Kevin Barnham

Distribution of isomerized and racemized amyloid β isoforms in sporadic Alzheimer’s disease using ion‐mobility mass spectrometry

Soumya Mukherjee, Keyla Perez, Larissa Cristina Lago, Stephan Klatt, Ian Birchall, Kevin J Barnham, Colin L Masters, Blaine Russell Roberts

Journal article  |  2020  |  Alzheimer's & Dementia

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism

Leah C Beauchamp, Victor L Villemagne, David Finkelstein, Vincent Dore, Ashley Bush, Kevin J Barnham, Christopher C Rowe

Journal article  |  2020  |  SCIENTIFIC REPORTS

Motor deficits in parkinsonism are caused by degeneration of dopaminergic nigral neurons. The success of disease-modifying therapi..

Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E Marioni, Margaret J Wright, Alison M Goate, Edoardo Marcora, Kuan-lin Huang, Tenielle Porter, Simon M Laws, Perminder S Sachdev, Karen A Mather, Nicola J Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yang, Naomi R Wray, Allan F McRae, Peter M Visscher

Journal article  |  2020  |  NATURE COMMUNICATIONS

Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD)...

Reduced Striatal VMAT2 in REM Sleep Behavior Disorder: A Gateway to Preclinical Parkinson's Disease

K Barnham, L Beauchamp, V Villemagne, D Finnkelstein, V Dore, A Bush, C Rowe

Conference Proceedings  |  2020  |  MOVEMENT DISORDERS

Cu-II(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

Adam Southon, Kathryn Szostak, Karla M Acevedo, Krista A Dent, Irene Volitakis, Abdel A Belaidi, Kevin J Barnham, Peter J Crouch, Scott Ayton, Paul S Donnelly, Ashley Bush

Journal article  |  2020  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Diacetyl-bis(4-methyl-3-thiosemicarbazonato)copperII (CuII (atsm)) ameliorates neurodegeneration and delay..

Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles

Lesley Cheng, Laura J Vella, Kevin J Barnham, Catriona McLean, Colin L Masters, Andrew F Hill

Journal article  |  2020  |  JOURNAL OF EXTRACELLULAR VESICLES

Alzheimer's disease is a progressive neurodegenerative disorder, with the strongest disease-associated changes observed at clinica..

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups

Brett M Paterson, Carleen Cullinane, Peter J Crouch, Anthony R White, Kevin J Barnham, Peter D Roselt, Wayne Noonan, David Binns, Rodney J Hicks, Paul S Donnelly

Journal article  |  2019  |  INORGANIC CHEMISTRY

The synthesis of new bis(thiosemicarbazonato)copper(II) complexes featuring polyamine substituents via selective transamination re..

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies

Simon McKenzie-Nickson, Jacky Chan, Keyla Perez, Lin W Hung, Lesley Cheng, Amelia Sedjahtera, Lydia Gunawan, Paul A Adlard, David J Hayne, Lachlan E McInnes, Paul S Donnelly, David Finkelstein, Andrew F Hill, Kevin J Barnham

Journal article  |  2018  |  ACS CHEMICAL NEUROSCIENCE

Alzheimer's disease (AD) is the leading cause of dementia worldwide accounting for around 70% of all cases. There is currently no ..

The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours

Ryan J Keenan, Jacky Chan, Paul S Donnelly, Kevin J Barnham, Laura H Jacobson

Journal article  |  2018  |  NEUROBIOLOGY OF STRESS

Depression is a highly prevalent psychiatric disorder, yet its etiology is not well understood. The validation of animal models is..

Targeting metals rescues the phenotype in an animal model of tauopathy

Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Lin Wai Hung, Jack Parsons, Nobuyuki Okamura, Victor L Villemagne, Kazuhiko Yanai, Xiang M Liu, Jacky Chan, Ashley I Bush, David I Finkelstein, Kevin J Barnham, Robert A Cherny, Paul A Adlard

Journal article  |  2018  |  METALLOMICS

Tauopathies are characterized by the pathological accumulation of the microtubule associated protein tau within the brain. We demo..