Kevin Barnham

Cu-II(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Adam Southon, Kathryn Szostak, Karla M Acevedo, Krista A Dent, Irene Volitakis, Abdel A Belaidi, Kevin J Barnham, Peter J Crouch, Scott Ayton, Paul S Donnelly, Ashley Bush

Journal article  |  2020  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Diacetyl-bis(4-methyl-3-thiosemicarbazonato)copperII (CuII (atsm)) ameliorates neurodegeneration and delay..

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups

Brett M Paterson, Carleen Cullinane, Peter J Crouch, Anthony R White, Kevin J Barnham, Peter D Roselt, Wayne Noonan, David Binns, Rodney J Hicks, Paul S Donnelly

Journal article  |  2019  |  Inorganic Chemistry

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies

Simon McKenzie-Nickson, Jacky Chan, Keyla Perez, Lin W Hung, Lesley Cheng, Amelia Sedjahtera, Lydia Gunawan, Paul A Adlard, David J Hayne, Lachlan E McInnes, Paul S Donnelly, David Finkelstein, Andrew F Hill, Kevin J Barnham

Journal article  |  2018  |  ACS Chemical Neuroscience

The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours

Ryan J Keenan, Jacky Chan, Paul S Donnelly, Kevin J Barnham, Laura H Jacobson

Journal article  |  2018  |  Neurobiology of Stress

Targeting metals rescues the phenotype in an animal model of tauopathy

Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Lin Wai Hung, Jack Parsons, Nobuyuki Okamura, Victor L Villemagne, Kazuhiko Yanai, Xiang M Liu, Jacky Chan, Ashley I Bush, David I Finkelstein, Kevin J Barnham, Robert A Cherny, Paul A Adlard

Journal article  |  2018  |  Metallomics

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnham

Journal article  |  2018  |  Acta Neuropathologica Communications

Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux

Karla M Acevedo, David J Hayne, Lachlan E McInnes, Asif Noor, Clare Duncan, Diane Moujalled, Irene Volitakis, Angela Rigopoulos, Kevin J Barnham, Victor L Villemagne, Anthony R White, Paul S Donnelly

Journal article  |  2018  |  Journal of Medicinal Chemistry

A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study.

Victor L Villemagne, Christopher C Rowe, Kevin J Barnham, Robert Cherny, Michael Woodward, Svetlana Bozinosvski, Olivier Salvado, Pierrick Bourgeat, Keyla Perez, Christopher Fowler, Alan Rembach, Paul Maruff, Craig Ritchie, Rudy Tanzi, Colin L Masters

Journal article  |  2017  |  Alzheimer's & Dementia: Translational Research & Clinical Interventions

Introduction: We are developing a second generation 8-OH quinoline (2-(dimethylamino) methyl-5, 7-dichloro-8-hydroxyquinoline [PBT..

A rigorous method to enrich for exosomes from brain tissue

Laura J Vella, Benjamin J Scicluna, Lesley Cheng, Emma G Bawden, Colin L Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J Barnham, Andrew F Hill

Journal article  |  2017  |  Journal of Extracellular Vesicles

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, et al.

Journal article  |  2017  |  Acta Neuropathologica Communications

Characterization and Identification of Dityrosine Cross-Linked Peptides Using Tandem Mass Spectrometry

Soumya Mukherjee, Eugene A Kapp, Amber Lothian, Anne M Roberts, Yury V Vasil'ev, Berin A Boughton, Kevin J Barnham, W Mei Kok, Craig A Hutton, Colin L Masters, Ashley I Bush, Joseph S Beckmann, Somdatta Ghosh Dey, Blaine R Roberts

Journal article  |  2017  |  Analytical Chemistry

Synthesis of Oxorhenium(V) and Oxotechnetium(V) Complexes That Bind to Amyloid-beta Plaques

David J Hayne, Jonathan M White, Catriona A McLean, Victor L Villemagne, Kevin J Barnham, Paul S Donnelly

Journal article  |  2016  |  Inorganic Chemistry

Restoration of intestinal function in an MPTP model of Parkinson's Disease

LJ Ellett, LW Hung, R Munckton, NA Sherratt, J Culvenor, A Grubman, JB Furness, AR White, DI Finkelstein, KJ Barnham, VA Lawson

Journal article  |  2016  |  Scientific Reports

Preface

Nitin Kumar, Sivakumar Vasireddy, Devendra Pakhare

Book Chapter  |  2016  |  Catalysis Today

Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status

Ya Hui Hung, Mark Walterfang, Leonid Churilov, Lisa Bray, Laura H Jacobson, Kevin J Barnham, Nigel C Jones, Terence J O'Brien, Dennis Velakoulis, Ashley I Bush

Journal article  |  2016  |  Neurotherapeutics

Gene dysregulation is restored in the Parkinson's disease MPTP neurotoxic mice model upon treatment of the therapeutic drug Cu-II(atsm)

Lesley Cheng, Camelia YJ Quek, Lin W Hung, Robyn A Sharples, Nicki A Sherratt, Kevin J Barnham, Andrew F Hill

Journal article  |  2016  |  Scientific Reports

Bis(thiosemicarbazone) Metal Complexes as Therapeutics for Neurodegenerative Diseases

S Mckenzie-Nickson, AI Bush, KJ Barnham

Journal article  |  2016  |  Current Topics in Medicinal Chemistry

Amyloid-Beta Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization and Calcium-Influx in Neurons

A BUSH, AP Gunn, BX Wong, T Johanssen, JC Griffith, CL Masters, KJ Barnham, JA Duce, RA Cherny

Journal article  |  2016  |  Journal of Biological Chemistry

A Functional Role for A in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding

Mariusz Mital, Nina E Wezynfeld, Tomasz Fraczyk, Magdalena Z Wiloch, Urszula E Wawrzyniak, Arkadiusz Bonna, Carolin Tumpach, Kevin J Barnham, Cathryn L Haigh, Wojciech Bal, Simon C Drew

Journal article  |  2015  |  Angewandte Chemie International Edition

PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning

Timothy Johanssen, Nuttawat Suphantarida, Paul S Donnelly, Xiang M Liu, Steven Petrou, Andrew F Hill, Kevin J Barnham

Journal article  |  2015  |  Neurobiology of Disease

Stabilization of Nontoxic A beta-Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease

Timothy M Ryan, Blaine R Roberts, Gawain McColl, Dominic J Hare, Philip A Doble, Qiao-Xin Li, Monica Lind, Anne M Roberts, Haydyn DT Mertens, Nigel Kirby, Chi LL Pham, Mark G Hinds, Paul A Adlard, Kevin J Barnham, Cyril C Curtain, Colin L Masters

Journal article  |  2015  |  Journal of Neuroscience

The N-Terminal Residues 43 to 60 Form the Interface for Dopamine Mediated alpha-Synuclein Dimerisation

Su Ling Leong, Mark G Hinds, Andrea R Connor, David P Smith, Eva Illes-Toth, Chi LL Pham, Kevin J Barnham, Roberto Cappai

Journal article  |  2015  |  PLOS ONE

Synthesis of 2-Pyridyl-benzimidazole Iridium(III), Ruthenium(II), and Platinum(II) Complexes. Study of the Activity as Inhibitors of Amyloid-beta Aggregation and Neurotoxicity Evaluation

Gorakh S Yellol, Jyoti G Yellol, Vijaya B Kenche, Xiang Ming Liu, Kevin J Barnham, Antonio Donaire, Christoph Janiak, Jose Ruiz

Journal article  |  2015  |  Inorganic Chemistry

Rhenium and technetium complexes that bind to amyloid-beta plaques

David J Hayne, Andrea J North, Michelle Fodero-Tavoletti, Jonathan M White, Lin W Hung, Angela Rigopoulos, Catriona A McLean, Paul A Adlard, Uwe Ackermann, Henri Tochon-Danguy, Victor L Villemagne, Kevin J Barnham, Paul S Donnelly

Journal article  |  2015  |  Dalton Transactions

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

Cyril C Curtain, Nigel M Kirby, Haydyn DT Mertens, Kevin J Barnham, Robert B Knott, Colin L Masters, Roberto Cappai, Agata Rekas, Vijaya B Kenche, Timothy Ryan

Journal article  |  2015  |  Molecular BioSystems

High Order W02-Reactive Stable Oligomers of Amyloid-beta are Produced in vivo and in vitro via Dialysis and Filtration of Synthetic Amyloid-beta Monomer

Elysia Robb, Keyla Perez, Lin W Hung, Colin L Masters, Kevin J Barnham, Robert A Cherny, Ashley I Bush, Paul A Adlard, David I Finkelstein

Journal article  |  2015  |  Journal of Alzheimer's Disease

Peripheral alpha-Defensins 1 and 2 are Elevated in Alzheimer's Disease

Andrew D Watt, Keyla A Perez, Ching-Seng Ang, Paul O'Donnell, Alan Rembach, Kelly K Pertile, Rebecca L Rumble, Brett O Trounson, Christopher J Fowler, Noel G Faux, Colin L Masters, Victor L Villemagne, Kevin J Barnham

Journal article  |  2015  |  Journal of Alzheimer's Disease

Small angle X-ray scattering analysis of Cu2 -induced oligomers of the Alzheimer's amyloid beta peptide

Timothy M Ryan, Nigel Kirby, Haydyn DT Mertens, Blaine Roberts, Kevin J Barnham, Roberto Cappai, Chi Le Lan Pham, Colin L Masters, Cyril C Curtain

Journal article  |  2015  |  Metallomics

A commonly used Drosophila model of Alzheimer's disease generates an aberrant species of amyloid-beta with an additional N-terminal glutamine residue

Kirsten Allan, Keyla A Perez, Kevin J Barnham, James Camakaris, Richard Burke

Journal article  |  2014  |  FEBS Letters

Anti-A beta antibody target engagement: a response to Siemers et al.

