Kevin Barnham

Metal delivery agents and therapeutic uses of the same

K BARNHAM, P DONNELLY, A WHITE

Preparation of metal complexes for therapeutic uses

K BARNHAM, P DONNELLY, A WHITE

Method of treatment

GS BALDWIN, KJ BARNHAM, J PANNEQUIN, J TANTIONGCO, AA SHULKES, RS NORTON, S KOVAC, H HE, BP SHEHAN

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism

Leah C Beauchamp, Victor L Villemagne, David Finkelstein, Vincent Dore, Ashley Bush, Kevin J Barnham, Christopher C Rowe

Journal article  |  2020  |  Scientific Reports

Motor deficits in parkinsonism are caused by degeneration of dopaminergic nigral neurons. The success of disease-modifying therapi..

Cu-II(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Adam Southon, Kathryn Szostak, Karla M Acevedo, Krista A Dent, Irene Volitakis, Abdel A Belaidi, Kevin J Barnham, Peter J Crouch, Scott Ayton, Paul S Donnelly, Ashley Bush

Journal article  |  2020  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Diacetyl-bis(4-methyl-3-thiosemicarbazonato)copperII (CuII (atsm)) ameliorates neurodegeneration and delay..

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups

Brett M Paterson, Carleen Cullinane, Peter J Crouch, Anthony R White, Kevin J Barnham, Peter D Roselt, Wayne Noonan, David Binns, Rodney J Hicks, Paul S Donnelly

Journal article  |  2019  |  Inorganic Chemistry

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies

Simon McKenzie-Nickson, Jacky Chan, Keyla Perez, Lin W Hung, Lesley Cheng, Amelia Sedjahtera, Lydia Gunawan, Paul A Adlard, David J Hayne, Lachlan E McInnes, Paul S Donnelly, David Finkelstein, Andrew F Hill, Kevin J Barnham

Journal article  |  2018  |  ACS Chemical Neuroscience

The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours

Ryan J Keenan, Jacky Chan, Paul S Donnelly, Kevin J Barnham, Laura H Jacobson

Journal article  |  2018  |  Neurobiology of Stress

Targeting metals rescues the phenotype in an animal model of tauopathy

Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Lin Wai Hung, Jack Parsons, Nobuyuki Okamura, Victor L Villemagne, Kazuhiko Yanai, Xiang M Liu, Jacky Chan, Ashley I Bush, David I Finkelstein, Kevin J Barnham, Robert A Cherny, Paul A Adlard

Journal article  |  2018  |  Metallomics

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnham

Journal article  |  2018  |  ACTA NEUROPATHOLOGICA COMMUNICATIONS

Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux

Karla M Acevedo, David J Hayne, Lachlan E McInnes, Asif Noor, Clare Duncan, Diane Moujalled, Irene Volitakis, Angela Rigopoulos, Kevin J Barnham, Victor L Villemagne, Anthony R White, Paul S Donnelly

Journal article  |  2018  |  Journal of Medicinal Chemistry

A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study.

Victor L Villemagne, Christopher C Rowe, Kevin J Barnham, Robert Cherny, Michael Woodward, Svetlana Bozinosvski, Olivier Salvado, Pierrick Bourgeat, Keyla Perez, Christopher Fowler, Alan Rembach, Paul Maruff, Craig Ritchie, Rudy Tanzi, Colin L Masters

Journal article  |  2017  |  Alzheimer's and Dementia: Translational Research and Clinical Interventions

Introduction: We are developing a second generation 8-OH quinoline (2-(dimethylamino) methyl-5, 7-dichloro-8-hydroxyquinoline [PBT..

A rigorous method to enrich for exosomes from brain tissue

Laura J Vella, Benjamin J Scicluna, Lesley Cheng, Emma G Bawden, Colin L Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J Barnham, Andrew F Hill

Journal article  |  2017  |  Journal of Extracellular Vesicles