Frank Vajda

Folic acid dose, valproate, and fetal malformations

Frank JE Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Piero Perucca, Cecilie M Lander, Mervyn J Eadie

Journal article  |  2021  |  EPILEPSY & BEHAVIOR

OBJECTIVE: To determine whether there is a relationship between folic acid dose and the degree of protection against valproate-ass..

Twin pregnancy in women with epilepsy

Frank JE Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Piero Perucca, Cecilie M Lander, Mervyn J Eadie

Journal article  |  2020  |  EPILEPSIA

Objective We report data from the Raoul Wallenberg Australian Register of Antiepileptic Drugs in Pregnancy (APR) to see if there a..

The outcome of altering antiepileptic drug therapy before pregnancy

Frank John Emery Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Cecilie M Lander, Mervyn J Eadie

Journal article  |  2020  |  EPILEPSY & BEHAVIOR

We investigated the outcome of altering antiepileptic drug (AED) therapy in the year before pregnancy on 2233 occasions in Austral..

Antiepileptic drugs and depression during pregnancy in women with epilepsy

Frank JE Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Josephine Mitchell, David Horgan, Cecilie M Lander, Mervyn J Eadie

Journal article  |  2020  |  ACTA NEUROLOGICA SCANDINAVICA

OBJECTIVES: To assess the possibility that the occurrence of seizures or the use of antiepileptic drug (AED) therapy might have in..

A rat model of valproate teratogenicity from chronic oral treatment during pregnancy

Dana Jazayeri, Emma Braine, Stuart McDonald, Sebastian Dworkin, Kim L Powell, Karen Griggs, Frank JE Vajda, Terence J O'Brien, Nigel C Jones

Journal article  |  2020  |  EPILEPSIA

OBJECTIVE: Sodium valproate (VPA), the most effective antiepileptic drug for patients with genetic generalized epilepsy (GGE), is ..

Pregnancy after valproate withdrawal-Fetal malformations and seizure control

Frank JE Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Cecilie M Lander, Mervyn J Eadie

Journal article  |  2020  |  EPILEPSIA

OBJECTIVE: To assess the outcomes in women with epilepsy in relation to fetal malformation and epileptic seizure control during pr..

Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load

Piero Perucca, Alison Anderson, Dana Jazayeri, Alison Hitchcock, Janet Graham, Marian Todaro, Torbjorn Tomson, Dina Battino, Emilio Perucca, Meritxell Martinez Ferri, Anne Rochtus, Lieven Lagae, Maria Paola Canevini, Elena Zambrelli, Ellen Campbell, Bobby PC Koeleman, Ingrid E Scheffer, Samuel F Berkovic, Patrick Kwan, Sanjay M Sisodiya, et al.

Journal article  |  2020  |  ANNALS OF NEUROLOGY

OBJECTIVE: The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED-induced..

Preexisting illness, fetal malformation, and seizure control rates in pregnant women with epilepsy

Frank John Emery Vajda, Terence John O'Brien, Janet Elizabeth Graham, Alison Anne Hitchcock, Cecilie Margaret Lander, Mervyn John Eadie

Journal article  |  2020  |  EPILEPSY & BEHAVIOR

Data from 2182 pregnancies in the Australian Register of antiepileptic drugs in pregnancy that were followed to term, with 1965 fo..

Seizures in infancy in the offspring of women with epilepsy

Frank JE Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Cecilie M Lander, Mervyn J Eadie

Journal article  |  2020  |  ACTA NEUROLOGICA SCANDINAVICA

OBJECTIVES: To assess (a) the incidence of seizures in the first year of life in infants born to mothers with epilepsy and (b) fac..

Valproate under threat

Frank J Vajda

Journal article  |  2019  |  AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY