Dr Dagmar Wilhelm is a vertebrate developmental biologist with a background in molecular biology and cancer research, known internationally for her work on sex determination. The ultimate goal of her research is to understand the genetics of sex determination, gonad development, and reproduction, and how failure results in human disorders of sex development, infertility and testicular and ovarian cancer, using mouse as a model system.
Dagmar received her PhD in Cancer Biology at the German Cancer Research Centre, Heidelberg, Germany and completed her postdoctoral training with Prof Christoph Englert at the Research Centre Karlsruhe, Germany and Prof Peter Koopman at the Institute for Molecular Bioscience, Brisbane. After receiving a Career Development Award level II from the NHMRC she became a Laboratory head at the Institute for Molecular Bioscience at the University of Queensland. In 2011, Dagmar was awarded an ARC Future Fellowship and moved to the Department of Anatomy & Developmental Biology, Monash University, Melbourne. In November 2015, Dagmar moved with her laboratory to the University of Melbourne to take on a Senior lecturer position.
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Dagmar Wilhelm's highlights
Dagmar Wilhelm's selected work
A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primo..
Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial..
Displaying the 5 most recent projects by Dagmar Wilhelm.
Displaying the 102 most recent scholarly works by Dagmar Wilhelm.
The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice.
Stefan Bagheri-Fam, Huijun Chen, Sean Wilson, Katie Ayers, James Hughes, Frederique Sloan-Bena, Pierre Calvel, Gorjana Robevska, Beatriz Puisac, Kamila Kusz-Zamelczyk, Stefania Gimelli, Anna Spik, Jadwiga Jaruzelska, Alina Warenik-Szymankiewicz, Sultana Faradz, Serge Nef, Juan Pié, Paul Thomas, Andrew Sinclair, Dagmar Wilhelm
Journal article | 2020 | PLOS ONE
Disorders/differences of sex development (DSD) cause profound psychological and reproductive consequences for the affected individ..
A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primordial germ cell-specific genes prior to the sex-determination stage in medaka
Amaury Herpin, Cornelia Schmidt, Susanne Kneitz, Clara Gobe, Martina Regensburger, Aurelie Le Cam, Jerome Montfort, Mateus C Adolfi, Christina Lillesaar, Dagmar Wilhelm, Michael Kraeussling, Brigitte Mourot, Beatrice Porcon, Maelle Pannetier, Eric Pailhoux, Laurence Ettwiller, Dirk Dolle, Yann Guiguen, Manfred Schartl
Journal article | 2019 | PLOS Biology
Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries
Anqi Fu, Sydney M Oberholtzer, Stefan Bagheri-Fam, Raphael H Rastetter, Claire Holdreith, Valeria L Caceres, Steven V John, Sarah A Shaw, Kathleen J Krentz, Xiaoyun Zhang, Chi-chung Hui, Dagmar Wilhelm, Joan S Jorgensen
Journal article | 2018 | PLOS Genetics
Mutations in the HMGCS2 gene are associated with disorders of sex development
Stefan Bagheri-Fam, Michelle Wong, Sean Wilson, Katie Ayers, Raphael Rastetter, Paul Thomas, Serge Nef, Paulino Gomez-Puertas, Beatriz Puisac, Mar-A Hernandez-Marcos, Sergio Gil-Clavero, Juan Pie, Andrew Sinclair, Dagmar Wilhelm
Conference Proceedings | 2018 | CLINICAL ENDOCRINOLOGY
Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements
Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Yusuke Nagao, Hisashi Hashimoto, Chloe Bertin, Brigitte Mourot, Cornelia Schmidt, Dagmar Wilhelm, Lazaro Centanin, Yann Guiguen, Amaury Herpin
Journal article | 2018 | BMC Biology
Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary
M-C De Cian, E Pauper, R Bandiera, VPI Vidal, S Sacco, EP Gregoire, A-A Chassot, C Panzolini, D Wilhelm, E Pailhoux, SA Youssef, A de Bruin, K Teerds, A Schedl, I Gillot, M-C Chaboissier
Journal article | 2017 | Oncogene
WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary
Sonja E Gustin, Kirsten Hogg, Jessica M Stringer, Raphael H Rastetter, Emanuele Pelosi, Denise C Miles, Andrew H Sinclair, Dagmar Wilhelm, Patrick S Western
Journal article | 2016 | Developmental Biology
Loss of Function Mutation in the Palmitoyl-Transferase HHAT Leads to Syndromic 46,XY Disorder of Sex Development by Impeding Hedgehog Protein Palmitoylation and Signaling
Patrick Callier, Pierre Calvel, Armine Matevossian, Periklis Makrythanasis, Pascal Bernard, Hiroshi Kurosaka, Anne Vannier, Christel Thauvin-Robinet, Christelle Borel, Verine Mazaud-Guittot, Antoine Rolland, Christele Desdoits-Lethimonier, Michel Guipponi, Celine Zimmermann, Isabelle Stevant, Francoise Kuhne, Beatrice Conne, Federico Santoni, Sandy Lambert, Frederic Huet, et al.
Journal article | 2014 | PLoS Genetics
Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a
Shunsuke Kuroki, Shogo Matoba, Mika Akiyoshi, Yasuko Matsumura, Hitoshi Miyachi, Nathan Mise, Kuniya Abe, Atsuo Ogura, Dagmar Wilhelm, Peter Koopman, Masami Nozaki, Yoshiakira Kanai, Yoichi Shinkai, Makoto Tachibana
Journal article | 2013 | Science
SOX9 Regulates MicroRNA miR-202-5p/3p Expression During Mouse Testis Differentiation
Elanor N Wainwright, Joan S Jorgensen, Youngha Kim, Truong Vy, Stefan Bagheri-Fam, Tara Davidson, Terje Svingen, Selene L Fernandez-Valverde, Kathryn S McClelland, Ryan J Taft, Vincent R Harley, Peter Koopman, Dagmar Wilhelm
Journal article | 2013 | Biology of Reproduction
MicroRNAs-140-5p/140-3p Modulate Leydig Cell Numbers in the Developing Mouse Testis
Joanna Rakoczy, Selene L Fernandez-Valverde, Evgeny A Glazov, Elanor N Wainwright, Tempei Sato, Shuji Takada, Alexander N Combes, Darren J Korbie, David Miller, Sean M Grimmond, Melissa H Little, Hiroshi Asahara, John S Mattick, Ryan J Taft, Dagmar Wilhelm
Journal article | 2013 | Biology of Reproduction
Insulin and IGF1 Receptors Are Essential for XX and XY Gonadal Differentiation and Adrenal Development in Mice
Jean-Luc Pitetti, Pierre Calvel, Yannick Romero, Beatrice Conne, Truong Vy, Marilena D Papaioannou, Olivier Schaad, Mylene Docquier, Pedro Luis Herrera, Dagmar Wilhelm, Serge Nef
Journal article | 2013 | PLoS Genetics
Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes
Dennis K Gascoigne, Seth W Cheetham, Pierre B Cattenoz, Michael B Clark, Paulo P Amaral, Ryan J Taft, Dagmar Wilhelm, Marcel E Dinger, John S Mattick
Journal article | 2012 | Bioinformatics
Excess DAX1 Leads to XY Ovotesticular Disorder of Sex Development (DSD) in Mice by Inhibiting Steroidogenic Factor-1 (SF1) Activation of the Testis Enhancer of SRY-box-9 (Sox9)
Louisa M Ludbrook, Pascal Bernard, Stefan Bagheri-Fam, Janelle Ryan, Ryohei Sekido, Dagmar Wilhelm, Robin Lovell-Badge, Vincent R Harley
Journal article | 2012 | Endocrinology
Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice
Yuko Katoh-Fukui, Kanako Miyabayashi, Tomoko Komatsu, Akiko Owaki, Takashi Baba, Yuichi Shima, Tomohide Kidokoro, Yoshiakira Kanai, Andreas Schedl, Dagmar Wilhelm, Peter Koopman, Yasushi Okuno, Ken-ichirou Morohashi
Journal article | 2012 | Endocrinology
Expression of distinct RNAs from 3 ' untranslated regions
Tim R Mercer, Dagmar Wilhelm, Marcel E Dinger, Giulia Solda, Darren J Korbie, Evgeny A Glazov, Truong Vy, Maren Schwenke, Cas Simons, Klaus I Matthaei, Robert Saint, Peter Koopman, John S Mattick
Journal article | 2011 | Nucleic Acids Research
Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination
Debora Bogani, Pam Siggers, Rachel Brixey, Nick Warr, Sarah Beddow, Jessica Edwards, Debbie Williams, Dagmar Wilhelm, Peter Koopman, Richard A Flavell, Hongbo Chi, Harry Ostrer, Sara Wells, Michael Cheeseman, Andy Greenfield
