Svenja Fritzlar

Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8 T Cells in the Face of Pre-Existing Humoral Immunity.

Ming ZM Zheng, Svenja Fritzlar, Zhongfang Wang, Tiong Kit Tan, Katherine Kedzierska, Alain Townsend, Patrick C Reading, Linda M Wakim

Journal article  |  2022  |  J Immunol

In this study, we investigated how pre-existing Ab immunity to influenza virus established from prior immunizations affects the de..

Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8( ) T Cells in the Face of Pre-Existing Humoral Immunity

Ming ZM Zheng, Svenja Fritzlar, Zhongfang Wang, Tiong Kit Tan, Katherine Kedzierska, Alain Townsend, Patrick C Reading, Linda M Wakim

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

In this study, we investigated how pre-existing Ab immunity to influenza virus established from prior immunizations affects the de..

UL49 is an essential subunit of the viral pre-initiation complex that regulates human cytomegalovirus gene transcription

Declan L Turner, Svenja Fritzlar, Sara Sadeghipour, Adele A Barugahare, Brendan E Russ, Stephen J Turner, Rommel A Mathias

Journal article  |  2022  |  ISCIENCE

More than half the world's population is infected with human cytomegalovirus (HCMV), causing congenital birth defects and impactin..

IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication

Tina Meischel, Svenja Fritzlar, Fernando Villalon-Letelier, Melkamu B Tessema, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

Journal article  |  2021  |  JOURNAL OF VIROLOGY

Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We..

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface expression, is used by many viruses to evade ..

Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2 alpha Axis

Svenja Fritzlar, Turgut E Aktepe, Yi-Wei Chao, Nathan D Kenney, Michael R McAllaster, Craig B Wilen, Peter A White, Jason M Mackenzie

Journal article  |  2019  |  MBIO

The integrated stress response (ISR) is a cellular response system activated upon different types of stresses, including viral inf..

The Microtubule-Associated Innate Immune Sensor GEF-H1 Does Not Influence Mouse Norovirus Replication in Murine Macrophages

Svenja Fritzlar, Peter A White, Jason M Mackenzie

Journal article  |  2019  |  VIRUSES-BASEL

Norovirus is an acute infection of the gastrointestinal tract causing rapid induction of vomiting and diarrhoea. The infection is ..

Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8( ) T Cell Recognition and Activation

Svenja Fritzlar, Sinthujan Jegaskanda, Turgut Esad Aktepe, Julia Emiley Prier, Lauren Elise Holz, Peter A White, Jason M Mackenzie

Journal article  |  2018  |  JOURNAL OF VIROLOGY

Human noroviruses are highly infectious single-stranded RNA (ssRNA) viruses and the major cause of nonbacterial gastroenteritis wo..

Interaction of mouse norovirus (MNV) with the cellular immune response of host cells

Svenja Fritzlar

Thesis / Dissertation  |  2017

Human noroviruses (HuNoV) cause the majority of non-bacterial gastroenteritis cases worldwide and generate an economic burden of 6..

Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response

Soroush T Sarvestani, Ben Cotton, Svenja Fritzlar, Tanya B O'Donnell, Jason M Mackenzie

Journal article  |  2016  |  JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Noroviruses (NoVs) belong to the Caliciviridae family of viruses and are responsible for causing the majority of gastroenteritis o..