Lauren Holz

Using Full-Spectrum Flow Cytometry to Phenotype Memory T and NKT Cell Subsets with Optimized Tissue-Specific Preparation Protocols.

Kathryn Farrand, Lauren E Holz, Laura Ferrer-Font, Michael D Wilson, Mitch Ganley, Jordan J Minnell, Ching-Wen Tang, Gavin F Painter, William R Heath, Ian F Hermans, Olivia K Burn

Journal article  |  2022  |  Curr Protoc

Full-spectrum flow cytometry is now routinely used in many laboratories internationally, and the demand for this technology is rap..

The liver contains distinct interconnected networks of CX3CR1( ) macrophages, XCR1( ) type 1 and CD301a( ) type 2 conventional dendritic cells embedded within portal tracts

Kieran English, Sioh Yang Tan, Rain Kwan, Lauren E Holz, Frederic Sierro, Claire McGuffog, Tsuneyasu Kaisho, William R Heath, Kelli PA MacDonald, Geoffrey W McCaughan, David G Bowen, Patrick Bertolino

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Portal tracts are key intrahepatic structures where leukocytes accumulate during immune responses. They contain the blood inflow, ..

Differential location of NKT and MAIT cells within lymphoid tissue

Darryl N Johnson, Zheng Ruan, Emma Petley, Sapna Devi, Lauren E Holz, Adam P Uldrich, Jeffrey YW Mak, Jyh Liang Hor, Scott N Mueller, James McCluskey, David P Fairlie, Phillip K Darcy, Paul A Beavis, William R Heath, Dale Godfrey

Journal article  |  2022  |  SCIENTIFIC REPORTS

Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant α..

6 ''-Modifed alpha-GalCer-peptide conjugate vaccine candidates protect against liver-stage malaria

Michael A Meijlink, Yu Cheng Chua, Susanna TS Chan, Regan J Anderson, Matthew W Rosenberg, Anton Cozijnsen, Vanessa Mollard, Geoffrey McFadden, Sarah L Draper, Lauren E Holz, Ian F Hermans, William R Heath, Gavin F Painter, Benjamin J Compton

Journal article  |  2022  |  RSC CHEMICAL BIOLOGY

Self-adjuvanting vaccines consisting of peptide epitopes conjugated to immune adjuvants are a powerful way of generating antigen-s..

The Batman and Robin of liver-stage immunity to malaria

William R Heath, Lauren E Holz, Daniel Fernandez-Ruiz

Journal article  |  2021  |  TRENDS IN PARASITOLOGY

Malaria parasites replicate within the liver shortly after infection. This stage can be controlled by CD8 T cells, but which subse..

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

Sapna Devi, Yannick O Alexandre, Joon Keit Loi, Ryan Gillis, Nazanin Ghazanfari, Sarah J Creed, Lauren E Holz, David Shackleford, Laura K Mackay, William R Heath, Erica K Sloan, Scott N Mueller

Journal article  |  2021  |  IMMUNITY

The sympathetic nervous system (SNS) controls various physiological functions via the neurotransmitter noradrenaline. Activation o..

Development of Plasmodium-specific liver-resident memory CD8( ) T cells after heat-killed sporozoite immunization in mice

Sonia Ghilas, Matthias H Enders, Rose May, Lauren E Holz, Daniel Fernandez-Ruiz, Anton Cozijnsen, Vanessa Mollard, Ian A Cockburn, Geoffrey McFadden, William R Heath, Lynette Beattie

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Malaria remains a major cause of mortality in the world and an efficient vaccine is the best chance of reducing the disease burden..

Harnessing liver-resident memory T cells for protection against malaria

Daniel Fernandez-Ruiz, Maria N de Menezes, Lauren E Holz, Sonia Ghilas, William R Heath, Lynette Beattie

Journal article  |  2021  |  EXPERT REVIEW OF VACCINES

INTRODUCTION: Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in pe..

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  CELL HOST & MICROBE

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria

Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.

Journal article  |  2020  |  SCIENCE IMMUNOLOGY

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..