Marc Fellous, Eva M Eicher, Peter Koopman

Journal article  |  2009  |  Mechanisms of Development

Three-Dimensional Visualization of Testis Cord Morphogenesis, a Novel Tubulogenic Mechanism in Development

Alexander N Combes, Emmanuelle Lesieur, Vincent R Harley, Andrew H Sinclair, Melissa H Little, Dagmar Wilhelm, Peter Koopman

Journal article  |  2009  |  Developmental Dynamics

Ex Vivo Magnetofection: A Novel Strategy for the Study of Gene Function in Mouse Organogenesis

Terje Svingen, Dagmar Wilhelm, Alexander N Combes, Brett Hosking, Vincent R Harley, Andrew H Sinclair, Peter Koopman

Journal article  |  2009  |  Developmental Dynamics

Endothelial cell migration directs testis cord formation

Alexander N Combes, Dagmar Wilhelm, Tara Davidson, Elisabetta Dejana, Vincent Harley, Andrew Sinclair, Peter Koopman

Journal article  |  2009  |  Developmental Biology

Functional analysis of the SRY-KRAB interaction in mouse sex determination

Juan Carlos Polanco, Dagmar Wilhelm, Hirofumi Mizusaki, Andrew Jackson, Catherine Browne, Tara Davidson, Vincent Harley, Andrew Sinclair, Peter Koopman

Journal article  |  2009  |  Biology of the Cell

A critical time window of Sry action in gonadal sex determination in mice

Ryuji Hiramatsu, Shogo Matoba, Masami Kanai-Azuma, Naoki Tsunekawa, Yuko Katoh-Fukui, Masamichi Kurohmaru, Ken-ichirou Morohashi, Dagmar Wilhelm, Peter Koopman, Yoshiakira Kanai

Journal article  |  2009  |  Development

Sox18 induces development of the lymphatic vasculature in mice

Mathias Francois, Andrea Caprini, Brett Hosking, Fabrizio Orsenigo, Dagmar Wilhelm, Catherine Browne, Karri Paavonen, Tara Karnezis, Ramin Shayan, Meredith Downes, Tara Davidson, Desmond Tutt, Kathryn SE Cheah, Steven A Stacker, George EO Muscat, Marc G Achen, Elisabetta Dejana, Peter Koopman

Journal article  |  2008  |  Nature

Sox8 is a critical regulator of adult Sertoli cell function and male fertility

Moira K O'Bryan, Shuji Takada, Claire L Kennedy, Greg Scott, Shun-ichi Harada, Manas K Ray, Qunsheng Dai, Dagmar Wilhelm, David M de Kretser, E Mitch Eddy, Peter Koopman, Yuji Mishina

Journal article  |  2008  |  Developmental Biology

SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development

Dagmar Wilhelm, Ryuji Hiramatsu, Hirofumi Mizusaki, Laura Widjaja, Alexander N Combes, Yoshiakira Kanai, Peter Koopman

Journal article  |  2007  |  Journal of Biological Chemistry

R-spondin1 - discovery of the long-missing, mammalian female-determining gene?

Dagmar Wilhelm

Journal article  |  2007  |  BioEssays

Sex determination and gonadal development in mammals

Dagmar Wilhelm, Stephen Palmer, Peter Koopman

Journal article  |  2007  |  Physiological Reviews

Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation

Terje Svingen, Annemiek Beverdam, Pali Verma, Dagmar Wilhelm, Peter Koopman

Journal article  |  2007  |  The International Journal of Developmental Biology

Comparative analysis of anti-mouse SRY antibodies

ST Bradford, D Wilhelm, P Koopman

Journal article  |  2007  |  Sexual Development

Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development

Neville Young, Christopher N Hahn, Alisa Poh, Carolyn Dong, Dagmar Wilhelm, Jane Olsson, George EO Muscat, Peter Parsons, Jennifer R Gamble, Peter Koopman

Journal article  |  2006  |  JNCI: Journal of the National Cancer Institute

The makings of maleness: towards an integrated view of male sexual development

Dagmar Wilhelm, Peter Koopman

Journal article  |  2006  |  Nature Reviews Genetics

Retinoid signaling determines germ cell fate in mice

J Bowles, D Knight, C Smith, D Wilhelm, J Richman, S Mamiya, K Yashiro, K Chawengsaksophak, MJ Wilson, J Rossant, H Hamada, P Koopman

Journal article  |  2006  |  Science

Comparative proteomic analysis to study molecular events during gonad development in mice

Dagmar Wilhelm, Eugene Huang, Terje Svingen, Scott Stanfield, Diane Dinnis, Peter Koopman

Journal article  |  2006  |  genesis

Gonadal sex determination and differentiation

P Koopman, D WILHELM

Book Chapter  |  2006

Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination

D Wilhelm, F Martinson, S Bradford, MJ Wilson, AN Combes, A Beverdam, J Bowles, H Mizusaki, P Koopman

Journal article  |  2005  |  Developmental Biology

Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis

A Jeanes, D Wilhelm, MJ Wilson, J Bowles, PJ McClive, AH Sinclair, P Koopman

Journal article  |  2005  |  Reproduction

Pisrt1, a gene implicated in XX sex reversal, is expressed in gonads of both sexes during mouse development

KA Loffler, AN Combes, D Wilhelm, A Beverdam, J Bowles, P Koopman

Journal article  |  2005  |  Molecular Genetics and Metabolism

Sox genes and Cancer

C Dong, D WILHELM, P Koopman

Book Chapter  |  2004

Sox genes and cancer

C Dong, D Wilhelm, P Koopman

Journal article  |  2004  |  Cytogenetic and Genome Research

SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro

G Schepers, M Wilson, D Wilhelm, P Koopman

Journal article  |  2003  |  Journal of Biological Chemistry

Molecular characterization of three gonad cell lines

A Beverdam, D Wilhelm, P Koopman

Journal article  |  2003  |  Cytogenetic and Genome Research

The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation

XJ Du, P Hublitz, T Gunther, D Wilhelm, C Englert, R Schule

Journal article  |  2002  |  Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1

D Wilhelm, C Englert

Journal article  |  2002  |  GENES & DEVELOPMENT

Parathyroid Hormone Inhibits c-Jun N-Terminal Kinase Activity in Rat Osteoblastic Cells by a Protein Kinase A-Dependent Pathway

Teresa A Doggett, John T Swarthout, Stephen C Jefcoat, Dagmar Wilhelm, Andreas Dieckmann, Peter Angel, Nicola C Partridge

Journal article  |  2002  |  Endocrinology

Abstract Treatment of osteoblastic cells with PTH initiates dual signaling cascades resulting in activation of both..

Parathyroid hormone inhibits c-Jun N-terminal kinase activity in rat osteoblastic cells by a protein kinase A-dependent pathway

TA Doggett, JT Swarthout, SC Jefcoat, D Wilhelm, A Dieckmann, P Angel, NC Partridge

Journal article  |  2002  |  Endocrinology

The Wilms' tumor gene Wt1 is required for normal development of the retina

KD Wagner, N Wagner, VPI Vidal, G Schley, D Wilhelm, A Schedl, C Englert, H Scholz

Journal article  |  2002  |  The EMBO Journal

NF kappa B activation is required for interferon regulatory factor-1-mediated interferon beta induction

S Kirchhoff, D Wilhelm, P Angel, H Hauser

Journal article  |  1999  |  European Journal of Biochemistry

JNK/SAPK activity contributes to TRAIL-induced apoptosis

I Herr, D Wilhelm, E Meyer, I Jeremias, P Angel, KM Debatin

Journal article  |  1999  |  Cell Death and Differentiation

JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha.

I Herr, D Wilhelm, T Böhler, P Angel, KM Debatin

Journal article  |  1999  |  International Journal of Cancer

We report here that stress stimuli such as gamma-irradiation or the anticancer drug doxorubicin activate expression of the death-i..

JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, trail and TNF-alpha

I Herr, D Wilhelm, T Bohler, P Angel, KM Debatin

Journal article  |  1999  |  International Journal of Cancer

NFκB activation is required for interferon regulatory factor-1-mediated interferon beta induction

S Kirchhoff, D WILHELM, P Angel, H Hauser

Journal article  |  1999  |  European journal of biochemistry

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

I Herr, D Wilhelm, T Bohler, P Angel, KM Debatin

Journal article  |  1997  |  The EMBO Journal

The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents

D Wilhelm, K Bender, A Knebel, P Angel

Journal article  |  1997  |  Molecular and Cellular Biology

Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.

AJ Bannister, T Oehler, D Wilhelm, P Angel, T Kouzarides

Journal article  |  1995  |  Oncogene

The CBP protein mediates PKA induced transcription by binding to the PKA phosphorylated activation domain of CREB. Here we show th..

Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro

AJ Bannister, T Oehler, D Wilhelm, P Angel, T Kouzarides

Journal article  |  1995  |  Oncogene

BOTH ATF-2 AND C-JUN ARE PHOSPHORYLATED BY STRESS-ACTIVATED PROTEIN-KINASES IN RESPONSE TO UV IRRADIATION

D WILHELM, H VANDAM, I HERR, B BAUMANN, P HERRLICH, P ANGEL

Journal article  |  1995  |  Immunobiology

ATF-2 IS PREFERENTIALLY ACTIVATED BY STRESS-ACTIVATED PROTEIN-KINASES TO MEDIATE C-JUN INDUCTION IN RESPONSE TO GENOTOXIC AGENTS

H VANDAM, D WILHELM, I HERR, A STEFFEN, P HERRLICH, P ANGEL

Journal article  |  1995  |  The EMBO Journal