Emma Grace Bawden

CRISPitope: A generic platform to model target antigens for adoptive T cell transfer therapy in mouse tumor models.

Maike Effern, Nicole Glodde, Emma Bawden, Jana Liebing, Daniel Hinze, Thomas Tüting, Thomas Gebhardt, Michael Hölzel

Journal article  |  2022  |  STAR Protoc

This protocol details the procedure for CRISPR-assisted insertion of epitopes (CRISPitope), a flexible approach for generating tum..

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas.

Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich

Journal article  |  2020  |  Epigenetics

CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A bette..

Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Maike Effern, Nicole Glodde, Matthias Braun, Jana Liebing, Helena N Boll, Michelle Yong, Emma Bawden, Daniel Hinze, Debby Van den Boorn-Konijnenberg, Mila Daoud, Pia Aymans, Jennifer Landsberg, Mark J Smyth, Lukas Flatz, Thomas Tueting, Tobias Bald, Thomas Gebhardt, Michael Hoelzel

Journal article  |  2020  |  IMMUNITY

Tumor immune escape limits durable responses to T cell therapy. Here, we examined how regulation and function of gene products tha..

Tumor-Necrosis-Factor-Receptor TNFRSF9 (4-1BB) DNA Methylation in a Correlation Analysis with molecular and clinico-pathological properties, Immune Cell Infiltration and Therapeutic Response to Immunotherapy in Melanoma

A Froehlich, S Loick, EG Bawden, S Fietz, J Dietrich, E Diekmann, G Saavedra, H Froehlich, D Niebel, J Sirokay, R Zarbl, GH Gielen, G Kristiansen, F Bootz, J Landsberg, D Dietrich

Conference Proceedings  |  2020  |  JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Treatment Response Monitoring in Patients with Advanced Malignancies Using Cell-Free SHOX2 and SEPT9 DNA Methylation in Blood: An Observational Prospective Study.

Luka de Vos, Maria Jung, Ruth-Miriam Koerber, Emma G Bawden, Tobias AW Holderried, Jörn Dietrich, Friedrich Bootz, Peter Brossart, Glen Kristiansen, Dimo Dietrich

Journal article  |  2020  |  The Journal of Molecular Diagnostics

Patients with incurable cancer usually receive palliative treatment with significant toxicity and limited efficacy. Methylation an..

LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma.

Niklas Klümper, Damian J Ralser, Emma Grace Bawden, Jenny Landsberg, Romina Zarbl, Glen Kristiansen, Marieta Toma, Manuel Ritter, Michael Hölzel, Jörg Ellinger, Dimo Dietrich

Journal article  |  2020  |  J Immunother Cancer

BACKGROUND: Lymphocyte activating 3 (LAG3, LAG-3, CD223) is a promising target for immune checkpoint inhibition in clear cell rena..

Comprehensive analysis of tumor necrosis factor receptor TNFRSF9 (4-1BB) DNA methylation with regard to molecular and clinicopathological features, immune infiltrates, and response prediction to immunotherapy in melanoma.

Anne Fröhlich, Sophia Loick, Emma Grace Bawden, Simon Fietz, Jörn Dietrich, Eric Diekmann, Gonzalo Saavedra, Holger Fröhlich, Dennis Niebel, Judith Sirokay, Romina Zarbl, Gerrit H Gielen, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich

Journal article  |  2020  |  EBioMedicine

BACKGROUND: Immunotherapy, including checkpoint inhibition, has remarkably improved prognosis in advanced melanoma. Despite this s..

Melanoma immunosurveillance by CD4 T cells

Emma Grace Bawden

Thesis / Dissertation  |  2020

The immune system can recognise and control cancer cells in a process termed cancer immunosurveillance. There is increasing eviden..

Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma.

Tobias AW Holderried, Luka de Vos, Emma Grace Bawden, Timo J Vogt, Joern Dietrich, Romina Zarbl, Friedrich Bootz, Glen Kristiansen, Peter Brossart, Jennifer Landsberg, Dimo Dietrich

Journal article  |  2019  |  Clin Epigenetics

BACKGROUND: The T cell immunoglobulin and mucin-domain containing-3 receptor TIM-3 (also known as hepatitis A virus cellular recep..