Andrew D Watt, Gabriela AN Crespi, Russell A Down, David B Ascher, Adam Gunn, Keyla A Perez, Catriona A McLean, Victor L Villemagne, Michael W Parker, Kevin J Barnham, Luke A Miles

Journal article  |  2014  |  Acta Neuropathologica

beta-amyloid in biological samples: not all A beta detection methods are created equal

Paul A Adlard, Qiao-Xin Li, Catriona McLean, Colin L Masters, Ashley I Bush, Michelle Fodero-Tavoletti, Victor Villemagne, Kevin J Barnham

Journal article  |  2014  |  Frontiers in Aging Neuroscience

Oral Treatment with Cu-II(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Blaine R Roberts, Nastasia KH Lim, Erin J McAllum, Paul S Donnelly, Dominic J Hare, Philip A Doble, Bradley J Turner, Katherine A Price, Sin Chun Lim, Brett M Paterson, James L Hickey, Timothy W Rhoads, Jared R Williams, Katja M Kanninen, Lin W Hung, Jeffrey R Liddell, Alexandra Grubman, Jean-Francois Monty, Roxana M Llanos, David R Kramer, et al.

Journal article  |  2014  |  Journal of Neuroscience

Cu2 Coordination of Covalently Cross-linked beta-Amyloid Dimers (vol 44, pg 927, 2013)

Simon C Drew, W Mei Kok, Craig A Hutton, Kevin J Barnham

Journal article  |  2014  |  Applied Magnetic Resonance

Do current therapeutic anti-A beta antibodies for Alzheimer's disease engage the target?

Andrew D Watt, Gabriela AN Crespi, Russell A Down, David B Ascher, Adam Gunn, Keyla A Perez, Catriona A McLean, Victor L Villemagne, Michael W Parker, Kevin J Barnham, Luke A Miles

Journal article  |  2014  |  Acta Neuropathologica

C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to alpha-cleavage

Vanessa A Johanssen, Timothy Johanssen, Colin L Masters, Andrew F Hill, Kevin J Barnham, Steven J Collins

Journal article  |  2014  |  Biochemical Journal

Mixed Ligand Cu(II) Complexes of a Model Therapeutic with Alzheimer's Amyloid-beta Peptide and Monoamine Neurotransmitters

S Drew, V Kenche, C Masters, K Barnham, I Zawisza, W Bal, K Barnham, S Drew

Conference Proceedings  |  2014  |  JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Pathogenic Mutations within the Hydrophobic Domain of the Prion Protein Lead to the Formation of Protease-Sensitive Prion Species with Increased Lethality

Bradley M Coleman, Christopher F Harrison, Belinda Guo, Colin L Masters, Kevin J Barnham, Victoria A Lawson, Andrew F Hill

Journal article  |  2014  |  Journal of Virology

Metals in Neurodegeneration: Therapeutic Opportunities

K Barnham

Conference Proceedings  |  2014  |  JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function

Su Ling Leong, Tessa R Young, Kevin J Barnham, Anthony G Wedd, Mark G Hinds, Zhiguang Xiao, Roberto Cappai

Journal article  |  2014  |  Metallomics: integrated biometal science

Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease

Alan Rembach, Noel G Faux, Andrew D Watt, Kelly K Pertile, Rebecca L Rumble, Brett O Trounson, Christopher J Fowler, Blaine R Roberts, Keyla A Perez, Qiao-Xin Li, Simon M Laws, Kevin Taddei, Stephanie Rainey-Smith, Joanne S Robertson, Manu Vandijck, Hugo Vanderstichele, Kevin J Barnham, Kathryn A Ellis, Cassandra Szoeke, Lance Macaulay, et al.

Journal article  |  2014  |  Alzheimers Dement

Guanidine hydrochloride denaturation of dopamine-induced alpha-synuclein oligomers: A small-angle X-ray scattering study

Chi LL Pham, Nigel Kirby, Kathleen Wood, Timothy Ryan, Blaine Roberts, Anna Sokolova, Kevin J Barnham, Colin L Masters, Robert B Knott, Roberto Cappai, Cyril C Curtain, Agata Rekas

Journal article  |  2014  |  Proteins: Structure, Function, and Bioinformatics

Biological metals and metal-targeting compounds in major neurodegenerative diseases

Kevin J Barnham, Ashley I Bush

Journal article  |  2014  |  Chem. Soc. Rev.

Therapeutic effects of Cu-II(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

Erin J McAllum, Nastasia K-H Lim, James L Hickey, Brett M Paterson, Paul S Donnelly, Qiao-Xin Li, Jeffrey R Liddell, Kevin J Barnham, Anthony R White, Peter J Crouch

Journal article  |  2013  |  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Diagnostic Imaging Agents for Alzheimer's Disease: Copper Radiopharmaceuticals that Target A beta Plaques

James L Hickey, SinChun Lim, David J Hayne, Brett M Paterson, Jonathan M White, Victor L Villemagne, Peter Roselt, David Binns, Carleen Cullinane, Charmaine M Jeffery, Roger I Price, Kevin J Barnham, Paul S Donnelly

Journal article  |  2013  |  Journal of the American Chemical Society

Progress towards a consensus on biomarkers for Alzheimer's disease: a review of peripheral analytes

Alan Rembach, Tim M Ryan, Blaine R Roberts, James D Doecke, William J Wilson, Andrew D Watt, Kevin J Barnham, Colin L Masters

Journal article  |  2013  |  Biomarkers in Medicine

Cu2 Coordination of Covalently Cross-linked beta-Amyloid Dimers

Simon C Drew, W Mei Kok, Craig A Hutton, Kevin J Barnham

Journal article  |  2013  |  Applied Magnetic Resonance

Mixed Ligand Cu2 Complexes of a Model Therapeutic with Alzheimer's Amyloid-beta Peptide and Monoamine Neurotransmitters

Vijaya B Kenche, Izabela Zawisza, Colin L Masters, Wojciech Bal, Kevin J Barnham, Simon C Drew

Journal article  |  2013  |  Inorganic Chemistry

Oligomers, fact or artefact? SDS-PAGE induces dimerization of beta-amyloid in human brain samples

Andrew D Watt, Keyla A Perez, Alan Rembach, Nicki A Sherrat, Lin Wai Hung, Timothy Johanssen, Catriona A McLean, Woan Mei Kok, Craig A Hutton, Michelle Fodero-Tavoletti, Colin L Masters, Victor L Villemagne, Kevin J Barnham

Journal article  |  2013  |  Acta Neuropathologica

Amine oxidase activity of beta-amyloid precursor protein modulates systemic and local catecholamine levels

JA Duce, S Ayton, AA Miller, A Tsatsanis, LQ Lam, L Leone, JE Corbin, H Butzkueven, TJ Kilpatrick, JT Rogers, KJ Barnham, DI Finkelstein, AI Bush

Journal article  |  2013  |  Molecular Psychiatry

Metals, Membranes, and Amyloid-beta Oligomers: Key Pieces in the Alzheimer's Disease Puzzle?