Journal article | 2009 | PLoS Biology
Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice
Brett Hosking, Mathias Francois, Dagmar Wilhelm, Fabrizio Orsenigo, Andrea Caprini, Terje Svingen, Desmond Tutt, Tara Davidson, Catherine Browne, Elisabetta Dejana, Peter Koopman
Journal article | 2009 | Development
The Cerebellin 4 Precursor Gene Is a Direct Target of SRY and SOX9 in Mice
Stephen T Bradford, Ryuji Hiramatsu, Madhavi P Maddugoda, Pascal Bernard, Marie-Christine Chaboissier, Andrew Sinclair, Andreas Schedl, Vincent Harley, Yoshiakira Kanai, Peter Koopman, Dagmar Wilhelm
Journal article | 2009 | Biology of Reproduction
Sox18 induces development of the lymphatic vasculature in mice
Mathias Francois, Andrea Caprini, Brett Hosking, Fabrizio Orsenigo, Dagmar Wilhelm, Catherine Browne, Karri Paavonen, Tara Karnezis, Ramin Shayan, Meredith Downes, Tara Davidson, Desmond Tutt, Kathryn SE Cheah, Steven A Stacker, George EO Muscat, Marc G Achen, Elisabetta Dejana, Peter Koopman
Journal article | 2008 | Nature
Sox8 is a critical regulator of adult Sertoli cell function and male fertility
Moira K O'Bryan, Shuji Takada, Claire L Kennedy, Greg Scott, Shun-ichi Harada, Manas K Ray, Qunsheng Dai, Dagmar Wilhelm, David M de Kretser, E Mitch Eddy, Peter Koopman, Yuji Mishina
Journal article | 2008 | Developmental Biology
Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development
Neville Young, Christopher N Hahn, Alisa Poh, Carolyn Dong, Dagmar Wilhelm, Jane Olsson, George EO Muscat, Peter Parsons, Jennifer R Gamble, Peter Koopman
Journal article | 2006 | JNCI: Journal of the National Cancer Institute
JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha.
I Herr, D Wilhelm, T Böhler, P Angel, KM Debatin
Journal article | 1999 | International Journal of Cancer
We report here that stress stimuli such as gamma-irradiation or the anticancer drug doxorubicin activate expression of the death-i..
Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.
AJ Bannister, T Oehler, D Wilhelm, P Angel, T Kouzarides
Journal article | 1995 | Oncogene
The CBP protein mediates PKA induced transcription by binding to the PKA phosphorylated activation domain of CREB. Here we show th..
Honours, Awards and Fellowships
ANZSCDB Young Investigator Award
Travel fellowship and one year membership
Finalist of the Queensland Premiers Award for Health and Medical Research
Senior Lecturer In Developmental Biology
Anatomy And Neuroscience
Society for Reproductive Biology
Society for Developmental Biology
Society for the Study of Reproduction
The Endocrine Society
National Association of Research Fellows
Queensland Representative 2009/2010
Australian and New Zealand Society for Cell and Developmental Biology
Graduate Certificate in University Teaching
University of Melbourne
University of Karlsruhe
Diploma in Biology
University of Karlsruhe