Andrew D Watt, Victor L Villemagne, Kevin J Barnham

Journal article  |  2013  |  Journal of Alzheimer's Disease

Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer's Disease

Vijaya B Kenche, Lin W Hung, Keyla Perez, Irene Volitakes, Guiseppe Ciccotosto, Jeffrey Kwok, Nicole Critch, Nikki Sherratt, Mikhalina Cortes, Varsha Lal, Colin L Masters, Kazuma Murakami, Roberto Cappai, Paul A Adlard, Kevin J Barnham

Journal article  |  2013  |  Angewandte Chemie - International Edition

Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-beta peptide

Victor A Streltsov, V Chandana Epa, Simon A James, Quentin I Churches, Joanne M Caine, Vijaya B Kenche, Kevin J Barnham

Journal article  |  2013  |  Chemical Communications

Synthetic dityrosine-linked beta-amyloid dimers form stable, soluble, neurotoxic oligomers

W Mei Kok, Jade M Cottam, Giuseppe D Ciccotosto, Luke A Miles, John A Karas, Denis B Scanlon, Blaine R Roberts, Michael W Parker, Roberto Cappai, Kevin J Barnham, Craig A Hutton

Journal article  |  2013  |  Chemical Science

Role of the Amyloid Precursor Protein and Copper in Alzheimer's Disease

Loredana Spoerri, Kevin J Barnham, Gerd Multhaup, Roberto Cappai

Book Chapter  |  2013

Metals, Membranes, and Amyloid-beta Oligomers: Key Pieces in the Alzheimer's Disease Puzzle?

Andrew D Watt, Victor L Villemagne, Kevin J Barnham

Journal article  |  2013  |  Advances in Alzheimer's Disease

Utility of an improved model of amyloid-beta (A beta(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny

Journal article  |  2012  |  Molecular Neurodegeneration

Therapeutic Redistribution of Metal Ions To Treat Alzheimer's Disease

Peter J Crouch, Kevin J Barnham

Journal article  |  2012  |  Accounts of Chemical Research

The Amyloid Precursor Protein Copper Binding Domain Histidine Residues 149 and 151 Mediate APP Stability and Metabolism

Loredana Spoerri, Laura J Vella, Chi LL Pham, Kevin J Barnham, Roberto Cappai

Journal article  |  2012  |  Journal of Biological Chemistry

Modulating metals as a therapeutic strategy for Alzheimer's disease

Lin W Hung, Kevin J Barnham

Journal article  |  2012  |  Future Medicinal Chemistry

The hypoxia imaging agent Cu-II(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

Lin W Hung, Victor L Villemagne, Lesley Cheng, Nicki A Sherratt, Scott Ayton, Anthony R White, Peter J Crouch, SinChun Lim, Su Ling Leong, Simon Wilkins, Jessica George, Blaine R Roberts, Chi LL Pham, Xiang Liu, Francis CK Chiu, David M Shackleford, Andrew K Powell, Colin L Masters, Ashley I Bush, Graeme O'Keefe, et al.

Journal article  |  2012  |  Journal of Experimental Medicine

Generating recombinant C-terminal prion protein fragments of exact native sequence

VA Johanssen, KJ Barnham, CL Masters, AF Hill, SJ Collins

Journal article  |  2012  |  Neurochemistry International

Variability in Blood-Based Amyloid-beta Assays: The Need for Consensus on Pre-Analytical Processing

Andrew D Watt, Keyla A Perez, Alan R Rembach, Colin L Masters, Victor L Villemagne, Kevin J Barnham

Journal article  |  2012  |  Journal of Alzheimer's Disease

Microwave Synthesis of Prion Protein Fragments up to 111 Amino Acids in Length Generates Biologically Active Peptides

John A Karas, Martin Boland, Cathryn Haigh, Vanessa Johanssen, Andrew Hill, Kevin Barnham, Steven Collins, Denis Scanlon

Journal article  |  2012  |  International Journal of Peptide Research and Therapeutics

Misfolded conformers of the prion protein are aetiologically implicated in neurodegenerative conditions termed prion diseases (als..

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid beta Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

Kazuma Murakami, Nakaba Murata, Yoshihiro Noda, Shoichi Tahara, Takao Kaneko, Noriaki Kinoshita, Hiroyuki Hatsuta, Shigeo Murayama, Kevin J Barnham, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu

Journal article  |  2011  |  Journal of Biological Chemistry

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (Cu-II(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

Cynthia PW Soon, Paul S Donnelly, Bradley J Turner, Lin W Hung, Peter J Crouch, Nicki A Sherratt, Jiang-Li Tan, Nastasia K-H Lim, Linh Lam, Laura Bica, SinChun Lim, James L Hickey, Julia Morizzi, Andrew Powell, David I Finkelstein, Janetta G Culvenor, Colin L Masters, James Duce, Anthony R White, Kevin J Barnham, et al.

Journal article  |  2011  |  Journal of Biological Chemistry

The Heterogeneous Nature of Cu2 Interactions with Alzheimer's Amyloid-beta Peptide

Simon C Drew, Kevin J Barnham

Journal article  |  2011  |  Accounts of Chemical Research

The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity

Peter J Crouch, Maria S Savva, Lin W Hung, Paul S Donnelly, Alexandra I Mot, Sarah J Parker, Mark A Greenough, Irene Volitakis, Paul A Adlard, Robert A Cherny, Colin L Masters, Ashley I Bush, Kevin J Barnham, Anthony R White

Journal article  |  2011  |  Journal of Neurochemistry

Amyloid-beta: The seeds of darkness

Michelle T Fodero-Tavoletti, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Kevin J Barnham, Roberto Cappai

Journal article  |  2011  |  International Journal of Biochemistry and Cell Biology

Alzheimer's disease & metals: therapeutic opportunities

Vijaya B Kenche, Kevin J Barnham

Journal article  |  2011  |  British Journal of Pharmacology

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease.

Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagne

Journal article  |  2011  |  Brain

While considerable effort has focused on developing positron emission tomography β-amyloid imaging radiotracers for the early diag..

F-18-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagne

Journal article  |  2011  |  Brain

Alzheimer's disease and metals: a review of the involvement of cellular membrane receptors in metallosignalling.

Pavithra C Amadoruge, Kevin J Barnham

Journal article  |  2011  |  International Journal of Alzheimer's Disease

Alzheimer's disease (AD) is a debilitating form of dementia. The hallmark protein associated with the disease is the amyloid beta ..

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

Laura Bica, Jodi Meyerowitz, Sarah J Parker, Aphrodite Caragounis, Tai Du, Brett M Paterson, Kevin J Barnham, Peter J Crouch, Anthony R White, Paul S Donnelly

Journal article  |  2011  |  Biometals

Optical Imaging Detects Apoptosis in the Brain and Peripheral Organs of Prion-Infected Mice

Simon C Drew, Cathryn L Haigh, Helen MJ Klemm, Colin L Masters, Steven J Collins, Kevin J Barnham, Victoria A Lawson

Journal article  |  2011  |  Journal of Neuropathology and Experimental Neurology

Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity

Giuseppe D Ciccotosto, Deborah J Tew, Simon C Drew, Danielle G Smith, Timothy Johanssen, Varsha Lal, Tong-Lay Lau, Keyla Perez, Cyril C Curtain, John D Wade, Frances Separovic, Colin L Masters, Jeffrey P Smith, Kevin J Barnham, Roberto Cappai

Journal article  |  2011  |  Neurobiology of Aging

alpha-Helix unfolding in simple shear flow

Innocent B Bekard, Kevin J Barnham, Lee R White, Dave E Dunstan

Journal article  |  2011  |  Soft Matter

Increasing the Predictive Accuracy of Amyloid-beta Blood-Borne Biomarkers in Alzheimer's Disease

Andrew D Watt, Keyla A Perez, Noel G Faux, Kerryn E Pike, Christopher C Rowe, Pierrick Bourgeat, Olivier Salvado, Colin L Masters, Victor L Villemagne, Kevin J Barnham

Journal article  |  2011  |  Journal of Alzheimer's Disease

Alzheimer's A beta Peptides with Disease-Associated N-Terminal Modifications: Influence of Isomerisation, Truncation and Mutation on Cu2 Coordination

Simon C Drew, Colin L Masters, Kevin J Barnham

Journal article  |  2010  |  PLoS One

Near-Infrared Fluorescence Imaging of Apoptotic Neuronal Cell Death in a Live Animal Model of Prion Disease

Victoria A Lawson, Cathryn L Haigh, Blaine Roberts, Vijaya B Kenche, Helen MJ Klemm, Colin L Masters, Steven J Collins, Kevin J Barnham, Simon C Drew

Journal article  |  2010  |  ACS Chemical Neuroscience

Anionic Phospholipid Interactions of the Prion Protein N Terminus Are Minimally Perturbing and Not Driven Solely by the Octapeptide Repeat Domain

Martin P Boland, Claire R Hatty, Frances Separovic, Andrew F Hill, Deborah J Tew, Kevin J Barnham, Cathryn L Haigh, Michael James, Colin L Masters, Steven J Collins

Journal article  |  2010  |  Journal of Biological Chemistry

Iron-Export Ferroxidase Activity of beta-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

James A Duce, Andrew Tsatsanis, Michael A Cater, Simon A James, Elysia Robb, Krutika Wikhe, Su Ling Leong, Keyla Perez, Timothy Johanssen, Mark A Greenough, Hyun-Hee Cho, Denise Galatis, Robert D Moir, Colin L Masters, Catriona McLean, Rudolph E Tanzi, Roberto Cappai, Kevin J Barnham, Giuseppe D Ciccotosto, Jack T Rogers, et al.

Journal article  |  2010  |  Cell

The structure of dopamine induced alpha-synuclein oligomers

Agata Rekas, Robert B Knott, Anna Sokolova, Kevin J Barnham, Keyla A Perez, Colin L Masters, Simon C Drew, Roberto Cappai, Cyril C Curtain, Chi LL Pham

Journal article  |  2010  |  European Biophysics Journal with Biophysics Letters

Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease

Katarina Kagedal, Woojin Scott Kim, Hanna Appelqvist, Sharon Chan, Danni Cheng, Lotta Agholme, Kevin Barnham, Heather McCann, Glenda Halliday, Brett Garner

Journal article  |  2010  |  Biochimica et Biophysica Acta: Molecular and Cell biology of Lipids

Conservation of a Glycine-rich Region in the Prion Protein Is Required for Uptake of Prion Infectivity

Christopher F Harrison, Victoria A Lawson, Bradley M Coleman, Yong-Sun Kim, Colin L Masters, Roberto Cappai, Kevin J Barnham, Andrew F Hill

Journal article  |  2010  |  Journal of Biological Chemistry

Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: A DFT study

Fredrik Haeffner, Kevin J Barnham, Ashley I Bush, Tore Brinck

Journal article  |  2010  |  Journal of Molecular Modeling

Blood-Borne Amyloid-beta Dimer Correlates with Clinical Markers of Alzheimer's Disease

Victor L Villemagne, Keyla A Perez, Kerryn E Pike, W Mei Kok, Christopher C Rowe, Anthony R White, Pierrick Bourgeat, Olivier Salvado, Justin Bedo, Craig A Hutton, Noel G Faux, Colin L Masters, Kevin J Barnham

Journal article  |  2010  |  Journal of Neuroscience

Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies

SinChun Lim, Katherine A Price, Siow-Feng Chong, Brett M Paterson, Aphrodite Caragounis, Kevin J Barnham, Peter J Crouch, Josephine M Peach, Jonathan R Dilworth, Anthony R White, Paul S Donnelly

Journal article  |  2010  |  Journal of Biological Inorganic Chemistry

Histidine 14 Modulates Membrane Binding and Neurotoxicity of the Alzheimer's Disease Amyloid-beta Peptide

Danielle G Smith, Giuseppe D Ciccotosto, Deborah J Tew, Keyla Perez, Cyril C Curtain, John F Boas, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2010  |  Journal of Alzheimer's Disease

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques

SinChun Lim, Brett M Paterson, Michelle T Fodero-Tavoletti, Graeme J O'Keefe, Roberto Cappai, Kevin J Barnham, Victor L Villemagne, Paul S Donnelly

Journal article  |  2010  |  Chemical Communications

Increased ATP-Binding Cassette Transporter A1 Expression in Alzheimer's Disease Hippocampal Neurons

Woojin Scott Kim, Surabhi Bhatia, David A Elliott, Lotta Agholme, Katarina Kagedal, Heather McCann, Glenda M Halliday, Kevin J Barnham, Brett Garner

Journal article  |  2010  |  Journal of Alzheimer's Disease

Bis(thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease

Michelle T Fodero-Tavoletti, Victor L Villemagne, Brett M Paterson, Anthony R White, Qiao-Xin Li, James Camakaris, Graeme J O'Keefe, Roberto Cappai, Kevin J Barnham, Paul S Donnelly

Journal article  |  2010  |  Journal of Alzheimer's Disease

Copper Coordination by Familial Mutants of Parkinson's Disease-Associated alpha-Synuclein

Simon C Drew, Deborah J Tew, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2009  |  Applied Magnetic Resonance

Sustained Activation of Glial Cell Epidermal Growth Factor Receptor by Bis(thiosemicarbazonato) Metal Complexes Is Associated with Inhibition of Protein Tyrosine Phosphatase Activity

Katherine Ann Price, Aphrodite Caragounis, Brett M Paterson, Gulay Filiz, Irene Volitakis, Colin L Masters, Kevin J Barnham, Paul S Donnelly, Peter J Crouch, Anthony R White

Journal article  |  2009  |  Journal of Medicinal Chemistry

Modulation of alpha-Synuclein Aggregation by Dopamine: A Review

Su Ling Leong, Roberto Cappai, Kevin Jeffrey Barnham, Chi Le Lan Pham

Journal article  |  2009  |  Neurochemical Research

THE GLYCINE RICH REGION OF THE PRION PROTEIN IS A DOMINANT MODULATOR OF PRION INFECTIVITY

AF Hill, C Harrison, VA Lawson, CL Masters, R Cappai, KJ Barnham

Conference Proceedings  |  2009  |  JOURNAL OF NEUROCHEMISTRY

MODULATING COPPER BIO-AVAILABILITY TO TREAT NEURODEGENERATIVE DISEASES

PJ Crouch, LW Hung, CP Soon, PA Adlard, A Bush, CL Masters, QX Li, PS Donnelly, KJ Barnham, AR White

Conference Proceedings  |  2009  |  JOURNAL OF NEUROCHEMISTRY

The Caenorhabditis elegans A beta(1-42) Model of Alzheimer Disease Predominantly Expresses A beta(3-42)

Gawain Mccoll, Blaine R Roberts, Adam P Gunn, Keyla A Perez, Deborah J Tew, Colin L Masters, Kevin J Barnham, Robert A Cherny, Ashley I Bush

Journal article  |  2009  |  Biological Chemistry

Alanine-2 Carbonyl is an Oxygen Ligand in Cu2 Coordination of Alzheimer's Disease Amyloid-beta Peptide - Relevance to N-Terminally Truncated Forms

Simon C Drew, Colin L Masters, Kevin J Barnham

Journal article  |  2009  |  Journal of the American Chemical Society

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

Su Ling Leong, Chi LL Pham, Denise Galatis, Michelle T Fodero-Tavoletti, Keyla Perez, Andrew F Hill, Colin L Masters, Feda E Ali, Kevin J Barnham, Roberto Cappai

Journal article  |  2009  |  Free Radical Biology and Medicine

Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response

Cathryn L Haigh, Simon C Drew, Martin P Boland, Colin L Masters, Kevin J Barnham, Victoria A Lawson, Steven J Collins

Journal article  |  2009  |  Journal of Cell Science

Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of alpha-Synuclein in a pH-Dependent Manner

Chi LL Pham, Su Ling Leong, Feda E Ali, Vijaya B Kenche, Andrew F Hill, Sally L Gras, Kevin J Barnham, Roberto Cappai

Journal article  |  2009  |  Journal of Molecular Biology

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

Peter J Crouch, Deborah J Tew, Tai Du, Diem Ngoc Nguyen, Aphrodite Caragounis, Gulay Filiz, Rachel E Blake, Ian A Trounce, Cynthia PW Soon, Katrina Laughton, Keyla A Perez, Qiao-Xin Li, Robert A Cherny, Colin L Masters, Kevin J Barnham, Anthony R White

Journal article  |  2009  |  Journal of Neurochemistry

Pleomorphic Copper Coordination by Alzheimer's Disease Amyloid-beta Peptide

Simon C Drew, Christopher J Noble, Colin L Masters, Graeme R Hanson, Kevin J Barnham

Journal article  |  2009  |  Journal of the American Chemical Society

Increasing Cu bioavailability inhibits A beta oligomers and tau phosphorylation

Peter J Crouch, Lin Wai Hung, Paul A Adlard, Mikhalina Cortes, Varsha Lal, Gulay Filiz, Keyla A Perez, Milawaty Nurjono, Aphrodite Caragounis, Tai Du, Katrina Laughton, Irene Volitakis, Ashley I Bush, Qiao-Xin Li, Colin L Masters, Roberto Cappai, Robert A Cherny, Paul S Donnelly, Anthony R White, Kevin J Barnham

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide

W Mei Kok, Denis B Scanlon, John A Karas, Luke A Miles, Deborah J Tew, Michael W Parker, Kevin J Barnham, Craig A Hutton

Journal article  |  2009  |  Chemical Communications

Pharmacotherapeutic targets in Alzheimer's disease

Yif'at Biran, Colin L Masters, Kevin J Barnham, Ashley I Bush, Paul A Adlard

Journal article  |  2009  |  Journal of Cellular and Molecular Medicine

Is Covalently Crosslinked A beta Responsible for Synaptotoxicity in Alzheimer's Disease?

R Naylor, AF Hill, KJ Barnham

Journal article  |  2008  |  Current Alzheimer Research

Amyloid-beta Peptide (A beta) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A beta Dimers and Trimers Correlate with Neurotoxicity

Lin Wai Hung, Giuseppe D Ciccotosto, Eleni Giannakis, Deborah J Tew, Keyla Perez, Colin L Masters, Roberto Cappai, John D Wade, Kevin J Barnham

Journal article  |  2008  |  Journal of Neuroscience

Analysis of Abeta interactions using ProteinChip technology.

E Giannakis, LW Hung, KP Camacaro, DP Smith, KJ Barnham, JD Wade

Journal article  |  2008  |  Methods in molecular biology (Clifton, N.J.)

The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease

Victor A Streltsov, Stephen J Titmuss, V Chandana Epa, Kevin J Barnham, Colin L Masters, Joseph N Varghese

Journal article  |  2008  |  Biophysical Journal

Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli

Simon C Drew, Karrera Y Djoko, Lianyi Zhang, Melissa Koay, John F Boas, John R Pilbrow, Zhiguang Xiao, Kevin J Barnham, Anthony G Wedd

Journal article  |  2008  |  Journal of Biological Inorganic Chemistry

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial A beta

Paul A Adlard, Robert A Cherny, David I Finkelstein, Elisabeth Gautier, Elysia Robb, Mikhalina Cortes, Irene Volitakis, Xiang Liu, Jeffrey P Smith, Keyla Perez, Katrina Laughton, Qiao-Xin Li, Susan A Charman, Joseph A Nicolazzo, Simon Wilkins, Karolina Deleva, Toni Lynch, Gaik Kok, Craig W Ritchie, Rudolph E Tanzi, et al.

Journal article  |  2008  |  Neuron

Cu2 binding modes of recombinant alpha-synuclein - Insights from EPR spectroscopy

Simon C Drew, Su Ling Leong, Chi LL Pham, Deborah J Tew, Colin L Masters, Luke A Miles, Roberto Cappai, Kevin J Barnham

Journal article  |  2008  |  Journal of the American Chemical Society

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

Kevin J Barnham, Vijaya B Kenche, Giuseppe D Ciccotosto, David P Smith, Deborah J Tew, Xiang Liu, Keyla Perez, Greg A Cranston, Timothy J Johanssen, Irene Volitakis, Ashley I Bush, Colin L Masters, Anthony R White, Jeffrey P Smith, Robert A Cherny, Roberto Cappai

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the A beta peptides associated with Alzheimer's disease

Kwok S Wun, Luke A Miles, Gabriela AN Crespi, Kaye Wycherley, David B Ascher, Kevin J Barnham, Roberto Cappai, Konrad Beyreuther, Colin L Masters, Michael W Parker, William J McKinstry

Journal article  |  2008  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

Robyn A Sharples, Laura J Vella, Rebecca M Nisbet, Ryan Naylor, Keyla Perez, Kevin J Barnham, Colin L Masters, Andrew F Hill

Journal article  |  2008  |  FASEB Journal

Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide

Deborah J Tew, Stephen P Bottomley, David P Smith, Giuseppe D Ciccotosto, Jeffrey Babon, Mark G Hinds, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2008  |  Biophysical Journal

Metals in Alzheimer's and Parkinson's diseases

Kevin J Barnham, Ashley I Bush

Journal article  |  2008  |  Current Opinion in Chemical Biology

Dimeric structures of alpha-synuclein bind preferentially to lipid membranes

Eleni Giannakis, Jessica Pacifico, David P Smith, Lin Wai Hung, Colin L Masters, Roberto Cappai, John D Wade, Kevin J Barnhain

Journal article  |  2008  |  Biochimica et Biophysica Acta-Biomembranes

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-Cell epitope

Luke A Miles, Kwok S Wun, Gabriela AN Crespi, Michelle T Fodero-Tavoletti, Denise Galatis, Christopher J Bagley, Konrad Beyreuther, Colin L Masters, Roberto Cappai, William J McKinstry, Kevin J Barnham, Michael W Parker

Journal article  |  2008  |  Journal of Molecular Biology

Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible?

Ryan Naylor, Andrew F Hill, Kevin J Barnham

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

Delineating the mechanism of Alzheimer's disease A beta peptide neurotoxicity

Roberto Cappai, Kevin J Barnham

Journal article  |  2008  |  Neurochemical Research

Copper binding to the Alzheimer's disease amyloid precursor protein

Geoffrey K-W Kong, Luke A Miles, Gabriela AN Crespi, Craig J Morton, Hooi Ling Ng, Kevin J Barnham, William J McKinstry, Roberto Cappai, Michael W Parker

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

Selective intracellular release of copper and zinc ions from bis( thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

Paul S Donnelly, Aphrodite Caragounis, Tai Du, Katrina M Laughton, Irene Volitakis, Robert A Cherny, Robyn A Sharples, Andrew F Hill, Qiao-Xin Li, Colin L Masters, Kevin J Barnham, Anthony R White

Journal article  |  2008  |  Journal of Biological Chemistry

Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein

David P Smith, Deborah J Tew, Andrew F Hill, Stephen P Bottomley, Colin L Masters, Kevin J Barnham, Roberto Cappai

Journal article  |  2008  |  Biochemistry

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

Katherine A Price, Gulay Filiz, Aphrodite Caragounis, Tai Du, Katrina M Laughton, Colin L Masters, Robyn A Sharples, Andrew F Hill, Qiao-Xin Li, Paul S Donnelly, Kevin J Barnham, Peter J Crouch, Anthony R White

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Metal delivery agents and therapeutic uses of the same

K BARNHAM, P DONNELLY, A WHITE

Patent  |  2008

Biophysical investigations of the prion protein using electron paramagnetic resonance

SC Drew, KJ Barnham

Journal article  |  2008  |  Methods in Molecular Biology

Analysis of Abeta interactions using ProteinChip technology.

Eleni Giannakis, Lin-Wai Hung, Keyla Perez Camacaro, David P Smith, Kevin J Barnham, John D Wade

Journal article  |  2008  |  Methods in Molecular Biology

Abeta peptides are now acknowledged to play a central role in the pathogenesis of Alzheimer's disease. Their generation results fr..

Preparation of metal complexes for therapeutic uses

K BARNHAM, P DONNELLY, A WHITE

Patent  |  2008

Biophysical investigations of the prion protein using electron paramagnetic resonance.

Simon C Drew, Kevin J Barnham

Book Chapter  |  2008  |  Methods in Molecular Biology

The binding of paramagnetic metal ions is thought to be an essential function of the prion protein and lends itself to interrogati..

Cholesterol and Clioquinol modulation of A beta(1-42) interaction with phospholipid bilayers and metals

Tong-Lay Lau, John D Gehman, John D Wade, Colin L Masters, Kevin J Barnham, Frances Separovic

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

The aβcentric pathway of alzheimer's disease

VL Villemagne, R Cappai, KJ Barnham, RA Cherny, C Opazo, KE Novakovic, CC Rowe, CL Masters

Book Chapter  |  2007

Copper coordination by β-amyloid and the neuropathology of alzheimer's disease

CC Curtain, KJ Barnham

Book Chapter  |  2007

Neurotoxic species in prion disease: a role for PrP isoforms?

Christopher F Harrison, Kevin J Barnham, Andrew F Hill

Journal article  |  2007  |  Journal of Neurochemistry

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands

Aphrodite Caragounis, Tai Du, Gulay Filiz, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Robert A Cherny, Colin L Masters, Simon C Drew, Andrew F Hill, Qiao-Xin Li, Peter J Crouch, Kevin J Barnham, Anthony R White

Journal article  |  2007  |  Biochemical Journal

Membrane interactions and the effect of metal ions of the amyloidogenic fragment A beta(25-35) in comparison to A beta(1-42)

Tong-Lay Lau, John D Gehman, John D Wade, Keyla Perez, Colin L Masters, Kevin J Barnham, Frances Separovic

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies

Michelle T Fodero-Tavoletti, David P Smith, Catriona A McLean, Paul A Adlard, Kevin J Barnham, Lisa E Foster, Laura Leone, Keyla Perez, Mikhalina Cortes, Janetta G Culvenor, Qiao-Xin Li, Katrina M Laughton, Christopher C Rowe, Colin L Masters, Roberto Cappai, Victor L Villemagne

Journal article  |  2007  |  Journal of Neuroscience

The redox chemistry of the Alzheimer's disease amyloid beta peptide

Danielle G Smith, Roberto Cappai, Kevin J Barnham

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

Modulation of Alzheimer's disease amyloid beta peptide turnover by metal ligands

A Caragounis, T Du, G Filiz, KA Price, KM Laughton, CL Masters, AF Hill, Q Li, KJ Barnham, PJ Crouch, AR White

Conference Proceedings  |  2007  |  JOURNAL OF NEUROCHEMISTRY

Molecular determinants of Alzheimer's disease Aβ peptide neurotoxicity

R Cappai, KJ Barnham

Journal article  |  2007  |  Future Neurology

Response to Ji et al: why prion diseases are precluded by non-mammals

Andrew F Hill, Kevin J Barnham

Journal article  |  2007  |  Trends in Biochemical Sciences

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

Geoffrey K-W Kong, Julian J Adams, Hugh H Harris, John F Boas, Cyril C Curtain, Denise Galatis, Colin L Masters, Kevin J Barnham, William J McKinstry, Roberto Cappai, Michael W Parker

Journal article  |  2007  |  Journal of Molecular Biology

Concentration dependent Cu2 induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide

David P Smith, Giuseppe D Ciccotosto, Deborah J Tew, Michelle T Fodero-Tavoletti, Timothy Johanssen, Colin L Masters, Kevin J Barnham, Roberto Cappai

Journal article  |  2007  |  Biochemistry

Amyloid precursor protein

SL LEONG, K BARNHAM, undefined Multhaup, R CAPPAI

Scholarly edition  |  2007

Copper and zinc bis(thiosemicarbazonato) complexes for the treatment of Alzheimer's disease

P DONNELLY, K BARNHAM, A WHITE

Journal article  |  2007  |  Journal of Biological Inorganic Chemistry

La lunga attesa: towards a molecular approach to neuroimaging and therapeutics in Alzheimer's disease.

VL Villemagne, S Ng, R Cappai, KJ Barnham, MT Fodero-Tavoletti, CC Rowe, CL Masters

Journal article  |  2006  |  The Neuroradiology Journal

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by the gradual onset of dementia. The pathologi..

Copper-dependent inhibition of cytochrome c oxidase by A beta(1-42) requires reduced methionine at residue 35 of the A beta peptide

Peter J Crouch, Kevin J Barnham, James A Duce, Rachel E Blake, Colin L Masters, Ian A Trounce

Journal article  |  2006  |  Journal of Neurochemistry

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase (vol 116, pg 2828, 2006)

Luigi Puglielli, Avi L Friedlich, Kenneth DR Setchell, Seiichi Nagano, Carlos Opazo, Robert A Cherny, Kevin J Barnham, John D Wade, Simon Melov, Dora M Kovacs, Ashley I Bush

Journal article  |  2006  |  Journal of Clinical Investigation

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

Peter J Crouch, Kevin J Barnham, Ashley I Bush, Anthony R White

Journal article  |  2006  |  Drug News & Perspectives

Delineating common molecular mechanisms in Alzheimer's and prion diseases

Kevin J Barnham, Roberto Cappai, Konrad Beyreuther, Colin L Masters, Andrew F Hill

Journal article  |  2006  |  Trends in Biochemical Sciences

Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases

AR White, T Du, KM Laughton, I Volitakis, RA Sharples, DE Hoke, RMD Holsinger, G Evin, RA Cherny, AF Hill, KJ Barnham, QX Li, A Bush, CL Masters

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

The role of redox reactions in AP neurotoxicity

KJ Barnham

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

Identification and characterization of disease associated epitopes of mammalian prion proteins

S Han, CC Curtain, KJ Barnham, CL Masters, R Cappai, AF Hill

Conference Proceedings  |  2006  |  JOURNAL OF NEUROCHEMISTRY

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

Anthony R White, Tai Du, Katrina M Laughton, Irene Volitakis, Robyn A Sharples, Michel E Xilinas, David E Hoke, RM Damian Holsinger, Genevieve Evin, Robert A Cherny, Andrew F Hill, Kevin J Barnham, Qiao-Xin Li, Ashley I Bush, Colin L Masters

Journal article  |  2006  |  Journal of Biological Chemistry

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

David P Smith, Danielle G Smith, Cyril C Curtain, John F Boas, John R Pilbrow, Giuseppe D Ciccotosto, Tong-Lay Lau, Deborah J Tew, Keyla Perez, John D Wade, Ashley I Bush, Simon C Drew, Frances Separovic, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2006  |  Journal of Biological Chemistry

Copper and zinc mediated oligomerisation of A beta peptides

Feda E Ali, Frances Separovic, Colin J Barrow, Shenggen Yao, Kevin J Barnham

Journal article  |  2006  |  International Journal of Peptide Research and Therapeutics

Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

Colin L Masters, Roberto Cappai, Kevin J Barnham, Victor L Villemagne

Journal article  |  2006  |  Journal of Neurochemistry

Metal homeostasis in Alzheimer's disease

Anthony R White, Kevin J Barnham, Ashley I Bush

Journal article  |  2006  |  Expert Review of Neurotherapeutics

Metal homeostasis in Alzheimer's disease.

Anthony R White, Kevin J Barnham, Ashley I Bush

Journal article  |  2006  |  Expert Review of Neurotherapeutics

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by neuronal dysfunction and the formation of am..

Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions

TL Lau, EE Ambroggio, DJ Tew, R Cappai, CL Masters, GD Fidelio, KJ Barnham, F Separovic

Journal article  |  2006  |  Journal of Molecular Biology

Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn2 complexes in Alzheimer's disease

C Opazo, S Luza, VL Villemagne, I Volitakis, C Rowe, KJ Barnham, D Strozyk, CL Masters, RA Cherny, AI Bush

Journal article  |  2006  |  Aging Cell

Dimerisation of N-acetyl-L-tyrosine ethyl ester and A beta peptides via formation of dityrosine

FE Ali, A Leung, RA Cherny, C Mavros, KJ Barnham, F Separovic, CJ Barrow

Journal article  |  2006  |  Free Radical Research

Free radicals, metal ions and Abeta aggregation and neurotoxicity

K BARNHAM, A BUSH

Book Chapter  |  2006

Model studies of cholesterol and ascorbate oxidation by copper complexes: Relevance to Alzheimer's disease beta-amyloid metallochemistry

F Haeffner, DG Smith, KJ Barnham, AI Bush

Journal article  |  2005  |  Journal of Inorganic Biochemistry

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase

L Puglielli, AL Friedlich, KDR Setchell, S Nagano, C Opazo, RA Cherny, KJ Barnham, JD Wade, S Melov, DM Kovacs, AI Bush

Journal article  |  2005  |  Journal of Clinical Investigation

Modulation of alpha-synuclein aggregation

R Cappai, S Leck, DJ Tew, NA Williamson, DP Smith, D Galatis, RA Sharples, CC Curtain, FE Ali, RA Cherny, JG Culvenor, SP Bottomley, CL Masters, KJ Barnham, AF Hill

Conference Proceedings  |  2005  |  JOURNAL OF NEUROCHEMISTRY

Dopamine promotes α‐synuclein aggregation into SDS‐resistant soluble oligomers via a distinct folding pathway

Roberto Cappai, Su‐Ling Leck, Deborah J Tew, Nicholas A Williamson, David P Smith, Denise Galatis, Robyn A Sharpies, Cyril C Curtain, Feda' E Ali, Robert A Cherny, Janetta G Culvenor, Stephen P Bottomley, Colin L Masters, Kevin J Barnham, Andrew F Hill

Journal article  |  2005  |  FASEB Journal

Exploring the role of the histidine residues in the Alzheimer's disease Amyloid-beta peptide

DG Smith, GG Ciccotosto, CC Curtain, CL Masters, R Cappai, KJ Barnham

Conference Proceedings  |  2005  |  FEBS JOURNAL

Methionine regulates copper/hydrogen peroxide oxidation products of A beta

FE Ali, F Separovic, CJ Barrow, RA Cherny, F Fraser, AI Bush, CL Masters, KJ Barnham

Journal article  |  2005  |  Journal of Peptide Science

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

R Cappai, SL Leck, DJ Tew, NA Williamson, DP Smith, D Galatis, RA Sharples, CC Curtain, FE Ali, RA Cherny, JG Culvenor, SP Bottomley, CL Masters, KJ Barnham, AF Hill

Journal article  |  2005  |  FASEB Journal

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutaselike structures and inhibition of neurotoxicity

AK Tickler, DG Smith, GD Ciccotosto, DJ Tew, CC Curtain, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, JD Wade, KJ Barnham

Journal article  |  2005  |  Journal of Biological Chemistry

Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: A membrane-disrupting peptide

EE Ambroggio, DH Kim, F Separovic, CJ Barrow, CJ Barrow, KJ Barnham, LA Bagatolli, GD Fidelio

Journal article  |  2005  |  Biophysical Journal

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta(1-42)

PJ Crouch, R Blake, JA Duce, GD Ciccotosto, QX Li, KJ Barnham, CC Curtain, RA Cherny, R Cappai, T Dyrks, CL Masters, IA Trounce

Journal article  |  2005  |  Journal of Neuroscience

Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease

GKW Kong, D Galatis, KJ Barnham, G Polekhina, JJ Adams, CL Masters, R Cappai, MW Parker, WJ McKinstry

Journal article  |  2005  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

GD Ciccotosto, D Tew, CC Curtain, D Smith, D Carrington, CL Masters, AI Bush, RA Cherny, R Cappai, KJ Barnham

Journal article  |  2004  |  Journal of Biological Chemistry

Biological activity and ferric ion binding of fragments of glycine-extended gastrin

H He, BP Shehan, KJ Barnham, RS Norton, A Shulkes, GS Baldwin

Journal article  |  2004  |  Biochemistry

Interaction of the molecular chaperone alpha B-crystallin with alpha-synuclein: Effects on amyloid fibril formation and chaperone activity

A Rekas, CG Adda, JA Aquilina, KJ Barnham, M Sunde, D Galatis, NA Williamson, CL Masters, RF Anders, CV Robinson, R Cappai, JA Carver

Journal article  |  2004  |  Journal of Molecular Biology

Mutagenesis-toxicity studies of the amyloid beta peptide of Alzheimer's disease

GD Ciccotosto, CC Curtain, D Tew, D Carrington, CL Masters, RA Cherny, AI Bush, R Cappai, KJ Barnham

Conference Proceedings  |  2004  |  Neurobiology of Aging

The mechanism by which A beta produces hydrogen peroxide and its role in neurotoxicity

KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, CL Masters, RA Chemy, R Cappai, AI Bush

Conference Proceedings  |  2004  |  Neurobiology of Aging

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

KJ Barnham, F Haeffner, GD Ciccotosto, CC Curtain, D Tew, C Mavros, K Beyreuther, D Carrington, CL Masters, RA Cherny, R Cappai, AI Bush

Journal article  |  2004  |  FASEB Journal

Iron inhibits neurotoxicity induced by trace copper and biological reductants

AR White, KJ Barnham, X Huang, I Voltakis, K Beyreuther, CL Masters, RA Cherny, AI Bush, R Cappai

Journal article  |  2004  |  Journal of Biological Inorganic Chemistry

Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR

SG Yao, RA Cherny, AI Bush, CL Masters, KJ Barnham

Journal article  |  2004  |  Journal of Peptide Science

Neurodegenerative diseases and oxidative stress

KJ Barnham, CL Masters, AI Bush

Journal article  |  2004  |  Nature Reviews Drug Discovery

Redox-mediated A beta neurotoxicity

KJ Barnham, R Cappai, RA Cherny, AI Bush, CL Masters

Conference Proceedings  |  2004  |  JOURNAL OF NEUROCHEMISTRY

A novel effect of bismuth ions - Selective inhibition of the biological activity of glycine-extended gastrin

J Pannequin, S Kovac, JP Tantiongco, RS Norton, A Shulkes, KJ Barnham, GS Baldwin

Journal article  |  2004  |  Journal of Biological Chemistry

Metal-Protein Attenuating Compounds (MPACs) for the Treatment of Alzheimers Disease

Kevin Barnham, Robert Cherny, Roberto Cappai, Simon Melov, Colin Masters, Ashley Bush

Journal article  |  2004  |  Drug Design Reviews Online

Metal catalyzed oxidation of tyrosine residues by different oxidation systems of copper/hydrogen peroxide

FE Ali, KJ Barnham, CJ Barrow, F Separovic

Journal article  |  2004  |  Journal of Inorganic Biochemistry

Method of treatment

GS BALDWIN, KJ BARNHAM, J PANNEQUIN, J TANTIONGCO, AA SHULKES, RS NORTON, S KOVAC, H HE, BP SHEHAN

Patent  |  2004

Metal-catalyzed oxidative damage and oligomerization of the amyloid-peptide of Alzheimer's disease

FEA Ali, KJ Barnham, CJ Barrow, F Separovic

Journal article  |  2004  |  Australian Journal of Chemistry

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

KJ Barnham, GD Ciccotosto, AK Tickler, FE Ali, DG Smith, NA Williamson, YH Lam, D Carrington, D Tew, G Kocak, I Volitakis, F Separovic, CJ Barrow, JD Wade, CL Masters, RA Cherny, CC Curtain, AI Bush, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Cu2 -induced modification of the kinetics of A beta(1-42) channels

R Bahadi, PV Farrelly, BL Kenna, CC Curtain, CL Masters, R Cappai, KJ Barnham, JI Kourie

Journal article  |  2003  |  American Journal of Physiology - Cell Physiology

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain - A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments

JI Kourie, BL Kenna, D Tew, MF Jobling, CC Curtain, CL Masters, KJ Barnham, R Cappai

Journal article  |  2003  |  Journal of Membrane Biology

Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

CC Curtain, FE Ali, DG Smith, AI Bush, CL Masters, KJ Barnham

Journal article  |  2003  |  Journal of Biological Chemistry

Magnetic resonance studies of beta-amyloid peptides

TL Lau, KJ Barnham, CC Curtain, CL Masters, F Separovic

Journal article  |  2003  |  Australian Journal of Chemistry

Methionine oxidation: Implications for the mechanism of toxicity of the beta-amyloid peptide from Alzheimer's disease

GD Ciccotosto, KJ Barnham, RA Cherny, CL Masters, AI Bush, CC Curtain, R Cappai, D Tew

Journal article  |  2003  |  Letters in Peptide Science

Copper catalysed oxidation of amino acids and Alzheimer's disease

FE Ali, KJ Barnham, CJ Barrow, F Separovic

Journal article  |  2003  |  Letters in Peptide Science

Aβ metallobiology and the development of novel metal-compounds (MPACs) for Alzheimer's disease

CC CURTAIN, KJ BARNHAM, AI BUSH

Journal article  |  2003  |  Current Medicinal Chemistry - Immunology, Endocrine and Metabolic Agents

Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.

G EVIN, undefined Sernee, K BARNHAM, undefined Holsinger, J CULVENOR, D HOKE, Q LI, undefined Smith, C MAYNARD, N WILLIAMSON, G CICCOTOSTO, S MOK, I VOLITAKIS, G KOCAK, undefined Carrington, undefined Opazo, AK TICKLER, undefined Huang, undefined Beyreuther, R CAPPAI, et al.

Book Chapter  |  2003

Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin

J Pannequin, KJ Barnham, F Hollande, A Shulkes, RS Norton, GS Baldwin

Journal article  |  2002  |  Journal of Biological Chemistry

Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif

LA Miles, CY Dy, J Nielsen, KJ Barnham, MG Hinds, BM Olivera, G Bulaj, RS Norton

Journal article  |  2002  |  Journal of Biological Chemistry

Factors regulating the interactions between amyloid-beta and membrane lipids

K Barnham, D Smith, D Carrington, G Kocak, I Volitakis, R Cherny, R Cappai, C Masters, A Bush, C Curtain, F Ali, C Barrow, A Tickler, J Wade

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Structure-function of the amyloid precursor protein copper-binding domain

R Cappai, K Barnham, N Williamson, C Masters, W McKinstry, D Galatis, C Curtain, M Parker, G Multhaup, K Beyreuther, A White, M Hinds, R Norton

Journal article  |  2002  |  NEUROBIOLOGY OF AGING

Structure and activity of D-Pro(14) melittin

DR Hewish, KJ Barnham, JA Werkmeister, A Kirkpatrick, N Bartone, ST Liu, RS Norton, C Curtain, DE Rivett

Journal article  |  2002  |  Journal of Protein Chemistry

Antiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein

JJ Gorman, JL Mckimm-Breschkin, RS Norton, KJ Barnham

Journal article  |  2001  |  Journal of Biological Chemistry

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator

G Corzo, P Escoubas, E Villegas, KJ Barnham, WL He, RS Norton, T Nakajima

Journal article  |  2001  |  Biochemical Journal

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126

MF Jobling, XD Huang, LR Stewart, KJ Barnham, C Curtain, I Volitakis, M Perugini, AR White, RA Cherny, CL Masters, CJ Barrow, SJ Collins, AI Bush, R Cappai

Journal article  |  2001  |  Biochemistry

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

CC Curtain, F Ali, I Volitakis, RA Cherny, RS Norton, K Beyreuther, CJ Barrow, CL Masters, AI Bush, KJ Barnham

Journal article  |  2001  |  Journal of Biological Chemistry

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice

RA Cherny, CS Atwood, ME Xilinas, DN Gray, WD Jones, CA McLean, KJ Barnham, I Volitakis, FW Fraser, YS Kim, XD Huang, LE Goldstein, RD Moir, JT Lim, K Beyreuther, H Zheng, RE Tanzi, CL Masters, AI Bush

Journal article  |  2001  |  Neuron

The Val-210-Ile pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrPC

AJ Thompson, KJ Barnham, RS Norton, CJ Barrow

Journal article  |  2001  |  Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology

Chelation and intercalation: Complementary properties in a compound for the treatment of Alzheimer's disease

RA Cherny, KJ Barnham, T Lynch, I Volitakis, QX Li, CA McLean, G Multhaup, K Beyreuher, RE Tanzi, CL Masters, AI Bush

Journal article  |  2000  |  Journal of Structural Biology

Helical structure and self-association in a 13 residue neuropeptide YY2 receptor agonist: relationship to biological activity

KJ Barnham, F Catalfamo, PK Pallaghy, GJ Howlett, RS Norton

Journal article  |  1999  |  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Identification of platination sites on human serum transferrin using (13)C and (15)N NMR spectroscopy.

MC Cox, KJ Barnham, TA Frenkiel, JD Hoeschele, AB Mason, QY He, RC Woodworth, PJ Sadler

Journal article  |  1999  |  JBIC Journal of Biological Inorganic Chemistry

Reactions between various apo and metal-bound forms of human serum transferrin (80 kDa) and the recombinant N-lobe (40 kDa) with [..

[1H,15N] N.M.R. Kinetic studies of reactions of cis- and trans-[PtCl2(15NH3)(c-C6H 1115NH2)] with guanosine 5′-monophosphate

SJ Barton, KJ Barnham, U Frey, A Habtemariam, RE Sue, PJ Sadler

Journal article  |  1999  |  Australian Journal of Chemistry

cis-[PtCl2(15NH3)(c-C6H11NH2)] is an active metabolite of the oral platinum(IV) anticancer drug cis,trans,cis-[PtCl2(CH3CO2)2(NH2)..

Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.

KJ Barnham, AM Torres, D Alewood, PF Alewood, T Domagala, EC Nice, RS Norton

Journal article  |  1998  |  Protein Science

Two synthetic analogues of murine epidermal growth factor, [Abu6, 20] mEGF4-48 (where Abu denotes amino-butyric acid) and [G1, M3,..

Cisplatin binding sites on human albumin.

AI Ivanov, J Christodoulou, JA Parkinson, KJ Barnham, A Tucker, J Woodrow, PJ Sadler

Journal article  |  1998  |  Journal of Biological Chemistry

Reactions of cisplatin (cis-[PtCl2(NH3)2]) with albumin are thought to play an important role in the metabolism of this anticancer..

pKa values of aqua ligands of platinum(II) anticancer complexes: [1H, 15N] and 195Pt NMR studies of cis- and trans-[PtCl2 (NH3)(cyclohexylamine)]

SJ Barton, KJ Barnham, A Habtemariam, RE Sue, PJ Sadler

Journal article  |  1998  |  Inorganica Chimica Acta

Structure of neurotoxin B-IV from the marine worm Cerebratulus lacteus: a helical hairpin cross-linked by disulphide bonding.

KJ Barnham, TR Dyke, WR Kem, RS Norton

Journal article  |  1997  |  Journal of Molecular Biology

B-IV is a 55-residue, crustacean-selective, neurotoxin secreted by Cerebratulus lacteus, a large marine worm found along the north..

Solution structure of a polypeptide from the N terminus of the HIV protein Nef

KJ Barnham, SA Monks, MG Hinds, AA Azad, RS Norton

Journal article  |  1997  |  Biochemistry

Structural transitions of a GG-platinated DNA duplex induced by pH, temperature and box A of high-mobility-group protein 1.

SJ Berners-Price, A Corazza, Z Guo, KJ Barnham, PJ Sadler, Y Ohyama, M Leng, D Locker

Journal article  |  1997  |  European Journal of Biochemistry

[1H, 15N] and 1H NMR, and CD spectroscopy are used to show that the duplex d(A-T-A-C-A-T-Pt 7G-Pt7G-T-A-C-A-T-A).d(T-A-T-G-T-A-C-C..

Kinetic analysis of the stepwise platination of single- and double-stranded GG oligonucleotides with cisplatin and cis-[PtCl(H2O)(NH 3)2]

SJ Berners-Price, KJ Barnham, U Frey, PJ Sadler

Journal article  |  1996  |  Chemistry - A European Journal

Kinetic analysis of the stepwise platination of single- and double- stranded GG oligonucleotides with cisplatin and cis-[PtCl(H2O)(NH3)2]

SJ Berners-Price, KJ Barnham, U Frey, PJ Sadler

Journal article  |  1996  |  Angewandte Chemie - International Edition in English

Ring-Opened Adducts of the Anticancer Drug Carboplatin with Sulfur Amino Acids

KJ Barnham, MI Djuran, PDS Murdoch, JD Ranford, PJ Sadler

Journal article  |  1996  |  Inorganic Chemistry

Stabilization of monofunctional platinum-nucleotide adducts: Reactions of N-acetyl-L-methionine complexes with guanosine 5′-monophosphate and guanylyl(3′-5′)guanosine

KJ Barnham, Z Guo, PJ Sadler

Journal article  |  1996  |  J. Chem. Soc., Dalton Trans.

X-ray crystal structure determination and spectroscopic characterization of trans-diamminedihydroxoplatinum(II) dihydrate

J Arpalahti, R Sillanpää, KJ Barnham, PJ Sadler

Journal article  |  1996  |  Acta Chemica Scandinavica

L-Methionine increases the rate of reaction of 5′-guanosine monophosphate with the anticancer drug cisplatin: Mixed-ligand adducts and reversible methionine binding

KJ Barnham, MI Djuran, P Del Socorro Murdoch, JD Ranford, PJ Sadler

Journal article  |  1995  |  J. Chem. Soc., Dalton Trans.

Reactions of Nitroplatinum Complexes. 2. Reactions of K2[Pt(NO2)4] and Related Complexes with Aqueous Acids (CH3CO2H, HClO4, CF3SO3H, HNO3, and H2S04) : Pathways to Platinum(III) Complexes with Acetate Bridges. Crystal Structure of K2[{Pt(N02)2(µ-CH3CO2)}2]·H2O

TG Appleton, KJ Barnham, KA Byriel, JR Hall, CHL Kennard, MT Mathieson, KG Penman

Journal article  |  1995  |  Inorganic Chemistry

Platination Pathways for Reactions of Cisplatin with GG Single‐Stranded and Double‐Stranded Decanucleotides

KJ Barnham, PJ Sadler, SJ Berners‐Price, TA Frenkiel, U Frey

Journal article  |  1995  |  Angewandte Chemie International Edition in English

Outer-Sphere Macrochelation in [Pd(en)(5′-GMP-N7)2]-9H20 and [Pt(en)(5′-GMP-N7)2] 9H20: X-ray Crystallography and NMR Spectroscopy in Solution

KJ Barnham, CJ Bauer, MI Djuran, MA Mazid, T Rau, PJ Sadler

Journal article  |  1995  |  Inorganic Chemistry

Intermolecular displacement of S-bound L-methionine on platinum(II) by guanosine 5′-monophosphate: Implications for the mechanism of action of anticancer drugs

KJ Barnham, MI Djuran, P Del Socorro Murdoch, PJ Sadler

Journal article  |  1994  |  J. Chem. Soc., Chem. Commun.

[Pd(CBDCA-O,O′)(NH3)2]: The PdII analogue of a platinum anticancer drug (CBDCA=cyclobutane-1,1-dicarboxylate)

KJ Barnham, MI Djuran, U Frey, MA Mazid, PJ Sadler

Journal article  |  1994  |  J. Chem. Soc., Chem. Commun.

[Pt(CBDCA-O)(NH3)2(L-Methionine-S)]: Ring-Opened Adduct of the Anticancer Drug Carboplatin (“Paraplatin”). Detection of a Similar Complex in Urine by NMR Spectroscopy

KJ Bamham, U Frey, P del Socorro Murdoch, JD Ranford, PJ Sadler, DR Newell

Journal article  |  1994  |  Journal of the American Chemical Society

Aspects of the Solution Chemistry of Trans-Diammineplatinum(II) Complexes

TG Appleton, AJ Bailey, KJ Baraham, JR Hall

Journal article  |  1992  |  Inorganic Chemistry

Reactions of Nitroplatinum Complexes. 1. 15N and 195Pt NMR Spectra of Platinum(II) Nitrite Complexes

TG Appleton, KJ Barnham, JR Hall, MT Mathieson

Journal article  |  1991  |  Inorganic Chemistry